SA112340077B1 - نظام إيصال siRNA داخل الكائن الحي يعتمد على الببتيدات - Google Patents
نظام إيصال siRNA داخل الكائن الحي يعتمد على الببتيداتInfo
- Publication number
- SA112340077B1 SA112340077B1 SA112340077A SA112340077A SA112340077B1 SA 112340077 B1 SA112340077 B1 SA 112340077B1 SA 112340077 A SA112340077 A SA 112340077A SA 112340077 A SA112340077 A SA 112340077A SA 112340077 B1 SA112340077 B1 SA 112340077B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- targeted
- peptide
- delivery system
- polynucleotides
- rnai
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000001727 in vivo Methods 0.000 title abstract 2
- 108020004459 Small interfering RNA Proteins 0.000 title 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 abstract 4
- 230000009368 gene silencing by RNA Effects 0.000 abstract 4
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 210000004027 cell Anatomy 0.000 abstract 2
- 108010036176 Melitten Proteins 0.000 abstract 1
- 210000003494 hepatocyte Anatomy 0.000 abstract 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical compound NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
- 230000002441 reversible effect Effects 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
يتعلق الاختراع الحالي بتركيبات لإيصال مستهدَف لأجل polynucleotides تداخل RNA (RNAi) لخلايا كبدية داخل الخلية الحية. ويتم إعطاء RNAi polynucleotides مستهدَفة مع ببتيدات إيصال melittin مستهدَفة بصورة مشتركة. وتؤدي ببتيدات الإيصال إلى توفير وظيفة اختراق الأغشية لتحريك RNAi polynucleotides من خارج الخلية إلى داخلها. ويؤدي التعديل القابل للانعكاس إلى إحداث استجابة فيزيولوجية لببتيدات الإيصال.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/326,433 US8501930B2 (en) | 2010-12-17 | 2011-12-15 | Peptide-based in vivo siRNA delivery system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA112340077B1 true SA112340077B1 (ar) | 2015-11-10 |
Family
ID=49224588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA112340077A SA112340077B1 (ar) | 2011-12-15 | 2012-12-12 | نظام إيصال siRNA داخل الكائن الحي يعتمد على الببتيدات |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR089244A1 (ar) |
| SA (1) | SA112340077B1 (ar) |
| TW (1) | TWI565476B (ar) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010129672A1 (en) * | 2009-05-05 | 2010-11-11 | Miragen Therapeutics | Lipophilic polynucleotide conjugates |
-
2012
- 2012-11-20 TW TW101143327A patent/TWI565476B/zh not_active IP Right Cessation
- 2012-12-12 SA SA112340077A patent/SA112340077B1/ar unknown
- 2012-12-14 AR ARP120104720 patent/AR089244A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR089244A1 (es) | 2014-08-06 |
| TWI565476B (zh) | 2017-01-11 |
| TW201325622A (zh) | 2013-07-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12013500741A1 (en) | Peptide-based in vivo sirna delivery system | |
| PH12012501596A1 (en) | Compositions for targeted delivery of sirna | |
| PH12014500213A1 (en) | Poly (acrylate) polymers for in vivo nucleic acid delivery | |
| PH12014500214A1 (en) | Poly (vinyl ester) polymers for in vivo nucleic acid delivery | |
| PT4335511T (pt) | Indução do gene trail de pequenas moléculas por células normais e tumorais enquanto terapia anticancro | |
| MX2021008465A (es) | Farmaco-enlazadores modificados con polietilenglicol para la farmacocinetica mejorada de conjugados de ligando-farmaco. | |
| MX356625B (es) | Oligonucleotidos para elaborar un cambio en la secuencia de una molécula de ácido ribonucleico objetivo presente en una célula viva. | |
| AU2012267467A8 (en) | Compounds for targeting drug delivery and enhancing siRNA activity | |
| CY1120560T1 (el) | Βελτιστοποιημενο συστημα παραδοσης in vivo me ενδοσωματολυτικους παραγοντες για συζευγματα νουκλεϊνικου οξεος | |
| SG195194A1 (en) | Nanogels | |
| WO2012075040A3 (en) | mRNA FOR USE IN TREATMENT OF HUMAN GENETIC DISEASES | |
| EA201270019A1 (ru) | Двуцепочечная рнк, включенная в липидный состав и мишенью которой является ген pcsk9 | |
| MX2012002502A (es) | Conjugados de polietilenglicol/peptidos enlazados por disulfuro para la transfeccion de acidos nucleicos. | |
| EA201890915A1 (ru) | Конъюгаты для доставки лекарственных средств и способы лечения заболеваний, вызванных клетками, экспрессирующими psma | |
| PH12014500348A1 (en) | Genes and proteins for alkanoyl-coa synthesis | |
| WO2011094335A3 (en) | Microrna signatures predicting responsiveness to anti-her2 therapy | |
| EP2657339A4 (en) | GENE GENERATING SYSTEM WITH IMPROVED TUMOR SPECIFIC EXPRESSION AND A SEQUENCE FOR REGULATING THE EXPRESSION OF RECOMBINANT GENES | |
| AU2012358181A8 (en) | Compositions and methods for the delivery of biologically active RNAs | |
| BRPI0920246A2 (pt) | método de preparação de alfa-beta peptídios biologicamente ativos. | |
| ZA202207211B (en) | Peptide docking vehicle for targeted nucleic acid delivery | |
| SA112340077B1 (ar) | نظام إيصال siRNA داخل الكائن الحي يعتمد على الببتيدات | |
| WO2012122290A3 (en) | Citrus greening (huanglongbing)-induced small rnas are potential early diagnosis markers | |
| BR112012027883A2 (pt) | composições de terapêutica de pequenas moléculas | |
| TW201129365A (en) | Compositions and methods for inhibiting expression of IKK2 genes | |
| UA110935C2 (uk) | Препарат інсуліну пролонгованої дії |