SE0201863D0 - Cell penetrating peptides - Google Patents

Cell penetrating peptides

Info

Publication number
SE0201863D0
SE0201863D0 SE0201863A SE0201863A SE0201863D0 SE 0201863 D0 SE0201863 D0 SE 0201863D0 SE 0201863 A SE0201863 A SE 0201863A SE 0201863 A SE0201863 A SE 0201863A SE 0201863 D0 SE0201863 D0 SE 0201863D0
Authority
SE
Sweden
Prior art keywords
cpp
present
relates
predicting
verifying
Prior art date
Application number
SE0201863A
Other languages
Unknown language ( )
English (en)
Inventor
Margus Pooga
Madis Metsis
Priit Kogerman
Andreas Valkna
Anne Meikas
Samir El-Andaloussi
Maria Lindgren
Astrid Graeslund
Goeran Eriksson
Claes Goeran Oestensson
Metka Budihna
Matjaz Zorko
Anna Elmquist
Ursel Soomets
Pontus Lundberg
Uelo Langel
Kalle Kilk
Mattias Haellbrink
Original Assignee
Cepep Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cepep Ab filed Critical Cepep Ab
Priority to SE0201863A priority Critical patent/SE0201863D0/
Publication of SE0201863D0 publication Critical patent/SE0201863D0/
Priority to PCT/IB2003/003163 priority patent/WO2003106491A2/fr
Priority to EP03760107A priority patent/EP1516184B1/fr
Priority to DE60315296T priority patent/DE60315296T2/de
Priority to US10/517,079 priority patent/US20080234183A1/en
Priority to AU2003253125A priority patent/AU2003253125A1/en
Priority to HK05108432.4A priority patent/HK1078130B/en
Priority to AT03760107T priority patent/ATE368853T1/de
Priority to JP2004513322A priority patent/JP4503435B2/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0446Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K51/0448Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil tropane or nortropane groups, e.g. cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Cardiology (AREA)
SE0201863A 2002-06-18 2002-06-18 Cell penetrating peptides SE0201863D0 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE0201863A SE0201863D0 (en) 2002-06-18 2002-06-18 Cell penetrating peptides
PCT/IB2003/003163 WO2003106491A2 (fr) 2002-06-18 2003-06-18 Peptides penetrant dans les cellules
EP03760107A EP1516184B1 (fr) 2002-06-18 2003-06-18 Système de délivrance vers une cellule spécifique
DE60315296T DE60315296T2 (de) 2002-06-18 2003-06-18 Zell-selektives Abgabe System
US10/517,079 US20080234183A1 (en) 2002-06-18 2003-06-18 Cell Penetrating Peptides
AU2003253125A AU2003253125A1 (en) 2002-06-18 2003-06-18 Cell penetrating peptides
HK05108432.4A HK1078130B (en) 2002-06-18 2003-06-18 Cell-selective delivery system
AT03760107T ATE368853T1 (de) 2002-06-18 2003-06-18 Zell-selektives abgabe system
JP2004513322A JP4503435B2 (ja) 2002-06-18 2003-06-18 細胞選択的送達系

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0201863A SE0201863D0 (en) 2002-06-18 2002-06-18 Cell penetrating peptides
US39178802P 2002-06-25 2002-06-25

Publications (1)

Publication Number Publication Date
SE0201863D0 true SE0201863D0 (en) 2002-06-18

Family

ID=29738564

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0201863A SE0201863D0 (en) 2002-06-18 2002-06-18 Cell penetrating peptides

Country Status (8)

Country Link
US (1) US20080234183A1 (fr)
EP (1) EP1516184B1 (fr)
JP (1) JP4503435B2 (fr)
AT (1) ATE368853T1 (fr)
AU (1) AU2003253125A1 (fr)
DE (1) DE60315296T2 (fr)
SE (1) SE0201863D0 (fr)
WO (1) WO2003106491A2 (fr)

Families Citing this family (193)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7192713B1 (en) 1999-05-18 2007-03-20 President And Fellows Of Harvard College Stabilized compounds having secondary structure motifs
US8003595B2 (en) 2000-03-01 2011-08-23 Cellectis Amino acid sequences facilitating penetration of a substance of interest into cells and/or cell nuclei
US7696168B2 (en) 2000-04-21 2010-04-13 Tufts Medical Center, Inc. G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
