RS55561B1 - Derivati tetrahidropirolotiazina kao inhibitori bace - Google Patents
Derivati tetrahidropirolotiazina kao inhibitori baceInfo
- Publication number
- RS55561B1 RS55561B1 RS20170016A RSP20170016A RS55561B1 RS 55561 B1 RS55561 B1 RS 55561B1 RS 20170016 A RS20170016 A RS 20170016A RS P20170016 A RSP20170016 A RS P20170016A RS 55561 B1 RS55561 B1 RS 55561B1
- Authority
- RS
- Serbia
- Prior art keywords
- mmol
- compound
- preparation
- dichloromethane
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718728P | 2012-10-26 | 2012-10-26 | |
| PCT/US2013/065418 WO2014066132A1 (fr) | 2012-10-26 | 2013-10-17 | Inhibiteurs de bace |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS55561B1 true RS55561B1 (sr) | 2017-05-31 |
Family
ID=49515508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20170016A RS55561B1 (sr) | 2012-10-26 | 2013-10-17 | Derivati tetrahidropirolotiazina kao inhibitori bace |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9328124B2 (fr) |
| EP (1) | EP2912041B1 (fr) |
| JP (1) | JP6243921B2 (fr) |
| CN (1) | CN104755484B (fr) |
| CA (1) | CA2886507C (fr) |
| CY (1) | CY1118623T1 (fr) |
| DK (1) | DK2912041T3 (fr) |
| ES (1) | ES2616835T3 (fr) |
| HR (1) | HRP20170025T1 (fr) |
| HU (1) | HUE031764T2 (fr) |
| LT (1) | LT2912041T (fr) |
| ME (1) | ME02576B (fr) |
| PL (1) | PL2912041T3 (fr) |
| PT (1) | PT2912041T (fr) |
| RS (1) | RS55561B1 (fr) |
| SI (1) | SI2912041T1 (fr) |
| WO (1) | WO2014066132A1 (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2902212C (fr) | 2013-03-01 | 2020-10-13 | Amgen Inc. | Composes perfluores 5,6-dihydro-4h-1,3-oxazine-2-amine substitues en tant qu'inhibiteurs de la beta-secretase et procedes d'utilisation correspondants |
| AP2015008716A0 (en) | 2013-03-08 | 2015-09-30 | Amgen Inc | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| TWI684452B (zh) * | 2014-03-14 | 2020-02-11 | 美國禮來大藥廠 | 胺基噻嗪化合物 |
| US9550762B2 (en) | 2014-08-08 | 2017-01-24 | Amgen, Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| WO2017024180A1 (fr) | 2015-08-06 | 2017-02-09 | Amgen Inc. | Composés thiazin-2-amine fusionnée à un vinyl fluorure cyclopropyle en tant qu'inhibiteurs de la bêta-secrétase et leurs procédés d'utilisation |
| EP3555085B1 (fr) | 2016-12-15 | 2020-12-02 | Amgen Inc. | Derivés thiazine fusionnés à un cyclopropyle utilisés en tant qu'inhibiteurs de la bêta-sécrétase et procédés d'utilisation |
| JP7149271B2 (ja) | 2016-12-15 | 2022-10-06 | アムジエン・インコーポレーテツド | β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法 |
| WO2018112084A1 (fr) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Dérivés de thiazine et d'oxazine bicycliques en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation |
| US10947223B2 (en) | 2016-12-15 | 2021-03-16 | Amgen Inc. | Substituted oxazines as beta-secretase inhibitors |
| JP7149272B2 (ja) | 2016-12-15 | 2022-10-06 | アムジエン・インコーポレーテツド | β－セクレターゼ阻害剤としてのチアジン誘導体および使用方法 |
| CN106632001A (zh) * | 2016-12-28 | 2017-05-10 | 山东诚汇双达药业有限公司 | 一种4‑（溴乙酰基）吡啶氢溴酸盐的制备方法 |
| CN110452179A (zh) * | 2019-06-25 | 2019-11-15 | 南京普锐达医药科技有限公司 | 一种2-氯-4-甲氧基-5-氰基嘧啶的合成方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007016180A (es) * | 2005-06-14 | 2008-03-07 | Schering Corp | Inhibidores de aspartil proteasas. |
| EP2151435A4 (fr) | 2007-04-24 | 2011-09-14 | Shionogi & Co | Composition pharmaceutique pour le traitement de la maladie d'alzheimer |
