RS51855B - Mikrobiološki postupak za dobijanje 7alfa-supstituisanih 11alfa-hidroksisteroida - Google Patents

Mikrobiološki postupak za dobijanje 7alfa-supstituisanih 11alfa-hidroksisteroida

Info

Publication number: RS51855B
Authority: RS; Serbia
Prior art keywords: substituted; general formula; stands; compounds; atcc
Prior art date: 2002-07-24

Application number

YU20050045A

Other languages

English (en)

Serbian (sr)

Inventor

Rolf Bohlmann

Hermann Künzer

Reinhard Nubbemeyer

Hans-Peter Muhn

Ludwig Zorn

Norbert Gallus

Original Assignee

Bayer Schering Pharma Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-24

Filing date

2003-07-24

Publication date

2012-02-29

2002-07-24 Priority claimed from DE10233723A external-priority patent/DE10233723A1/de

2003-07-24 Application filed by Bayer Schering Pharma Aktiengesellschaft filed Critical Bayer Schering Pharma Aktiengesellschaft

2007-06-04 Publication of RS20050045A publication Critical patent/RS20050045A/sr

2012-02-29 Publication of RS51855B publication Critical patent/RS51855B/sr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/06—Hydroxylating
- C12P33/08—Hydroxylating at 11 position
- C12P33/10—Hydroxylating at 11 position at 11 alpha-position
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P33/00—Preparation of steroids
- C12P33/12—Acting on D ring
- C12P33/16—Acting at 17 position

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Reproductive Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Steroid Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

YU20050045A 2002-07-24 2003-07-24 Mikrobiološki postupak za dobijanje 7alfa-supstituisanih 11alfa-hidroksisteroida RS51855B (sr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10233723A DE10233723A1 (de)	2002-07-24	2002-07-24	Mikrobiologische Verfahren zur Herstellung von 7α-substituierten 11α-Hydroxysteroiden, daraus herstellbare 7α,17α-substituierte 11β-Halogensteroide, deren Herstellungsverfahren und Verwendung sowie pharmazeutische Präparate, die diese Verbindungen enthalten, sowie daraus herstellbare 7α-substituierte Estra-1,3,5(10)-triene
US40295302P	2002-08-14	2002-08-14
PCT/EP2003/008111 WO2004011663A2 (fr)	2002-07-24	2003-07-24	Procedes microbiologiques pour la production de 11-$g(a) hydroxysteroides 7-$g(a) substitues

Publications (2)

Publication Number	Publication Date
RS20050045A RS20050045A (sr)	2007-06-04
RS51855B true RS51855B (sr)	2012-02-29

Family

ID=31189296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU20050045A RS51855B (sr)	2002-07-24	2003-07-24	Mikrobiološki postupak za dobijanje 7alfa-supstituisanih 11alfa-hidroksisteroida

Country Status (19)

Country	Link
EP (1)	EP1523568A2 (fr)
JP (1)	JP4417838B2 (fr)
KR (1)	KR101041328B1 (fr)
CN (1)	CN100339486C (fr)
BR (1)	BR0313210A (fr)
CA (1)	CA2492079C (fr)
CO (1)	CO5690563A2 (fr)
CR (1)	CR7672A (fr)
EA (2)	EA008147B1 (fr)
EC (1)	ECSP055630A (fr)
HR (1)	HRP20050172A2 (fr)
IL (1)	IL166358A0 (fr)
MX (1)	MXPA05001024A (fr)
NO (1)	NO20050980L (fr)
NZ (2)	NZ537871A (fr)
PH (1)	PH12005500143B1 (fr)
PL (1)	PL373808A1 (fr)
RS (1)	RS51855B (fr)
WO (1)	WO2004011663A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100982540B1 (ko) *	2005-10-27	2010-09-16	다이호야쿠힌고교 가부시키가이샤	스테로이드 화합물의 제조법
RU2377309C1 (ru) *	2008-04-22	2009-12-27	Валентина Александровна Андрюшина	МИКРОБИОЛОГИЧЕСКИЙ СПОСОБ ПОЛУЧЕНИЯ 7α-ГИДРОКСИАНДРОСТЕНОВ
CN103834712B (zh) *	2012-11-26	2016-03-30	复旦大学	去氧孕烯中间体纳米脂质体生物转化的优化方法
CN103214543B (zh) *	2012-12-25	2015-09-02	中国人民解放军海军医学研究所	新山楂酸衍生物、其制备方法及其在抗肿瘤药物中的应用
CN104862323B (zh) *	2015-06-02	2018-01-16	中国农业科学院生物技术研究所	修饰苯二酚类化合物的羟化酶基因
PL246071B1 (pl) *	2022-08-26	2024-11-25	Wrocław University Of Environmental And Life Sciences	Sposób wytwarzania 11α-hydroksy-19-nortestosteronu