EP2348047A1 (fr) * 2000-04-21 2011-07-27 New England Medical Center Agonistes et antagonistes du récepteur couplé à la protéine G (GPCR) et procédés d'activation et d'inhibition de GPCR au moyen de ces agonistes et antagonistes
GB0313132D0 (en) * 2003-06-06 2003-07-09 Ich Productions Ltd Peptide ligands
EP1512696A1 (fr) * 2003-08-14 2005-03-09 Diatos Séquences d'acides aminés facilitant la pénétration d'une substance d'intérêt dans les cellules et/ou le noyau
DE602004022056D1 (de) 2003-08-14 2009-08-27 Diatos Antibakterielle zusammensetzung, vor allem zur bekämpfung gramnegativer bakterien, umfassend ein peptid und ein vorteilhafterweise hydrophobes antibakterielles agens
ES2586387T3 (es) 2003-11-05 2016-10-14 Dana-Farber Cancer Institute, Inc. Péptidos alfa helicoidales adecuados para activar o inhibir la muerte celular
US20060040882A1 (en) 2004-05-04 2006-02-23 Lishan Chen Compostions and methods for enhancing delivery of nucleic acids into cells and for modifying expression of target genes in cells
JP2007536253A (ja) * 2004-05-04 2007-12-13 ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド 細胞内への核酸の送達を増強し、細胞中の標的遺伝子の発現を修飾するための組成物及び方法
KR100897915B1 (ko) * 2004-11-03 2009-05-18 포휴먼텍(주) 경피전달을 위한 약제 조성물
JP2008519039A (ja) * 2004-11-04 2008-06-05 ニュー イングランド メデカル センター ホスピタルズ インク Gタンパク質共役型受容体アゴニストおよびアンタゴニストならびに使用方法
FR2877946B1 (fr) 2004-11-12 2011-02-11 Commissariat Energie Atomique Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet
CN101142233A (zh) 2004-12-22 2008-03-12 利波佩普蒂德有限公司 抑制cathelin样蛋白hCAP18/LL-17的试剂
WO2006078816A2 (fr) 2005-01-18 2006-07-27 The Board Of Governors For Higher Education Distribution selective de molecule dans des cellules ou marquage de cellules dans des regions tissulaires malades au moyen d'un peptide transmembranaire sensible a l'environnement
WO2007031098A1 (fr) 2005-09-12 2007-03-22 Xigen S.A. Inhibiteurs peptidiques permeables aux cellules de la voie de transduction de signal jnk
PT2236608T (pt) 2005-10-04 2017-03-01 Soligenix Inc Péptidos novos para tratar e prevenir distúrbios relacionados com a imunidade, incluindo tratar e prevenir infecção por modulação da imunidade inata
EP2003198A2 (fr) * 2006-03-13 2008-12-17 Keio University Peptide pour l'inhibition de l'infection par influenza, inhibiteur d'une infection par influenza, liposome, et agent prophylactique/thérapeutique pour l'influenza
US8642559B2 (en) * 2006-10-13 2014-02-04 University Of Southern California C-terminal domain truncation of mGluR1α by calpain and uses thereof
EP2341142B8 (fr) 2006-12-28 2015-01-14 International Institute of Cancer Immunology, Inc. Peptide WT1 à restriction HLA-A*1101 et composition pharmaceutique le contenant
EP2837636B1 (fr) * 2007-01-29 2018-04-11 Procell Therapeutics Inc. Nouveaux domaines de transduction de macromolecules et procedes d'identification et utilisations correspondantes
DK2118123T3 (en) 2007-01-31 2016-01-25 Dana Farber Cancer Inst Inc Stabilized p53 peptides and uses thereof
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
WO2009009441A2 (fr) 2007-07-06 2009-01-15 Cedars-Sinai Medical Center Complexe s'auto-assemblant pour cibler des agents chimiques sur des cellules
AU2008295509A1 (en) 2007-08-29 2009-03-12 Tufts University Methods of making and using a cell penetrating peptide for enhanced delivery of nucleic acids, proteins, drugs, and adenovirus to tissues and cells, and compositions and kits
WO2009041902A1 (fr) * 2007-09-25 2009-04-02 Loefgren Kajsa Peptides pénétrant une cellule dérivée d'une protéine prion et leurs utilisations
TW200932260A (en) * 2007-11-28 2009-08-01 Oncotherapy Science Inc STAT3 epitope peptides
DE112009000300T5 (de) 2008-02-08 2011-01-20 Aileron Therapeutics, Inc., Cambridge Therapeutische Peptidomimetische Makrocyclen
EP2090584A1 (fr) 2008-02-13 2009-08-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identification d'un nouveau peptide à pénétration de cellule riche en cystéine
