RU2007123797A - Предотвращение формирования и/или стабилизации тромбов - Google Patents

Предотвращение формирования и/или стабилизации тромбов Download PDF

Info

Publication number
RU2007123797A
RU2007123797A RU2007123797/14A RU2007123797A RU2007123797A RU 2007123797 A RU2007123797 A RU 2007123797A RU 2007123797/14 A RU2007123797/14 A RU 2007123797/14A RU 2007123797 A RU2007123797 A RU 2007123797A RU 2007123797 A RU2007123797 A RU 2007123797A
Authority
RU
Russia
Prior art keywords
inhibitor
antibody
formation
fxii
trypsin
Prior art date
Application number
RU2007123797/14A
Other languages
English (en)
Other versions
RU2514878C2 (ru
Inventor
Бернхард НИЕСВАНДТ (DE)
Бернхард НИЕСВАНДТ
Томас РЕНЕ (DE)
Томас РЕНЕ
Original Assignee
Ксл Бехринг Гмбх (De)
Ксл Бехринг Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ксл Бехринг Гмбх (De), Ксл Бехринг Гмбх filed Critical Ксл Бехринг Гмбх (De)
Publication of RU2007123797A publication Critical patent/RU2007123797A/ru
Application granted granted Critical
Publication of RU2514878C2 publication Critical patent/RU2514878C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/556—Angiotensin converting enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/56—Protease inhibitors from plants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Botany (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (16)

1. Использование, по меньшей мере, одного антитела и/или одного ингибитора для ингибирования фактора коагуляции XII и предотвращения формирования и/или стабилизации тромбов и предотвращения, таким образом, внутрипросветного роста трехмерного тромба.
2. Использование по п.1, в котором указанное антитело представляет собой антитело анти-FXII.
3. Использование по п.1, в котором указанное антитело представляет собой ингибитор активизации FXII.
4. Использование по п.1, в котором указанный ингибитор представляет собой ингибитор протеазы.
5. Использование по п.1, в котором указанный ингибитор представляет собой ингибитор серин-протеазы.
6. Использование по п.3, в котором указанный ингибитор протеазы выбран из группы, содержащей ингибитор AT III, ангиотензин, ингибитор преобразования фермента, ингибитор С1, апротинин, ингибитор протеазы альфа-1, антиболевое средство ([(S)-1-карбокси-2-фенилэтил]-карбамоил-L-аргинал-L-вал-аргинал) ацетат Z-про-про-альдегид-диметил, DX88, леупептин, ингибиторы пролил олигопептидазы, такие как Fmoc-Ala-Pyr-CN, ингибитор корн-трипсина, мутанты бычьего панкреатического ингибитора трипсина, экотин, YAP (желтый одиночный белок антикоагулянта) и ингибитор-V трипсина семени тыквы и изоингибитор семени тыквы.
7. Использование антитела и/или ингибитора согласно любому из пп.1-4 в медицине.
8. Использование антитела и/или ингибитора по любому из пп.1-4 при изготовлении лекарственных средств.
9. Использование антитела и/или ингибитора по любому из пп.1-4 для лечения или профилактики условия или нарушений, связанных с формированием венозного или артериального тромба, особенно инсульт или инфаркт миокарда, воспаление, активация комплемента, фибринолиз, ангиогенез и/или болезни, связанные с вызванным FXII формированием кинина, такие как наследственная болезнь Квинке, бактериальные инфекции легкого, инфекции трипаносомы, гипотензивный шок, панкреатит, болезнь Шагаса или суставная подагра.
10. Фармацевтический препарат, содержащий, по меньшей мере, одно антитело и/или один ингибитор, который подходит для ингибирования фактора XII и который предотвращает формирование и/или стабилизацию патологических тромбов.
11. Препарат по п.8, в котором указанное антитело представляет собой антитело анти-FXII.
12. Препарат по п.8, в котором указанное антитело ингибирует активацию FXII.
13. Препарат по п.8, в котором указанный ингибитор представляет собой ингибитор протеазы.
14. Препарат по п.8, в котором указанное ингибитор представляет собой ингибитор серин-протеазы.
15. Препарат по п.10, в котором указанное ингибитор протеазы выбран из использования по п.3, в котором указанный ингибитор протеазы выбран из группы, содержащей ингибитор AT III, ангиотензин, ингибитор преобразования фермента, ингибитор С1, апротинин, ингибитор протеазы альфа-1, антиболевое средство ([(S)-1-карбокси-2-фенилэтил]-карбамоил-L-аргинал-L-вал-аргинал) ацетат Z-про-про-альдегид-диметил, DX88, леупептин, ингибиторы пролил олигопептидазы, такие как Fmoc-Ala-Pyr-CN, ингибитор корн-трипсина, мутанты бычьего панкреатического ингибитора трипсина, экотин, YAP (желтый одиночный белок антикоагулянта) и ингибитор-V трипсина семени тыквы и изоингибитор семени тыквы.
16. Использование фактора XII в качестве антитромбического средства ингибированным фактором XII, по меньшей мере, одним антителом и/или одним ингибитором и, следовательно, предотвращение формирования и/или стабилизации тромбов или роста тромба.
RU2007123797/14A 2004-12-23 2005-12-20 Предотвращение образования и/или стабилизации тромбов RU2514878C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04030593 2004-12-23
EP04030593.0 2004-12-23
PCT/EP2005/013714 WO2006066878A1 (en) 2004-12-23 2005-12-20 Prevention of thrombus formation and/or stabilization

