RO129526A2 - Anti-vitiligo cream - Google Patents

Abstract

The invention relates to a dermatological cream product for treating vitiligo. According to the invention, the product comprises 0.5...1 parts of chestnut tincture, 2...8 parts of St. John's wort and vitamin E, respectively, 0.2...1 part of marigold tincture and raspberry, respectively, 8...14 parts of coconut oil, 25...33 parts of lanolin, 16...23 parts of paraffin, 2...5 parts of denatured alcohol, 5...14 parts of glyceryl stearate and 0.1...0.3 parts of usual preservative, the parts being expressed by mass.

Description

The invention relates to a dermatological cream product for vitiligo. The product according to the invention consists, in mass parts, of 0,5 ... 1 parts tanning of chestnut, 2 ... 8 parts, respectively, vitamin E, 0,2 ... 1 parts tincture of yellows, respectively, raspberries, 8 ... 14 parts coconut oil, 25 ... 33 parts lanolin, 16 ... 23 parts paraffin, 2 ... 5 parts denatured alcohol, 5 ... 14 parts glycerol stearate, 0.1. .03 parts usual preservative.

Claims: 1

Starting from the date of publication of the patent application, the application provides, provisionally, the applicant, the protection conferred according to the provisions of art. 32 of Law no; 64/1991, except in cases where the patent application has been rejected, withdrawn or considered to be withdrawn, the extent of the protection conferred by the patent application is determined by the claims contained in the application published in accordance with article 23 paragraph. (l) - (3).

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The pot ucD v z a Ϋ / j 2 j ~ 1 «-« CREAM FOR THE ELIMINATION OF VITILIGO

The invention relates to a cream product for the elimination of Vitiiigo, used in the field of cosmetic, natural therapies, for any age.

The product according to the invention has a new and different formula from other similar products existing in the world and in the country.

This invention broadens the range of cosmetics and solves the problem of eliminating Vitiiigo.

Other similar products can be: A) DRULA vitiiigo pigment cream with the composition: active substance a dihydroxyacetone complex (DHA), erythrosis and a brown pigment, in microcapsules, preservative with glutaronitrile and phenoxyethanol, methyldibromide, cauliflower and dihydroxyacetone (DHA) self-tanning, PH value = 5.5; B) Faviderm FVS4-Vitiiigo cream, ingredients: Vaseline, beeswax, green walnut extract, propolis; C) Vitix Gel (anti-vitiligo gel), ingredient: Water, propylene glycol, maltodextrine. Watermelon extract (Cucumis melo), carbomer, acrylates, CI0-30 Alkyl Acrylic Crospolimer, sodium hydroxide, propylene glycol, diazolidinyl urea, methylparaben, propylparaben.

The advantages of the new formula are based on natural active substances existing in the plants of the formula.

The main therapeutic and pharmacodynamic effects are the following: sudorific, anti-inflammatory, healing, eczema, wounds, colds, burns, warts, blows, astringent, vasoconstrictor. fluidization of peripheral blood flow, venous tonic, varicose veins, anti-hemorrhoids, phlebitis, sciatica, antibiotic, sedative, invigorating, remineralizing, wounds, strengthening of hair and hair root, disinfectant, inflammatory processes.

Other benefits of the new product are: no contraindications, no side effects, easy to administer.

The phytotherapeutic product for eliminating Vitiiigo, cream type, consists of: 25-33 lanolin parts; 2-5 parts Alcohol denatured; 16-23 parts Paraffin; 0.5-1.0 parts tincture Castan (Aesculus hippocastanum); 5-14 parts Glyceril stearate; 2-8 parts Stinging oil (Hypericum perforatum); 0.2-1 parts yellowish tincture (Calendula officinalis); 2-8 parts vitamin E (tocopherol); 0.2-1 parts tincture of raspberry (Rubus idaeus); 8-14 parts coconut oil (Cocos nucifera); 0.1-0.3 nipagin parts; the parts are expressed in volume.

