RS66254B1 - Farmakofor koji indukuje trail - Google Patents

Farmakofor koji indukuje trail

Info

Publication number: RS66254B1
Authority: RS; Serbia
Prior art keywords: compound; derived; trail; cells; cell
Prior art date: 2014-03-31

Application number

RS20241340A

Other languages

English (en)

Serbian (sr)

Inventor

Kim D Janda

Nicholas T Jacob

Jonathan W Lockner

Original Assignee

Scripps Research Inst

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-03-31

Filing date

2015-03-30

Publication date

2024-12-31

2015-03-30 Application filed by Scripps Research Inst filed Critical Scripps Research Inst

2024-12-31 Publication of RS66254B1 publication Critical patent/RS66254B1/sr

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Hematology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

RS20241340A 2014-03-31 2015-03-30 Farmakofor koji indukuje trail RS66254B1 (sr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US201461972689P	2014-03-31	2014-03-31
EP19218049.5A EP3662910B1 (en)	2014-03-31	2015-03-30	Pharmacophore for trail induction

Publications (1)

Publication Number	Publication Date
RS66254B1 true RS66254B1 (sr)	2024-12-31

Family

ID=54241169

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
RS20241340A RS66254B1 (sr)	2014-03-31	2015-03-30	Farmakofor koji indukuje trail
RS20200336A RS60163B1 (sr)	2014-03-31	2015-03-30	Farmakofor koji indukuje trail

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
RS20200336A RS60163B1 (sr)	2014-03-31	2015-03-30	Farmakofor koji indukuje trail

Country Status (20)

Country	Link
US (5)	US10239877B2 (2)
EP (3)	EP3125898B1 (2)
JP (4)	JP6756435B2 (2)
KR (2)	KR102473930B1 (2)
CN (2)	CN111499636B (2)
AU (4)	AU2015241069B2 (2)
CA (2)	CA3158795A1 (2)
CY (1)	CY1123093T1 (2)
DK (2)	DK3125898T3 (2)
ES (2)	ES2999685T3 (2)
FI (1)	FI3662910T3 (2)
HR (2)	HRP20200478T1 (2)
HU (2)	HUE069651T2 (2)
LT (2)	LT3662910T (2)
PL (2)	PL3662910T3 (2)
PT (2)	PT3125898T (2)
RS (2)	RS66254B1 (2)
SI (2)	SI3662910T1 (2)
SM (2)	SMT202000219T1 (2)
WO (1)	WO2015153468A1 (2)

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WO2014160130A1 (en)	2013-03-13	2014-10-02	Oncoceutics, Inc.	Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one
US9376437B2 (en)	2013-03-13	2016-06-28	Oncoceutics, Inc	7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
US9688679B2 (en)	2013-03-13	2017-06-27	Oncoceutics, Inc.	7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
IL311202A (en) *	2013-11-15	2024-05-01	Oncoceutics Inc	7-Benzyl-4-(2-methylbenzyl)-2, 4, 6, 7, 8, 9-hexahydroimidazo [1,2-A] pyrido[3,4-E] pyrimidine-5(1H)one, its salts and methods Use
LT3662910T (lt)	2014-03-31	2024-12-27	The Scripps Research Institute	Trail geno indukcijai skirtas farmakoforas
WO2016123571A1 (en) *	2015-01-30	2016-08-04	Oncoceutics Inc.	7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy
CN104860948B (zh)	2015-05-15	2017-09-26	南京盖特医药技术有限公司	咪唑并嘧啶酮类化合物及其制备方法和应用
PL3408298T3 (pl) *	2016-01-29	2025-03-31	Oncoceutics, Inc.	Modulacja przez imiprydony receptora sprzężonego z białkiem g (gpcr)
WO2018031987A1 (en)	2016-08-12	2018-02-15	Nanjing Gator Meditech Company, Ltd.	Protein kinase regulators
US10172862B2 (en)	2017-01-30	2019-01-08	Oncoceutics, Inc.	Imipridones for gliomas
GB2596010B (en) *	2019-02-11	2023-03-01	Madera Therapeutics Llc	Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
AU2020228047B2 (en)	2019-02-27	2025-11-20	Madera Therapeutics, LLC	Use of caseinolytic protease P function as a biomarker of drug response to imipridone-like agents
MX2023001576A (es)	2020-08-06	2023-05-09	Eoetvoes Lorand Tudomanyegyetem	Síntesis de nuevos derivados de imipridona y su evaluación de su actividad anticáncerigena.
CN115448921B (zh) *	2021-06-08	2023-08-01	四川大学	一类咪唑烷并嘧啶酮化合物及在治疗HsClpP介导的疾病中的用途
CN116751199B (zh) *	2023-06-02	2025-03-18	中国科学院基础医学与肿瘤研究所(筹)	一种线粒体蛋白酶靶向嵌合体、制备方法及用途
EP4684834A1 (de) *	2024-07-26	2026-01-28	BRIU GmbH	Kristallformen onkologisch wirksamer imipridone und verfahren zu deren herstellung