Publications (2)

Publication Number Publication Date
RU2007123797A true RU2007123797A (ru) 2009-01-10
RU2514878C2 RU2514878C2 (ru) 2014-05-10

Family

ID=34927953

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2007123797/14A RU2514878C2 (ru) 2004-12-23 2005-12-20 Предотвращение образования и/или стабилизации тромбов

Country Status (14)

Country Link
US (3) US8119137B2 (ru)
EP (2) EP1830924B1 (ru)
JP (1) JP5118492B2 (ru)
KR (1) KR101277097B1 (ru)
CN (1) CN101102819A (ru)
AU (1) AU2005318464B2 (ru)
BR (1) BRPI0519349A8 (ru)
CA (1) CA2591786C (ru)
DK (1) DK1830924T3 (ru)
ES (1) ES2407965T3 (ru)
MX (1) MX2007006997A (ru)
PL (1) PL1830924T3 (ru)
RU (1) RU2514878C2 (ru)
WO (1) WO2006066878A1 (ru)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057287A (en) 1994-01-11 2000-05-02 Dyax Corp. Kallikrein-binding "Kunitz domain" proteins and analogues thereof
ES2348230T3 (es) 2002-06-07 2010-12-01 Dyax Corp. Prevención y reducción de la isquemia.
US7153829B2 (en) 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
EP2386310B1 (en) 2002-08-28 2018-11-07 Dyax Corp. Methods for preserving organs and tissues
US7235530B2 (en) 2004-09-27 2007-06-26 Dyax Corporation Kallikrein inhibitors and anti-thrombolytic agents and uses thereof
GB0607515D0 (en) * 2006-04-13 2006-05-24 Axis Shield Diagnostics Ltd Anti-factor xlla therapy
WO2008016883A2 (en) 2006-07-31 2008-02-07 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
CA2678001C (en) 2007-02-12 2017-07-11 Stefan Schulte Therapeutic application of kazal-type serine protease inhibitors
WO2009026539A1 (en) * 2007-08-23 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
AU2008315938B2 (en) * 2007-10-22 2014-11-27 Georg Dewald Disorders of vasoregulation and methods of diagnosing them
EP2103311A1 (en) 2008-03-20 2009-09-23 CSL Behring GmbH The calcium sensor STIM1 is essential for pathological thrombus formation
EP2145900A1 (en) 2008-07-15 2010-01-20 CSL Behring GmbH Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation
US8637454B2 (en) 2009-01-06 2014-01-28 Dyax Corp. Treatment of mucositis with kallikrein inhibitors
EP2269597A1 (en) 2009-06-22 2011-01-05 CSL Behring GmbH CLEC-2 is an essential platelet activating receptor in hemostasis and thrombosis
EP2272874A1 (en) 2009-07-10 2011-01-12 CSL Behring GmbH Role of PLD1 in thrombus formation and integrin alpha IIb beta 3 activation
SMT201800552T1 (it) 2010-01-06 2018-11-09 Dyax Corp Proteine che legano la callicreina plasmatica
EP2371857A1 (en) * 2010-04-01 2011-10-05 CSL Behring GmbH Factor XII inhibitors for treating interstitial lung disease
US9150864B2 (en) * 2010-11-08 2015-10-06 Isis Pharmaceuticals, Inc. Methods for modulating factor 12 expression
KR102320178B1 (ko) 2011-01-06 2021-11-02 다케다 파머수티컬 컴패니 리미티드 혈장 칼리크레인 결합 단백질