An example embodiment of the present invention comprises the following plants: 32 ml. Lanolin; 4 ml. Denatured alcohol; 22 ml. Paraffin; 0.9 ml. Marigold; 7 ml. vitamin E; 1 ml. Chestnut tincture; 13 ml. Glyceryl stearate; 7 ml. Ringing oil; 0.8 ml. Raspberry tincture; 12 ml. Coconut oil, 0.3 ml. Nipagin.

Method of production: Melt Lanolina and Paraffin in a bath of water, stir continuously, then add the soothing oil, vitamin E, coconut oil and glycerol stearate, and under continuous stirring of the bath, while the composition cools, continuously adds the other elements such as: Chestnut tincture, ζν-2 O 1 7. - 9 1 O ap - -

O -12- 2012 tincture of Zmeur, tincture of Yellows, Denatured Alcohol and Nipagin, then water, until cool. After a perfect homogenization, a cream with a soft, yellowish-white color is obtained, and the odor is typical of the plants in the composition.

It is known that disorders of the central nervous system are observed in vitiligo patients. This depigmented spot can appear even under the hair, under the eyebrows or under the eyebrows. Her appearance is not accompanied by any itching or pain. The absence of melanocytes (pigment-containing cells) contributes to hypopigmentation (a low innate or acquired level of melanin synthesis) on well-delimited or symmetrically shaped skin portions, from one to two spots to almost the entire surface of the body. The cause of this disease is not known. One of the theories claims that Vitiligo is a disease of the whole organism, a disease caused by a lot of factors, caused mainly by the disorders that occur in the nutrition of tissues and metabolism. The appearance of white spots on the skin is only a warning, an external signal that announces an internal disturbance. This can be an inherited disorder in the metabolism of the substances: thus, any injury to the fetus and insufficient nutrition during the intrauterine development period; disorders in the activity of the internal secretory glands (thyroid, adrenal gland); insufficient supply of tissues as a result of chronic digestive disorders; the consequence of stress leading to vascular disorders and disorders of the circulation of nutrients and products resulting from metabolism in cells. Very sensitive to ammonia are the cells of the central nervous system, the one that regulates the activity of the whole body and in particular, is responsible for the formation of the pigment that protects our skin. Glutaminic acid acts as an excitatory that the body produces in large quantities to compensate for the poisoning of the central nervous system with ammonia. In order to increase the intoxication, the nervous excitation is accentuated. The patient is very often found to be oppressed, even the most insignificant events can provoke an inappropriate reaction or, on the contrary, a depression.

The product works subcutaneously for a long time.

The treatment considered to be effective, according to preliminary tests, is by applying 3 times a day, in the first week, then twice a week, the depigmented areas.

The control of the raw materials is done on the standardized organoleptic qualities: smell, taste, appearance and color.

The powdered product can be presented as capsules, or powder packed in bottles with threaded plugs.

Arguments for supporting the inventive activity are: the association in the predetermined reports, of the indigenous plants, presents an increased efficiency, resulting from the mutual potentiation of the components, between which there is a synergistic effect, resulting in a cumulative action regarding the effect on the subcutaneous circulatory blood system, but and regeneration, energizing, anti-inflammatory, healing, astringent,

2012-01049-2 0 -12- 2012 vasoconstrictor, fluidizes peripheral blood flow, venous tonic, antivaric, antibiotic, sedative, revigoram, remineralizing, the effect being lasting and without side effects.

Modern medical studies show that the amount of vitamin C that is assimilated into the body plays a crucial role in controlling and improving our ability to protect ourselves against many diseases. Organic acids, such as malic acid, citric acid can raise the acidity level of the gastric juice, but also for the prevention and treatment of hyperlipidemia, lowering the cholesterol content in the blood, even subcutaneously.

Thus, the conscious ones potentiate each other, namely: antioxidants such as vitamin C from: Yellow, Raspberry, Coconut; volatile oil from: Yellows, Rings, Raspberries, Coconuts; saponins from: Yellows, Chestnuts, Sunflowers, flavonoids from: Raspberries, Chestnuts; but also other substances that are contained in the plants mentioned above: carotene, gums, high substances, malic acid, calendulin, vitamin E. esculine, escuioid, fraxin, coumarin, astragaline, quercitin, phylloquinone, escine, valerianic acid, choline, routine, galactose, hyperin, hypericin, tannin, fragrance, sugars, proteins, minerals, saturated hydrocarbons, which demonstrates the complementation and enhancement of the plant qualities of the product claimed in the invention.

