RO95573B1 - Procedeu de obtinere a amikacinei - Google Patents
Procedeu de obtinere a amikacineiInfo
- Publication number
- RO95573B1 RO95573B1 RO124210A RO12421086A RO95573B1 RO 95573 B1 RO95573 B1 RO 95573B1 RO 124210 A RO124210 A RO 124210A RO 12421086 A RO12421086 A RO 12421086A RO 95573 B1 RO95573 B1 RO 95573B1
- Authority
- RO
- Romania
- Prior art keywords
- solvent
- metal cation
- amikacin
- kanamycin
- cadmium
- Prior art date
Links
- 229960004821 amikacin Drugs 0.000 title abstract 2
- LKCWBDHBTVXHDL-RMDFUYIESA-N amikacin Chemical compound O([C@@H]1[C@@H](N)C[C@H]([C@@H]([C@H]1O)O[C@@H]1[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O1)O)NC(=O)[C@@H](O)CCN)[C@H]1O[C@H](CN)[C@@H](O)[C@H](O)[C@H]1O LKCWBDHBTVXHDL-RMDFUYIESA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 abstract 2
- 150000001768 cations Chemical class 0.000 abstract 2
- 229910052751 metal Inorganic materials 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052793 cadmium Inorganic materials 0.000 abstract 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 229910017052 cobalt Inorganic materials 0.000 abstract 1
- 239000010941 cobalt Substances 0.000 abstract 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 239000012043 crude product Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229960000318 kanamycin Drugs 0.000 abstract 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 abstract 1
- 229930182823 kanamycin A Natural products 0.000 abstract 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052759 nickel Inorganic materials 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Se descrie un procedeu pentru sinteza de amikacina plecând de la kanamicina A, protejata în pozitiile 3 si 6' cuprinzând reactia acesteia din urma cu o sare de un cation metalic bivalent ales dintre zinc, nichel, fier, cobalt, mangan, cupru si cadmiu, în prezenta de apa ca solvent sau cosolvent, urmata de reactia în situ a complexului rezultat cu un derivat reactiv de acid L-amino-2-hidroxibutiric, îndepartarea cationului metalic din grupele protectoare si purificarea produsului brut astfel obt inut. Acilarea în aceste conditii este selectiva. Compusul se utilizeaza în medicina terapeutica.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO124210A RO95573B1 (ro) | 1986-07-18 | 1986-07-18 | Procedeu de obtinere a amikacinei |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO124210A RO95573B1 (ro) | 1986-07-18 | 1986-07-18 | Procedeu de obtinere a amikacinei |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO95573B1 true RO95573B1 (ro) | 1988-10-01 |
Family
ID=40904808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO124210A RO95573B1 (ro) | 1986-07-18 | 1986-07-18 | Procedeu de obtinere a amikacinei |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO95573B1 (ro) |
-
1986
- 1986-07-18 RO RO124210A patent/RO95573B1/ro unknown
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