RO75099A - Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina - Google Patents

Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina

Info

Publication number: RO75099A
Authority: RO; Romania
Prior art keywords: stability; procedure; preparation; antibiotic; tetracycline
Prior art date: 1977-04-27

Application number

RO7893756A

Other languages

English (en)

French (fr)

Inventor

William W Armstrong

Original Assignee

Pfizer Inc,Us

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-27

Filing date

1978-04-08

Publication date

1980-12-30

1978-04-08 Application filed by Pfizer Inc,Us filed Critical Pfizer Inc,Us

1980-12-30 Publication of RO75099A publication Critical patent/RO75099A/ro

Links

239000004098 Tetracycline Substances 0.000 title 1
230000003115 biocidal effect Effects 0.000 title 1
229960002180 tetracycline Drugs 0.000 title 1
229930101283 tetracycline Natural products 0.000 title 1
235000019364 tetracycline Nutrition 0.000 title 1
150000003522 tetracyclines Chemical class 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Hydrogenated Pyridines (AREA)

RO7893756A 1977-04-27 1978-04-08 Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina RO75099A (ro)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/791,627 US4126680A (en)	1977-04-27	1977-04-27	Tetracycline antibiotic compositions

Publications (1)

Publication Number	Publication Date
RO75099A true RO75099A (ro)	1980-12-30

Family

ID=25154289

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RO78102215A RO77953A (ro)	1977-04-27	1978-04-08	Procedeu de preparare a unor compozitii stabile continin clortetraciclina
RO7893756A RO75099A (ro)	1977-04-27	1978-04-08	Procedeu de preparare a unor compozitii stabile de antibiotice continind tetraciclina

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
RO78102215A RO77953A (ro)	1977-04-27	1978-04-08	Procedeu de preparare a unor compozitii stabile continin clortetraciclina

Country Status (38)

