PY0202788A - Inhibidores de la metaloproteinasa de la matriz - Google Patents

Inhibidores de la metaloproteinasa de la matriz

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Publication number
PY0202788A
PY0202788A PY200200202788A PY0202788A PY0202788A PY 0202788 A PY0202788 A PY 0202788A PY 200200202788 A PY200200202788 A PY 200200202788A PY 0202788 A PY0202788 A PY 0202788A PY 0202788 A PY0202788 A PY 0202788A
Authority
PY
Paraguay
Prior art keywords
matrix metalloproteinase
metalloproteinase inhibitors
osteoporosis
atherosclerosis
arthritis
Prior art date
Application number
PY200200202788A
Other languages
English (en)
Inventor
Charles Andrianjara
Daniel Fred Ortwine
Alexander Gregory Pavlovsky
Willian Howard Roark
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of PY0202788A publication Critical patent/PY0202788A/es

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
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    • C07D285/32—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 3
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  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Esta invencion se relaciona con compuestos que inhiben las enzimas de la metaloproteinasa de la matriz y que, por lo tanto, resultan de utilidad en el tratamiento de enfermedades que resultan de la rotura de los tejidos, tales como las enfermedades,cardiacas, esclerosis multiple, artritis, aterosclerosis y osteoporosis.
PY200200202788A 2001-02-14 2002-02-13 Inhibidores de la metaloproteinasa de la matriz PY0202788A (es)

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SV (1) SV2002000874A (es)
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CA2437643A1 (en) 2002-08-22
AR033859A1 (es) 2004-01-07
HN2002000037A (es) 2002-07-09
UY27174A1 (es) 2002-09-30
US20050004126A1 (en) 2005-01-06
PA8539301A1 (es) 2002-09-30
BR0207864A (pt) 2004-03-09
PE20020873A1 (es) 2002-10-26
SV2002000874A (es) 2002-11-29
US20030078276A1 (en) 2003-04-24
MXPA03007250A (es) 2005-07-25
EP1361873A2 (en) 2003-11-19
JP2004529874A (ja) 2004-09-30
AU2002228302A1 (en) 2002-08-28
WO2002064080A2 (en) 2002-08-22
EP1361873A4 (en) 2005-10-26
WO2002064080A3 (en) 2002-12-12

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