| RU2476431C2 (ru) * | 2008-01-18 | 2013-02-27 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Конденсированное производное аминодигидротиазина |
| US8450331B2 (en) | 2008-04-22 | 2013-05-28 | Merck Sharp & Dohme Corp. | Thiophenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use |
| WO2009151098A1 (fr) | 2008-06-13 | 2009-12-17 | 塩野義製薬株式会社 | DÉRIVÉ HÉTÉROCYCLIQUE CONTENANT DU SOUFRE AYANT UNE ACTIVITÉ INHIBANT LA β-SÉCRÉTASE |
| KR20110076965A (ko) | 2008-09-30 | 2011-07-06 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 신규한 축합 아미노 디하이드로티아진 유도체 |
| AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
| GB0912778D0 (en) * | 2009-07-22 | 2009-08-26 | Eisai London Res Lab Ltd | Fused aminodihydro-oxazine derivatives |
| EP2511269A4 (fr) * | 2009-12-11 | 2013-04-24 | Shionogi & Co | Composé hétérocyclique fusionné comportant un groupement amino |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| WO2012162334A1 (fr) | 2011-05-24 | 2012-11-29 | Bristol-Myers Squibb Company | Composés destinés à la réduction de la production de bêta-amyloïdes |
| JO3143B1 (ar) | 2012-04-03 | 2017-09-20 | Lilly Co Eli | مركبات تتراهيدرو بيرولو ثيازين |
| GB201212871D0 (en) | 2012-07-20 | 2012-09-05 | Eisai Ltd | Novel compounds |
| TWI593692B (zh) | 2013-03-12 | 2017-08-01 | 美國禮來大藥廠 | 四氫吡咯并噻嗪化合物 |
-
2013
- 2013-10-17 PL PL13785730T patent/PL2912041T3/pl unknown
- 2013-10-17 WO PCT/US2013/065418 patent/WO2014066132A1/fr not_active Ceased
- 2013-10-17 EP EP13785730.6A patent/EP2912041B1/fr active Active
- 2013-10-17 RS RS20170016A patent/RS55561B1/sr unknown
- 2013-10-17 HR HRP20170025TT patent/HRP20170025T1/hr unknown
- 2013-10-17 CA CA2886507A patent/CA2886507C/fr not_active Expired - Fee Related
- 2013-10-17 DK DK13785730.6T patent/DK2912041T3/en active
- 2013-10-17 ES ES13785730.6T patent/ES2616835T3/es active Active
- 2013-10-17 SI SI201330463T patent/SI2912041T1/sl unknown
- 2013-10-17 LT LTEP13785730.6T patent/LT2912041T/lt unknown
- 2013-10-17 US US14/427,648 patent/US9328124B2/en not_active Expired - Fee Related
- 2013-10-17 PT PT137857306T patent/PT2912041T/pt unknown
- 2013-10-17 JP JP2015539666A patent/JP6243921B2/ja not_active Expired - Fee Related
- 2013-10-17 CN CN201380055699.5A patent/CN104755484B/zh not_active Expired - Fee Related
- 2013-10-17 HU HUE13785730A patent/HUE031764T2/en unknown
-
2017
- 2017-02-10 CY CY20171100191T patent/CY1118623T1/el unknown
- 2017-02-10 ME MEP-2017-4A patent/ME02576B/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20170025T1 (hr) | 2017-03-10 |
| WO2014066132A1 (fr) | 2014-05-01 |
| CA2886507A1 (fr) | 2014-05-01 |
| EP2912041B1 (fr) | 2016-12-14 |
| HUE031764T2 (en) | 2017-07-28 |
| JP2015535247A (ja) | 2015-12-10 |
| DK2912041T3 (en) | 2017-02-27 |
| ES2616835T3 (es) | 2017-06-14 |
| SI2912041T1 (sl) | 2017-02-28 |
| LT2912041T (lt) | 2017-03-10 |
| CN104755484A (zh) | 2015-07-01 |
| PT2912041T (pt) | 2017-02-13 |
| US20150232483A1 (en) | 2015-08-20 |
| EP2912041A1 (fr) | 2015-09-02 |
| CA2886507C (fr) | 2016-09-20 |
| CN104755484B (zh) | 2016-02-17 |
| JP6243921B2 (ja) | 2017-12-06 |
| PL2912041T3 (pl) | 2017-06-30 |
| US9328124B2 (en) | 2016-05-03 |
| ME02576B (fr) | 2017-06-20 |
| CY1118623T1 (el) | 2017-07-12 |
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