RU2006117320A - Кристаллические формы гидрохлорида 3-бета-амино-17-метиленандростан-6-альфа-7-бета-диола - Google Patents

Кристаллические формы гидрохлорида 3-бета-амино-17-метиленандростан-6-альфа-7-бета-диола Download PDF

Info

Publication number: RU2006117320A
Authority: RU; Russia
Prior art keywords: beta; alpha; amino; methyleneandrostan; diol
Prior art date: 2003-10-20

Application number

RU2006117320/04A

Other languages

English (en)

Russian (ru)

Inventor

Колетт КОЛЛАДАН (FR)

Колетт Колладан

Дени ПРА (FR)

Дени ПРА

Паскаль БИЙО (FR)

Паскаль Бийо

Александр ЖИЮЛИАНИ (FR)

Александр ЖИЮЛИАНИ

Ажи ЭЛЬМАЛЕ (FR)

Ажи Эльмале

Марк-Антуан ПЕРРЭН (FR)

Марк-Антуан ПЕРРЭН

Original Assignee

Инфлазим Фармасьютикалз, Лтд. (Ca)

Инфлазим Фармасьютикалз, Лтд.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-20

Filing date

2004-10-20

Publication date

2007-11-27

2003-10-20 Priority claimed from FR0312257A external-priority patent/FR2861077B1/fr

2004-10-20 Application filed by Инфлазим Фармасьютикалз, Лтд. (Ca), Инфлазим Фармасьютикалз, Лтд. filed Critical Инфлазим Фармасьютикалз, Лтд. (Ca)

2007-11-27 Publication of RU2006117320A publication Critical patent/RU2006117320A/ru

Links

VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 title 1
239000013078 crystal Substances 0.000 title 1
230000003595 spectral effect Effects 0.000 claims 5
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
239000003814 drug Substances 0.000 claims 2
OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 2
238000000034 method Methods 0.000 claims 2
239000000203 mixture Substances 0.000 claims 2
239000000843 powder Substances 0.000 claims 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
239000000654 additive Substances 0.000 claims 1
238000010533 azeotropic distillation Methods 0.000 claims 1
238000002425 crystallisation Methods 0.000 claims 1
230000008025 crystallization Effects 0.000 claims 1
239000003085 diluting agent Substances 0.000 claims 1
229940079593 drug Drugs 0.000 claims 1
208000027866 inflammatory disease Diseases 0.000 claims 1
239000008194 pharmaceutical composition Substances 0.000 claims 1
238000000634 powder X-ray diffraction Methods 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

RU2006117320/04A 2003-10-20 2004-10-20 Кристаллические формы гидрохлорида 3-бета-амино-17-метиленандростан-6-альфа-7-бета-диола RU2006117320A (ru)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US51267903P	2003-10-20	2003-10-20
FR0312257		2003-10-20
FR0312257A FR2861077B1 (fr)	2003-10-20	2003-10-20	Formes cristallines du chlorydrate de 3-beta-amino, 17-methylene, androstane-6-alpha, 7-beta-diol
US60/512,679		2003-10-20

Publications (1)

Publication Number	Publication Date
RU2006117320A true RU2006117320A (ru)	2007-11-27

Family

ID=34466415

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2006117320/04A RU2006117320A (ru)	2003-10-20	2004-10-20	Кристаллические формы гидрохлорида 3-бета-амино-17-метиленандростан-6-альфа-7-бета-диола

Country Status (8)

Country	Link
EP (1)	EP1680441A1 (de)
JP (1)	JP2007509050A (de)
KR (1)	KR20070007766A (de)
AU (1)	AU2004281998A1 (de)
CA (1)	CA2542821A1 (de)
MX (1)	MXPA06005679A (de)
RU (1)	RU2006117320A (de)
WO (1)	WO2005037851A1 (de)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1278763B1 (de) *	2000-04-28	2007-02-14	Inflazyme Pharmaceuticals, Ltd.	3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon

2004
- 2004-10-20 MX MXPA06005679A patent/MXPA06005679A/es unknown
- 2004-10-20 EP EP04769678A patent/EP1680441A1/de not_active Withdrawn
- 2004-10-20 WO PCT/IB2004/003426 patent/WO2005037851A1/fr not_active Ceased
- 2004-10-20 AU AU2004281998A patent/AU2004281998A1/en not_active Abandoned
- 2004-10-20 RU RU2006117320/04A patent/RU2006117320A/ru not_active Application Discontinuation
- 2004-10-20 JP JP2006534854A patent/JP2007509050A/ja active Pending
- 2004-10-20 CA CA002542821A patent/CA2542821A1/fr not_active Abandoned
- 2004-10-20 KR KR1020067009800A patent/KR20070007766A/ko not_active Withdrawn

Also Published As

Publication number	Publication date
CA2542821A1 (fr)	2005-04-28
AU2004281998A1 (en)	2005-04-28
MXPA06005679A (es)	2006-08-17
WO2005037851A1 (fr)	2005-04-28
EP1680441A1 (de)	2006-07-19
KR20070007766A (ko)	2007-01-16
JP2007509050A (ja)	2007-04-12

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Legal Events

Date	Code	Title	Description
2009-03-27	FA92	Acknowledgement of application withdrawn (lack of supplementary materials submitted)	Effective date: 20090209