RO72475A - Procede d'obtention des derives de pyrimidine a activite pharmacologique - Google Patents

Procede d'obtention des derives de pyrimidine a activite pharmacologique

Info

Publication number
RO72475A
RO72475A RO7688851A RO8885176A RO72475A RO 72475 A RO72475 A RO 72475A RO 7688851 A RO7688851 A RO 7688851A RO 8885176 A RO8885176 A RO 8885176A RO 72475 A RO72475 A RO 72475A
Authority
RO
Romania
Prior art keywords
pirimidine
pharmacological activity
obtaining derivatives
derivatives
obtaining
Prior art date
Application number
RO7688851A
Other languages
English (en)
Romanian (ro)
Inventor
Thomas H Brown
Charon R Ganellin
Graham J Durant
Original Assignee
Smith Kline & French Laboratories Ltd,Gb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline & French Laboratories Ltd,Gb filed Critical Smith Kline & French Laboratories Ltd,Gb
Publication of RO72475A publication Critical patent/RO72475A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
RO7688851A 1975-12-29 1976-12-27 Procede d'obtention des derives de pyrimidine a activite pharmacologique RO72475A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5300175 1975-12-29

Publications (1)

Publication Number Publication Date
RO72475A true RO72475A (fr) 1982-10-26

Family

ID=10466233

Family Applications (1)

Application Number Title Priority Date Filing Date
RO7688851A RO72475A (fr) 1975-12-29 1976-12-27 Procede d'obtention des derives de pyrimidine a activite pharmacologique

Country Status (37)

Country Link
JP (1) JPS5283388A (fr)
AR (1) AR222290A1 (fr)
AT (1) AT360024B (fr)
AU (1) AU508123B2 (fr)
BE (1) BE849810A (fr)
BG (1) BG29722A3 (fr)
CA (1) CA1073458A (fr)
CH (1) CH631981A5 (fr)
CS (1) CS203995B2 (fr)
DD (1) DD128588A5 (fr)
DE (1) DE2658267A1 (fr)
DK (1) DK587076A (fr)
EG (1) EG12439A (fr)
ES (1) ES454656A1 (fr)
FI (1) FI62668C (fr)
FR (1) FR2336935A1 (fr)
GR (1) GR62441B (fr)
HU (1) HU175171B (fr)
IE (1) IE45082B1 (fr)
IL (1) IL51040A (fr)
IT (2) IT1124740B (fr)
LU (1) LU76481A1 (fr)
MW (1) MW5076A1 (fr)
MX (1) MX5119E (fr)
NL (1) NL7614538A (fr)
NO (1) NO146396C (fr)
NZ (1) NZ182759A (fr)
OA (1) OA05526A (fr)
PH (1) PH14723A (fr)
PL (1) PL104376B1 (fr)
PT (1) PT65949B (fr)
RO (1) RO72475A (fr)
SE (1) SE431544B (fr)
SU (1) SU791235A3 (fr)
YU (1) YU311676A (fr)
ZA (1) ZA767198B (fr)
ZM (1) ZM14376A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ186511A (en) 1977-03-19 1980-11-14 Smith Kline French Lab 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones
IL56265A (en) * 1977-12-28 1982-08-31 Om Lab Sa Process for preparing imidazolyl methylthio guanidine derivatives and a novel intermediate therefor
US4539207A (en) * 1978-02-13 1985-09-03 Smith Kline & French Laboratories Limited Pyrimidine compounds
IN151188B (fr) * 1978-02-13 1983-03-05 Smith Kline French Lab
IL57005A (en) * 1978-04-11 1983-11-30 Smith Kline French Lab Process for the preparation of 2-amino pyrimid-4-one derivatives and novel 2-nitroaminopyrimid-4-ones as intermediates therefor
ZA792607B (en) * 1978-05-30 1980-07-30 Smith Kline French Lab Nitro compounds
ZA793392B (en) * 1978-07-15 1980-08-27 Smith Kline French Lab Isoureas and isothioureas
US4374836A (en) 1978-10-16 1983-02-22 Imperial Chemical Industries Ltd. Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them
US4309435A (en) 1978-10-16 1982-01-05 Imperial Chemical Industries Ltd. Antisecretory guanidine derivatives and pharmaceutical compositions containing them
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
US4255428A (en) 1979-03-24 1981-03-10 Smith Kline & French Laboratories Limited 5-(Hydroxypyridylalkyl)-4-pyrimidones
JPS55133379A (en) * 1979-04-05 1980-10-17 Smith Kline French Lab Pyrimidone compound
DE2962542D1 (en) * 1979-04-11 1982-06-03 Smith Kline French Lab Pyrimidone derivatives, process for preparing them and pharmaceutical compositions containing them
JPS55145683A (en) * 1979-04-26 1980-11-13 Smith Kline French Lab Pyrimidone derivative
CA1155842A (fr) * 1980-03-29 1983-10-25 Thomas H. Brown Composes
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
PT75074B (en) * 1981-06-27 1986-02-26 Smith Kline French Lab Process for preparing certain pyrimidone derivatives and compositions containing them
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) * 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
IN146736B (fr) * 1975-10-02 1979-08-25 Smith Kline French Lab

Also Published As

Publication number Publication date
YU311676A (en) 1983-01-21
FI62668C (fi) 1983-02-10
HU175171B (hu) 1980-05-28
FR2336935B1 (fr) 1980-03-21
MW5076A1 (en) 1978-02-08
IL51040A (en) 1980-12-31
GR62441B (en) 1979-04-12
IT1124740B (it) 1986-05-14
DD128588A5 (de) 1977-11-30
IL51040A0 (en) 1977-02-28
AU2097676A (en) 1978-07-06
CS203995B2 (en) 1981-03-31
IE45082L (en) 1977-06-29
OA05526A (fr) 1981-04-30
CA1073458A (fr) 1980-03-11
LU76481A1 (fr) 1977-06-15
AT360024B (de) 1980-12-10
ES454656A1 (es) 1977-11-16
NL7614538A (nl) 1977-07-01
JPS6129355B2 (fr) 1986-07-05
ZA767198B (en) 1977-11-30
IT7919107A0 (it) 1979-01-05
AU508123B2 (en) 1980-03-13
PT65949B (pt) 1978-06-15
SE431544B (sv) 1984-02-13
AR222290A1 (es) 1981-05-15
DE2658267A1 (de) 1977-07-07
NO146396C (no) 1982-09-22
FR2336935A1 (fr) 1977-07-29
NO764370L (fr) 1977-06-30
ATA960876A (de) 1980-05-15
SU791235A3 (ru) 1980-12-23
PL104376B1 (pl) 1979-08-31
PT65949A (pt) 1977-01-01
BE849810A (fr) 1977-06-23
MX5119E (es) 1983-03-24
IE45082B1 (en) 1982-06-16
SE7614620L (sv) 1977-06-30
ZM14376A1 (en) 1977-08-22
PH14723A (en) 1981-11-13
FI763664A7 (fr) 1977-06-30
EG12439A (en) 1979-09-30
DK587076A (da) 1977-06-30
CH631981A5 (en) 1982-09-15
JPS5283388A (en) 1977-07-12
BG29722A3 (bg) 1981-01-15
NO146396B (no) 1982-06-14
NZ182759A (en) 1978-06-02
FI62668B (fi) 1982-10-29

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