RS59301B1 - Derivati imidazopiridazina kao pi3kbeta inhibitori - Google Patents
Derivati imidazopiridazina kao pi3kbeta inhibitoriInfo
- Publication number
- RS59301B1 RS59301B1 RSP20191225A RS59301B1 RS 59301 B1 RS59301 B1 RS 59301B1 RS P20191225 A RSP20191225 A RS P20191225A RS 59301 B1 RS59301 B1 RS 59301B1
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- RS
- Serbia
- Prior art keywords
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- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Pregnancy & Childbirth (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Transplantation (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Taps Or Cocks (AREA)
Description
PLASTIČNI LOPTASTI VENTIL SA RADIJALNO - AKSIJALNIM
ZAPTIVAČEM
Oblast tehnike na koju se pronalazak odnosi
Pronalazak pripada oblasti armature za hemijsku industriju.
Tehnički problem
Pronalazak rešava problem zaptivanja plastičnih loptastih ventila ali na drugačiji, jednostavniji način nego kako se to do sada radilo.
Stanje tehnike
Postojeći plastični loptasti ventili u kućištu imaju deo, nosač zaptivača, na kome se nalaze tri zaptivača. Prvi je najčešće od teflona, naleže na loptu ventila i nije bitan za ovo razmatranje, drugi je od kiselootporne gume ili vitona i naleže na kućište ventila (radijalno statičko zaptivanje) a treći, koji je takođe od kiselootporne gume ili vitona, naleže na spojnicu ventila za koju se spaja cevovod (aksijalno statičko zaptivanje). Sa tim zaptivačima, izuzimajući zaptivač vratila ventila koji takođe nije bitan za ovo razmatranje, plastičnim loptastim ventilima omogućeno je normalno funkcionisanje uz zaptivanje svih mesta gde mogu nastati procurivanja van ventila. Znači, ovakva konstrukcija plastičnih loptastih ventila, a za ovo razmatranje bitna, ima dva mesta na kojima se sa dva zaptivača sprečava procurivanje.
Izlaganje suštine pronalaska
Pronalazak se sastoji od spojnice (1), holenderske navrtke (2), kućišta ventila (3), nosača zaptivača X-4X lopte (5), vratila (6), ručice (7), radijalno - aksijalnog zaptivača od kiselootporne gume ili vitona (8), zaptivača lopte od teflona (9) i zaptivača vratila od kiselootporne gume ili vitona (10).
Kod plastičnog loptastog ventila sa radijalno - aksijalnim zaptivačem kućište ventila i nosač zaptivača su tako konstruisani da se radijalno i alsijalno procurivanje, za razliku od klasičnih plastičnih ventila kod kojih se ono sprečava na dva mesta sa dva zaptivača, ovde sprečava samo najednom mestu i to sa jednim zaptivačem.
Kratak opis slike nacrta
Slika prikazuje četvrtinu preseka gornje polovine plastičnog loptastog ventila sa radijalno - aksijalnim zaptivačem.
Detaljan opis pronalaska
Plastični loptasti ventili nalaze primenu svuda gde se radi sa agresivnim tečnim fluidima a naročito u hemijskoj i farmaceutskoj industriji, u metalurškim kombinatima, u laboratorijama fakulteta i instituta i td
Plastični loptasti ventil sa radijalno - aksijalnim zaptivačem sastoji se od spojnice (1), holenderske navrtke (2), kućišta ventila (3), nosača zaptivača (4), lopte (5), vratila (6), ručice (7), radijalno - aksijalnog zaptivača od kiselootporne gume ili vitona (8), zaptivača lopte od teflona (9) i zaptivača vratila od kiselootporne gume ili vitona (10).
Za rad ventila karakteristična su tri položaja lopte ventila: 1) lopta zatvara ceo otvor u nosaču zaptivača - ventil je zatvoren, 2) lopta zatvara deo otvora u nosaču zaptivača - ventil reguliše protok fluida i 3) lopta uopšte ne zatvara otvor u nosaču zaptivača - ventil je otvoren.