Country	Link
US (1)	US4126680A (ro)
JP (1)	JPS53136514A (ro)
AR (1)	AR217844A1 (ro)
AT (1)	AT360148B (ro)
AU (1)	AU503139B1 (ro)
BE (1)	BE866419A (ro)
BG (1)	BG47943A3 (ro)
CA (1)	CA1100875A (ro)
CH (1)	CH630260A5 (ro)
CS (1)	CS199527B2 (ro)
DD (1)	DD135445A5 (ro)
DE (1)	DE2817335C3 (ro)
DK (1)	DK155977C (ro)
EG (1)	EG14348A (ro)
ES (1)	ES468749A1 (ro)
FI (3)	FI801196A7 (ro)
FR (1)	FR2388561A1 (ro)
GB (1)	GB1563478A (ro)
GR (1)	GR70062B (ro)
HU (1)	HU179050B (ro)
IE (1)	IE47049B1 (ro)
IL (1)	IL54581A0 (ro)
IN (1)	IN148197B (ro)
IT (1)	IT1094557B (ro)
LU (1)	LU79547A1 (ro)
MX (1)	MX6087E (ro)
NL (1)	NL7804455A (ro)
NO (1)	NO148280C (ro)
NZ (1)	NZ187046A (ro)
OA (1)	OA05949A (ro)
PH (1)	PH12962A (ro)
PL (1)	PL110459B1 (ro)
PT (1)	PT67895B (ro)
RO (2)	RO77953A (ro)
SE (1)	SE443507B (ro)
YU (1)	YU87178A (ro)
ZA (1)	ZA782400B (ro)
ZM (1)	ZM3878A1 (ro)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
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US4386083A (en) *	1980-04-10	1983-05-31	Walter Hacke	Injectable oxytetracycline compositions
US4399127A (en) *	1980-04-10	1983-08-16	Diamond Shamrock Corporation	Injectable oxytetracycline compositions
US4806529A (en) *	1982-11-18	1989-02-21	Trustees Of Tufts College, Tufts University	Tetracycline activity enhancement
US5589470A (en) *	1990-02-26	1996-12-31	Trustees Of Tufts College	Reducing tetracycline resistance in living cells
US5064821A (en) *	1982-11-18	1991-11-12	Trustees Of Tufts College	Method and compositions for overcoming tetracycline resistance within living cells
US4769232A (en) *	1984-03-22	1988-09-06	Pfizer Inc.	Parenteral formulations of indolmycin
US6756365B2 (en)	1991-11-06	2004-06-29	Trustees Of Tufts College	Reducing tetracycline resistance in living cells
EP0621033A1 (en) *	1993-04-20	1994-10-26	Nostras S.A.	Antibiotic composition containing oxytetracycline and glycofurol
US8106225B2 (en) *	1999-09-14	2012-01-31	Trustees Of Tufts College	Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6500812B2 (en)	1999-09-14	2002-12-31	Paratek Pharmaceuticals, Inc.	13-substituted methacycline compounds
PT1240133E (pt)	1999-09-14	2006-07-31	Tufts College	Processos para preparar tetraciclinas substituidas com quimicas baseadas em metais de transicao
US6849615B2 (en)	1999-09-14	2005-02-01	Paratek Pharmaceuticals, Inc.	13-substituted methacycline compounds
CA2397863A1 (en)	2000-01-24	2001-07-26	Trustees Of Tufts College	Tetracycline compounds for treatment of cryptosporidium parvum related disorders
WO2001074761A1 (en) *	2000-03-31	2001-10-11	Trustees Of Tufts College	7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
US6642270B2 (en)	2000-05-15	2003-11-04	Paratek Pharmaceuticals, Inc.	7-substituted fused ring tetracycline compounds
US20040224927A1 (en) *	2000-06-16	2004-11-11	Trustees Of Tufts College	7-N-substituted phenyl tetracycline compounds
WO2001098236A2 (en)	2000-06-16	2001-12-27	Trustees Of Tufts College	7-phenyl-substituted tetracycline compounds
US20020132798A1 (en) *	2000-06-16	2002-09-19	Nelson Mark L.	7-phenyl-substituted tetracycline compounds
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IL153672A0 (en) *	2000-07-07	2003-07-06	Tufts College	7-substituted tetracycline compounds
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SI1301467T1 (sl)	2000-07-07	2007-02-28	Tufts College	9-substituirane minociklinske spojine
ATE504562T1 (de)	2000-07-07	2011-04-15	Tufts College	7-, 8- und 9-substitutierte tetracyclinverbindungen
US7553828B2 (en)	2001-03-13	2009-06-30	Paratek Pharmaceuticals, Inc.	9-aminomethyl substituted minocycline compounds
AU2002250331A1 (en)	2001-03-13	2002-09-24	Paratek Pharmaceuticals, Inc.	7-pyrollyl tetracycline compounds and methods of use thereof
EP1368305B1 (en)	2001-03-13	2008-08-13	Paratek Pharmaceuticals, Inc.	7, 9-substituted tetracycline compounds
WO2002072031A2 (en)	2001-03-14	2002-09-19	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds as synergistic antifungal agents
CA2457234A1 (en)	2001-03-14	2002-09-19	Mark L. Nelson	Substituted tetracycline compounds as antifungal agents
DE60235083D1 (de)	2001-04-24	2010-03-04	Paratek Pharm Innc	Substituierte tetracyclin-verbindungen zur behandlung von malaria
US8088820B2 (en) *	2001-04-24	2012-01-03	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
ES2551708T3 (es)	2002-01-08	2015-11-23	Paratek Pharmaceuticals, Inc.	Compuestos de 4-desdimetilamino tetraciclina
EP1482926A4 (en)	2002-03-08	2006-04-12	Paratek Pharm Innc	AMINO METHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
WO2003079984A2 (en)	2002-03-21	2003-10-02	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds
EA200900540A1 (ru)	2002-07-12	2009-12-30	Пэрэтек Фамэсьютикэлс, Инк.	Замещённые соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
AU2003287218C1 (en)	2002-10-24	2010-07-15	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for the treatment of malaria
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WO2006084265A1 (en)	2005-02-04	2006-08-10	Paratek Pharmaceuticals, Inc.	11a, 12-DERIVATIVES OF TETRACYCLINE COMPOUNDS
US7919483B2 (en) *	2005-06-24	2011-04-05	Medicis Pharmaceutical Corporation	Method for the treatment of acne
US8722650B1 (en)	2005-06-24	2014-05-13	Medicis Pharmaceutical Corporation	Extended-release minocycline dosage forms
US7541347B2 (en) *	2007-04-02	2009-06-02	Medicis Pharmaceutical Coropration	Minocycline oral dosage forms for the treatment of acne
US20080241235A1 (en) *	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US7544373B2 (en) *	2007-04-02	2009-06-09	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US8252776B2 (en)	2007-04-02	2012-08-28	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US20080242642A1 (en) *	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en)	2008-08-06	2015-11-24	Medicis Pharmaceutical Corporation	Method for the treatment of acne and certain dosage forms thereof
US9078811B2 (en) *	2006-01-24	2015-07-14	Paratek Pharmaceuticals, Inc.	Methods of increasing oral bioavailability of tetracyclines
CN101489987A (zh) *	2006-04-17	2009-07-22	特瓦制药工业有限公司	四环素衍生物的分离
US8198470B2 (en) *	2006-04-24	2012-06-12	Teva Pharmaceutical Industries Ltd.	Crystalline form II of tigecycline and processes for preparation thereof
DK2016045T3 (en) *	2006-04-24	2015-02-02	Teva Pharma	TIGECYCLIN CRYSTAL FORM AND PROCEDURES FOR PREPARING IT
CA2652347A1 (en) *	2006-05-15	2007-11-22	Paratek Pharmaceuticals, Inc.	Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
ES2315123B1 (es) *	2006-09-25	2009-12-30	Divasa-Farmavic, S.A.	Composiciones farmaceuticas estables de tetraciclinas en solucion, procedimiento para su obtencion y sus usos.
US8440646B1 (en)	2006-10-11	2013-05-14	Paratek Pharmaceuticals, Inc.	Substituted tetracycline compounds for treatment of Bacillus anthracis infections
EP2450347B1 (en)	2006-12-21	2015-06-24	Paratek Pharmaceuticals, Inc.	Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections
PT2120963T (pt)	2006-12-21	2018-12-17	Paratek Pharm Innc	Compostos tetraciclina substituídos para tratamento de distúrbios inflamatórios da pele
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US20080241197A1 (en) *	2007-04-02	2008-10-02	Medicis Pharmaceutical Corporation	Minocycline dosage forms for the treatment of acne
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Family Cites Families (9)