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
JP2011514160A (ja) * 2008-02-21 2011-05-06 バーナム インスティテュート フォー メディカル リサーチ C末端エレメントを有するペプチドおよびタンパク質に関する方法および組成物
GB0804496D0 (en) 2008-03-11 2008-04-16 Theryte Ltd Treating cancer
WO2009120993A2 (fr) * 2008-03-28 2009-10-01 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Analogues synthétiques du domaine juxtamembranaire de l'igf1r et leurs utilisations
WO2009137689A2 (fr) * 2008-05-07 2009-11-12 Surmodics, Inc. Administration de complexe d’acide nucléique à partir de particules
WO2009143865A1 (fr) 2008-05-30 2009-12-03 Xigen S.A. Utilisation d'inhibiteurs peptidiques des voies de traduction du signal jnk perméables aux cellules pour le traitement de diverses maladies
WO2009143864A1 (fr) 2008-05-30 2009-12-03 Xigen S.A. Utilisation d'inhibiteurs peptidiques perméables aux cellules de la voie de transduction du signal jnk pour le traitement de maladies digestives inflammatoires chroniques ou non chroniques
WO2009149214A2 (fr) * 2008-06-03 2009-12-10 Aileron Therapeutics, Inc. Compositions et procédés pour améliorer le transport cellulaire de biomolécules
WO2009147368A1 (fr) * 2008-06-04 2009-12-10 Medical Research Council Peptides
WO2009149560A1 (fr) 2008-06-12 2009-12-17 Centre For Addiction And Mental Health Compositions et procédés pour moduler l'interaction et la fonction du récepteur d1-d2 dopaminergique
US20110218334A1 (en) * 2008-07-11 2011-09-08 Alnylam Pharmaceuticals, Inc. PHOSPHOROTHIOATE OLIGONUCLEOTIDES AND NON-NUCLEOSIDIC PHOSPHOROTHIOATES AS DELIVERY AGENTS FOR iRNA AGENTS
EP2356139A4 (fr) 2008-07-23 2013-01-09 Harvard College Ligature de polypeptides agrafés
CN102203126A (zh) 2008-09-22 2011-09-28 爱勒让治疗公司 用于制备纯化的多肽组合物的方法
US20140248296A1 (en) * 2008-10-16 2014-09-04 Kathleen Cogan Farinas Sustained drug delivery system
US20110294738A1 (en) * 2008-11-04 2011-12-01 Yong Ren Pthr1 receptor compounds
WO2010053547A2 (fr) * 2008-11-04 2010-05-14 Anchor Therapeutics, Inc. Composés de récepteur cxcr5
WO2010072228A1 (fr) 2008-12-22 2010-07-01 Xigen S.A. Nouvelles constructions transporteuses et molécules conjuguées cargo/transporteuses
EP2641911A3 (fr) * 2008-12-23 2014-01-01 Vivoscript, Inc. Compositions et procédés de reprogrammation cellulaire sans modification génétique
US9175047B2 (en) 2009-01-14 2015-11-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010085665A2 (fr) 2009-01-23 2010-07-29 Cedars-Sinai Medical Center Système d'administration ciblée
SG175077A1 (en) 2009-04-07 2011-11-28 Roche Glycart Ag Trivalent, bispecific antibodies
WO2010115286A1 (fr) * 2009-04-09 2010-10-14 Centre For Addiction And Mental Health Interaction récepteur d2 de la dopamine-disc1, compositions et procédés pour moduler celle-ci
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
GB0910620D0 (en) 2009-06-19 2009-08-05 Immunovia Ab Agents and uses thereof
WO2011005540A1 (fr) 2009-06-22 2011-01-13 Burnham Institute For Medical Research Procédés et compositions utilisant des peptides et des protéines dotés d’éléments c-terminaux
AU2010273220B2 (en) 2009-07-13 2015-10-15 President And Fellows Of Harvard College Bifunctional stapled polypeptides and uses thereof
WO2011038002A1 (fr) * 2009-09-22 2011-03-31 Yale University Epitopes immunogènes en tant que cibles pour des vaccins universels contre le cancer
CN102712675A (zh) 2009-09-22 2012-10-03 爱勒让治疗公司 拟肽大环化合物
AU2010306940A1 (en) 2009-10-12 2012-06-07 Smith, Larry Methods and compositions for modulating gene expression using oligonucleotide based drugs administered in vivo or in vitro
WO2011072292A2 (fr) * 2009-12-11 2011-06-16 Dicerna Pharmaceuticals, Inc. Formulations à changement de phase d'arn et de dérivés d'arn
US20110159098A1 (en) * 2009-12-30 2011-06-30 Surmodics, Inc. Stabilization and delivery of nucleic acid complexes
