PT99961A - Processo para a preparacao de novos analogos de estatona difluorados com accao antiviral - Google Patents
Processo para a preparacao de novos analogos de estatona difluorados com accao antiviralInfo
- Publication number
- PT99961A PT99961A PT99961A PT9996191A PT99961A PT 99961 A PT99961 A PT 99961A PT 99961 A PT99961 A PT 99961A PT 9996191 A PT9996191 A PT 9996191A PT 99961 A PT99961 A PT 99961A
- Authority
- PT
- Portugal
- Prior art keywords
- preparation
- analogs
- estatone
- difluorated
- new
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 1
- PQIOSYKVBBWRRI-UHFFFAOYSA-N methylphosphonyl difluoride Chemical group CP(F)(F)=O PQIOSYKVBBWRRI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP91400005 | 1991-01-02 | ||
| US08/788,098 US5716973A (en) | 1991-01-02 | 1997-01-23 | Anti-viral compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT99961A true PT99961A (pt) | 1993-01-29 |
| PT99961B PT99961B (pt) | 1999-06-30 |
Family
ID=26129945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99961A PT99961B (pt) | 1991-01-02 | 1991-12-31 | Processo para a preparacao de novos analogos de estatona difluorados com accao antiviral |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5716973A (pt) |
| EP (1) | EP0565631B1 (pt) |
| JP (1) | JP3198416B2 (pt) |
| AT (1) | ATE143025T1 (pt) |
| AU (1) | AU649766B2 (pt) |
| CA (1) | CA2098020C (pt) |
| DE (1) | DE69122266T2 (pt) |
| DK (1) | DK0565631T3 (pt) |
| ES (1) | ES2094344T3 (pt) |
| FI (1) | FI106466B (pt) |
| GR (1) | GR3021988T3 (pt) |
| HU (1) | HU210647B (pt) |
| IE (1) | IE75381B1 (pt) |
| IL (1) | IL100477A (pt) |
| NO (1) | NO180334C (pt) |
| NZ (1) | NZ241099A (pt) |
| PT (1) | PT99961B (pt) |
| WO (1) | WO1992012123A1 (pt) |
| ZA (1) | ZA9110141B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07504654A (ja) * | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| US5888992A (en) * | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) * | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| MXPA93002392A (es) | 1992-03-11 | 2005-02-04 | Narhex Ltd | Derivados amino de hidrocarburos-oxo e hidroxi-substituidos. |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| GB9303518D0 (en) * | 1993-02-22 | 1993-04-07 | Merrell Dow Pharma | Combinations of retroviral inhibitors |
| US5939430A (en) * | 1993-02-22 | 1999-08-17 | Merrell Pharmaceuticals Inc. | Combinations of retroviral inhibitors |
| HUT73411A (en) * | 1993-07-08 | 1996-07-29 | Merrell Dow Pharma | Difluoro statone analogs |
| CN1130898A (zh) * | 1993-09-09 | 1996-09-11 | 默里尔药物公司 | 二氟斯特酮抗病毒类似物 |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5977074A (en) * | 1993-10-01 | 1999-11-02 | Merrell Pharmaceuticals, Inc. | Inhibitors of β-amyloid protein production |
| FI963073L (fi) * | 1994-02-04 | 1996-08-02 | Merrell Pharma Inc | Makrosykliset difluorisatonijohdannaiset, jotka ovat käyttökelpoisia viruksia vastustavina aineina |
| JPH10505582A (ja) * | 1994-07-15 | 1998-06-02 | メリル・フアーマシユウテイカルズ・インコーポレイテツド | ジフルオロスタトン抗ウイルス剤 |
| US6114380A (en) * | 1995-12-18 | 2000-09-05 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
| MXPA03011558A (es) | 2001-06-12 | 2004-03-26 | Wellstat Therapeutics Corp | Compuestos para el tratamiento de desordenes metabolicos. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1171103A (en) * | 1966-03-24 | 1969-11-19 | Gas Council | Hydrogenation of Hydrocarbons. |
| US5066643A (en) * | 1985-02-19 | 1991-11-19 | Sandoz Ltd. | Fluorine and chlorine statine or statone containing peptides and method of use |
| CH672792A5 (pt) * | 1985-02-19 | 1989-12-29 | Sandoz Ag | |
| WO1986006379A1 (en) * | 1985-04-19 | 1986-11-06 | The Upjohn Company | Dihalo-statine substituted renin inhibitors |
| GB8619182D0 (en) * | 1986-08-06 | 1986-09-17 | Sandoz Ltd | Peptides & derivatives |