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Publication number	Priority date	Publication date	Assignee	Title
US1913323A (en) *	1931-02-28	1933-06-06	Hoffmann La Roche	Stable concentrated solution for therapeutic purposes
DE647766C (de) *	1931-03-01	1937-07-12	Hoffmanni La Roche & Co Akt Ge	Verfahren zur Darstellung haltbarer, konzentrierter, waessriger Loesungen der Cinchonaalkaloide
GB381012A (en) *	1931-12-04	1932-09-29	Andrew Home Morton	Process for the manufacture of stable concentrated solutions for therapeutic use
DE662812C (de) *	1931-12-08	1938-07-22	Hoffmanni La Roche & Co Akt Ge	Verfahren zur Herstellung haltbarer, waessriger Arzneimittelloesungen
DE673500C (de) *	1933-01-15	1939-03-23	Hoffmann La Roche & Co Akt Ges	Verfahren zur Herstellung von haltbaren Loesungen schwer loeslicher Arzneimittel
GB1019164A (en) *	1963-01-30	1966-02-02	Chugai Pharmaceutical Co Ltd	Hemostatic preparation for injection and process for the production thereof
DK129969B (da) *	1973-01-11	1974-12-09	Rosco Ak	Fremgangsmåde til fremstilling af en klar, stabil, i det væsentlige vandig opløsning af oxytetracyclin.
GB1508601A (en) *	1974-01-19	1978-04-26	Norbrook Labor Ltd	Oxytetracycline solution
US4018889A (en) *	1976-01-02	1977-04-19	Pfizer Inc.	Oxytetracycline compositions

