SA517381981B1 - أجسام مضادة لترانس ثيرتين - Google Patents
أجسام مضادة لترانس ثيرتينInfo
- Publication number
- SA517381981B1 SA517381981B1 SA517381981A SA517381981A SA517381981B1 SA 517381981 B1 SA517381981 B1 SA 517381981B1 SA 517381981 A SA517381981 A SA 517381981A SA 517381981 A SA517381981 A SA 517381981A SA 517381981 B1 SA517381981 B1 SA 517381981B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- ttr
- antibodies
- transthyretin
- accumulation
- amyloidosis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
أجسام مضادة لترانس ثيرتين ANTI-TRANSTHYRETIN ANTIBODIES الملخـــص يتعلق الاختراع الحالي بتوفير أجسام مضادة antibodies ترتبط بشكل خاص بترانس ثيرتين transthyretin (TTR). يمكن استخدام الأجسام المضادة antibodies لعلاج أو تفعيل الوقاية effecting prophylaxis من الأمراض diseases أو الاضطرابات disorders المصحوبة بتراكم TTR TTR accumulation أو تراكم رواسب TTR accumulation of TTR deposits (على سبيل المثال، الداء النشواني amyloidosis الناتج عن TTR). يمكن أيضًا استخدام الأجسام المضادة antibodies لتشخيص الداء النشواني amyloidosis الناتج عن TTR وتثبيط أو خفض تَكَدُّس TTR reducing aggregation of TTR، من بين تطبيقات أخرى. الشكل 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562109004P | 2015-01-28 | 2015-01-28 | |
| US201562266555P | 2015-12-11 | 2015-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA517381981B1 true SA517381981B1 (ar) | 2022-05-17 |
Family
ID=55300737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA517381981A SA517381981B1 (ar) | 2015-01-28 | 2017-07-25 | أجسام مضادة لترانس ثيرتين |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20160257737A1 (ar) |
| EP (1) | EP3250593B1 (ar) |
| JP (1) | JP7101927B2 (ar) |
| KR (1) | KR102649788B1 (ar) |
| CN (1) | CN107406500B (ar) |
| AU (1) | AU2016210889C1 (ar) |
| CA (1) | CA2974993A1 (ar) |
| CO (1) | CO2017008482A2 (ar) |
| CU (1) | CU20170098A7 (ar) |
| DK (1) | DK3250593T3 (ar) |
| EA (1) | EA036014B1 (ar) |
| ES (1) | ES2925716T3 (ar) |
| HR (1) | HRP20220918T1 (ar) |
| HU (1) | HUE059592T2 (ar) |
| MX (1) | MX389911B (ar) |
| MY (1) | MY193701A (ar) |
| PE (1) | PE20180218A1 (ar) |
| PL (1) | PL3250593T3 (ar) |
| PT (1) | PT3250593T (ar) |
| RS (1) | RS63513B1 (ar) |
| SA (1) | SA517381981B1 (ar) |
| SG (2) | SG10201906696RA (ar) |
| SI (1) | SI3250593T1 (ar) |
| TW (2) | TWI769570B (ar) |
| WO (1) | WO2016120811A1 (ar) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9879080B2 (en) | 2015-01-28 | 2018-01-30 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10633433B2 (en) | 2015-01-28 | 2020-04-28 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| US10464999B2 (en) | 2015-01-28 | 2019-11-05 | Prothena Biosciences Limited | Anti-transthyretin antibodies |
| JP7017013B2 (ja) * | 2016-07-02 | 2022-02-08 | プロセナ バイオサイエンシーズ リミテッド | 抗トランスサイレチン抗体 |
| US12269898B2 (en) | 2017-10-04 | 2025-04-08 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| CN111757730A (zh) | 2017-10-06 | 2020-10-09 | 普罗塞纳生物科学有限公司 | 检测甲状腺素运载蛋白的方法 |
| CU24731B1 (es) | 2017-10-06 | 2025-01-15 | Prothena Biosciences Ltd | Anticuerpos anti-transtiretina |
| CU20200042A7 (es) | 2017-11-29 | 2021-03-11 | Prothena Biosciences Ltd | Formulación liofilizada de un anticuerpo monoclonal contra la transtirretina |
| US12006357B2 (en) | 2018-06-26 | 2024-06-11 | Mor Research Applications Ltd. | Transthyretin antibodies and uses thereof |
| CN111018976B (zh) * | 2018-10-10 | 2022-04-01 | 东莞市朋志生物科技有限公司 | 一种抗人心肌肌钙蛋白i的重组抗体 |
| US20210400932A1 (en) * | 2018-11-09 | 2021-12-30 | Neurimmune Ag | Patient-derived amyloid xenograft non-human animal model |
| EP3981788A4 (en) * | 2019-06-04 | 2023-03-22 | Jiangsu Hengrui Medicine Co., Ltd. | ANTIBODY CAPABLE OF BINDING THYMIC STROMAL LYMPHOPOIETIN AND ITS USE |
| EP3997112A1 (en) * | 2019-07-08 | 2022-05-18 | Amgen, Inc | Multispecific transthyretin immunoglobulin fusions |
