RU2003133773A - Фармацевтическое применение бисфосфонатов - Google Patents
Фармацевтическое применение бисфосфонатов Download PDFInfo
- Publication number
- RU2003133773A RU2003133773A RU2003133773/14A RU2003133773A RU2003133773A RU 2003133773 A RU2003133773 A RU 2003133773A RU 2003133773/14 A RU2003133773/14 A RU 2003133773/14A RU 2003133773 A RU2003133773 A RU 2003133773A RU 2003133773 A RU2003133773 A RU 2003133773A
- Authority
- RU
- Russia
- Prior art keywords
- bisphosphonate
- prostate cancer
- diphosphonic acid
- acid
- patient
- Prior art date
Links
- 229940122361 Bisphosphonate Drugs 0.000 title claims 13
- 150000004663 bisphosphonates Chemical class 0.000 title 1
- 206010060862 Prostate cancer Diseases 0.000 claims 9
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 7
- MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 claims 4
- 206010027476 Metastases Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 claims 4
- PMXAPNNYCFBALB-UHFFFAOYSA-N (1-hydroxy-1-phosphono-3-pyrrolidin-1-ylpropyl)phosphonic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CCN1CCCC1 PMXAPNNYCFBALB-UHFFFAOYSA-N 0.000 claims 3
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 claims 3
- IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 claims 3
- WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- NPLHDPAQRZJWHX-UHFFFAOYSA-N [5,5-bis(diethoxyphosphoryl)-1,4-dihydropyrazol-3-yl]-phenylmethanone Chemical compound N1C(P(=O)(OCC)OCC)(P(=O)(OCC)OCC)CC(C(=O)C=2C=CC=CC=2)=N1 NPLHDPAQRZJWHX-UHFFFAOYSA-N 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- -1 for example Chemical compound 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 208000010658 metastatic prostate carcinoma Diseases 0.000 claims 2
- VMMKGHQPQIEGSQ-UHFFFAOYSA-N minodronic acid Chemical compound C1=CC=CN2C(CC(O)(P(O)(O)=O)P(O)(O)=O)=CN=C21 VMMKGHQPQIEGSQ-UHFFFAOYSA-N 0.000 claims 2
- 230000001582 osteoblastic effect Effects 0.000 claims 2
- 229960004276 zoledronic acid Drugs 0.000 claims 2
- RDFHOSXBGDLRQF-UHFFFAOYSA-N (2-anilino-1-phosphono-2-sulfanylideneethyl)phosphonic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)C(=S)NC1=CC=CC=C1 RDFHOSXBGDLRQF-UHFFFAOYSA-N 0.000 claims 1
- HLNJFEXZDGURGZ-UHFFFAOYSA-M 1-methylpyridin-1-ium;iodide Chemical class [I-].C[N+]1=CC=CC=C1 HLNJFEXZDGURGZ-UHFFFAOYSA-M 0.000 claims 1
- NEAHTABRXFKZGG-UHFFFAOYSA-N 2-pyridin-4-yl-3h-imidazo[4,5-c]pyridine Chemical compound C1=NC=CC(C=2NC3=CN=CC=C3N=2)=C1 NEAHTABRXFKZGG-UHFFFAOYSA-N 0.000 claims 1
- PQBAWAQIRZIWIV-UHFFFAOYSA-N N-methylpyridinium Chemical class C[N+]1=CC=CC=C1 PQBAWAQIRZIWIV-UHFFFAOYSA-N 0.000 claims 1
- VADUXZPJGJBSLQ-UHFFFAOYSA-N [1-hydroxy-3-(1-methylpyridin-1-ium-3-yl)-1-phosphonopropyl]phosphonic acid;hydroxide Chemical compound [OH-].C[N+]1=CC=CC(CCC(O)(P(O)(O)=O)P(O)(O)=O)=C1 VADUXZPJGJBSLQ-UHFFFAOYSA-N 0.000 claims 1
- QWCNOXMFNSYEKF-UHFFFAOYSA-N [1-hydroxy-3-[methyl(2-phenylsulfanylethyl)amino]-1-phosphonopropyl]phosphonic acid Chemical compound OP(=O)(O)C(O)(P(O)(O)=O)CCN(C)CCSC1=CC=CC=C1 QWCNOXMFNSYEKF-UHFFFAOYSA-N 0.000 claims 1