1977
- 1977-04-27 US US05/791,627 patent/US4126680A/en not_active Expired - Lifetime
1978
- 1978-02-16 SE SE7801816A patent/SE443507B/sv not_active IP Right Cessation
- 1978-03-30 IN IN234/DEL/78A patent/IN148197B/en unknown
- 1978-04-03 PH PH20970A patent/PH12962A/en unknown
- 1978-04-07 DD DD78204656A patent/DD135445A5/xx unknown
- 1978-04-07 MX MX787004U patent/MX6087E/es unknown
- 1978-04-08 RO RO78102215A patent/RO77953A/ro unknown
- 1978-04-08 RO RO7893756A patent/RO75099A/ro unknown
- 1978-04-11 ZM ZM38/78A patent/ZM3878A1/xx unknown
- 1978-04-12 PT PT67895A patent/PT67895B/pt unknown
- 1978-04-12 YU YU00871/78A patent/YU87178A/xx unknown
- 1978-04-13 ES ES468749A patent/ES468749A1/es not_active Expired
- 1978-04-13 PL PL1978206050A patent/PL110459B1/pl unknown
- 1978-04-13 HU HU78PI616A patent/HU179050B/hu not_active IP Right Cessation
- 1978-04-14 BG BG039431A patent/BG47943A3/xx unknown
- 1978-04-14 CS CS782444A patent/CS199527B2/cs unknown
- 1978-04-14 AR AR271783A patent/AR217844A1/es active
- 1978-04-15 EG EG256/78A patent/EG14348A/xx active
- 1978-04-20 DE DE2817335A patent/DE2817335C3/de not_active Expired
- 1978-04-21 NZ NZ187046A patent/NZ187046A/xx unknown
- 1978-04-24 JP JP4865978A patent/JPS53136514A/ja active Granted
- 1978-04-24 AU AU35378/78A patent/AU503139B1/en not_active Expired
- 1978-04-25 GB GB16167/78A patent/GB1563478A/en not_active Expired
- 1978-04-25 CA CA301,904A patent/CA1100875A/en not_active Expired
- 1978-04-26 BE BE187143A patent/BE866419A/xx not_active IP Right Cessation
- 1978-04-26 AT AT300478A patent/AT360148B/de not_active IP Right Cessation
- 1978-04-26 IE IE828/78A patent/IE47049B1/en not_active IP Right Cessation
- 1978-04-26 FI FI801196A patent/FI801196A7/fi not_active Application Discontinuation
- 1978-04-26 FI FI801197A patent/FI801197A7/fi not_active Application Discontinuation
- 1978-04-26 FI FI781300A patent/FI781300A7/fi not_active Application Discontinuation
- 1978-04-26 IL IL54581A patent/IL54581A0/xx not_active IP Right Cessation
- 1978-04-26 FR FR7812299A patent/FR2388561A1/fr active Granted
- 1978-04-26 OA OA56480A patent/OA05949A/xx unknown
- 1978-04-26 IT IT22720/78A patent/IT1094557B/it active
- 1978-04-26 GR GR56113A patent/GR70062B/el unknown
- 1978-04-26 DK DK182578A patent/DK155977C/da active
- 1978-04-26 NO NO781457A patent/NO148280C/no unknown
- 1978-04-26 NL NL7804455A patent/NL7804455A/xx not_active Application Discontinuation
- 1978-04-26 ZA ZA00782400A patent/ZA782400B/xx unknown
- 1978-04-26 CH CH453678A patent/CH630260A5/fr not_active IP Right Cessation
- 1978-04-27 LU LU79547A patent/LU79547A1/xx unknown

