RU2259193C2 - Содержащее цинк средство уменьшенной остроты для чистки зубов - Google Patents

Содержащее цинк средство уменьшенной остроты для чистки зубов Download PDF

Info

Publication number: RU2259193C2
Authority: RU; Russia
Prior art keywords: zinc; composition; pyrophosphate; salt; anionic polycarboxylate
Prior art date: 2000-12-05

Application number

RU2003120062/15A

Other languages

English (en)

Russian (ru)

Other versions

RU2003120062A (ru

Inventor

Диего А. ОИК (US)

Диего А. ОИК

Майкл ПРЕНСАЙП (US)

Майкл ПРЕНСАЙП

Берни БЛЭКУЭЛЛ (US)

Берни БЛЭКУЭЛЛ

Джеймс Р. БРАУН (US)

Джеймс Р. БРАУН

Махмуд ХАССАН (US)

Махмуд ХАССАН

Original Assignee

Колгейт-Палмолив Компани

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-05

Filing date

2001-12-04

Publication date

2005-08-27

2001-12-04 Application filed by Колгейт-Палмолив Компани filed Critical Колгейт-Палмолив Компани

2005-02-10 Publication of RU2003120062A publication Critical patent/RU2003120062A/ru

2005-08-27 Application granted granted Critical

2005-08-27 Publication of RU2259193C2 publication Critical patent/RU2259193C2/ru

Links

HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title claims abstract description 11
229910052725 zinc Inorganic materials 0.000 title claims abstract description 11
239000011701 zinc Substances 0.000 title claims abstract description 11
239000003795 chemical substances by application Substances 0.000 title abstract 4
239000000203 mixture Substances 0.000 claims abstract description 51
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims abstract description 22
150000003751 zinc Chemical class 0.000 claims abstract description 20
229920005646 polycarboxylate Polymers 0.000 claims abstract description 18
125000000129 anionic group Chemical group 0.000 claims abstract description 16
229920000642 polymer Polymers 0.000 claims abstract description 16
235000011180 diphosphates Nutrition 0.000 claims abstract description 9
229920001577 copolymer Polymers 0.000 claims description 7
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
239000003906 humectant Substances 0.000 claims description 6
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical group [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 6
239000011746 zinc citrate Substances 0.000 claims description 5
235000006076 zinc citrate Nutrition 0.000 claims description 5
229940068475 zinc citrate Drugs 0.000 claims description 5
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical group [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
230000001154 acute effect Effects 0.000 claims 2
QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical group C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 claims 1
229920001567 vinyl ester resin Polymers 0.000 claims 1
235000019640 taste Nutrition 0.000 abstract description 5
239000000126 substance Substances 0.000 abstract description 3
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000000551 dentifrice Substances 0.000 description 15
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
-1 alkali metal salts Chemical class 0.000 description 9
239000000047 product Substances 0.000 description 9
239000004615 ingredient Substances 0.000 description 8
229920000388 Polyphosphate Polymers 0.000 description 7
239000001205 polyphosphate Substances 0.000 description 7
206010006326 Breath odour Diseases 0.000 description 5
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 5
230000015572 biosynthetic process Effects 0.000 description 5
235000014113 dietary fatty acids Nutrition 0.000 description 5
239000000194 fatty acid Substances 0.000 description 5
229930195729 fatty acid Natural products 0.000 description 5
235000003599 food sweetener Nutrition 0.000 description 5
238000005755 formation reaction Methods 0.000 description 5
235000011176 polyphosphates Nutrition 0.000 description 5
150000003839 salts Chemical class 0.000 description 5
239000011734 sodium Substances 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
239000003765 sweetening agent Substances 0.000 description 5
239000002562 thickening agent Substances 0.000 description 5
239000000377 silicon dioxide Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
208000032139 Halitosis Diseases 0.000 description 3
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000003082 abrasive agent Substances 0.000 description 3
239000013078 crystal Substances 0.000 description 3
150000004665 fatty acids Chemical class 0.000 description 3
210000000214 mouth Anatomy 0.000 description 3
229910052700 potassium Inorganic materials 0.000 description 3
239000011591 potassium Substances 0.000 description 3
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000002253 acid Substances 0.000 description 2
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
229920006318 anionic polymer Polymers 0.000 description 2
239000001506 calcium phosphate Substances 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010418 carrageenan Nutrition 0.000 description 2
239000000679 carrageenan Substances 0.000 description 2
229920001525 carrageenan Polymers 0.000 description 2
229940113118 carrageenan Drugs 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
239000003205 fragrance Substances 0.000 description 2
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 2
239000000499 gel Substances 0.000 description 2
235000011187 glycerol Nutrition 0.000 description 2
FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 description 2
239000002304 perfume Substances 0.000 description 2
239000000049 pigment Substances 0.000 description 2
229920003023 plastic Polymers 0.000 description 2
239000004033 plastic Substances 0.000 description 2
235000019633 pungent taste Nutrition 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 2
235000019333 sodium laurylsulphate Nutrition 0.000 description 2