- UGEPSJNLORCRBO-UHFFFAOYSA-N [3-(dimethylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid Chemical compound CN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O UGEPSJNLORCRBO-UHFFFAOYSA-N 0.000 claims 1
- 229940062527 alendronate Drugs 0.000 claims 1
- 229960004343 alendronic acid Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- JFGHPLSPUGOSLV-UHFFFAOYSA-L disodium;[3-(dimethylamino)-1-hydroxy-1-[hydroxy(oxido)phosphoryl]propyl]-hydroxyphosphinate Chemical compound [Na+].[Na+].CN(C)CCC(O)(P(O)(O)=O)P([O-])([O-])=O JFGHPLSPUGOSLV-UHFFFAOYSA-L 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229940015872 ibandronate Drugs 0.000 claims 1
- 229960005236 ibandronic acid Drugs 0.000 claims 1
- PUUSSSIBPPTKTP-UHFFFAOYSA-N neridronic acid Chemical compound NCCCCCC(O)(P(O)(O)=O)P(O)(O)=O PUUSSSIBPPTKTP-UHFFFAOYSA-N 0.000 claims 1
- 229940046231 pamidronate Drugs 0.000 claims 1
- 229960003978 pamidronic acid Drugs 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229940089617 risedronate Drugs 0.000 claims 1
- 229960000759 risedronic acid Drugs 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
- A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Claims (12)
1. Способ лечения рака предстательной железы у больного, нуждающегося в таком лечении, включающий введение больному эффективного количества N-бисфосфоната.
2. Применение N-бисфосфоната для приготовления лекарственного средства для лечения рака предстательной железы.
3. Применение N-бисфосфоната для лечения остеобластных метастазов, связанных со злокачественными заболеваниями или состояниями у млекопитающих.
4. Применение N-бисфосфоната для приготовлении лекарственного средства для лечения остеобластных метастазов, связанных со злокачественными заболеваниями или состояниями у млекопитающих.
5. Способ лечения метастазов, связанных с раком предстательной железы, у больного, нуждающегося в таком лечении, включающий введение больному эффективного количества N-бисфосфоната.
6. Применение N-бисфосфоната для приготовления лекарственного средства для лечения метастазов, связанных с раком предстательной железы, у больного, нуждающегося в таком лечении.
7. Способ уменьшения связанных с изменениями в костях скелета явлений, обусловленных метастатическим раком предстательной железы, у больного раком предстательной железы, включающий введение больному эффективного количества N-бисфосфоната.
8. Применение N-бисфосфоната для приготовлении лекарственного средства для уменьшения связанных с изменениями в костях скелета явлений, обусловленных метастатическим раком предстательной железы, у больного раком предстательной железы.
9. Способ по п.1 или применение по п.2, где N-бисфосфонат представляет собой соединение формулы I
где X означает водород, гидроксил, аминогруппу, алканоил или аминогруппу, замещенную (С1-С4)алкилом или алканоилом;
R означает водород или (С1-С4)алкил и
Rx означает боковую цепь, которая содержит необязательно замещенную аминогруппу, или азотсодержащий гетероцикл (включая ароматические азотсодержащие гетероциклы),
или его фармацевтически приемлемыми солями или любым его гидратом.