| NZ223148A (en) * | 1987-01-16 | 1989-10-27 | Merrell Dow Pharma | Peptide derivatives having peptidase inhibition activity |
| BE1002213A5 (fr) * | 1987-04-23 | 1990-10-16 | Sandoz Sa | Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments. |
| FR2624513A1 (fr) * | 1987-12-15 | 1989-06-16 | Sandoz Sa | Peptides contenant du silicium, leur preparation et leur utilisation comme medicaments |
| IL90872A0 (en) * | 1988-07-08 | 1990-02-09 | Smithkline Beckman Corp | Retroviral protease binding peptides |
| HUT58764A (en) * | 1988-07-08 | 1992-03-30 | Smithkline Beckman Corp | Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates |
| CA2010531A1 (en) * | 1989-03-06 | 1990-09-06 | Werner Neidhart | Amino acid derivatives |
| US5151438A (en) * | 1989-05-23 | 1992-09-29 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5559140A (en) * | 1991-01-02 | 1996-09-24 | Merrell Pharmaceuticals Inc. | Difluoro statone analogs |
| AU3748393A (en) * | 1992-03-25 | 1993-10-21 | Pfizer Inc. | Antiviral peptides |
| AU667376B2 (en) * | 1992-05-21 | 1996-03-21 | Monsanto Company | Retroviral protease inhibitors |
-
1991
- 1991-12-20 ES ES92904336T patent/ES2094344T3/es not_active Expired - Lifetime
- 1991-12-20 JP JP50439692A patent/JP3198416B2/ja not_active Expired - Lifetime
- 1991-12-20 AT AT92904336T patent/ATE143025T1/de not_active IP Right Cessation
- 1991-12-20 AU AU91790/91A patent/AU649766B2/en not_active Ceased
- 1991-12-20 WO PCT/US1991/009741 patent/WO1992012123A1/en not_active Ceased
- 1991-12-20 EP EP92904336A patent/EP0565631B1/en not_active Expired - Lifetime
- 1991-12-20 NZ NZ241099A patent/NZ241099A/xx unknown
- 1991-12-20 DE DE69122266T patent/DE69122266T2/de not_active Expired - Lifetime
- 1991-12-20 CA CA002098020A patent/CA2098020C/en not_active Expired - Fee Related
- 1991-12-20 HU HU9301918A patent/HU210647B/hu not_active IP Right Cessation
- 1991-12-20 DK DK92904336.2T patent/DK0565631T3/da active
- 1991-12-23 ZA ZA9110141A patent/ZA9110141B/xx unknown
- 1991-12-23 IL IL10047791A patent/IL100477A/en not_active IP Right Cessation
- 1991-12-31 IE IE458091A patent/IE75381B1/en not_active IP Right Cessation
- 1991-12-31 PT PT99961A patent/PT99961B/pt not_active IP Right Cessation
-
1993
- 1993-06-29 FI FI932997A patent/FI106466B/fi active
- 1993-06-29 NO NO932377A patent/NO180334C/no not_active IP Right Cessation
-
1996
- 1996-12-11 GR GR960403424T patent/GR3021988T3/el unknown
-
1997
- 1997-01-23 US US08/788,098 patent/US5716973A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| NO932377D0 (no) | 1993-06-29 |
| FI932997A0 (fi) | 1993-06-29 |
| WO1992012123A1 (en) | 1992-07-23 |
| ATE143025T1 (de) | 1996-10-15 |
| DK0565631T3 (da) | 1996-10-07 |
| HU9301918D0 (en) | 1993-12-28 |
| AU649766B2 (en) | 1994-06-02 |
| IE75381B1 (en) | 1997-09-10 |
| DE69122266D1 (de) | 1996-10-24 |
| AU9179091A (en) | 1992-08-17 |
| ZA9110141B (en) | 1992-10-28 |
| JPH07502255A (ja) | 1995-03-09 |
| GR3021988T3 (en) | 1997-03-31 |
| EP0565631B1 (en) | 1996-09-18 |
| JP3198416B2 (ja) | 2001-08-13 |
| IL100477A (en) | 1996-07-23 |
| ES2094344T3 (es) | 1997-01-16 |
| PT99961B (pt) | 1999-06-30 |
| FI106466B (fi) | 2001-02-15 |
| CA2098020C (en) | 2003-10-21 |
| HUT65739A (en) | 1994-07-28 |
| EP0565631A1 (en) | 1993-10-20 |
| NO932377L (no) | 1993-06-29 |
| NO180334C (no) | 1997-04-02 |
| IE914580A1 (en) | 1992-07-15 |
| US5716973A (en) | 1998-02-10 |
| NO180334B (no) | 1996-12-23 |
| CA2098020A1 (en) | 1992-07-03 |
| NZ241099A (en) | 1994-08-26 |
| FI932997L (fi) | 1993-06-29 |
| DE69122266T2 (de) | 1997-03-27 |
| HU210647B (en) | 1995-06-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19920827 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19990309 |
|
| MM4A | Annulment/lapse due to non-payment of fees, searched and examined patent |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20090909 |