235000019832 sodium triphosphate Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
239000004408 titanium dioxide Substances 0.000 description 2
239000000606 toothpaste Substances 0.000 description 2
JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
RPZANUYHRMRTTE-UHFFFAOYSA-N 2,3,4-trimethoxy-6-(methoxymethyl)-5-[3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[3,4,5-tris(2-hydroxybutoxy)-6-[4,5,6-tris(2-hydroxybutoxy)-2-(2-hydroxybutoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]butan-2-ol Chemical compound COC1C(OC)C(OC)C(COC)OC1OC1C(OC)C(OC)C(OC)OC1COC.CCC(O)COC1C(OCC(O)CC)C(OCC(O)CC)C(COCC(O)CC)OC1OC1C(OCC(O)CC)C(OCC(O)CC)C(OCC(O)CC)OC1COCC(O)CC RPZANUYHRMRTTE-UHFFFAOYSA-N 0.000 description 1
LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical group CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
JNRLEMMIVRBKJE-UHFFFAOYSA-N 4,4'-Methylenebis(N,N-dimethylaniline) Chemical compound C1=CC(N(C)C)=CC=C1CC1=CC=C(N(C)C)C=C1 JNRLEMMIVRBKJE-UHFFFAOYSA-N 0.000 description 1
MOMKYJPSVWEWPM-UHFFFAOYSA-N 4-(chloromethyl)-2-(4-methylphenyl)-1,3-thiazole Chemical compound C1=CC(C)=CC=C1C1=NC(CCl)=CS1 MOMKYJPSVWEWPM-UHFFFAOYSA-N 0.000 description 1
RFRMMZAKBNXNHE-UHFFFAOYSA-N 6-[4,6-dihydroxy-5-(2-hydroxyethoxy)-2-(hydroxymethyl)oxan-3-yl]oxy-2-(hydroxymethyl)-5-(2-hydroxypropoxy)oxane-3,4-diol Chemical compound CC(O)COC1C(O)C(O)C(CO)OC1OC1C(O)C(OCCO)C(O)OC1CO RFRMMZAKBNXNHE-UHFFFAOYSA-N 0.000 description 1
QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
208000006558 Dental Calculus Diseases 0.000 description 1
235000019739 Dicalciumphosphate Nutrition 0.000 description 1
RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 1
QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 1
239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
244000246386 Mentha pulegium Species 0.000 description 1
235000016257 Mentha pulegium Nutrition 0.000 description 1
235000004357 Mentha x piperita Nutrition 0.000 description 1
239000004909 Moisturizer Substances 0.000 description 1
HSHXDCVZWHOWCS-UHFFFAOYSA-N N'-hexadecylthiophene-2-carbohydrazide Chemical compound CCCCCCCCCCCCCCCCNNC(=O)c1cccs1 HSHXDCVZWHOWCS-UHFFFAOYSA-N 0.000 description 1
BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
229920002582 Polyethylene Glycol 600 Polymers 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
239000000654 additive Substances 0.000 description 1
238000004220 aggregation Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
125000000217 alkyl group Chemical group 0.000 description 1
150000008051 alkyl sulfates Chemical class 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
239000002585 base Substances 0.000 description 1
239000000440 bentonite Substances 0.000 description 1
229910000278 bentonite Inorganic materials 0.000 description 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000006229 carbon black Substances 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
229920002678 cellulose Polymers 0.000 description 1
239000001913 cellulose Substances 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000008367 deionised water Substances 0.000 description 1
229910021641 deionized water Inorganic materials 0.000 description 1
229940023487 dental product Drugs 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
229940038472 dicalcium phosphate Drugs 0.000 description 1
239000000975 dye Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000004673 fluoride salts Chemical class 0.000 description 1
238000005187 foaming Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
229940005740 hexametaphosphate Drugs 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
229910000037 hydrogen sulfide Inorganic materials 0.000 description 1
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
230000003993 interaction Effects 0.000 description 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
150000002688 maleic acid derivatives Chemical class 0.000 description 1
239000000463 material Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
244000005700 microbiome Species 0.000 description 1
230000001333 moisturizer Effects 0.000 description 1
239000000178 monomer Substances 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
239000000025 natural resin Substances 0.000 description 1
229940023486 oral product Drugs 0.000 description 1
239000013588 oral product Substances 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
239000006072 paste Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
238000005498 polishing Methods 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
229940099402 potassium metaphosphate Drugs 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
235000011151 potassium sulphates Nutrition 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000002265 prevention Effects 0.000 description 1
210000003296 saliva Anatomy 0.000 description 1
108700004121 sarkosyl Proteins 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
235000019983 sodium metaphosphate Nutrition 0.000 description 1
235000019830 sodium polyphosphate Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
AGGIJOLULBJGTQ-UHFFFAOYSA-N sulfoacetic acid Chemical class OC(=O)CS(O)(=O)=O AGGIJOLULBJGTQ-UHFFFAOYSA-N 0.000 description 1
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
229940034610 toothpaste Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
150000004684 trihydrates Chemical class 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1
229940085658 zinc citrate trihydrate Drugs 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8164—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers, e.g. poly (methyl vinyl ether-co-maleic anhydride)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical & Material Sciences (AREA)
Birds (AREA)
Inorganic Chemistry (AREA)
Oral & Maxillofacial Surgery (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cosmetics (AREA)
Medicinal Preparation (AREA)