Also Published As

Publication number	Publication date
FR2388561B1 (ro)	1980-07-18
IE47049B1 (en)	1983-12-14
BG47943A3 (bg)	1990-10-15
AR217844A1 (es)	1980-04-30
DK182578A (da)	1978-10-28
LU79547A1 (fr)	1979-11-07
PT67895A (en)	1978-05-01
IT1094557B (it)	1985-08-02
YU87178A (en)	1984-04-30
SE443507B (sv)	1986-03-03
DD135445A5 (de)	1979-05-09
PH12962A (en)	1979-10-19
DE2817335B2 (de)	1981-06-11
JPS5632290B2 (ro)	1981-07-27
NL7804455A (nl)	1978-10-31
CH630260A5 (fr)	1982-06-15
HU179050B (en)	1982-08-28
OA05949A (fr)	1981-06-30
NO781457L (no)	1978-10-30
AU503139B1 (en)	1979-08-23
PL206050A1 (pl)	1979-03-26
SE7801816L (sv)	1978-10-28
US4126680A (en)	1978-11-21
RO77953A (ro)	1981-12-25
NZ187046A (en)	1980-03-05
MX6087E (es)	1984-11-08
CA1100875A (en)	1981-05-12
IT7822720A0 (it)	1978-04-26
ZA782400B (en)	1979-04-25
BE866419A (fr)	1978-10-26
FI801197A7 (fi)	1981-01-01
NO148280B (no)	1983-06-06
JPS53136514A (en)	1978-11-29
AT360148B (de)	1980-12-29
IL54581A0 (en)	1978-07-31
FR2388561A1 (fr)	1978-11-24
ES468749A1 (es)	1979-01-01
CS199527B2 (en)	1980-07-31
DK155977C (da)	1989-10-30
DE2817335C3 (de)	1982-04-22
FI781300A7 (fi)	1978-10-28
DE2817335A1 (de)	1978-11-16
FI801196A7 (fi)	1981-01-01
GB1563478A (en)	1980-03-26
GR70062B (ro)	1982-07-26
DK155977B (da)	1989-06-12
ZM3878A1 (en)	1978-11-21
ATA300478A (de)	1980-05-15
PT67895B (en)	1979-11-14
NO148280C (no)	1983-09-21
IE780828L (en)	1978-10-27
PL110459B1 (en)	1980-07-31
IN148197B (ro)	1980-11-29
EG14348A (en)	1984-09-30

Publication	Publication Date	Title
DK182578A (da)	1978-10-28	Stabile antibiotikapraeparater
BR7804867A (pt)	1979-04-17	Adaptador de sincronizacao de canal-para-canal
RO74888A (ro)	1980-10-30	Procedeu pentru prepararea unor 4-acilamino-feniletanolamino
AU517161B2 (en)	1981-07-09	Alph-halomethyl derivatives of amines
NO145837C (no)	1982-06-09	Fremgangsmaate for fremstilling av en voks-flegmatisk spengstoffblanding
DK364178A (da)	1979-02-19	Fremgangsmaade til fremstilling af antibiotikum
RO77417A (ro)	1981-11-04	Procedeu pentru prepararea unui complex antibiotic deoxinarazinic
DK144657C (da)	1982-11-22	Fremgangsmaade til fremstilling af antibiotikum c-15003 p-3
RO75804A (ro)	1981-02-28	Procedeu de preparare a unor cefalosporine
SE7813384L (sv)	1979-07-01	Nytt antibiotikum
AR222792A1 (es)	1981-06-30	Un procedimiento de preparacion de derivados de la tienopiridina
SE7808702L (sv)	1979-02-19	Nytt forfarande for framstellning av antibiotiska aminoglykosider
JPS5470335A (en)	1979-06-06	Preparation of linear transsquinacridone gammaamodified crystal
GB2009165B (en)	1982-04-21	Derivatives of isothiazole
RO73274A (ro)	1981-11-24	Procedeu pentru prepararea unor derivati de azetidin-4-ona
DK232078A (da)	1978-12-02	Fremgangsmaade til fremstilling af et antibiotikum benaevnt 46192
IT7848280A0 (it)	1978-03-03	Antibiotici ottenuti a partire da streptomiceti e procedimento per laloro preparazione
DK28078A (da)	1978-07-21	Fremgangsmaade til fremstilling af et tetraalkylthiuramdisulfid
PL201541A1 (pl)	1978-10-09	Sposob wytwarzania nowego antybiotyku
AU514875B2 (en)	1981-03-05	17-acetylene derivatives of androst-4-ene
RO74147A (ro)	1982-10-26	Procedeu pentru prepararea unor triazolotienodiazepin-1-one
RO78489A (ro)	1982-02-26	Procedeu pentru prepararea tiadiazolil-benzamidelor
SU632858A1 (ru)	1978-11-15	Устройство дл изменени длины втулочно-роликовой цепи
PL207755A1 (pl)	1979-07-02	Sposob wytwarzania nowego antybiotyku
BR7806108A (pt)	1979-05-02	Preparacao de ciano-acetato de alquenila