RU93046709A - Способ получения нуклеозидов - Google Patents

Способ получения нуклеозидов

Info

Publication number
RU93046709A
RU93046709A RU93046709/04A RU93046709A RU93046709A RU 93046709 A RU93046709 A RU 93046709A RU 93046709/04 A RU93046709/04 A RU 93046709/04A RU 93046709 A RU93046709 A RU 93046709A RU 93046709 A RU93046709 A RU 93046709A
Authority
RU
Russia
Prior art keywords
producing nucleosides
anomeric
nucleosides
producing
fluorucleosides
Prior art date
Application number
RU93046709/04A
Other languages
English (en)
Other versions
RU2131880C1 (ru
Inventor
Чоу Та-Сен
Мишель Потит Лаури
Пэттон Къелл Дуглас
Сю Гроссман Кора
Вейн Хертел Ларри
Элмер Холмс Ричард
Дэвид Джоунс Чарльз
Эдвард Мэбри Томас
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of RU93046709A publication Critical patent/RU93046709A/ru
Application granted granted Critical
Publication of RU2131880C1 publication Critical patent/RU2131880C1/ru

Links

Claims (1)

  1. Описывается стереоселективный процесс гликозилирования для получения бета-аномерных фторнуклеозидов с помощью SN2 замещения аномерной сульфонилоксигруппы обогащенного альфа-аномером фторкарбогидрата нуклеооснованием.
RU93046709A 1992-06-22 1993-06-21 Способ получения обогащенных бета-аномером нуклеозидов RU2131880C1 (ru)

Applications Claiming Priority (21)

Application Number Priority Date Filing Date Title
US90215092A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US90230292A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US07/902.302 1992-06-22
US07/902.313 1992-06-22
US07/902.135 1992-06-22
US07/902.112 1992-06-22
US07/902,150 1992-06-22
US07/902.312 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US07/902,112 1992-06-22
US07/902.150 1992-06-22
US07/902,135 1992-06-22
US08/044.312 1993-04-07
US08/044.309 1993-04-07
US08/044.345 1993-04-07
US08/044.343 1993-04-07
US08/044.996 1993-04-07
US08/044.315 1993-04-07

Publications (2)

Publication Number Publication Date
RU93046709A true RU93046709A (ru) 1996-12-27
RU2131880C1 RU2131880C1 (ru) 1999-06-20

Family

ID=27560338

Family Applications (1)

Application Number Title Priority Date Filing Date
RU93046709A RU2131880C1 (ru) 1992-06-22 1993-06-21 Способ получения обогащенных бета-аномером нуклеозидов

Country Status (1)

Country Link
RU (1) RU2131880C1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
CN101080417B (zh) * 2004-12-17 2011-01-19 伊莱利利公司 吉西他滨的酰胺前体药物、其组合物以及应用
WO2006070985A1 (en) * 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
RU2355400C2 (ru) * 2007-07-11 2009-05-20 Закрытое Акционерное Общество "Биокад" Способ получения и очистки гемцитабина гидрохлорида

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

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