Paraffin is known to be a solid, white substance, consisting of a mixture of saturated hydrocarbons, obtained by the distillation of crude oil and used in many fields. Paraffin treatments also have beauty benefits. The paraffin baths soothe and moisturize the skin. This allows moisture to penetrate the skin and thus obtain the most effective hydration. It is recommended for conditions such as: arthritis, eczema, tendonitis, inflammation, muscle spasms, muscle pain, psoriasis, scar tissue, elbows and stiff knees.

It is known that sodium Nipage M has several additional advantages: it is very soluble in cold water, does not need the heating stage for incorporation, thus saving energy and time, increasing the antimicrobial activity at aicalin pH. It is a broad spectrum antimicrobial agent designed to keep a wide range of cosmetics, toiletries and pharmaceuticals. The recommended level of use, to keep most types of products, is normally in the range 0.1 - 0.3%, by total weight, of the finished product. It has many advantages as preservatives, as a broad spectrum antimicrobial activity, compatible with a wide range of cosmetic ingredients, colorless, odorless, acceptable, well documented toxicologically and dermatologically, used in cosmetics, food and pharmaceuticals.

Cosmetics help to disguise vitiligo (camouflage cosmetic), it does not solve the problem, because it is an internal problem, but it helps in keeping the color temporary.

TESTS CARRIED OUT:

Comparison of the claimed product proposed in the invention with respect to product A, product B and C.

Thus, with the help of the radiesthetic measurements we have appeared the following data: for the product claimed in

Cv-1 O 1 2 - O 1 O 4 9 - 2 O -12- 2012 demand appeared 20,300 eu, product A appeared 10,900 eu, product B measured 8,600 eu, and product C measured 10,000 eu (u.e = energy units) ....

This test, however, is well correlated with the test regarding the Kirlian effect, in which the three products were also tested, obtaining the following results: the length of the strimers measured for the claimed product were 4.1-4.5 mm, and for product A it is 2.5-2.9 mm, the product in document B is 1.2-1.5 mm, and the product in document C is 2.4-2.7 mm.

The conclusion is that the claimed product has an energy capacity between 41-375% higher than the products in documents A, B and C, so compared to product A with 55-90%, compared to product B with 250375%, and compared to product C with 66-100%, and in conjunction with the previous test it can be observed that the therapeutic effect of the claimed product is synergistic and complex, with strong regeneration, energizing, anti-inflammatory, healing, astringent, vasoconstrictor, blood fluidizing, venous tonic, sedative, invigorating effect. , remineralizing, disinfecting, compared to the products in the documents presented.

METHOD Between January 2011 - December 2012, 30 patients aged 20 to 50 years were clinically monitored and followed at the phytotherapeutic consultancy.

Patients presented to the office with functional disorders in the dermatological sphere: depigmentation of the skin, the appearance of fine or pronounced wrinkles, aging of the skin.

Patients were presented to the clinic with complete medical documentation (paraclinical investigations), as well as the allopathic therapeutic schemes up to that date. Following the presentation of the patients to the practice and following the corroboration of the anamnestic, clinical and paraclinical data, the adjuvant treatment with this product was instituted.

Following the administration of the individual treatment schemes (because the acute conditions presented by each patient were taken into account), which involved the accompanying product with other dietary supplements recommended for the respective associated acute diseases, most of the patients have updated their clinical investigations and paraclinical, so that the clinical observations and laboratory data found before and after the adjuvant treatment could be compared with the product studied. Patients were presented to the clinic with complete medical documentation (paraclinical investigations), as well as the allopathic therapeutic schemes up to that date. All patients followed the proposed allopathic therapies, supplementing them with the product claimed. All have requested and accepted their completion with a cosmetic treatment corresponding to their condition.