10. Способ или применение по п.9, где N-бисфосфонат означает одно из следующих соединений или его фармацевтически приемлемую соль или любой его гидрат: 3-амино-1-гидроксипропан-1,1-дифосфоновую кислоту (памидроновая кислота), например памидронат (APD); 3-(N,N-диметиламино)-1-гидроксипропан-1,1-дифосфоновую кислоту, например, диметил-APD; 4-амино-1-гидроксибутан-1,1-дифосфоновую кислоту (алендроновую кислоту), например алендронат; 1-гидрокси-3-(метилпентиламино)пропилиденбисфосфоновую кислоту (ибандроновую кислоту), например ибандронат; 6-амино-1-гидроксигексан-1,1-дифосфоновую кислоту, например аминогексил-ВР; 3-(N-метил-N-н-пентиламино)-1-гидроксипропан-1,1-дифосфоновую кислоту, например метилпентил-APD (=ВМ 21.0955); 1-гидрокси-2-(имидазол-1-ил)этан-1,1-дифосфоновую кислоту, например золедроновую кислоту; 1-гидрокси-2-(3-пиридил)этан-1,1-дифосфоновую кислоту (ризедроновую кислоту), например ризедронат, включая ее N-метилпиридиниевые соли, например иодиды N-метилпиридиния, как, например, NE-10244 или NE-10446; 3-[N-(2-фенилтиоэтил)-N-метиламино]-1-гидроксипропан-1,1-дифосфоновую кислоту; 1-гидрокси-3-(пирролидин-1-ил)пропан-1,1-дифосфоновую кислоту, например ЕВ 1053 (Leo); 1-(N-фениламинотиокарбонил)метан-1,1-дифосфоновую кислоту, например FR 78844 (Fujisawa); тетраэтиловый эфир 5-бензоил-3,4-дигидро-2Н-пиразол-3,3-дифосфоновой кислоты, например U-81581 (Upjohn); и 1-гидрокси-2-(имидазо[1,2-а]пиридин-3-ил)-этан-1,1-дифосфоновую кислоту, например YM 529.
11. Способ по п.1 или применение по п.2, где применяемый N-бисфосфонат представляет собой 2-(имидазол-1-ил)-1-гидроксиэтан-1,1-дифосфоновую кислоту (золедроновую кислоту) или ее фармакологически приемлемую соль.
12. Способ лечения больных раком предстательной железы, включающий комбинированное лечение N-бисфосфонатом и другим средством против рака предстательной железы или терапию против рака предстательной железы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28822001P | 2001-05-02 | 2001-05-02 | |
| US60/288,220 | 2001-05-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003133773A true RU2003133773A (ru) | 2005-02-10 |
| RU2297229C2 RU2297229C2 (ru) | 2007-04-20 |
Family
ID=23106248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003133773/14A RU2297229C2 (ru) | 2001-05-02 | 2002-04-30 | Фармацевтическое применение бисфосфонатов |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20040157799A1 (ru) |
| EP (1) | EP1418897A2 (ru) |
| JP (1) | JP2004528340A (ru) |
| KR (1) | KR20040015230A (ru) |
| CN (1) | CN1277545C (ru) |
| AR (1) | AR033175A1 (ru) |
| AU (1) | AU2002257802B2 (ru) |
| BR (1) | BR0209365A (ru) |
| CA (1) | CA2443625A1 (ru) |
| CZ (1) | CZ20032950A3 (ru) |
| HU (1) | HUP0400096A2 (ru) |
| IL (1) | IL158273A0 (ru) |
| MX (1) | MXPA03010007A (ru) |
| MY (1) | MY141584A (ru) |
| NO (1) | NO20034877L (ru) |
| NZ (1) | NZ528676A (ru) |
| PL (1) | PL363507A1 (ru) |
| RU (1) | RU2297229C2 (ru) |
| SK (1) | SK13512003A3 (ru) |
| WO (1) | WO2002087555A2 (ru) |
| ZA (1) | ZA200307666B (ru) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| CA2525929A1 (en) | 2003-05-13 | 2004-11-25 | Chiron Corporation | Methods of modulating metastasis and skeletal related events resulting from metastases |
| GB0320806D0 (en) * | 2003-09-05 | 2003-10-08 | Astrazeneca Ab | Therapeutic treatment |
| WO2005027921A1 (en) * | 2003-09-19 | 2005-03-31 | Pfizer Products Inc. | Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate |