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BE786028A (fr) *	1971-07-08	1973-01-08	Boehringer Sohn Ingelheim	2,3-dihydro-oxo-imidazo(1,2-a)-pyrimidines, leurs sels d'addition avec des acides et procedes pour les fabriquer
DE2150062A1 (de)	1971-10-07	1973-04-12	Boehringer Sohn Ingelheim	Imidazo- eckige klammer auf 1,2-a eckige klammer zu -pyrido- eckige klammer auf 4,3-d eckige klammer zu -pyrimidine, deren saeureadditionssalze und verfahren zu deren herstellung
JPS5374893A (en)	1976-12-15	1978-07-03	Fujitsu Ltd	Driving method for semiconductor photosensitive device
JPS6132833U (ja)	1984-07-31	1986-02-27	日信工業株式会社	デイスクブレ−キ装置
WO2004039774A2 (en) *	2002-05-23	2004-05-13	Merck & Co., Inc.	Mitotic kinesin inhibitors
PL2303264T3 (pl) *	2008-06-09	2018-08-31	Allergan, Inc.	Sposoby leczenia stanów pośredniczonych alfa-adrenergicznie z użyciem pochodnych imidazoliny
AU2011239537A1 (en) *	2010-04-16	2012-11-15	Curis, Inc.	Treatment of cancers having K-ras mutations
WO2012078448A1 (en) *	2010-12-06	2012-06-14	Schering Corporation	Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors
UA113508C2 (xx) *	2011-03-15	2017-02-10		Ізоксазолідинові похідні
EP2694678A2 (en) *	2011-04-04	2014-02-12	Netherland Cancer Institute	Methods and compositions for predicting resistance to anticancer treatment
FI4335511T3 (fi)	2011-04-29	2026-01-29	Penn State Res Found	Pienimolekyylinen normaalien ja kasvainsolujen trail-geenin indusointi syöpähoitona
US9688679B2 (en)	2013-03-13	2017-06-27	Oncoceutics, Inc.	7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-A]pyrido[3,4-E]pyrimidin-5 (1H)-one, salts thereof and methods of using the same in combination therapy
WO2014160130A1 (en) *	2013-03-13	2014-10-02	Oncoceutics, Inc.	Combination therapy with 7-benzyl-10-(2-methylbenzyl)-2,6,7,8,9,10-hexahydroimidazo[1,2-a]pyrido[4,3-d]pyrimidin-5(3h)-one
WO2015073072A1 (en) *	2013-11-15	2015-05-21	Oncoceutics, Inc.	7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one
US9376437B2 (en)	2013-03-13	2016-06-28	Oncoceutics, Inc	7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one, salts thereof and methods of using the same in combination therapy
US9181237B2 (en) *	2013-10-04	2015-11-10	Mallinckrodt Llc	Substituted berbines and their synthesis
LT3662910T (lt)	2014-03-31	2024-12-27	The Scripps Research Institute	Trail geno indukcijai skirtas farmakoforas