Usled pritiska, agresivni tečni fluid može procuriti van instalacije između spojnice i nosača zaptivača, kada je ventil zatvoren i između kućišta ventila i nosača zaptivača, kada ventil reguliše protok. Da bi se procurivanje sprečilo na ta dva mesta postavljaju se zaptivači od kiselootporne gume ili vitona.
Kod plastičnog loptastog ventila sa radijalno - aksijalnim zaptivačem kućište ventila i nosač zaptivača su tako konstruisani da se radijalno i alsijalno procurivanje sprečava samo na jednom mestu i to sa jednim zaptivačem. To praktično znači da ovde jedan zaptivač istovremeno naleže i zaptiva površine od tri dela, od kućišta ventila, nosača zaptivača i od spojnice pa time sprečava sva procurivanja van ventila.
Način industrijske ili druge primene pronalaska
Pronalazak se može primeniti svuda gde se vrši manipulacija ili skladištenje agresivnih tečnih fluida.
Claims (1)
- Plastični loptasti ventil sa radijalno - aksijalnim zaptivačem sastoji se od spojnice (1), holenderske navrtke (2), kućišta (3), nosača zaptivača (4), lopte (5), vratila (6), ručice (7), zaptivača lopte od teflona (9) i zaptivača vratila od kiselootporne gume ili vitona (10),naznačen time,što se zaptivanje između spojnice (1), nosača zaptivača (4) i kućišta ventila (3) ostvaruje samo sa jednim, radijalno - aksijalnim zaptivačem (8) koji istovremeno naleže na površine sva ta tri dela i time sprečava procurivanje agresivnog tečnog fluida van ventila.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14199322 | 2014-12-19 | ||
| PCT/EP2015/080604 WO2016097347A1 (en) | 2014-12-19 | 2015-12-18 | IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS |
| EP15810784.7A EP3233862B1 (en) | 2014-12-19 | 2015-12-18 | Imidazopyridazine derivatives as pi3kbeta inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS59301B1 true RS59301B1 (sr) | 2019-10-31 |
Family
ID=52134002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP20191225 RS59301B1 (sr) | 2014-12-19 | 2015-12-18 | Derivati imidazopiridazina kao pi3kbeta inhibitori |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US10087187B2 (sr) |
| EP (1) | EP3233862B1 (sr) |
| JP (1) | JP6568588B2 (sr) |
| KR (1) | KR20170095239A (sr) |
| CN (1) | CN107108634B (sr) |
| AU (1) | AU2015366190B2 (sr) |
| BR (1) | BR112017012930A2 (sr) |
| CA (1) | CA2967551A1 (sr) |
| CY (1) | CY1122381T1 (sr) |
| DK (1) | DK3233862T3 (sr) |
| EA (1) | EA029789B1 (sr) |
| ES (1) | ES2761051T3 (sr) |
| HR (1) | HRP20191550T1 (sr) |
| HU (1) | HUE045220T2 (sr) |
| IL (1) | IL252866B (sr) |
| LT (1) | LT3233862T (sr) |
| MA (1) | MA41174B1 (sr) |
| MD (1) | MD3233862T2 (sr) |
| ME (1) | ME03517B (sr) |
| MX (1) | MX2017008074A (sr) |
| PL (1) | PL3233862T3 (sr) |
| PT (1) | PT3233862T (sr) |
| RS (1) | RS59301B1 (sr) |
| SI (1) | SI3233862T1 (sr) |
| SM (1) | SMT201900509T1 (sr) |
| WO (1) | WO2016097347A1 (sr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6912460B2 (ja) | 2015-10-09 | 2021-08-04 | ヤンセン ファーマシューティカ エヌ．ベー． | ＰＩ３Ｋβ阻害剤としてのキノキサリンおよびピリドピラジン誘導体 |