| CA3183994A1 (en) | 2020-06-24 | 2021-12-30 | Philip James Dolan Iii | Antibodies recognizing sortilin |
| CN118059229A (zh) * | 2020-10-14 | 2024-05-24 | 维里迪安治疗公司 | 用于治疗甲状腺眼病的组合物和方法 |
| CN119792512A (zh) | 2020-10-14 | 2025-04-11 | 维里迪安治疗公司 | 用于治疗甲状腺眼病的组合物和方法 |
| MX2023006596A (es) * | 2020-12-03 | 2023-06-19 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Composicion farmaceutica de anticuerpo anti-tslp y uso de la misma. |
| JP2023554422A (ja) * | 2020-12-16 | 2023-12-27 | メルス ナムローゼ フェンノートシャップ | がんの治療のための多重特異性抗体 |
| CN117916599A (zh) | 2021-09-07 | 2024-04-19 | 美国西门子医学诊断股份有限公司 | 生物标记物组合物及其使用方法 |
| CN116804186B (zh) * | 2023-07-05 | 2023-12-22 | 中国兽医药品监察所 | 一种抗鸡传染性贫血病毒单克隆抗体杂交瘤细胞株、单克隆抗体、试剂或试剂盒及其应用 |
| WO2025125544A1 (en) | 2023-12-15 | 2025-06-19 | Novo Nordisk A/S | Stable liquid formulations |
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| ATE300615T1 (de) | 1990-08-29 | 2005-08-15 | Genpharm Int | Transgene mäuse fähig zur produktion heterologer antikörper |
| US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5871907A (en) | 1991-05-15 | 1999-02-16 | Medical Research Council | Methods for producing members of specific binding pairs |
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| CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
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| KR101149777B1 (ko) | 2002-11-29 | 2012-06-11 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | 신규한 네오마이신 포스포트랜스퍼라제 유전자 및 고생산성 재조합 세포의 선별 방법 |
| DE10338531A1 (de) | 2003-08-19 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Reklonierung von Produktionszellen |
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| WO2007124345A2 (en) | 2006-04-21 | 2007-11-01 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Beta-amyloid pet imaging agents |
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-
2016
- 2016-01-27 TW TW109138086A patent/TWI769570B/zh active
- 2016-01-27 TW TW105102532A patent/TWI711631B/zh active
- 2016-01-28 HR HRP20220918TT patent/HRP20220918T1/hr unknown
- 2016-01-28 PE PE2017001289A patent/PE20180218A1/es unknown
- 2016-01-28 RS RS20220788A patent/RS63513B1/sr unknown
- 2016-01-28 EA EA201791710A patent/EA036014B1/ru unknown
- 2016-01-28 DK DK16702990.9T patent/DK3250593T3/da active
- 2016-01-28 ES ES16702990T patent/ES2925716T3/es active Active
- 2016-01-28 WO PCT/IB2016/050416 patent/WO2016120811A1/en not_active Ceased
- 2016-01-28 PT PT167029909T patent/PT3250593T/pt unknown
- 2016-01-28 CA CA2974993A patent/CA2974993A1/en active Pending
- 2016-01-28 HU HUE16702990A patent/HUE059592T2/hu unknown
- 2016-01-28 PL PL16702990.9T patent/PL3250593T3/pl unknown
- 2016-01-28 AU AU2016210889A patent/AU2016210889C1/en active Active
- 2016-01-28 SG SG10201906696RA patent/SG10201906696RA/en unknown
- 2016-01-28 MY MYPI2017702752A patent/MY193701A/en unknown
- 2016-01-28 SG SG11201706126WA patent/SG11201706126WA/en unknown
- 2016-01-28 MX MX2017009803A patent/MX389911B/es unknown
- 2016-01-28 EP EP16702990.9A patent/EP3250593B1/en active Active
- 2016-01-28 JP JP2017540250A patent/JP7101927B2/ja active Active
- 2016-01-28 SI SI201631572T patent/SI3250593T1/sl unknown
- 2016-01-28 CN CN201680015343.2A patent/CN107406500B/zh active Active
- 2016-01-28 CU CUP2017000098A patent/CU20170098A7/es unknown
- 2016-01-28 KR KR1020177023750A patent/KR102649788B1/ko active Active
- 2016-01-28 US US15/009,667 patent/US20160257737A1/en not_active Abandoned
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2017
- 2017-07-25 SA SA517381981A patent/SA517381981B1/ar unknown
- 2017-08-22 CO CONC2017/0008482A patent/CO2017008482A2/es unknown
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
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