2015
- 2015-03-30 LT LTEP19218049.5T patent/LT3662910T/lt unknown
- 2015-03-30 SI SI201532040T patent/SI3662910T1/sl unknown
- 2015-03-30 DK DK15772254.7T patent/DK3125898T3/da active
- 2015-03-30 PT PT157722547T patent/PT3125898T/pt unknown
- 2015-03-30 EP EP15772254.7A patent/EP3125898B1/en active Active
- 2015-03-30 SI SI201531141T patent/SI3125898T1/sl unknown
- 2015-03-30 KR KR1020167029994A patent/KR102473930B1/ko active Active
- 2015-03-30 CN CN202010184181.3A patent/CN111499636B/zh active Active
- 2015-03-30 CA CA3158795A patent/CA3158795A1/en active Pending
- 2015-03-30 SM SM20200219T patent/SMT202000219T1/it unknown
- 2015-03-30 CN CN201580021658.3A patent/CN106456643B/zh active Active
- 2015-03-30 RS RS20241340A patent/RS66254B1/sr unknown
- 2015-03-30 HR HRP20200478TT patent/HRP20200478T1/hr unknown
- 2015-03-30 KR KR1020227042050A patent/KR102611067B1/ko active Active
- 2015-03-30 PL PL19218049.5T patent/PL3662910T3/pl unknown
- 2015-03-30 SM SM20240497T patent/SMT202400497T1/it unknown
- 2015-03-30 ES ES19218049T patent/ES2999685T3/es active Active
- 2015-03-30 RS RS20200336A patent/RS60163B1/sr unknown
- 2015-03-30 EP EP19218049.5A patent/EP3662910B1/en active Active
- 2015-03-30 ES ES15772254T patent/ES2779979T3/es active Active
- 2015-03-30 JP JP2016559887A patent/JP6756435B2/ja active Active
- 2015-03-30 LT LTEP15772254.7T patent/LT3125898T/lt unknown
- 2015-03-30 AU AU2015241069A patent/AU2015241069B2/en active Active
- 2015-03-30 CA CA2944452A patent/CA2944452C/en active Active
- 2015-03-30 PL PL15772254T patent/PL3125898T3/pl unknown
- 2015-03-30 HU HUE19218049A patent/HUE069651T2/hu unknown
- 2015-03-30 DK DK19218049.5T patent/DK3662910T3/da active
- 2015-03-30 HR HRP20241680TT patent/HRP20241680T1/hr unknown
- 2015-03-30 EP EP24192819.1A patent/EP4470617A3/en active Pending
- 2015-03-30 PT PT192180495T patent/PT3662910T/pt unknown
- 2015-03-30 HU HUE15772254A patent/HUE049013T2/hu unknown
- 2015-03-30 FI FIEP19218049.5T patent/FI3662910T3/fi active
- 2015-03-30 WO PCT/US2015/023362 patent/WO2015153468A1/en not_active Ceased
- 2015-03-30 US US15/126,192 patent/US10239877B2/en active Active
2019
- 2019-03-20 US US16/359,633 patent/US10633385B2/en active Active
- 2019-09-10 JP JP2019164086A patent/JP6873201B2/ja active Active
2020
- 2020-03-20 CY CY20201100267T patent/CY1123093T1/el unknown
- 2020-04-14 US US16/848,032 patent/US20200283440A1/en not_active Abandoned
- 2020-12-11 AU AU2020286314A patent/AU2020286314A1/en not_active Abandoned
2021
- 2021-04-20 JP JP2021071035A patent/JP7186256B2/ja active Active
- 2021-07-12 US US17/372,894 patent/US11891392B2/en active Active
2022
- 2022-11-28 JP JP2022188821A patent/JP7688245B2/ja active Active
- 2022-12-08 AU AU2022283729A patent/AU2022283729A1/en not_active Abandoned
2023
- 2023-12-20 US US18/391,420 patent/US20240190877A1/en active Pending
2024
- 2024-07-19 AU AU2024204977A patent/AU2024204977B2/en active Active