| BRPI0710503A2 (pt) * | 2006-04-07 | 2011-08-16 | Merrion Res Iii Ltd | uso de uma composição farmacêutica, composição farmacêutica, e, forma de dosagem oral |
| RU2517135C2 (ru) * | 2008-05-07 | 2014-05-27 | Меррион Рисерч Iii Лимитед | Композиции пептидов и способы их получения |
| RU2407746C2 (ru) * | 2008-09-29 | 2010-12-27 | ЗАО "Фарм-Синтез" | Радиофармацевтическое средство для диагностики и лечения (терапии) костных поражений скелета и способ его получения |
| CA2751854A1 (en) * | 2009-02-25 | 2010-09-02 | Merrion Research Iii Limited | Composition and drug delivery of bisphosphonates |
| CA2769633C (en) * | 2009-07-31 | 2017-06-06 | Thar Pharma, Llc | Crystallization method and bioavailability |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| EP2289900A1 (en) * | 2009-08-26 | 2011-03-02 | Humboldt Universität zu Berlin | Bisphosphonates as inhibitors of acid sphingomyelinase |
| DK2473172T3 (en) * | 2009-09-01 | 2015-06-15 | Univ Duke | BISPHOSPHONATSAMMENSÆTNINGER and Methods for treating congestive heart failure |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| US9089484B2 (en) * | 2010-03-26 | 2015-07-28 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor Xa inhibitors for oral administration |
| WO2012071517A2 (en) | 2010-11-24 | 2012-05-31 | Thar Pharmaceuticals, Inc. | Novel crystalline forms |
| KR20140026354A (ko) | 2011-01-07 | 2014-03-05 | 메리온 리서치 Ⅲ 리미티드 | 경구 투여용 철의 제약 조성물 |
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| US10111837B2 (en) | 2012-05-14 | 2018-10-30 | Antecip Bioventures Ii Llc | Dosage forms for oral administration of zoledronic acid or related compounds |
| US9999628B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Neridronic acid for treating complex regional pain syndrome |
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| US10028908B2 (en) | 2012-05-14 | 2018-07-24 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9700570B2 (en) | 2014-05-27 | 2017-07-11 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US9999629B2 (en) | 2012-05-14 | 2018-06-19 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
| US10004756B2 (en) | 2014-05-15 | 2018-06-26 | Antecip Bioventures Ii Llc | Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome |
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| KR20190009428A (ko) * | 2013-10-25 | 2019-01-28 | 안테씨프 바이오벤쳐스 투 엘엘씨 | 질병의 치료를 위한, 졸레드론산 또는 관련 화합물의 경구 투여용 조성물 |
| US9127069B1 (en) | 2014-06-11 | 2015-09-08 | Antecip Bioventures LLC | Compositions comprising rank/rankl antagonists and related compounds for treating pain |
| US9688765B2 (en) | 2014-06-11 | 2017-06-27 | Antecip Bioventures Ii Llc | Methods using RANK/RANKL antagonist antibodies for treating pain |
| JO3394B1 (ar) * | 2014-07-04 | 2019-10-20 | Osteo Pharma B V | تركيبات ومنتجات للاستعمال في علاج كسور وعيوب العظام |
| EP3194972B1 (en) * | 2014-09-17 | 2021-04-14 | Merck Patent GmbH | A method of treating bone metastasis diseases, medicaments therefore, and a method of predicting the clinical outcome of treating bone metastasis diseases |
| WO2016041614A1 (en) | 2014-09-17 | 2016-03-24 | Merck Patent Gmbh | A method of treating solid cancers and/or metastases thereof, medicaments therefore, and a method of predicting the clinical outcome of treating solid cancers and/or metastases thereof |
| JP6659689B2 (ja) * | 2014-11-27 | 2020-03-04 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | ガス・センサー・システム及びガス・センシング方法 |