US9352016B2 (en) 2011-03-09 2016-05-31 Csl Behring Gmbh Factor XII inhibitors for the administration with medical procedures comprising contact with artificial surfaces
EP2497489A1 (en) * 2011-03-09 2012-09-12 CSL Behring GmbH Factor XII inhibitors for the treatment of silent brain ischemia and ischemia of other organs
WO2012170947A2 (en) 2011-06-10 2012-12-13 Isis Pharmaceuticals, Inc. Methods for modulating factor 12 expression
IL230564B2 (en) 2011-07-22 2023-09-01 Csl Ltd Anticoagulant monoclonal antibodies anti–factor xii/fxiia, a method for their preparation, a pharmaceutical compound containing them and medical uses.
EP2548892A1 (en) 2011-07-22 2013-01-23 CSL Behring GmbH Inhibitory anti-Factor XII/XIIa monoclonal Antibodies and their uses
US20140296146A1 (en) * 2011-08-23 2014-10-02 Synapse B.V. Thermostable Inhibitors of Activation of the Blood Clotting System Through Contact with Foreign Surfaces
EP2623110A1 (en) * 2012-01-31 2013-08-07 CSL Behring GmbH Factor XII inhibitors for the treatment of neurological inflammatory disorders
US9574013B2 (en) * 2012-12-07 2017-02-21 Vanderbilt University Antibodies against factor XII and uses thereof
CN105188750A (zh) 2013-03-08 2015-12-23 德国杰特贝林生物制品有限公司 治疗和预防远端缺血-再灌注损伤
CA2916399C (en) * 2013-06-28 2022-08-02 Marc Nolte Combination therapy using a factor xii inhibitor and a c1-inhibitor
JP7109160B2 (ja) 2014-06-18 2022-07-29 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー 神経外傷性障害において第ｘｉｉ因子インヒビターを使用する療法
CN107405399B (zh) 2015-01-02 2022-02-08 武田药品工业株式会社 针对血浆激肽释放酶和因子xii的双特异性抗体
CN107810190A (zh) * 2015-04-28 2018-03-16 洛桑联邦政府综合工科学校（Epfl) 酶活化因子XII (FXIIa)的新型抑制剂
AU2016297018B9 (en) 2015-07-21 2022-12-01 Takeda Pharmaceutical Company Limited A monoclonal antibody inhibitor of factor XIIa
EP3387018A1 (en) 2015-12-11 2018-10-17 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
US11174321B2 (en) 2016-04-06 2021-11-16 Csl Limited Method of treating atherosclerosis
AU2018382222B2 (en) 2017-12-15 2025-09-04 Csl Limited Use of a FXIIa-inhibitor in the treatment of renal fibrosis and/or chronic kidney disease
AU2019288299B2 (en) 2018-06-19 2026-02-05 Regeneron Pharmaceuticals, Inc. Anti-factor XII/XIIa antibodies and uses thereof
US12134657B2 (en) 2018-11-28 2024-11-05 Oregon Health & Science University Therapeutic factor XII antibody
BR112022000113A2 (pt) 2019-07-08 2022-03-15 Activesite Pharmaceuticals Inc Processos para preparação de inibidores de calicreí-na de plasma
EP4090427A1 (en) 2020-01-13 2022-11-23 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack
US20240352150A2 (en) * 2020-06-16 2024-10-24 Ningbo Comgen Biotech Co., Ltd. Anti-factor xii (fxii) nanobody or antigen-binding fragment thereof, and use thereof
WO2022133278A2 (en) 2020-12-18 2022-06-23 Ionis Pharmaceuticals, Inc. Compounds and methods for modulating factor xii
IL325613A (en) 2023-07-19 2026-02-01 Regeneron Pharma Antibodies against factor xii/xiia and their uses