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE496261A (fr)	1949-06-11
US2658023A (en) *	1953-04-21	1953-11-03	Pfizer & Co C	Oxygenation of steroids
US2985563A (en) *	1958-11-13	1961-05-23	Schering Corp	11alpha-hydroxylation of steroids by glomerella
US3004047A (en) *	1959-03-13	1961-10-10	Olin Mathieson	6alpha-halo-11alpha-hydroxy steroids of the pregnane series and esters thereof
US3341557A (en)	1961-06-05	1967-09-12	Upjohn Co	7-methyltestosterones
US3203869A (en) *	1962-10-11	1965-08-31	Syntex Corp	11alpha-hydroxylation of 6-substituted-11-desoxy steroids with microorganisms of thegenus fusarium, liseola section
US5342834A (en)	1989-04-07	1994-08-30	The Population Council, Inc.	Method for androgen supplementation
EP1170299A3 (fr) *	1995-12-11	2004-11-10	G.D. Searle & Co.	Produits intermédiares pour la production des stéroides 9,11-époxy et un procédé pour leur production
KR19990072066A (ko)	1995-12-12	1999-09-27	이.에이치. 리링크	미생물에 의한 스테로이드류의 11α-히드록실화 반응
GB9525194D0 (en)	1995-12-12	1996-02-07	Zeneca Ltd	Pharmaceutical composition
US6767902B2 (en)	1997-09-17	2004-07-27	The Population Council, Inc.	Androgen as a male contraceptive and non-contraceptive androgen replacement
US20020012694A1 (en) *	1997-09-17	2002-01-31	Alfred J. Moo-Young	Transdermal administration of ment
US5952319A (en)	1997-11-26	1999-09-14	Research Triangle Institute	Androgenic steroid compounds and a method of making and using the same
HUP0300128A3 (en)	2000-02-15	2004-03-29	Schering Ag	Male contraceptive composition comprising norethisterone and its use
DE10104327A1 (de)	2001-01-24	2002-07-25	Schering Ag	11beta-Halogensteroide, deren Herstellung und Verwendung zur Herstellung von Arzneimitteln sowie 11beta-Halogensteroide enthaltende pharmazeutische Präparate
DE50308933D1 (de) *	2002-07-25	2008-02-14	Bayer Schering Pharma Ag	Zusammensetzung, enthaltend ein androgenes 11-b-halogensteroid und ein gestagen sowie m nnliches kontrazeptivum auf basis dieser zusammensetzung

2003
- 2003-07-24 CA CA2492079A patent/CA2492079C/fr not_active Expired - Fee Related
- 2003-07-24 CN CNB038176963A patent/CN100339486C/zh not_active Expired - Fee Related
- 2003-07-24 PL PL03373808A patent/PL373808A1/xx not_active Application Discontinuation
- 2003-07-24 MX MXPA05001024A patent/MXPA05001024A/es active IP Right Grant
- 2003-07-24 WO PCT/EP2003/008111 patent/WO2004011663A2/fr not_active Ceased
- 2003-07-24 BR BR0313210-2A patent/BR0313210A/pt not_active IP Right Cessation
- 2003-07-24 JP JP2004523777A patent/JP4417838B2/ja not_active Expired - Fee Related
- 2003-07-24 EA EA200500224A patent/EA008147B1/ru not_active IP Right Cessation
- 2003-07-24 NZ NZ537871A patent/NZ537871A/en not_active IP Right Cessation
- 2003-07-24 HR HR20050172A patent/HRP20050172A2/hr not_active Application Discontinuation
- 2003-07-24 RS YU20050045A patent/RS51855B/sr unknown
- 2003-07-24 EP EP03740474A patent/EP1523568A2/fr not_active Withdrawn
- 2003-07-24 NZ NZ549529A patent/NZ549529A/en not_active IP Right Cessation
- 2003-07-24 KR KR1020057001140A patent/KR101041328B1/ko not_active Expired - Fee Related
- 2003-07-24 EA EA200601030A patent/EA010572B1/ru not_active IP Right Cessation
2005
- 2005-01-18 IL IL16635805A patent/IL166358A0/xx not_active IP Right Cessation
- 2005-01-21 PH PH12005500143A patent/PH12005500143B1/en unknown
- 2005-02-03 CR CR7672A patent/CR7672A/es not_active Application Discontinuation
- 2005-02-21 CO CO05015699A patent/CO5690563A2/es not_active Application Discontinuation
- 2005-02-23 NO NO20050980A patent/NO20050980L/no not_active Application Discontinuation
- 2005-02-24 EC EC2005005630A patent/ECSP055630A/es unknown

