RO83723B1 - Phenacetine preparation process - Google Patents
Phenacetine preparation processInfo
- Publication number
- RO83723B1 RO83723B1 RO105820A RO10582081A RO83723B1 RO 83723 B1 RO83723 B1 RO 83723B1 RO 105820 A RO105820 A RO 105820A RO 10582081 A RO10582081 A RO 10582081A RO 83723 B1 RO83723 B1 RO 83723B1
- Authority
- RO
- Romania
- Prior art keywords
- phenacetine
- preparation process
- sodium acetate
- acetic anhydride
- reaction
- Prior art date
Links
- CPJSUEIXXCENMM-UHFFFAOYSA-N phenacetin Chemical compound CCOC1=CC=C(NC(C)=O)C=C1 CPJSUEIXXCENMM-UHFFFAOYSA-N 0.000 title abstract 3
- 229960003893 phenacetin Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 2
- 239000001632 sodium acetate Substances 0.000 abstract 2
- 235000017281 sodium acetate Nutrition 0.000 abstract 2
- IMPPGHMHELILKG-UHFFFAOYSA-N 4-ethoxyaniline Chemical compound CCOC1=CC=C(N)C=C1 IMPPGHMHELILKG-UHFFFAOYSA-N 0.000 abstract 1
- PQLVXDKIJBQVDF-UHFFFAOYSA-N acetic acid;hydrate Chemical compound O.CC(O)=O PQLVXDKIJBQVDF-UHFFFAOYSA-N 0.000 abstract 1
- 230000021736 acetylation Effects 0.000 abstract 1
- 238000006640 acetylation reaction Methods 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940117803 phenethylamine Drugs 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea fenacetinei prin acetilarea p-fenetidinei cu anhidrida acetica, caracterizat prin aceea ca reactia se efectueaza la un raport molar p-fenetidina: anhidrida acetica de 1: 1,06 într-un interval de temperatura de 35...96 degree C, cu adaos de Na2S2O5 în masa de reactie, si se folosesc apele-mume acetice de la fabricarea acetatului de sodiu sub forma de solutie concentrata sau acetat de sodiu cristalizat.The invention relates to a process for the preparation of phenacetin by acetylation of phenetidine with acetic anhydride, characterized in that the reaction is carried out at a molar ratio of p-phenethylamine: acetic anhydride of 1: 1.06 over a temperature range of 35 ° C. .97 ° C with the addition of Na2 S2 O5 in the reaction mixture and using acetic acid water from the manufacture of sodium acetate as a concentrated solution or crystallized sodium acetate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO105820A RO83723B1 (en) | 1981-11-19 | 1981-11-19 | Phenacetine preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO105820A RO83723B1 (en) | 1981-11-19 | 1981-11-19 | Phenacetine preparation process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO83723A2 RO83723A2 (en) | 1984-04-02 |
| RO83723B1 true RO83723B1 (en) | 1984-04-30 |
Family
ID=20110671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO105820A RO83723B1 (en) | 1981-11-19 | 1981-11-19 | Phenacetine preparation process |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO83723B1 (en) |
-
1981
- 1981-11-19 RO RO105820A patent/RO83723B1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RO83723A2 (en) | 1984-04-02 |
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