CA2797093C (fr) 2010-04-26 2019-10-29 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, de diagnostic et d'anticorps se rapportant a des fragments proteiques de la cysteinyl-arnt synthetase
EP2563381B1 (fr) 2010-04-27 2017-08-09 aTyr Pharma, Inc. Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps se rapportant à des fragments protéiques d'isoleucyl arnt synthétases
CN103097524B (zh) 2010-04-28 2016-08-03 Atyr医药公司 与丙氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2797374C (fr) 2010-04-29 2021-02-16 Pangu Biopharma Limited Decouverte innovante de compositions therapeutiques, diagnostiques et a based' anticorps associees a des fragments proteiques d'asparaginyl-arnt-synthetases
EP2563383B1 (fr) 2010-04-29 2017-03-01 Atyr Pharma, Inc. Découverte innovatrice de compositions thérapeutiques, diagnostiques, et d'anticorps associées aux fragments protéiques des valyle arnt synthétases
CN103096925A (zh) 2010-05-03 2013-05-08 Atyr医药公司 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
ES2668207T3 (es) 2010-05-03 2018-05-17 Atyr Pharma, Inc. Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas
AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
JP6008844B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ, インコーポレイテッド p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
EP2568996B1 (fr) 2010-05-14 2017-10-04 aTyr Pharma, Inc. Compositions thérapeutique, diagnostique et à base d'anticorps contenant des fragments protéiques de phénylalanyl-bêta-arnt synthétases
CN103096913B (zh) 2010-05-27 2017-07-18 Atyr 医药公司 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
CA2800281C (fr) 2010-06-01 2021-01-12 Atyr Pharma, Inc. Decouverte innovante de compositions therapeutiques, diagnostiques, et d'anticorps associes a des fragments de proteine de lysyl-tarn synthetases
US9540680B2 (en) * 2010-06-07 2017-01-10 The Trustees Of The University Of Pennsylvania Transcriptome in vivo analysis
RU2556800C2 (ru) 2010-06-14 2015-07-20 Ф.Хоффманн-Ля Рош Аг Пептиды, проникающие в клетки, и их применения
WO2011160653A1 (fr) 2010-06-21 2011-12-29 Xigen S.A. Nouvelles molécules inhibant jnk
JP2013534525A (ja) * 2010-06-23 2013-09-05 ヴィヴォスクリプト,インコーポレイテッド 心臓疾患の治療のために遺伝子改変を伴わずに細胞を再プログラミングするための組成物および方法
AU2011289831C1 (en) 2010-07-12 2017-06-15 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
WO2012021144A1 (fr) 2010-08-12 2012-02-16 New York University Oligooxopipérazines et procédés pour leur préparation et leur utilisation
ES2711526T3 (es) 2010-08-13 2019-05-06 Aileron Therapeutics Inc Macrociclos peptidomiméticos
CN103068847B (zh) * 2010-08-24 2019-05-07 罗切格利卡特公司 可活化的双特异性抗体
CN103068846B9 (zh) 2010-08-24 2016-09-28 弗·哈夫曼-拉罗切有限公司 包含二硫键稳定性Fv片段的双特异性抗体
CN103108650A (zh) 2010-08-25 2013-05-15 Atyr医药公司 与酪氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
WO2012040459A2 (fr) 2010-09-22 2012-03-29 President And Fellows Of Harvard College Peptides de ciblage de la béta-caténine et leurs utilisations
WO2012048721A1 (fr) 2010-10-14 2012-04-19 Xigen S.A. Utilisation d'inhibiteurs peptidiques, aptes à pénétrer dans les cellules, de la voie de transduction du signal jnk pour le traitement de maladies oculaires inflammatoires chroniques ou non-chroniques
US9518105B2 (en) * 2010-12-08 2016-12-13 The Research Foundation For The State University Of New York Polypeptides derived from calcitonin receptors and methods of use
WO2012090150A2 (fr) 2010-12-27 2012-07-05 Compugen Ltd Nouveaux peptides pénétrant dans les cellules et leurs utilisations
US8901092B2 (en) 2010-12-29 2014-12-02 Surmodics, Inc. Functionalized polysaccharides for active agent delivery
WO2012118778A1 (fr) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Peptides car tronqués, procédés et compositions les utilisant
AR085404A1 (es) 2011-02-28 2013-09-25 Hoffmann La Roche Proteinas de union a antigeno
MX342034B (es) 2011-02-28 2016-09-12 Hoffmann La Roche Proteinas monovalentes que se unen a antigenos.
