RU2010141996A - Ингибитор ммр-2 и/или ммр-9 - Google Patents
Ингибитор ммр-2 и/или ммр-9 Download PDFInfo
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- RU2010141996A RU2010141996A RU2010141996/04A RU2010141996A RU2010141996A RU 2010141996 A RU2010141996 A RU 2010141996A RU 2010141996/04 A RU2010141996/04 A RU 2010141996/04A RU 2010141996 A RU2010141996 A RU 2010141996A RU 2010141996 A RU2010141996 A RU 2010141996A
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- Prior art keywords
- mmp
- inhibitor
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- substituents
- treatment
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- 102100026802 72 kDa type IV collagenase Human genes 0.000 title claims abstract 9
- 101710151806 72 kDa type IV collagenase Proteins 0.000 title claims abstract 9
- 102100030412 Matrix metalloproteinase-9 Human genes 0.000 title claims abstract 9
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 title claims abstract 9
- 239000003112 inhibitor Substances 0.000 title claims abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 4
- 150000003839 salts Chemical class 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 150000007979 thiazole derivatives Chemical class 0.000 claims abstract 4
- XDBHURGONHZNJF-UHFFFAOYSA-N 6-[2-(3,4-diethoxyphenyl)-1,3-thiazol-4-yl]pyridine-2-carboxylic acid Chemical group C1=C(OCC)C(OCC)=CC=C1C1=NC(C=2N=C(C=CC=2)C(O)=O)=CS1 XDBHURGONHZNJF-UHFFFAOYSA-N 0.000 claims abstract 2
- 206010014561 Emphysema Diseases 0.000 claims abstract 2
- 206010016654 Fibrosis Diseases 0.000 claims abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims abstract 2
- 239000004480 active ingredient Substances 0.000 claims abstract 2
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 230000004761 fibrosis Effects 0.000 claims abstract 2
- 125000004076 pyridyl group Chemical group 0.000 claims abstract 2
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract
1. Ингибитор ММР-2 и/или ММР-9, включающий в качестве активного ингредиента, по меньшей мере, одно соединение, выбранное из группы, состоящей из производных тиазола, представленных формулой 1): ! ! где R1 представляет собой фенильную группу, которая может иметь от 1 до 3 низших алкоксигрупп в качестве заместителей у фенильного кольца, и R2 представляет собой пиридильную группу, которая может иметь от 1 до 3 карбоксильных групп в качестве заместителей у пиридинового кольца, и их солей. ! 2. Ингибитор ММР-2 и/или ММР-9 по п.1, где производное тиазола представляет собой 6-[2-(3,4-диэтоксифенил)тиазол-4-ил]пиридин-2-карбоновую кислоту или ее соль. ! 3. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении фиброза. ! 4. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении легочной эмфиземы.
Claims (4)
1. Ингибитор ММР-2 и/или ММР-9, включающий в качестве активного ингредиента, по меньшей мере, одно соединение, выбранное из группы, состоящей из производных тиазола, представленных формулой 1):
где R1 представляет собой фенильную группу, которая может иметь от 1 до 3 низших алкоксигрупп в качестве заместителей у фенильного кольца, и R2 представляет собой пиридильную группу, которая может иметь от 1 до 3 карбоксильных групп в качестве заместителей у пиридинового кольца, и их солей.
2. Ингибитор ММР-2 и/или ММР-9 по п.1, где производное тиазола представляет собой 6-[2-(3,4-диэтоксифенил)тиазол-4-ил]пиридин-2-карбоновую кислоту или ее соль.
3. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении фиброза.
4. Ингибитор ММР-2 и/или ММР-9 по п.1 или 2 для применения при лечении легочной эмфиземы.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008-065455 | 2008-03-14 | ||
| JP2008065455 | 2008-03-14 | ||
| PCT/JP2009/055545 WO2009113736A1 (en) | 2008-03-14 | 2009-03-13 | Mmp-2 and/or mmp-9 inhibitor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010141996A true RU2010141996A (ru) | 2012-04-20 |
| RU2487131C2 RU2487131C2 (ru) | 2013-07-10 |
Family
ID=40613081
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010141996/04A RU2487131C2 (ru) | 2008-03-14 | 2009-03-13 | Ингибитор ммр-2 и/или ммр-9 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20110054179A1 (ru) |
| EP (1) | EP2280708A1 (ru) |
| JP (2) | JP2011513203A (ru) |
| KR (1) | KR20100135255A (ru) |
| CN (3) | CN103463084A (ru) |
| AR (1) | AR070882A1 (ru) |
| AU (1) | AU2009224209B2 (ru) |
| BR (1) | BRPI0909288A2 (ru) |
| CA (1) | CA2718005A1 (ru) |
| IL (2) | IL207816A0 (ru) |
| MX (1) | MX2010010073A (ru) |
