RU2662668C2 - Способ непрерывной многостадийной очистки антител - Google Patents

Способ непрерывной многостадийной очистки антител Download PDF

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Publication number
RU2662668C2
RU2662668C2 RU2015151869A RU2015151869A RU2662668C2 RU 2662668 C2 RU2662668 C2 RU 2662668C2 RU 2015151869 A RU2015151869 A RU 2015151869A RU 2015151869 A RU2015151869 A RU 2015151869A RU 2662668 C2 RU2662668 C2 RU 2662668C2
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chromatographic
buffer
protein
chromatographic column
passing
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RU2015151869A
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Russian (ru)
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RU2015151869A (ru
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Дидье ДЮТ
Селин ЭМЕ
Лор ЛАНДРИК-БЮРТЕН
Бенуа МОТ
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Санофи
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
RU2015151869A 2013-05-06 2014-05-06 Способ непрерывной многостадийной очистки антител RU2662668C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13305593 2013-05-06
EP13305593.9 2013-05-06
PCT/EP2014/059246 WO2014180852A1 (en) 2013-05-06 2014-05-06 Continuous multistep process for purifying antibodies

Publications (2)

Publication Number Publication Date
RU2015151869A RU2015151869A (ru) 2017-06-13
RU2662668C2 true RU2662668C2 (ru) 2018-07-26

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RU2015151869A RU2662668C2 (ru) 2013-05-06 2014-05-06 Способ непрерывной многостадийной очистки антител

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US (1) US10793622B2 (2)
EP (2) EP3301115B1 (2)
JP (2) JP6463734B2 (2)
KR (1) KR102272851B1 (2)
CN (2) CN116003579A (2)
AU (1) AU2014264697B2 (2)
BR (1) BR112015027812B1 (2)
CA (1) CA2911462C (2)
CY (1) CY1125281T1 (2)
DK (2) DK2994485T3 (2)
ES (2) ES2905675T3 (2)
HU (2) HUE038741T2 (2)
IL (1) IL242408B (2)
MX (1) MX368177B (2)
NO (1) NO2994485T3 (2)
RU (1) RU2662668C2 (2)
SG (1) SG11201508968XA (2)
TW (2) TWI631132B (2)
WO (1) WO2014180852A1 (2)

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Also Published As

Publication number Publication date
TWI631132B (zh) 2018-08-01
CN116003579A (zh) 2023-04-25
WO2014180852A1 (en) 2014-11-13
EP3301115B1 (en) 2021-11-10
CA2911462C (en) 2021-04-06
TW201522363A (zh) 2015-06-16
JP6463734B2 (ja) 2019-02-06
ES2905675T3 (es) 2022-04-11
DK3301115T3 (da) 2022-01-31
US10793622B2 (en) 2020-10-06
NO2994485T3 (2) 2018-06-09
BR112015027812B1 (pt) 2021-03-30
HUE057119T2 (hu) 2022-04-28
AU2014264697A1 (en) 2015-11-26
CA2911462A1 (en) 2014-11-13
CN105358572A (zh) 2016-02-24
DK2994485T3 (en) 2018-04-23
JP2019104735A (ja) 2019-06-27
TWI675041B (zh) 2019-10-21
RU2015151869A (ru) 2017-06-13
KR20160005047A (ko) 2016-01-13
EP2994485B1 (en) 2018-01-10
MX368177B (es) 2019-09-23
TW201908331A (zh) 2019-03-01
HUE038741T2 (hu) 2018-11-28
SG11201508968XA (en) 2015-11-27
KR102272851B1 (ko) 2021-07-02
BR112015027812A2 (pt) 2017-07-25
ES2665645T3 (es) 2018-04-26
IL242408B (en) 2020-04-30
CY1125281T1 (el) 2023-06-09
EP3301115A1 (en) 2018-04-04
EP2994485A1 (en) 2016-03-16
MX2015015482A (es) 2016-03-21
JP2016519137A (ja) 2016-06-30
US20160083454A1 (en) 2016-03-24
AU2014264697B2 (en) 2019-08-22

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