EP3351641A1 (fr) 2011-04-08 2018-07-25 Tufts Medical Center, Inc. Conception et utilisation de pepducine
WO2012159164A1 (fr) * 2011-05-23 2012-11-29 Phylogica Limited Procédé de détermination, d'identification ou d'isolement de peptides pénétrant dans des cellules
AU2012262488A1 (en) 2011-05-31 2014-01-16 Airware, Inc. Re-calibration of AB NDIR gas sensors
US9487562B2 (en) 2011-06-17 2016-11-08 President And Fellows Of Harvard College Stabilized polypeptides as regulators of RAB GTPase function
EP2537858A1 (fr) 2011-06-20 2012-12-26 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Petites peptides à pénétration cellulaire efficace dérivées de la maurocalcine de toxine de scorpion
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
CN103998458B (zh) 2011-08-30 2018-10-09 医学研究理事会 具有中央疏水域的细胞穿透肽
EP2755679B1 (fr) * 2011-09-13 2017-08-02 Immunotope, Inc. Immunogènes induisant des lymphocytes t cytotoxiques utilisés pour la prévention, le traitement et le diagnostic du cancer
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
EP3375457B1 (fr) 2011-11-24 2020-06-24 Positec Power Tools (Suzhou) Co., Ltd Conception de séquences peptidiques et leur utilisation pour l'administration d'arnsi induite par des peptides
CN102532565B (zh) * 2011-12-19 2013-08-28 上海交通大学 可降解亚胺类聚阳离子及其合成方法、纳米颗粒
WO2013091670A1 (fr) 2011-12-21 2013-06-27 Xigen S.A. Nouvelles molécules inhibitrices de jnk pour le traitement de diverses maladies
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
EP2819688A4 (fr) 2012-02-15 2015-10-28 Aileron Therapeutics Inc Macrocycles peptidomimétiques réticulés par triazole et par thioéther
CN104334541A (zh) 2012-02-16 2015-02-04 纽约大学 使用低聚氧代哌嗪非肽螺旋模拟物对低氧诱导基因表达的控制
MX2014014464A (es) * 2012-06-26 2015-02-12 Hoffmann La Roche Peptidos penetrantes de celulas y metodos para identificar peptidos penetrantes de celulas.
US10036009B2 (en) 2012-08-03 2018-07-31 Cedars-Sinai Medical Center Isolating traffic-enhancing mutants of drug delivery protein
EP2708235A1 (fr) * 2012-09-17 2014-03-19 Commissariat A L'energie Atomique Et Aux Energies Alternatives Antagonistes peptidiques du récepteur vasopressin-2
WO2014052647A2 (fr) 2012-09-26 2014-04-03 President And Fellows Of Harvard College Peptides agrafés bloqués par la proline et leurs utilisations
WO2014071241A1 (fr) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Acides aminés disubstitués et procédés de préparation et d'utilisation de ceux-ci
WO2014082042A2 (fr) * 2012-11-25 2014-05-30 The Regents Of The University Of California Peptides qui stimulent l'adipogenèse sous-cutanée
ITMI20122263A1 (it) * 2012-12-28 2014-06-29 Azienda Ospedaliero Universitaria Di Parma Nuovi peptidi cationici ciclici ad attività antimicrobica
EP3391898A3 (fr) 2013-03-13 2019-02-13 President and Fellows of Harvard College Polypeptides piqués et agrafés et leurs utilisations
EP2981555B1 (fr) 2013-03-28 2020-04-15 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Nouveaux peptides d'uranium-chélateur dérivés de motif de liaison au calcium ef-hand utiles pour la biodétection et biodécontamination d'uranium
EP2784094A1 (fr) 2013-03-28 2014-10-01 Commissariat A L'energie Atomique Et Aux Energies Alternatives Nouveaux peptides d'uranium-chélateur dérivés de motif de liaison au calcium EF-hand utiles pour la biodétection et biodécontamination d'uranium
JP2016523241A (ja) 2013-06-14 2016-08-08 プレジデント アンド フェローズ オブ ハーバード カレッジ 安定化されたポリペプチドインスリン受容体調節剤
WO2014206427A1 (fr) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. Nouvelle utilisation d'inhibiteurs de peptides à perméabilité cellulaire dans la voie de transduction du signal jnk pour le traitement de diverses maladies
JP2016523088A (ja) * 2013-06-26 2016-08-08 フィロジカ リミテッドPhylogica Limited ペプチドの細胞輸送をモニタリングする方法
