CN116003579A - 用于纯化抗体的连续多步骤方法 - Google Patents

用于纯化抗体的连续多步骤方法 Download PDF

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Publication number
CN116003579A
CN116003579A CN202310118200.6A CN202310118200A CN116003579A CN 116003579 A CN116003579 A CN 116003579A CN 202310118200 A CN202310118200 A CN 202310118200A CN 116003579 A CN116003579 A CN 116003579A
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protein
chromatography
passing
buffer
column
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CN202310118200.6A
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Chinese (zh)
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D·杜斯
C·赫梅特
L·兰德里克-伯廷
B·莫茨
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Sanofi Aventis France
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Sanofi Aventis France
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN202310118200.6A 2013-05-06 2014-05-06 用于纯化抗体的连续多步骤方法 Pending CN116003579A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP13305593 2013-05-06
EP13305593.9 2013-05-06
PCT/EP2014/059246 WO2014180852A1 (en) 2013-05-06 2014-05-06 Continuous multistep process for purifying antibodies
CN201480038360.9A CN105358572A (zh) 2013-05-06 2014-05-06 用于纯化抗体的连续多步骤方法

Related Parent Applications (1)

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CN201480038360.9A Division CN105358572A (zh) 2013-05-06 2014-05-06 用于纯化抗体的连续多步骤方法

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CN116003579A true CN116003579A (zh) 2023-04-25

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CN202310118200.6A Pending CN116003579A (zh) 2013-05-06 2014-05-06 用于纯化抗体的连续多步骤方法
CN201480038360.9A Pending CN105358572A (zh) 2013-05-06 2014-05-06 用于纯化抗体的连续多步骤方法

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US (1) US10793622B2 (2)
EP (2) EP3301115B1 (2)
JP (2) JP6463734B2 (2)
KR (1) KR102272851B1 (2)
CN (2) CN116003579A (2)
AU (1) AU2014264697B2 (2)
BR (1) BR112015027812B1 (2)
CA (1) CA2911462C (2)
CY (1) CY1125281T1 (2)
DK (2) DK2994485T3 (2)
ES (2) ES2905675T3 (2)
HU (2) HUE038741T2 (2)
IL (1) IL242408B (2)
MX (1) MX368177B (2)
NO (1) NO2994485T3 (2)
RU (1) RU2662668C2 (2)
SG (1) SG11201508968XA (2)
TW (2) TWI631132B (2)
WO (1) WO2014180852A1 (2)

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TWI631132B (zh) 2018-08-01
WO2014180852A1 (en) 2014-11-13
EP3301115B1 (en) 2021-11-10
CA2911462C (en) 2021-04-06
TW201522363A (zh) 2015-06-16
JP6463734B2 (ja) 2019-02-06
ES2905675T3 (es) 2022-04-11
DK3301115T3 (da) 2022-01-31
US10793622B2 (en) 2020-10-06
NO2994485T3 (2) 2018-06-09
BR112015027812B1 (pt) 2021-03-30
HUE057119T2 (hu) 2022-04-28
AU2014264697A1 (en) 2015-11-26
CA2911462A1 (en) 2014-11-13
CN105358572A (zh) 2016-02-24
DK2994485T3 (en) 2018-04-23
JP2019104735A (ja) 2019-06-27
TWI675041B (zh) 2019-10-21
RU2015151869A (ru) 2017-06-13
KR20160005047A (ko) 2016-01-13
EP2994485B1 (en) 2018-01-10
MX368177B (es) 2019-09-23
TW201908331A (zh) 2019-03-01
HUE038741T2 (hu) 2018-11-28
SG11201508968XA (en) 2015-11-27
KR102272851B1 (ko) 2021-07-02
BR112015027812A2 (pt) 2017-07-25
ES2665645T3 (es) 2018-04-26
IL242408B (en) 2020-04-30
CY1125281T1 (el) 2023-06-09
EP3301115A1 (en) 2018-04-04
EP2994485A1 (en) 2016-03-16
MX2015015482A (es) 2016-03-21
RU2662668C2 (ru) 2018-07-26
JP2016519137A (ja) 2016-06-30
US20160083454A1 (en) 2016-03-24
AU2014264697B2 (en) 2019-08-22

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