Also Published As

Publication number	Publication date
WO2004011663A9 (fr)	2004-05-06
PH12005500143B1 (en)	2011-03-25
HK1081999A1 (zh)	2006-05-26
HRP20050172A2 (en)	2005-04-30
ECSP055630A (es)	2005-04-18
CA2492079C (fr)	2012-01-10
JP2006503813A (ja)	2006-02-02
NZ549529A (en)	2008-04-30
BR0313210A (pt)	2005-06-28
EA008147B1 (ru)	2007-04-27
IL166358A0 (en)	2006-01-16
EA010572B1 (ru)	2008-10-30
CO5690563A2 (es)	2006-10-31
CN100339486C (zh)	2007-09-26
NZ537871A (en)	2006-10-27
EA200500224A1 (ru)	2005-08-25
KR20050026507A (ko)	2005-03-15
EA200601030A1 (ru)	2006-10-27
CR7672A (es)	2006-05-29
MXPA05001024A (es)	2005-05-16
KR101041328B1 (ko)	2011-06-14
RS20050045A (sr)	2007-06-04
CA2492079A1 (fr)	2004-02-05
WO2004011663A2 (fr)	2004-02-05
NO20050980L (no)	2005-02-23
PL373808A1 (en)	2005-09-19
MX260952B (fr)	2008-10-01
CN1671858A (zh)	2005-09-21
AU2003281677A1 (en)	2004-02-16
WO2004011663A3 (fr)	2004-07-15
JP4417838B2 (ja)	2010-02-17
EP1523568A2 (fr)	2005-04-20

Publication	Publication Date	Title
US20070298456A1 (en)	2007-12-27	Microbiological process for the production of 7-substitued 11-hydroxy steroids, 7,17-substituted 11-halogen steroids, and uses thereof
RS51855B (sr)	2012-02-29	Mikrobiološki postupak za dobijanje 7alfa-supstituisanih 11alfa-hidroksisteroida
JP4339591B2 (ja)	2009-10-07	アンドロゲン性７−置換１１−ハロゲン化ステロイド
JP2003513102A (ja)	2003-04-08	選択的な作用を有するエストロゲンとしての１８−ノル−ステロイド
AU2002238516A1 (en)	2003-02-06	Androgenic 7-substituted 11-halogen steriods
RS59403B1 (sr)	2019-11-29	Komponenta koja provodi strujanje
EP1379253B1 (fr)	2006-03-29	Procedes de fabrication de formulations pharmaceutiques comprenant du 7alpha, 11beta-dimethy-17beta-hydroxyestra-4, 14-dien-3-one et des esters en position 17 de ce compose
HUP0300504A2 (hu)	2003-06-28	21,16alfa-laktongyűrűs 19-nor-17alfa-pregna-1,3,5(10)-trién-17béta-olok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HK1101588A (en)	2007-10-18	7α-SUBSTITUTED 11α-HYDROXY-STEROIDS AND MICROBIOLOGICAL METHOD FOR THE PREPARATION THEREOF
HK1081999B (en)	2008-03-20	Microbiological method for the production of 7 alpha-substituted 11 alpha-hydrox-ysteroids