WO2015197097A1 (fr) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. Nouvelle utilisation pour des molécules inhibitrices de la jnk, pour le traitement de diverses maladies
KR20160023669A (ko) 2013-06-26 2016-03-03 자이겐 인플라메이션 리미티드 다양한 질병의 치료를 위한 jnk 신호 전달 경로의 세포 투과성 펩타이드 억제자의 새로운 용도
EP2842566A1 (fr) 2013-09-03 2015-03-04 Centre National De La Recherche Scientifique Utilisation d'ARP dans un nouvel inhibiteur du complexe ARP2/3 pour le diagnostic et le traitement de maladies
BR112016006929A2 (pt) 2013-10-11 2017-09-19 Hoffmann La Roche Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo
WO2015068532A1 (fr) * 2013-11-05 2015-05-14 味の素株式会社 Procédé de production d'un hydrazide peptidique, d'un amide peptidique et d'un thioester peptidique
US11376333B2 (en) * 2013-12-23 2022-07-05 Covalab mTG substrates for covalent conjugation of compounds
WO2015105957A1 (fr) * 2014-01-08 2015-07-16 Shriners Hospitals For Children Peptides antagonistes de pten et procédés pour les utiliser
US10682388B2 (en) * 2014-01-15 2020-06-16 The Board Of Regents Of The University Of Texas System Targeting of PELP1 in cancer therapy
JP6608370B2 (ja) 2014-01-17 2019-11-20 シーダーズ―シナイ メディカル センター 受容体標的化構築物およびその使用
EP2905031A1 (fr) 2014-02-10 2015-08-12 B Cell Design Nouvel antigène de vaccin non-VIH depuis la flore vaginale capable d'induire une réponse des anticorps protecteurs de neutralisation des muqueuses contre l'infection par LE VIH
US9850293B2 (en) 2014-04-04 2017-12-26 Cedars-Sinai Medical Center Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle
CA2949535C (fr) 2014-05-21 2023-09-12 President And Fellows Of Harvard College Peptides inhibiteurs de ras et leurs utilisations
WO2015184125A1 (fr) 2014-05-28 2015-12-03 The Regents Of The University Of California Peptides, compositions et procédés pour stimuler l'adipogenèse sous-cutanée
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (fr) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
EP3227332B1 (fr) 2014-12-03 2019-11-06 F.Hoffmann-La Roche Ag Anticorps multi-spécifiques
WO2016154058A1 (fr) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
LT3388075T (lt) 2015-03-27 2023-11-10 Immatics Biotechnologies Gmbh Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš įvairius navikus (seq id 25 - mrax5-003)
GB201505305D0 (en) 2015-03-27 2015-05-13 Immatics Biotechnologies Gmbh Novel Peptides and combination of peptides for use in immunotherapy against various tumors
US9795624B2 (en) 2015-05-04 2017-10-24 Research Foundation Of The City University Of New York Cationic polymers as co-drugs for chemotherapeutic agents
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2017044633A1 (fr) 2015-09-10 2017-03-16 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques en tant que modulateurs de mcl-1
WO2017083618A1 (fr) 2015-11-13 2017-05-18 Oasis Pharmaceuticals, LLC Modulateurs du récepteur activé par protéase de type 2
US12050215B2 (en) * 2015-11-17 2024-07-30 The Regents Of The University Of Michigan Macromolecular structures and uses thereof
DK3430031T3 (da) * 2016-03-15 2022-01-17 Idp Discovery Pharma S L Peptider med anti-kræftaktivitet
GB201607521D0 (en) * 2016-04-29 2016-06-15 Oncolmmunity As Method
WO2018013912A1 (fr) * 2016-07-15 2018-01-18 The Board Of Regents Of The University Of Oklahoma Traitements anti-arid3a pour des troubles inflammatoires
GB201618432D0 (en) * 2016-11-01 2016-12-14 Matn Scient Ltd Detection and treatment of demyelinating diseases
US11351222B2 (en) 2016-11-09 2022-06-07 Ohio State Innovation Foundation Di-sulfide containing cell penetrating peptides and methods of making and using thereof
WO2018098282A2 (fr) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Peptides cycliques pénétrant dans les cellules comprenant des motifs en épingle à cheveux et leurs procédés de fabrication et d'utilisation