RU2003120062/15A 2000-12-05 2001-12-04 Содержащее цинк средство уменьшенной остроты для чистки зубов RU2259193C2 (ru)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US73014300A	2000-12-05	2000-12-05
US09/730,143		2000-12-05

Publications (2)

Publication Number	Publication Date
RU2003120062A RU2003120062A (ru)	2005-02-10
RU2259193C2 true RU2259193C2 (ru)	2005-08-27

Family

ID=24934113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
RU2003120062/15A RU2259193C2 (ru)	2000-12-05	2001-12-04	Содержащее цинк средство уменьшенной остроты для чистки зубов

Country Status (18)

Country	Link
EP (1)	EP1345581A2 (cs)
JP (1)	JP2004517833A (cs)
KR (1)	KR20030068166A (cs)
CN (1)	CN1220479C (cs)
AR (1)	AR031782A1 (cs)
AU (1)	AU2002232507A1 (cs)
BR (1)	BR0115949A (cs)
CA (1)	CA2431002A1 (cs)
CZ (1)	CZ20031836A3 (cs)
EC (1)	ECSP034678A (cs)
HU (1)	HUP0600590A2 (cs)
MX (1)	MXPA03004922A (cs)
PL (1)	PL361856A1 (cs)
RU (1)	RU2259193C2 (cs)
SK (1)	SK8642003A3 (cs)
WO (1)	WO2002045678A2 (cs)
YU (1)	YU44003A (cs)
ZA (1)	ZA200304561B (cs)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2559781C2 (ru) *	2010-01-29	2015-08-10	Колгейт-Палмолив Компани	Средство для полости рта по уходу за чувствительной эмалью