The monitoring period was 120 days, patients presenting to the control every 1-5-30 days,

a. TREATMENT

The composition was applied to 15 patients who showed signs of different degrees of skin depigmentation, 2-3 times daily, in the form of local applications, with circular massage, for a period of 3-4 months.

> 2 Ο 1 2 Ο 1 Ο 49 - 2 Ο -12 '2012

At the end of the administration period, the appearance of the skin was improved, with the depigmented appearance blurred.

They applied the cream (after washing the face with a cleaning lotion), depending on the case and the intensity of the symptoms. The product was very well tolerated and no adverse reactions were reported. The results after 3 months of treatment were favorable.

b. CLINICAL TESTS

CLINICAL TESTS: An evaluation of the therapeutic efficacy of the claimed product according to the invention has been performed as an adjuvant in the treatment of various disorders associated with diseases.

METHOD: Between January 2012 and November 2012, 16 patients aged between 22 and 55 years were clinically monitored and monitored at the phytotherapeutic consultancy.

c. RESULTS:

TREATMENT on moisturizing and re-moisturizing the skin on approximately 15% of the skin surface. The product was applied to 6 people with spots on the palms, face and chest. The application of the cream was done 2-3 times a day. The results after 2 weeks of treatment were favorable. The spots on the body and hands disappear after 3 weeks, and the ones on the face after 2 weeks. The body's response to treatment was favorable. The product works subcutaneously for a long time. The product was well tolerated.

TREATMENT of removing discolored stains on about 10% of the skin surface. The cream was applied, for 4 weeks, on the stained places, to 6 persons with whitish skin, with spots on the palms and face. The application of the cream was done 2-3 times a day. After only 2 weeks the coloration began to change to pink, which demonstrates the beneficial action on the skin tissues. The stains on the body disappeared after 4 weeks, and those on the face after 3 weeks. No skin adverse reactions were reported.

TREATMENT on vasodilation and elimination of depigmentation on approximately 30% of the skin surface, was observed in 3 other people, with whitish-colored skin, with white spots on the palms, face, chest and thighs. It was observed that the newest spots, being on the chest, began to color the first, change to pink, and return to the normal color the first, the time being 2 weeks. The following spots began to recur, the ones on the face, about 3 weeks ago. The most difficult were the patches on the palms and thighs, which responded to the treatment in 4 months, probably due to the fact that they are in the area of externalities, where the irrigation is made weaker. After only 2 weeks the coloration began to change to pink, which demonstrates the beneficial action on the subcutaneous nerve endings and on the peripheral circulatory system.

CONCUUZ11

The results obtained in this group of patients prove that using the product to treat dermatological aspects related to the skin in young and relatively young people has many benefits.

Ο 1 2 - Ο 1 Ο 4 9 - - ² Ο -12- 2012

The properties of the product are due to the active principles of the composition, which act synergistically, having the aforementioned effects.

These observations can be considered relevant for the inclusion of the product as an adjuvant treatment for a wide range of disorders, from the dermatological field, regarding the Vitiligo type depigmentation phenomenon.

Therefore the claimed invention, taken as a whole, with respect to the state of the art, closest to the products in the documents mentioned in the patent application, to the products A, B and C, depending on the technical problem that it solves, results that it is not obvious to a skilled person, because it would observe only the difference in content and not the product qualities obtained by enhancing the substances contained in the plants of the formula.

These observations may be considered relevant to the inclusion of the product as an adjuvant treatment to eliminate the condition called Vitiligo.

Claims (1)

Claim The herbal product intended for the elimination of Vitiligo, herbal, in powder form, is characterized in that it consists of: 25-33 parts Lanolin; 2-5 parts Alcohol denatured; 16-23 parts Paraffin; 0.5-1.0 parts tincture Castan (Aesculus hippocastanum); 5-14 parts Glyceril stearate; 2-8 parts Stinging oil (Hypericum perforatum); 0.2-1 parts yellow tincture (Calendula officinalis): 2-8 parts vitamin E (tocopherol); 0.2-1 parts tincture of raspberry (Rubus idaeus); 8-14 parts coconut oil (Cocos nucifera); 0.1-0.3 nipagin parts; the parts are expressed in volume.