WO2018106895A1 (fr) 2016-12-07 2018-06-14 Molecular Templates, Inc. Polypeptides effecteurs de sous-unité a de toxine shiga, échafaudages d'effecteur de toxine shiga et molécules ciblant des cellules pour une conjugaison spécifique à un site
US12410143B2 (en) 2017-01-17 2025-09-09 Michael David FORREST Therapeutic inhibitors of the reverse mode of ATP synthase
EP3360891B1 (fr) 2017-02-14 2022-03-30 Karlsruher Institut für Technologie Peptides de pénétration cellulaire d'origine humaine
US20200131231A1 (en) 2017-02-17 2020-04-30 Oxford University Innovation Limited Cell penetrating peptides
EP3628047A1 (fr) 2017-05-02 2020-04-01 Sanford Burnham Prebys Medical Discovery Institute Peptide liant des monocytes/macrophages associés à une tumeur et procédés d'utilisation associés
KR102095284B1 (ko) 2017-05-11 2020-04-01 (주)케어젠 메토트렉세이트와 펩타이드의 결합체
BR112019028172A2 (pt) 2017-07-13 2020-10-06 Michael David Forrest moduladores terapêuticos do modo reverso da atp sintase
JP2020528082A (ja) 2017-07-17 2020-09-17 ロイズマン,キース 加齢黄斑変性と他の眼疾患の治療用の細胞透過性ペプチドを使用する治療薬の局所送達
WO2019058263A1 (fr) * 2017-09-19 2019-03-28 Auckland Uniservices Limited Peptides pour le traitement d'états associés à un dysfonctionnement de l'adiponectine
CA3078504A1 (fr) 2017-10-04 2019-04-11 Ohio State Innovation Foundation Inhibiteurs peptidiques bicycliques
CN111386042B (zh) * 2017-12-04 2023-01-31 热生物制品有限公司 基于细胞的疫苗的生产
WO2019148195A2 (fr) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Inhibiteurs peptidyliques cycliques du domaine de liaison cal-pdz
EP3784697A4 (fr) * 2018-04-27 2022-07-06 Spark Therapeutics, Inc. Capsides modifiées de vaa à tropisme accru et vecteurs de vaa comprenant les capsides modifiées et leurs procédés de préparation et leurs méthodes d'utilisation
US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
KR102167755B1 (ko) 2018-05-23 2020-10-19 주식회사 큐어바이오 단편화된 grs 폴리펩타이드, 이의 변이체 및 이들의 용도
EP3817776A4 (fr) * 2018-07-02 2022-11-30 Ohio State Innovation Foundation Conjugués polypeptidiques pour l'administration intracellulaire d'acides nucléiques
GB201812980D0 (en) 2018-08-09 2018-09-26 Univ Oxford Innovation Ltd Cell-penetrating peptides
GB201812972D0 (en) 2018-08-09 2018-09-26 Univ Oxford Innovation Ltd Cell-penetrating peptides
US20220048953A1 (en) * 2018-09-26 2022-02-17 Kaneka Corporation Cell-penetrating peptide
US12465646B2 (en) * 2018-12-07 2025-11-11 Oxford University Innovation Limited Linkers
US11931416B2 (en) 2019-02-01 2024-03-19 The Board Of Trustees Of The Leland Stanford Junior University Immolative cell-penetrating complexes for nucleic acid delivery to the lung
US12583888B2 (en) * 2019-02-04 2026-03-24 University Of Tartu Bi-specific extracellular matrix binding peptides and methods of use thereof
WO2020180938A1 (fr) * 2019-03-05 2020-09-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions et méthodes de traitement de maladies associées à l'agrégation des protéines
CN112279921B (zh) 2019-07-11 2025-07-29 厦门大学 用于胞内递送分子的复合物
BR112022001229A2 (pt) 2019-07-22 2022-06-14 Octavio Franco Polipeptídeos tendo efeitos antissenescentes e usos dos mesmos
AR119529A1 (es) * 2019-08-02 2021-12-22 Idp Discovery Pharma S L Péptidos reguladores de melanocitos
JP7699588B2 (ja) * 2019-11-22 2025-06-27 アルカメナ・ステム・セル・セラピューティクス、エルエルシー Re1サイレンシング転写因子標的遺伝子を抑制解除する組成物
WO2021113434A1 (fr) 2019-12-03 2021-06-10 Rodan & Fields, Llc Peptides et compositions pour inhiber la croissance des cheveux
US20230054711A1 (en) 2019-12-31 2023-02-23 Xiamen University Multimerization delivery system for intracellular delivery of molecule
EP3906935A1 (fr) 2020-05-06 2021-11-10 Sorbonne Universite Peptides pour la prévention ou le traitement d'infections virales
CN113943778A (zh) * 2020-07-17 2022-01-18 通用电气医疗集团股份有限公司 用于核酸检测的分子探针及其制备方法和用途
MX2023007788A (es) 2021-01-24 2023-11-17 Michael David Forrest Inhibidores de la atp sintasa, usos cosmeticos y terapeuticos.