Also Published As

Publication number	Publication date
FI3662910T3 (fi)	2024-10-31
US20220002300A1 (en)	2022-01-06
LT3125898T (lt)	2020-04-10
EP3662910A1 (en)	2020-06-10
ES2999685T3 (en)	2025-02-26
CA2944452C (en)	2022-07-19
PT3125898T (pt)	2020-04-01
US20200283440A1 (en)	2020-09-10
EP3662910B1 (en)	2024-09-18
EP4470617A3 (en)	2025-02-26
EP3125898A4 (en)	2017-08-16
CY1123093T1 (el)	2021-10-29
JP2021119157A (ja)	2021-08-12
CA2944452A1 (en)	2015-10-08
US10633385B2 (en)	2020-04-28
SI3662910T1 (sl)	2025-05-30
JP7186256B2 (ja)	2022-12-08
CN111499636B (zh)	2023-01-13
JP2023022184A (ja)	2023-02-14
HRP20200478T1 (hr)	2020-07-24
US20240190877A1 (en)	2024-06-13
AU2024204977A1 (en)	2024-08-08
KR102473930B1 (ko)	2022-12-05
US20190284188A1 (en)	2019-09-19
HRP20241680T1 (hr)	2025-02-28
SMT202000219T1 (it)	2020-05-08
US10239877B2 (en)	2019-03-26
LT3662910T (lt)	2024-12-27
AU2024204977B2 (en)	2026-04-16
DK3662910T3 (en)	2024-11-04
HUE049013T2 (hu)	2020-08-28
PL3662910T3 (pl)	2025-08-11
JP6756435B2 (ja)	2020-09-16
KR20160138513A (ko)	2016-12-05
KR102611067B1 (ko)	2023-12-06
RS60163B1 (sr)	2020-05-29
AU2015241069A1 (en)	2016-10-20
US20170107221A1 (en)	2017-04-20
CA3158795A1 (en)	2015-10-08
JP2017511321A (ja)	2017-04-20
EP3125898A1 (en)	2017-02-08
SI3125898T1 (sl)	2020-07-31
AU2022283729A1 (en)	2023-02-02
WO2015153468A1 (en)	2015-10-08
PT3662910T (pt)	2024-11-27
SMT202400497T1 (it)	2025-01-14
JP6873201B2 (ja)	2021-05-19
HUE069651T2 (hu)	2025-03-28
PL3125898T3 (pl)	2020-11-16
AU2020286314A1 (en)	2021-01-21
ES2779979T3 (es)	2020-08-21
JP2020002170A (ja)	2020-01-09
CN111499636A (zh)	2020-08-07
AU2015241069B2 (en)	2020-10-15
JP7688245B2 (ja)	2025-06-04
KR20220163533A (ko)	2022-12-09
US11891392B2 (en)	2024-02-06
DK3125898T3 (da)	2020-03-30
CN106456643A (zh)	2017-02-22
CN106456643B (zh)	2020-04-17
EP4470617A2 (en)	2024-12-04
EP3125898B1 (en)	2019-12-25

Publication	Publication Date	Title
RS66254B1 (sr)	2024-12-31	Farmakofor koji indukuje trail
US10258626B2 (en)	2019-04-16	Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
HK40020077B (en)	2025-03-28	Pharmacophore for trail induction
HK40121084A (en)	2025-09-05	Pharmacophore for trail induction
HK40020077A (en)	2020-10-23	Pharmacophore for trail induction
HK40035689A (en)	2021-05-21	Pharmacophore for trail induction