RO92853B1 - Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide - Google Patents

Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide

Info

Publication number
RO92853B1
RO92853B1 RO121055A RO12105583A RO92853B1 RO 92853 B1 RO92853 B1 RO 92853B1 RO 121055 A RO121055 A RO 121055A RO 12105583 A RO12105583 A RO 12105583A RO 92853 B1 RO92853 B1 RO 92853B1
Authority
RO
Romania
Prior art keywords
carbon atoms
derivatives
preparation
combination
general formula
Prior art date
Application number
RO121055A
Other languages
English (en)
Other versions
RO92853A2 (ro
Inventor
Klaus Annen
Henry Laurent
Helmut Hofmeister
Rudolf Wiechert
Michael Topert
Hans Wendt
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of RO92853A2 publication Critical patent/RO92853A2/ro
Publication of RO92853B1 publication Critical patent/RO92853B1/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

Inventia de fata se refera la un procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide cu formula generala I : (vezi formula) în care .................. reprezinta o legatura simpla sau dubla, X reprezinta clor sau brom, Y reprezinta clor sau alcanoiloxi cu 2 sau 3 atomi de carbon, iar R1 este un radical alcoxialchil cu 2 sau 3 atomi de carbon sau alcanoil cu 2..4 atomi de carbon, prin tratarea unui compus cu formula generala II : (vezi formula) în care Y si R1 au semnificatiile de mai sus, cu N-bromusuccimida sau N-clorsucinimida în mediul de dioxan, la temperatura de 20 degreeC si în prezenta de acid percloric. Aceste substante utilizate în combinatie cu materiale de suport uzuale în combinatie cu materiale de suport uzuale în farmacia galenica pentru tratarea determatitelor de contact, eczemelor de diferite feluri, arsurilor si a altor boli de piele.
RO121055A 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide RO92853B1 (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3227312A DE3227312A1 (de) 1982-07-19 1982-07-19 Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
RO92853A2 RO92853A2 (ro) 1987-11-30
RO92853B1 true RO92853B1 (ro) 1987-12-01

Family

ID=6168986

Family Applications (4)

Application Number Title Priority Date Filing Date
RO83121056A RO92854A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide
RO83121037A RO92855A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide
RO121055A RO92853B1 (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide
RO83121058A RO92856A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RO83121056A RO92854A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide
RO83121037A RO92855A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO83121058A RO92856A (ro) 1982-07-19 1983-07-18 Procedeu pentru prepararea unor derivati de 6,16-dimetilcorticoide

Country Status (23)