| NZ (1) | NZ587591A (ru) |
| RU (1) | RU2487131C2 (ru) |
| SG (1) | SG188852A1 (ru) |
| TW (1) | TWI436767B (ru) |
| UA (1) | UA108979C2 (ru) |
| WO (1) | WO2009113736A1 (ru) |
| ZA (1) | ZA201005991B (ru) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012036293A1 (ja) * | 2010-09-17 | 2012-03-22 | 武田薬品工業株式会社 | 糖尿病治療剤 |
| CN119112885A (zh) * | 2018-03-16 | 2024-12-13 | 脑科学香料株式会社 | 缺氧障碍、缺血再灌注障碍或炎症的预防或治疗剂，移植用细胞保护剂，及生物体防腐剂 |
| CN112585136B (zh) | 2018-08-17 | 2024-06-25 | 诺华股份有限公司 | 作为smarca2/brm atp酶抑制剂的脲化合物和组合物 |
| CA3246572A1 (en) * | 2022-03-29 | 2023-10-05 | The Trustees Of The University Of Pennsylvania | METHODS OF TREATMENT, IMPROVEMENT AND/OR PREVENTION OF PROGRESSIVE OSSIFIANT FIBRODYSPLASIA AND HETEROTOPIC OSSIFICATION, AND RELATED KITS |
| TW202406565A (zh) * | 2022-04-18 | 2024-02-16 | 日商大正製藥股份有限公司 | 含有具有ｍｍｐ２抑制作用之化合物作為有效成分之肺之炎症及纖維症之預防或治療藥 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA962269A (en) * | 1971-05-05 | 1975-02-04 | Uniroyal Ltd. | Thiazoles, and their use as insecticides |
| US5639770A (en) * | 1992-05-29 | 1997-06-17 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivatives |
| JP3622015B2 (ja) * | 1992-10-08 | 2005-02-23 | 敏一 中村 | 肺傷害治療剤 |
| MY128323A (en) * | 1996-09-30 | 2007-01-31 | Otsuka Pharma Co Ltd | Thiazole derivatives for inhibition of cytokine production and of cell adhesion |
| EP1261331A4 (en) * | 2000-02-16 | 2005-01-05 | Univ Nebraska Medical Ct | METHOD AND COMPOSITIONS FOR TREATING FIBROSANT DISEASES |
| GB0007405D0 (en) * | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
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| EP1888033B1 (en) * | 2005-06-09 | 2014-02-19 | Meda AB | Method and composition for treating inflammatory disorders |
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-
2009
- 2009-03-13 CN CN2013103353496A patent/CN103463084A/zh active Pending
- 2009-03-13 CA CA2718005A patent/CA2718005A1/en not_active Abandoned
- 2009-03-13 BR BRPI0909288-9A patent/BRPI0909288A2/pt not_active IP Right Cessation
- 2009-03-13 UA UAA201012145A patent/UA108979C2/ru unknown
- 2009-03-13 NZ NZ587591A patent/NZ587591A/xx not_active IP Right Cessation
- 2009-03-13 AR ARP090100897A patent/AR070882A1/es unknown
- 2009-03-13 SG SG2013016746A patent/SG188852A1/en unknown
- 2009-03-13 US US12/922,374 patent/US20110054179A1/en not_active Abandoned
- 2009-03-13 TW TW098108215A patent/TWI436767B/zh not_active IP Right Cessation
- 2009-03-13 WO PCT/JP2009/055545 patent/WO2009113736A1/en not_active Ceased
- 2009-03-13 EP EP09719488A patent/EP2280708A1/en not_active Withdrawn
- 2009-03-13 KR KR1020107022827A patent/KR20100135255A/ko not_active Ceased
- 2009-03-13 JP JP2010536255A patent/JP2011513203A/ja active Pending
- 2009-03-13 CN CN201310533925.8A patent/CN103622962A/zh active Pending
- 2009-03-13 AU AU2009224209A patent/AU2009224209B2/en not_active Ceased
- 2009-03-13 MX MX2010010073A patent/MX2010010073A/es active IP Right Grant
- 2009-03-13 CN CN2009801087584A patent/CN101969949B/zh not_active Expired - Fee Related
- 2009-03-13 RU RU2010141996/04A patent/RU2487131C2/ru not_active IP Right Cessation
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2010
- 2010-08-23 ZA ZA2010/05991A patent/ZA201005991B/en unknown
- 2010-08-26 IL IL207816A patent/IL207816A0/en unknown
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2013
- 2013-09-17 IL IL228484A patent/IL228484A0/en unknown
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2014
- 2014-09-01 JP JP2014176705A patent/JP2014221839A/ja not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US20110054179A1 (en) | 2011-03-03 |
| ZA201005991B (en) | 2011-10-26 |
| EP2280708A1 (en) | 2011-02-09 |
| CN103463084A (zh) | 2013-12-25 |
| TWI436767B (zh) | 2014-05-11 |
| CN103622962A (zh) | 2014-03-12 |
| AU2009224209A1 (en) | 2009-09-17 |
| KR20100135255A (ko) | 2010-12-24 |
| SG188852A1 (en) | 2013-04-30 |
| WO2009113736A1 (en) | 2009-09-17 |
| BRPI0909288A2 (pt) | 2015-08-18 |
| JP2014221839A (ja) | 2014-11-27 |
| UA108979C2 (ru) | 2015-07-10 |
| IL228484A0 (en) | 2013-12-31 |
| JP2011513203A (ja) | 2011-04-28 |
| IL207816A0 (en) | 2010-12-30 |
| TW200942237A (en) | 2009-10-16 |
| AU2009224209B2 (en) | 2015-01-22 |
| CN101969949A (zh) | 2011-02-09 |
| RU2487131C2 (ru) | 2013-07-10 |
| CN101969949B (zh) | 2013-12-25 |
| MX2010010073A (es) | 2010-10-04 |
| AR070882A1 (es) | 2010-05-12 |
| NZ587591A (en) | 2012-10-26 |
| CA2718005A1 (en) | 2009-09-17 |
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