RU2013105456A - Составы, содержащие покрытые тонкодисперсные частицы - Google Patents

Составы, содержащие покрытые тонкодисперсные частицы Download PDF

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Publication number
RU2013105456A
RU2013105456A RU2013105456/15A RU2013105456A RU2013105456A RU 2013105456 A RU2013105456 A RU 2013105456A RU 2013105456/15 A RU2013105456/15 A RU 2013105456/15A RU 2013105456 A RU2013105456 A RU 2013105456A RU 2013105456 A RU2013105456 A RU 2013105456A
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RU
Russia
Prior art keywords
coated
particle containing
water
soluble saccharide
tablet
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RU2013105456/15A
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English (en)
Inventor
Кадзухиро НАКАМУРА
Теппеи ОГАВА
Томоя АКУТАГАВА
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Тейдзин Фарма Лимитед
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45441336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2013105456(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Тейдзин Фарма Лимитед filed Critical Тейдзин Фарма Лимитед
Publication of RU2013105456A publication Critical patent/RU2013105456A/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Быстро распадающаяся в полости рта таблетка, содержащая частицу, содержащую ядерную частицу, содержащую 2-(3-циано-4-изобутилоксифенил)-4-метил-5-тиазолкарбоновую кислоту, покрытую слоем, содержащим сополимер метакриловой кислоты и дополнительно нанесенным верхним слоем, содержащим водорастворимый сахарид.2. Таблетка по п. 1, в которой водорастворимый сахарид представляет собой маннит.3. Быстро распадающаяся в полости рта таблетка, полученная компрессионным формованием частицы, содержащей ядерную частицу, содержащую 2-(3-циано-4-изобутилоксифенил)-4-метил-5-тиазолкарбоновую кислоту, покрытую слоем, содержащим сополимер метакриловой кислоты и дополнительно нанесенным покрытием верхним слоем, содержащим водорастворимый сахарид и гранулу, содержащую частицу, содержащую разрыхлитель, покрытую разрыхлителем.4. Таблетка по п. 3, в которой разрыхлитель представляет собой кросповидон.

Claims (4)

1. Быстро распадающаяся в полости рта таблетка, содержащая частицу, содержащую ядерную частицу, содержащую 2-(3-циано-4-изобутилоксифенил)-4-метил-5-тиазолкарбоновую кислоту, покрытую слоем, содержащим сополимер метакриловой кислоты и дополнительно нанесенным верхним слоем, содержащим водорастворимый сахарид.
2. Таблетка по п. 1, в которой водорастворимый сахарид представляет собой маннит.
3. Быстро распадающаяся в полости рта таблетка, полученная компрессионным формованием частицы, содержащей ядерную частицу, содержащую 2-(3-циано-4-изобутилоксифенил)-4-метил-5-тиазолкарбоновую кислоту, покрытую слоем, содержащим сополимер метакриловой кислоты и дополнительно нанесенным покрытием верхним слоем, содержащим водорастворимый сахарид и гранулу, содержащую частицу, содержащую разрыхлитель, покрытую разрыхлителем.
4. Таблетка по п. 3, в которой разрыхлитель представляет собой кросповидон.
RU2013105456/15A 2010-07-09 2011-07-08 Составы, содержащие покрытые тонкодисперсные частицы RU2013105456A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2010-156874 2010-07-09
JP2010156874 2010-07-09
PCT/JP2011/065721 WO2012005365A1 (ja) 2010-07-09 2011-07-08 微粒子コーティング製剤

Publications (1)

Publication Number Publication Date
RU2013105456A true RU2013105456A (ru) 2014-08-20

Family

ID=45441336

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2013105456/15A RU2013105456A (ru) 2010-07-09 2011-07-08 Составы, содержащие покрытые тонкодисперсные частицы

Country Status (24)