| KR102472453B1 (ko) | 2016-06-16 | 2022-11-29 | 얀센 파마슈티카 엔.브이. | Pi3k 베타 저해제로서의 이환식 피리딘, 피라진, 및 피리미딘 유도체 |
| EP3601254B1 (en) | 2017-03-29 | 2022-05-25 | Janssen Pharmaceutica NV | Quinoxaline and pyridopyrazine derivatives as pi3k-beta inhibitors |
| JP7637328B2 (ja) | 2019-02-07 | 2025-02-28 | ベイジーン リミテッド | Ｔｌｒ７アゴニストとしてのイミダゾ［２，１－ｆ］［１，２，４］トリアジン－４－アミン誘導体 |
| CN110128505A (zh) * | 2019-05-21 | 2019-08-16 | 梯尔希（南京）药物研发有限公司 | 一种戈舍瑞林杂质的合成方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070078136A1 (en) | 2005-09-22 | 2007-04-05 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| US8217177B2 (en) | 2006-07-14 | 2012-07-10 | Amgen Inc. | Fused heterocyclic derivatives and methods of use |
| WO2008014219A2 (en) | 2006-07-24 | 2008-01-31 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as p13 kinase inhibitors |
| AU2007292924A1 (en) | 2006-09-07 | 2008-03-13 | Biogen Idec Ma Inc. | IRAK modulators for treating an inflammatory condition, cell proliferative disorder, immune disorder |
| PE20090215A1 (es) * | 2007-05-09 | 2009-03-30 | Novartis Ag | Compuestos derivados de imidazopiridazinas como inhibidores de cinasa |
| WO2009060197A1 (en) | 2007-11-08 | 2009-05-14 | Centro Nacional De Investigaciones Oncologicas (Cnio) | Imidazopyridazines for use as protein kinase inhibitors |
| PE20091468A1 (es) * | 2008-02-28 | 2009-10-22 | Novartis Ag | DERIVADOS DE 3-METIL-IMIDAZO-[1,2-b]-PIRIDAZINA |
| WO2010007099A1 (en) * | 2008-07-15 | 2010-01-21 | Cellzome Limited | 2-aminoimidazo[1,2-b]pyridazine derivatives as pi3k inhibitors |
| MY162604A (en) | 2009-08-17 | 2017-06-30 | Intellikine Llc | Heterocyclic compounds and uses thereof |
| DE102009049679A1 (de) * | 2009-10-19 | 2011-04-21 | Merck Patent Gmbh | Pyrazolopyrimidinderivate |
| WO2011058109A1 (en) | 2009-11-12 | 2011-05-19 | Ucb Pharma S.A. | Fused bicyclic pyrrole and imidazole derivatives as kinase inhibitors |
| UY33304A (es) | 2010-04-02 | 2011-10-31 | Amgen Inc | Compuestos heterocíclicos y sus usos |
| ES2616238T3 (es) | 2010-10-06 | 2017-06-12 | Glaxosmithkline Llc, Corporation Service Company | Derivados de bencimidazol como inhibidores de PI3 quinasa |
| EP2678016B1 (en) | 2011-02-23 | 2016-08-10 | Intellikine, LLC | Heterocyclic compounds and uses thereof |
| US9096605B2 (en) * | 2011-08-24 | 2015-08-04 | Glaxosmithkline Llc | Pyrazolopyrimidine derivatives as PI3 kinase inhibitors |
| WO2013095761A1 (en) | 2011-12-20 | 2013-06-27 | Glaxosmithkline Llc | Imidazopyridine derivatives as pi3 kinase inhibitors |
| US8778937B2 (en) | 2011-12-20 | 2014-07-15 | Glaxosmithkline Llc | Benzimidazole boronic acid derivatives as PI3 kinase inhibitors |
| TWI574962B (zh) * | 2012-11-14 | 2017-03-21 | 加拓科學公司 | 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途 |
| GB201321734D0 (en) * | 2013-12-09 | 2014-01-22 | Ucb Pharma Sa | Therapeutic Agents |
-
2015
- 2015-12-18 HU HUE15810784A patent/HUE045220T2/hu unknown