| RU2609871C1 (ru) * | 2015-08-10 | 2017-02-06 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Противоопухолевое средство |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
| CN108514645B (zh) * | 2018-04-08 | 2021-07-20 | 西南医科大学附属医院 | 一种兼具骨显像和骨转移瘤治疗的制剂及其制备和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634691A (en) * | 1980-10-07 | 1987-01-06 | The Procter & Gamble Company | Method for inhibiting tumor metastasis |
| FI89364C (fi) * | 1990-12-20 | 1993-09-27 | Leiras Oy | Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat |
| EP0805673A1 (en) * | 1994-10-20 | 1997-11-12 | The Procter & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| US6572874B1 (en) * | 1998-05-15 | 2003-06-03 | Umd, Inc. | Vaginal delivery of bisphosphonates |
| US6015801A (en) * | 1997-07-22 | 2000-01-18 | Merck & Co., Inc. | Method for inhibiting bone resorption |
| US6142383A (en) * | 1998-04-08 | 2000-11-07 | Hinsilblon Laboratories | Method of waterless large scale dispersion of essential oils and apparatus therefor |
| JP2002534483A (ja) * | 1999-01-15 | 2002-10-15 | ライト サイエンシーズ コーポレイション | 代謝性骨障害または骨転移のための治療的組成物 |
| GB9907908D0 (en) * | 1999-04-07 | 1999-06-02 | Bataille Regis | Organic compounds |
| KR100763064B1 (ko) * | 1999-05-21 | 2007-10-04 | 노파르티스 아게 | 제약 조성물 및 용도 |
| RU2153358C1 (ru) * | 1999-11-10 | 2000-07-27 | Центральный научно-исследовательский рентгенорадиологический институт МЗ России | Способ лечения остеолитических метастазов |
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- 2002-04-30 NZ NZ528676A patent/NZ528676A/xx unknown
- 2002-04-30 BR BR0209365-0A patent/BR0209365A/pt not_active IP Right Cessation
- 2002-04-30 JP JP2002584901A patent/JP2004528340A/ja active Pending
- 2002-04-30 RU RU2003133773/14A patent/RU2297229C2/ru not_active IP Right Cessation
- 2002-04-30 HU HU0400096A patent/HUP0400096A2/hu unknown
- 2002-04-30 SK SK1351-2003A patent/SK13512003A3/sk not_active Application Discontinuation
- 2002-04-30 CZ CZ20032950A patent/CZ20032950A3/cs unknown
- 2002-04-30 PL PL02363507A patent/PL363507A1/xx not_active Application Discontinuation
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- 2002-04-30 WO PCT/EP2002/004771 patent/WO2002087555A2/en not_active Ceased
- 2002-04-30 US US10/476,365 patent/US20040157799A1/en not_active Abandoned
- 2002-04-30 CN CNB028092236A patent/CN1277545C/zh not_active Expired - Fee Related
- 2002-04-30 CA CA002443625A patent/CA2443625A1/en not_active Abandoned
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| Publication number | Publication date |
|---|---|
| CN1277545C (zh) | 2006-10-04 |
| RU2297229C2 (ru) | 2007-04-20 |
| JP2004528340A (ja) | 2004-09-16 |
| US20040157799A1 (en) | 2004-08-12 |
| CA2443625A1 (en) | 2002-11-07 |
| ZA200307666B (en) | 2004-05-05 |
| PL363507A1 (en) | 2004-11-29 |
| IL158273A0 (en) | 2004-05-12 |
| NO20034877D0 (no) | 2003-10-31 |
| MXPA03010007A (es) | 2004-02-12 |
| SK13512003A3 (sk) | 2004-08-03 |
| WO2002087555A3 (en) | 2004-02-05 |
| AR033175A1 (es) | 2003-12-03 |
| AU2002257802B2 (en) | 2006-02-16 |
| CN1638778A (zh) | 2005-07-13 |
| BR0209365A (pt) | 2004-06-08 |
| NO20034877L (no) | 2003-12-19 |
| MY141584A (en) | 2010-05-14 |
| EP1418897A2 (en) | 2004-05-19 |
| NZ528676A (en) | 2006-03-31 |
| WO2002087555A2 (en) | 2002-11-07 |
| HK1080711A1 (en) | 2006-05-04 |
| HUP0400096A2 (hu) | 2004-04-28 |
| CZ20032950A3 (cs) | 2004-06-16 |
| KR20040015230A (ko) | 2004-02-18 |
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