SA112340077B1 - Peptide-based In vivo siRNA delivery system - Google Patents
Peptide-based In vivo siRNA delivery systemInfo
- Publication number
- SA112340077B1 SA112340077B1 SA112340077A SA112340077A SA112340077B1 SA 112340077 B1 SA112340077 B1 SA 112340077B1 SA 112340077 A SA112340077 A SA 112340077A SA 112340077 A SA112340077 A SA 112340077A SA 112340077 B1 SA112340077 B1 SA 112340077B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- targeted
- peptide
- delivery system
- polynucleotides
- rnai
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000001727 in vivo Methods 0.000 title abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 4
- 230000009368 gene silencing by RNA Effects 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 108010036176 Melitten Proteins 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is directed compositions for targeted delivery of RNA interference (RNAi) polynucleotides to hepatocytes in vivo. Targeted RNAi polynucleotides are administered together with co-targeted melittin delivery peptides. Delivery peptides provide membrane penetration function for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness to the delivery peptides.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/326,433 US8501930B2 (en) | 2010-12-17 | 2011-12-15 | Peptide-based in vivo siRNA delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA112340077B1 true SA112340077B1 (en) | 2015-11-10 |
Family
ID=49224588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA112340077A SA112340077B1 (en) | 2011-12-15 | 2012-12-12 | Peptide-based In vivo siRNA delivery system |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR089244A1 (en) |
| SA (1) | SA112340077B1 (en) |
| TW (1) | TWI565476B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5883381B2 (en) * | 2009-05-05 | 2016-03-15 | ミラゲン セラピューティクス，インコーポレイテッド | Lipophilic polynucleotide conjugate |
-
2012
- 2012-11-20 TW TW101143327A patent/TWI565476B/en not_active IP Right Cessation
- 2012-12-12 SA SA112340077A patent/SA112340077B1/en unknown
- 2012-12-14 AR ARP120104720 patent/AR089244A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TWI565476B (en) | 2017-01-11 |
| AR089244A1 (en) | 2014-08-06 |
| TW201325622A (en) | 2013-07-01 |
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