- 2015-12-18 CA CA2967551A patent/CA2967551A1/en active Pending
- 2015-12-18 EA EA201791396A patent/EA029789B1/ru not_active IP Right Cessation
- 2015-12-18 WO PCT/EP2015/080604 patent/WO2016097347A1/en not_active Ceased
- 2015-12-18 ES ES15810784T patent/ES2761051T3/es active Active
- 2015-12-18 LT LTEP15810784.7T patent/LT3233862T/lt unknown
- 2015-12-18 CN CN201580069133.7A patent/CN107108634B/zh not_active Expired - Fee Related
- 2015-12-18 EP EP15810784.7A patent/EP3233862B1/en active Active
- 2015-12-18 PT PT158107847T patent/PT3233862T/pt unknown
- 2015-12-18 HR HRP20191550 patent/HRP20191550T1/hr unknown
- 2015-12-18 MD MDE20170191 patent/MD3233862T2/ro not_active IP Right Cessation
- 2015-12-18 AU AU2015366190A patent/AU2015366190B2/en not_active Ceased
- 2015-12-18 SM SM20190509T patent/SMT201900509T1/it unknown
- 2015-12-18 JP JP2017532819A patent/JP6568588B2/ja not_active Expired - Fee Related
- 2015-12-18 DK DK15810784.7T patent/DK3233862T3/da active
- 2015-12-18 SI SI201530855T patent/SI3233862T1/sl unknown
- 2015-12-18 BR BR112017012930A patent/BR112017012930A2/pt active Search and Examination
- 2015-12-18 KR KR1020177016722A patent/KR20170095239A/ko not_active Ceased
- 2015-12-18 ME MEP-2019-263A patent/ME03517B/me unknown
- 2015-12-18 MX MX2017008074A patent/MX2017008074A/es active IP Right Grant
- 2015-12-18 RS RSP20191225 patent/RS59301B1/sr unknown
- 2015-12-18 US US15/537,551 patent/US10087187B2/en active Active
- 2015-12-18 PL PL15810784T patent/PL3233862T3/pl unknown
- 2015-12-18 MA MA41174A patent/MA41174B1/fr unknown
-
2017
- 2017-06-13 IL IL252866A patent/IL252866B/en active IP Right Grant
-
2019
- 2019-10-03 CY CY20191101031T patent/CY1122381T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3233862B1 (en) | 2019-07-03 |
| ME03517B (me) | 2020-04-20 |
| IL252866B (en) | 2020-09-30 |
| KR20170095239A (ko) | 2017-08-22 |
| BR112017012930A2 (pt) | 2018-01-09 |
| HUE045220T2 (hu) | 2019-12-30 |
| HRP20191550T1 (hr) | 2019-11-29 |
| PT3233862T (pt) | 2019-10-09 |
| EA201791396A1 (ru) | 2017-10-31 |
| ES2761051T3 (es) | 2020-05-18 |
| LT3233862T (lt) | 2019-09-10 |
| AU2015366190B2 (en) | 2020-01-23 |
| PL3233862T3 (pl) | 2020-01-31 |
| CN107108634A (zh) | 2017-08-29 |
| CN107108634B (zh) | 2020-09-15 |
| US20180002336A1 (en) | 2018-01-04 |
| SMT201900509T1 (it) | 2019-11-13 |
| JP2017538734A (ja) | 2017-12-28 |
| WO2016097347A1 (en) | 2016-06-23 |
| SI3233862T1 (sl) | 2019-09-30 |
| EA029789B1 (ru) | 2018-05-31 |
| CY1122381T1 (el) | 2021-01-27 |
| MA41174B1 (fr) | 2019-09-30 |
| AU2015366190A1 (en) | 2017-05-25 |
| EP3233862A1 (en) | 2017-10-25 |
| IL252866A0 (en) | 2017-08-31 |
| CA2967551A1 (en) | 2016-06-23 |
| MX2017008074A (es) | 2018-01-09 |
| JP6568588B2 (ja) | 2019-08-28 |
| MA41174A (fr) | 2017-10-25 |
| US10087187B2 (en) | 2018-10-02 |
| MD3233862T2 (ro) | 2019-11-30 |
| DK3233862T3 (da) | 2019-10-07 |
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