Country Link
US (1) US20130101670A1 (ru)
EP (1) EP2591781B1 (ru)
JP (1) JP5000017B2 (ru)
KR (1) KR20130113348A (ru)
CN (1) CN102958522B (ru)
AR (1) AR082139A1 (ru)
AU (1) AU2011274851A1 (ru)
BR (1) BR112013000298A2 (ru)
CA (1) CA2804874C (ru)
CL (1) CL2013000089A1 (ru)
CO (1) CO6650363A2 (ru)
EC (1) ECSP12012360A (ru)
ES (1) ES2644064T3 (ru)
MA (1) MA34460B1 (ru)
MX (1) MX2013000282A (ru)
NZ (1) NZ605562A (ru)
PE (1) PE20131064A1 (ru)
PH (1) PH12013500032A1 (ru)
RU (1) RU2013105456A (ru)
TN (1) TN2012000623A1 (ru)
TW (1) TW201217001A (ru)
UY (1) UY33499A (ru)
WO (1) WO2012005365A1 (ru)
ZA (1) ZA201300106B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20170306A1 (es) 2010-06-16 2017-05-06 Takeda Pharmaceuticals Usa Inc Nuevas formas de dosificacion de liberacion modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa
AU2011299153B2 (en) 2010-09-10 2014-10-30 Takeda Pharmaceuticals U.S.A., Inc. Methods for concomitant treatment of theophylline and febuxostat
CN106267220B (zh) * 2015-05-14 2019-06-28 北京科信必成医药科技发展有限公司 愈创甘油醚氢溴酸右美沙芬无水吞服掩味制剂
JP7108384B2 (ja) * 2016-07-13 2022-07-28 日本ケミファ株式会社 ２－［３－シアノ－４－（２－メチルプロポキシ）フェニル］－４－メチルチアゾール－５－カルボン酸の口腔内崩壊錠
GB202001237D0 (en) * 2020-01-29 2020-03-11 Sisteks D O O Granular pharmaceutical product for oral administration from a pre-filled straw and method of manufacturing such pharmaceutical product

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69934505T2 (de) 1998-05-18 2007-10-04 Takeda Pharmaceutical Co. Ltd. Im munde zerfallende tablette enthaltend ein benzimidazole
JP4300652B2 (ja) 1998-09-21 2009-07-22 大正製薬株式会社 経口用固形製剤
JP3389205B2 (ja) 1999-06-29 2003-03-24 武田薬品工業株式会社 口腔内速崩壊錠
AU2002366029B2 (en) * 2001-11-21 2008-01-31 Eisai R And D Management Co., Ltd. Preparation compositions containing acid-unstable physiologically active compounds and process for producing the same
JP2005023058A (ja) 2003-06-10 2005-01-27 Lion Corp 咀嚼型医薬製剤用薬物粒子及びその製造方法、並びに薬物粒子を含有する咀嚼型医薬固形製剤及びその製造方法
JP5062872B2 (ja) 2003-08-13 2012-10-31 東和薬品株式会社 不快な味を低減した口腔内崩壊錠剤
WO2007021033A1 (ja) * 2005-08-18 2007-02-22 Teijin Pharma Limited 複数の薬物保持部位がある錠剤
JP5123517B2 (ja) * 2005-11-14 2013-01-23 帝人ファーマ株式会社 アンブロキソール口腔内速崩性錠剤
PE20070698A1 (es) * 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
JP2008050324A (ja) * 2006-08-28 2008-03-06 Ohara Yakuhin Kogyo Kk 苦味遮蔽組成物。
JP5097488B2 (ja) 2006-09-13 2012-12-12 京都薬品工業株式会社 苦味マスキング
PE20170306A1 (es) * 2010-06-16 2017-05-06 Takeda Pharmaceuticals Usa Inc Nuevas formas de dosificacion de liberacion modificada de un inhibidor de la xantina oxidorreductasa o de inhibidores de xantina oxidasa

Also Published As

Publication number Publication date
CA2804874C (en) 2019-07-23
ES2644064T3 (es) 2017-11-27
EP2591781B1 (en) 2017-09-27
MA34460B1 (fr) 2013-08-01
CO6650363A2 (es) 2013-04-15
CL2013000089A1 (es) 2013-03-08
PH12013500032A1 (en) 2013-02-11
EP2591781A4 (en) 2014-12-03
TW201217001A (en) 2012-05-01
TN2012000623A1 (en) 2014-04-01
AU2011274851A1 (en) 2013-01-31
BR112013000298A2 (pt) 2016-05-31
AR082139A1 (es) 2012-11-14
KR20130113348A (ko) 2013-10-15
CN102958522B (zh) 2015-12-16
ZA201300106B (en) 2013-09-25
JPWO2012005365A1 (ja) 2013-09-05
UY33499A (es) 2012-01-31
PE20131064A1 (es) 2013-09-23
US20130101670A1 (en) 2013-04-25
NZ605562A (en) 2013-11-29
WO2012005365A1 (ja) 2012-01-12
ECSP12012360A (es) 2013-02-28
CN102958522A (zh) 2013-03-06
CA2804874A1 (en) 2012-01-12
MX2013000282A (es) 2013-02-11
JP5000017B2 (ja) 2012-08-15
EP2591781A1 (en) 2013-05-15

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