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CA2752337C (en) *	2005-12-21	2017-01-17	Colgate-Palmolive Company	Improved oral compositions comprising zinc citrate and/or tocopherol agents
US8628755B2 (en)	2007-01-30	2014-01-14	Colgate-Palmolive Company	Dentifrice containing zinc ions and polyphosphate ions
SG173838A1 (en) *	2009-04-02	2011-09-29	Colgate Palmolive Co	Dentifrice composition
TWI442937B (zh) *	2009-05-26	2014-07-01	美國棕欖公司	較高含量的含鋅薄膜
CA2775444C (en)	2009-10-29	2015-04-21	Colgate-Palmolive Company	Dentifrice comprising stannous fluoride plus zinc citrate and low levels of water
US20120308488A1 (en) *	2010-01-29	2012-12-06	Colgate-Palmolive Company	Oral care product for sensitive enamel care
AU2010363319B2 (en) *	2010-11-04	2015-02-19	Colgate-Palmolive Company	Dentifrice composition with reduced astringency
AU2012397149B2 (en)	2012-12-18	2015-11-05	Colgate-Palmolive Company	Stable metal ion containing compositions
US20170049671A1 (en)	2014-04-30	2017-02-23	Colgate-Palmolive Company	Oral Care Composition Containing Silica and Zinc Citrate
BR112016024176B1 (pt) *	2014-05-14	2020-12-08	The Procter & Gamble Company	composições para tratamento bucal tendo estabilidade aprimorada
US10736831B2 (en)	2015-07-17	2020-08-11	Colgate-Palmolive Company	Oral care compositions
WO2017079956A1 (en)	2015-11-13	2017-05-18	The Procter & Gamble Company	Dentifrice compositions with dual fluoride source with improved fluoride uptake
CN108348409B (zh)	2015-11-13	2021-06-18	宝洁公司	具有改善的氟化物稳定性的牙粉组合物
CN108348442A (zh) *	2015-11-13	2018-07-31	宝洁公司	具有抗牙垢和抗菌有益效果的牙粉组合物
WO2017079957A1 (en)	2015-11-13	2017-05-18	The Procter & Gamble Company	Dentifrice compositions with improved fluoride uptake
EP3454828B1 (en) *	2016-05-10	2025-04-30	Colgate-Palmolive Company	Use of an alginate in a dentifrice composition containing zinc compounds
CN106955244B (zh) *	2017-03-03	2019-09-24	广州薇美姿实业有限公司	一种遮盖不良口感的组合物及其在口腔护理产品中的应用
GB201811065D0 (en) *	2018-07-05	2018-08-22	GlaxoSmithKline Consumer Healthcare UK IP Ltd	Novel composition
WO2021175577A1 (en)	2020-03-03	2021-09-10	Unilever Ip Holdings B.V.	Transparent dentifrice comprising zinc
CN112315827B (zh) *	2020-09-25	2023-02-28	好维股份有限公司	一种口腔护理组合物及应用
JP2022100677A (ja) *	2020-12-24	2022-07-06	ライオン株式会社	歯磨剤組成物

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US4138477A (en) *	1976-05-28	1979-02-06	Colgate Palmolive Company	Composition to control mouth odor
US5000944A (en) *	1989-06-09	1991-03-19	Colgate-Palmolive Company	Zinc-containing oral products with reduced astringency
RU2132182C1 (ru) *	1992-07-16	1999-06-27	Колгейт-Палмолив Компани	Оральная композиция и способ обеспечения гигиены полости рта
RU2001116132A (ru) *	1998-11-12	2003-04-20	Блок Драг Компани, Инк.	Ароматическая смесь для маскировки неприятного вкуса соединений цинка

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JPH08504816A (ja) *	1992-12-18	1996-05-28	ザ、プロクター、エンド、ギャンブル、カンパニー	抗歯垢、抗歯石剤を含有した口内組成物
US6169118B1 (en) *	1998-11-12	2001-01-02	Block Drug Company, Inc.	Flavor blend for masking unpleasant taste of zinc compounds

2001
- 2001-12-04 AU AU2002232507A patent/AU2002232507A1/en not_active Abandoned
- 2001-12-04 RU RU2003120062/15A patent/RU2259193C2/ru not_active IP Right Cessation
- 2001-12-04 YU YU44003A patent/YU44003A/sh unknown
- 2001-12-04 KR KR10-2003-7007402A patent/KR20030068166A/ko not_active Withdrawn
- 2001-12-04 AR ARP010105634A patent/AR031782A1/es not_active Application Discontinuation
- 2001-12-04 SK SK864-2003A patent/SK8642003A3/sk unknown
- 2001-12-04 CN CNB01820063XA patent/CN1220479C/zh not_active Expired - Fee Related
- 2001-12-04 JP JP2002547464A patent/JP2004517833A/ja active Pending
- 2001-12-04 BR BR0115949-6A patent/BR0115949A/pt not_active IP Right Cessation
- 2001-12-04 EP EP01992031A patent/EP1345581A2/en not_active Withdrawn
- 2001-12-04 CA CA002431002A patent/CA2431002A1/en not_active Abandoned
- 2001-12-04 MX MXPA03004922A patent/MXPA03004922A/es not_active Application Discontinuation
- 2001-12-04 HU HU0600590A patent/HUP0600590A2/hu unknown
- 2001-12-04 CZ CZ20031836A patent/CZ20031836A3/cs unknown
- 2001-12-04 WO PCT/US2001/046895 patent/WO2002045678A2/en not_active Ceased
- 2001-12-04 PL PL01361856A patent/PL361856A1/xx not_active Application Discontinuation
2003
- 2003-06-11 ZA ZA200304561A patent/ZA200304561B/en unknown
- 2003-06-27 EC EC2003004678A patent/ECSP034678A/es unknown