Country Link
US (2) US4555507A (ro)
EP (1) EP0100874B1 (ro)
JP (1) JPS5967298A (ro)
AT (1) ATE50780T1 (ro)
AU (1) AU1694183A (ro)
BG (2) BG43692A3 (ro)
CA (1) CA1312856C (ro)
DD (1) DD214134A5 (ro)
DE (2) DE3227312A1 (ro)
DK (1) DK162232C (ro)
ES (1) ES524238A0 (ro)
FI (1) FI832575A7 (ro)
GB (1) GB2124230A (ro)
GR (1) GR78902B (ro)
HU (1) HU191539B (ro)
IE (1) IE55771B1 (ro)
IL (1) IL69230A (ro)
NO (1) NO157453C (ro)
PH (1) PH19976A (ro)
PL (1) PL141537B1 (ro)
PT (1) PT76995B (ro)
RO (4) RO92854A (ro)
ZA (1) ZA835249B (ro)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung
DE3400188A1 (de) * 1984-01-02 1985-07-11 Schering AG, Berlin und Bergkamen, 1000 Berlin Neue 6(alpha),16(alpha)-dimethylkortikoide
DE3401680A1 (de) * 1984-01-16 1985-07-18 Schering AG, 1000 Berlin und 4709 Bergkamen 6(alpha),16ss-dimethylkortikoide
PT78973A (en) * 1984-07-25 1984-08-01 Joao Emerico Villax New preparation process of the 9alpha-fluoro 17,21-acylates or hidroxilades in 17 and 21 chloro-corticosteroid
US5319115A (en) * 1987-08-25 1994-06-07 Cocensys Inc. Method for making 3α-hydroxy, 3β-substituted-pregnanes
US4866050A (en) * 1988-04-27 1989-09-12 Ben Amoz Daniel Ultrasonic transdermal application of steroid compositions
DE3915951C1 (ro) * 1989-05-12 1990-09-13 Schering Ag, 1000 Berlin Und 4709 Bergkamen, De
JPH05501115A (ja) * 1990-03-27 1993-03-04 シェリング・コーポレーション ９α―ヒドロキシ　ステロイドの脱水法
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.
DE4333920A1 (de) * 1993-10-05 1995-04-13 Hoechst Ag Corticoid-17,21-dicarbonsäureester sowie Corticosteroid-17-carbonsäureester-21-kohlensäureester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
DK2444092T3 (en) 2008-05-28 2015-09-28 Reveragen Biopharma Inc Non-hormonal steroidmodulatorer of NF-? B for the treatment of disease
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
WO2017004205A1 (en) 2015-06-29 2017-01-05 Reveragen Biopharma, Inc. NON-HORMONAL STEROID MODULATORS OF NF-κB FOR TREATMENT OF DISEASE
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU75903A1 (ro) * 1976-09-29 1978-05-16
GB931221A (en) * 1958-10-01 1963-07-17 Merck & Co Inc Steroid compounds
GB898292A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
GB898295A (en) * 1959-03-18 1962-06-06 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
CH429716A (de) * 1961-06-24 1967-02-15 Vismara Francesco Spa Verfahren zur Herstellung von 17a-Acyloxy-21-hydroxy-Steroiden
US3054811A (en) * 1961-09-14 1962-09-18 Merck & Co Inc Ring a unsaturated 6, 16-dimethyl steroids of the pregnane series
GB1047519A (en) * 1963-06-11 1966-11-02 Glaxo Lab Ltd 17ª‡,21-diesters of 11,17,21-trihydroxy steroid compounds
GB1047518A (en) * 1963-06-11 1966-11-02 Glaxo Lab Ltd 17ª‡-monoesters of 11,17,21-trihydroxy steroid compounds
GB1544642A (en) * 1976-06-04 1979-04-25 Bristol Myers Co 9,11-epoxy steroids and synthesis of corticosteroids therefrom
DE2645105C2 (de) * 1976-10-04 1986-03-13 Schering AG, 1000 Berlin und 4709 Bergkamen Derivate des 9-Chlorprednisolons, Verfahren zu ihrer Herstellung und diese enthaltendes pharmazeutisches Präparat
DE2715854A1 (de) * 1977-04-06 1978-10-19 Schering Ag Verfahren zur herstellung von 11alpha,21-dihydroxy-1,4-pregnadien- 3,20-dion-derivaten
US4086254A (en) * 1977-04-13 1978-04-25 The Upjohn Company Photocleavable steroids
DE2759135A1 (de) * 1977-12-30 1979-07-19 Lark Spa Neue steroidverbindungen und deren herstellung und verwendung
US4154748A (en) * 1978-01-20 1979-05-15 The Upjohn Company Phosphate catalyzed acylation of steroidal tertiary alcohols
DE2803661A1 (de) * 1978-01-25 1979-07-26 Schering Ag Neue in 17-position substituierte 11beta-hydroxysteroide der pregnanreihe, ihre herstellung und verwendung
DE2901561A1 (de) * 1979-01-12 1980-07-31 Schering Ag Verfahren zur herstellung von 11 beta, 17 alpha, 21-trihydroxy-4-pregnen-3,20dion-derivaten
ATE12237T1 (de) * 1980-12-23 1985-04-15 Schering Ag Neue 6-alpha-methylhydrocortison-derivate, ihre herstellung und verwendung.
DE3227312A1 (de) * 1982-07-19 1984-01-19 Schering AG, 1000 Berlin und 4709 Bergkamen Neue 6,16-dimethylkortikoide, ihre herstellung und verwendung

Also Published As

Publication number Publication date
PL141537B1 (en) 1987-08-31
ES8403929A1 (es) 1984-04-16
EP0100874B1 (de) 1990-03-07
CA1312856C (en) 1993-01-19
PT76995A (de) 1983-08-01
NO157453B (no) 1987-12-14
JPS5967298A (ja) 1984-04-16
JPH0415239B2 (ro) 1992-03-17
DK329183D0 (da) 1983-07-18
GB2124230A (en) 1984-02-15
GB8319363D0 (en) 1983-08-17
DK162232B (da) 1991-09-30
RO92855A (ro) 1987-11-30
US4701451A (en) 1987-10-20
EP0100874A2 (de) 1984-02-22
AU1694183A (en) 1984-01-26
FI832575L (fi) 1984-01-20
IE831658L (en) 1984-01-19
DD214134A5 (de) 1984-10-03
RO92853A2 (ro) 1987-11-30
NO832609L (no) 1984-01-20
US4555507A (en) 1985-11-26
ZA835249B (en) 1984-03-28
PH19976A (en) 1986-08-26
RO92854A (ro) 1987-11-30
IL69230A0 (en) 1983-11-30
NO157453C (no) 1988-03-23
FI832575A0 (fi) 1983-07-14
IL69230A (en) 1988-07-31
DE3381291D1 (de) 1990-04-12
EP0100874A3 (en) 1985-04-17
RO92856A (ro) 1987-11-30
DE3227312A1 (de) 1984-01-19
ATE50780T1 (de) 1990-03-15
HU191539B (en) 1987-03-30
BG43693A3 (bg) 1988-07-15
IE55771B1 (en) 1991-01-16
GR78902B (ro) 1984-10-02
DK329183A (da) 1984-01-20
BG43692A3 (en) 1988-07-15
PT76995B (de) 1986-01-09
FI832575A7 (fi) 1984-01-20
PL243082A1 (en) 1984-11-19
DK162232C (da) 1992-03-02
ES524238A0 (es) 1984-04-16

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