WO2022212513A1 (fr) * 2021-03-31 2022-10-06 University Of Southern California Compositions et méthodes pour la modulation de trouble inflammatoire et dégénératif
WO2022214522A2 (fr) 2021-04-07 2022-10-13 Astrazeneca Ab Compositions et procédés de modification spécifique à un site
CN115385987B (zh) * 2021-05-19 2024-08-02 中山大学 一种抗鱼类神经坏死病毒的穿膜肽及其应用
KR102504190B1 (ko) * 2021-06-03 2023-02-28 주식회사 레메디 화물분자 수송 도메인 rmmr1, 이의 변이체, 이를 포함하는 재조합 화물분자 및 이를 이용한 화물분자 수송 방법
KR102793149B1 (ko) * 2021-11-24 2025-04-09 주식회사 윙스타바이오 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도
KR102819567B1 (ko) * 2021-11-24 2025-06-13 주식회사 윙스타바이오 아밀로이드 전구체 단백질에 대한 저해 활성을 갖는 펩타이드 및 이의 용도
CN114349846B (zh) * 2022-01-07 2023-12-15 天津市泌尿外科研究所 一种人精子膜蛋白or1d2特异性多肽与抗体的制备方法
JP2025510046A (ja) * 2022-03-23 2025-04-14 カウンシル オブ サイエンティフィック アンド インダストリアル リサーチ α-シヌクレインアミロイドベースの障害を処置するためのペプチド
CN116444678B (zh) * 2022-10-18 2024-02-02 百葵锐(深圳)生物科技有限公司 一种具有真菌抗菌抑菌性能的新型多肽
JP2025540052A (ja) 2022-12-01 2025-12-11 イェール ユニバーシティー 細胞内ペイロード送達用刺激応答性トレースレス操作プラットフォーム
WO2025172421A1 (fr) 2024-02-14 2025-08-21 Astrazeneca Ab Compositions et procédés de traitement de la maladie de huntington
WO2025228328A1 (fr) * 2024-04-29 2025-11-06 苏州百迈生物医药有限公司 Vecteur polypeptidique zwitterionique et son utilisation dans l'administration de médicament à travers une barrière

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1263473A (zh) * 1997-05-21 2000-08-16 利兰·斯坦福青年大学托管委员会 增加跨生物膜转运的组合物和方法
WO1999030727A1 (fr) * 1997-12-17 1999-06-24 Enzon, Inc. Prodrogues polymeriques d'agents bioactifs contenant amine ou hydroxy
JP2002531113A (ja) * 1998-12-10 2002-09-24 ワシントン大学 蛋白質の形質導入システムおよびその使用法
AU2001268683A1 (en) * 2000-06-22 2002-01-02 Mount Sinai School Of Medicine Modification of mdm2 activity
FR2810985B1 (fr) * 2000-07-03 2004-12-24 Synt Em Peptides lineaires amphipathiques et les compositions les contenant
IL154589A0 (en) * 2000-08-25 2003-09-17 Aventis Pharma Inc Membrane penetrating peptides and uses thereof
EP2272947B1 (fr) * 2000-09-05 2016-08-10 Biosight Ltd Promedicaments peptidiques anticancereux conjugues
FR2818981A1 (fr) * 2001-01-03 2002-07-05 Synt Em Peptides amphipathiques et leur utilisation pour le transfert de substances d'interet dans les cellules
AU2002240201A1 (en) * 2001-02-02 2002-08-19 Yale University Peptides for facilitating composite receptor expression and translocation of macromolecules
AU2003208275A1 (en) * 2002-01-27 2003-09-02 Viromics Gmbh Trojan inhibitors, method for the production and use thereof

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US20080234183A1 (en) 2008-09-25
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