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4138477A (en) *	1976-05-28	1979-02-06	Colgate Palmolive Company	Composition to control mouth odor
US5000944A (en) *	1989-06-09	1991-03-19	Colgate-Palmolive Company	Zinc-containing oral products with reduced astringency
RU2132182C1 (ru) *	1992-07-16	1999-06-27	Колгейт-Палмолив Компани	Оральная композиция и способ обеспечения гигиены полости рта
RU2001116132A (ru) *	1998-11-12	2003-04-20	Блок Драг Компани, Инк.	Ароматическая смесь для маскировки неприятного вкуса соединений цинка

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2559781C2 (ru) *	2010-01-29	2015-08-10	Колгейт-Палмолив Компани	Средство для полости рта по уходу за чувствительной эмалью

Also Published As

Publication number	Publication date
AR031782A1 (es)	2003-10-01
CN1220479C (zh)	2005-09-28
SK8642003A3 (en)	2003-12-02
ZA200304561B (en)	2004-08-03
EP1345581A2 (en)	2003-09-24
YU44003A (sh)	2006-01-16
WO2002045678A2 (en)	2002-06-13
KR20030068166A (ko)	2003-08-19
JP2004517833A (ja)	2004-06-17
ECSP034678A (es)	2003-08-29
AU2002232507A1 (en)	2002-06-18
HUP0600590A2 (en)	2007-01-29
CN1479607A (zh)	2004-03-03
RU2003120062A (ru)	2005-02-10
BR0115949A (pt)	2003-11-04
MXPA03004922A (es)	2003-09-10
WO2002045678A3 (en)	2003-01-16
CA2431002A1 (en)	2002-06-13
CZ20031836A3 (cs)	2003-11-12
PL361856A1 (en)	2004-10-04

Legal Events

Date	Code	Title	Description
2007-12-20	MM4A	The patent is invalid due to non-payment of fees	Effective date: 20051205

Publication	Publication Date	Title
US5578293A (en)	1996-11-26	Oral compositions containing stabilized stannous compounds having antiplaque and antitartar efficacy
US5730959A (en)	1998-03-24	Storage stable aqueous dentifrice compositions having improved anticalculus properties
CA2290615C (en)	2008-07-15	Desensitizing dentifrice having limited astringency
US5180576A (en)	1993-01-19	Anticalculus dentifrices
CA2431002A1 (en)	2002-06-13	Zinc containing dentifrice of reduced astringency
TWI305497B (en)	2009-01-21	Dual component dentifrice for reducing mouth odors
US5932192A (en)	1999-08-03	Lower astringent two component stannous and potassium salt containing dentifrice
US5487906A (en)	1996-01-30	Method of forming stable aqueous solutions of stannous compounds
US5855871A (en)	1999-01-05	Effervescent two component bicarbonate and acid containing dentifrice
CN116669683A (zh)	2023-08-29	包含焦磷酸亚锡和水溶性碱金属聚磷酸盐的口腔护理组合物和方法
BR112019012472A2 (pt)	2020-04-14	composições para higiene bucal e métodos de uso
US5456903A (en)	1995-10-10	Method of making a tartar control baking soda dentifrice
WO2021127699A1 (en)	2021-06-24	Oral care compositions and methods of use
AU2019403912B2 (en)	2022-09-29	Dentifrice containing sodium bicarbonate and stannous fluoride
CA3008367C (en)	2023-09-26	Oral care product and methods of use and manufacture thereof
US5885556A (en)	1999-03-23	Tartar control oral compositions
JPH0558865A (ja)	1993-03-09	歯磨組成物及びその製造方法
JPH07285839A (ja)	1995-10-31	口腔用組成物
MXPA99010453A (en)	2000-09-04	Desensitizing dentifrice having limited astringency
MXPA97004415A (en)	1998-07-03	Formation of stable aqueous solutions of stanno compounds

RU2259193C2 - Содержащее цинк средство уменьшенной остроты для чистки зубов - Google Patents

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Publications (2)

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ID=24934113

Family Applications (1)

Country Status (18)

Cited By (1)

Families Citing this family (21)

Citations (4)

Family Cites Families (2)

Patent Citations (4)

Cited By (1)

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