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK225488D0 (da) * 1988-04-26 1988-04-26 Novo Industri As Polypeptid
US4963657A (en) * 1988-06-09 1990-10-16 Temple University Of The Commonwealth System Of Higher Education Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same
WO1994020535A1 (en) * 1992-12-11 1994-09-15 Corvas International, Inc. ECOTIN AS A FACTOR Xa, XIa, AND XIIa INHIBITOR
CA2170030A1 (en) 1993-09-14 1995-03-23 Robert A. Lazarus Pharmaceutical compositions containing ecotin and homologs thereof
ZA963619B (en) 1995-05-08 1996-11-22 Scios Inc Protease inhibitor peptides
US20030109680A1 (en) * 2001-11-21 2003-06-12 Sunol Molecular Corporation Antibodies for inhibiting blood coagulation and methods of use thereof
DE19725014A1 (de) * 1997-06-13 1998-12-17 Bayer Ag Aprotininvarianten mit verbesserten Eigenschaften und Bikunine von Aprotininvarianten
GB9800817D0 (en) 1998-01-16 1998-03-11 Bio Discovery Ltd Serine protease inhibitors
WO1999064622A1 (en) * 1998-06-08 1999-12-16 University Of Vermont And State Agriculture College Inhibition of coagulation in blood and blood products
WO2000018352A2 (en) * 1998-09-28 2000-04-06 Merck & Co., Inc. A method for treating inflammatory diseases by administering a thrombin inhibitor
DE60236386D1 (de) 2001-01-11 2010-07-01 D Collen Res Foundation Vzw Verfahren und pharmazeutische Zusammensetzung zur Vorbeugung und/oder Behandlung des Syndroms der systemischen entzündlichen Reaktion
US7153829B2 (en) * 2002-06-07 2006-12-26 Dyax Corp. Kallikrein-inhibitor therapies
ES2348230T3 (es) * 2002-06-07 2010-12-01 Dyax Corp. Prevención y reducción de la isquemia.
US20060093595A1 (en) 2002-07-05 2006-05-04 Mahesh Jayachandra Methods, compositions and kits for treating damage to excitable tissue
EP2386310B1 (en) * 2002-08-28 2018-11-07 Dyax Corp. Methods for preserving organs and tissues
US20040229778A1 (en) * 2003-05-13 2004-11-18 Elmaleh David R. Pharmaceutical compositions of antithrombin III for the treatment of retroviral diseases
WO2004110356A2 (en) 2003-05-15 2004-12-23 Cbr Institute For Biomedical Research, Inc. Methods for modulating cell-to-cell adhesion using an agonist of c1inh-type protein activity
CN100431604C (zh) 2003-05-16 2008-11-12 法明知识产权股份有限公司 用于瞬时性治疗的具有短半衰期的c1抑制剂
NZ546204A (en) * 2003-09-12 2009-12-24 Marinepolymer Tech Inc Vascular access preservation in haemodialysis patients
GB0411145D0 (en) 2004-05-19 2004-06-23 Imp College Innovations Ltd Protease inhibitors and their therapeutic applications
US8569277B2 (en) * 2004-08-11 2013-10-29 Palo Alto Investors Methods of treating a subject for a condition
GB0418877D0 (en) 2004-08-24 2004-09-29 Univ Edinburgh Heart
US20060104944A1 (en) * 2004-11-18 2006-05-18 Mousa Shaker A Activators and inhibitors of protease activated receptor2 (PAR2) and methods of use
DK1669074T3 (da) 2004-12-01 2010-09-27 Par Pharmaceuticals Inc Anvendelse af megestrolacetat til forbedring af hjertefunktion og behandling af hjerteinsufficiens

Also Published As

Publication number Publication date
EP1830924B1 (en) 2013-02-27
CA2591786C (en) 2013-07-16
AU2005318464B2 (en) 2012-02-23
EP2272565A3 (en) 2012-03-28
US8715672B2 (en) 2014-05-06
EP2272565A2 (en) 2011-01-12
MX2007006997A (es) 2007-10-10
JP2008525342A (ja) 2008-07-17
US20130164301A1 (en) 2013-06-27
US20120148688A1 (en) 2012-06-14
BRPI0519349A8 (pt) 2017-09-12
ES2407965T3 (es) 2013-06-17
WO2006066878A1 (en) 2006-06-29
EP1830924A1 (en) 2007-09-12
RU2514878C2 (ru) 2014-05-10
CN101102819A (zh) 2008-01-09
JP5118492B2 (ja) 2013-01-16
KR101277097B1 (ko) 2013-06-20
BRPI0519349A2 (pt) 2009-01-20
CA2591786A1 (en) 2006-06-29
US20080254039A1 (en) 2008-10-16
AU2005318464A1 (en) 2006-06-29
KR20070092303A (ko) 2007-09-12
DK1830924T3 (da) 2013-05-21
PL1830924T3 (pl) 2013-08-30
US8119137B2 (en) 2012-02-21

Similar Documents

Publication Publication Date Title
RU2007123797A (ru) Предотвращение формирования и/или стабилизации тромбов
JP2008525342A5 (ru)
Kutsogiannis et al. Regional citrate versus systemic heparin anticoagulation for continuous renal replacement in critically ill patients
DK175704B1 (da) Inhibering af arteriel thrombotisk okklusion eller thromboenboli
Schmaier et al. The plasma kallikrein–kinin system: its evolution from contact activation
Smith et al. How it all starts: Initiation of the clotting cascade
Hillmeister et al. The kallikrein-kinin system.
US20050245488A1 (en) Pharmaceutically active compounds and methods of use thereof
Mukaiyama et al. Abdominal aortic aneurysm complicated with chronic disseminated intravascular coagulopathy: a case of surgical treatment
EA013078B1 (ru) Применение диосметиновых соединений при лечении и профилактике тромботических патологий
Jeske et al. Pharmacology of argatroban
Espinosa et al. Vascular involvement in Behçet's disease
Hellstern et al. Arterial and venous thrombosis and normal response to streptokinase treatment in a young patient with severe Hageman factor deficiency
Gomazkov Damage to the vascular endothelium as a leading mechanism of COVID-19 systemic pathology
Dellalibera-Joviliano et al. Kinin system in lupus nephritis
Haberland The role of kininogenases, kinin formation and kininogenase inhibition in post traumatic shock and related conditions
Malyszko et al. Thrombin activatable fibrinolysis inhibitor in hypertensive kidney transplant recipients
Marks Coagulation disorders in the ICU
Sommoggy et al. Coagulation in aortofemoral bifurcation bypass grafting
Sanchez et al. Surface-adsorbed fibrinogen and fibrin may activate the contact activation system
Bhagat et al. Delayed massive pulmonary thromboembolic phenomenon following envenomation by Mojave rattlesnake (Crotalus scutulatus)
Sánchez et al. On the control of the plasma contact activation system on human endothelium: comparisons with heparin surface
Aasen et al. Peritoneal lavage efficiently eliminates protease-alpha-2-macroglobulin complexes and components of the contact system from the peritoneal cavity in patients with severe acute pancreatitis
Hill et al. Acquired heparin‐like anticoagulants: A second case in metastatic breast carcinoma and literature review
Porte et al. A comparative study on changes in hemostasis in orthotopic and auxiliary liver transplantation in pigs

Legal Events

Date Code Title Description
FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20101019

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20110812

FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20121101

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20131024