SE1043399T5 - Hepatit C virus cellkultursystem - Google Patents

Hepatit C virus cellkultursystem

Info

Publication number
SE1043399T5
SE1043399T5 SE00105929T SE00105929T SE1043399T5 SE 1043399 T5 SE1043399 T5 SE 1043399T5 SE 00105929 T SE00105929 T SE 00105929T SE 00105929 T SE00105929 T SE 00105929T SE 1043399 T5 SE1043399 T5 SE 1043399T5
Authority
SE
Sweden
Prior art keywords
hcv
hepatitis
cell culture
culture system
virus cell
Prior art date
Application number
SE00105929T
Other languages
English (en)
Swedish (sv)
Other versions
SE1043399T3 (sv
Inventor
Ralf Bartenschlager
Original Assignee
Bartenschlager R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bartenschlager R filed Critical Bartenschlager R
Publication of SE1043399T3 publication Critical patent/SE1043399T3/xx
Publication of SE1043399T5 publication Critical patent/SE1043399T5/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24241—Use of virus, viral particle or viral elements as a vector
    • C12N2770/24243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE00105929T 1999-04-03 2000-03-23 Hepatit C virus cellkultursystem SE1043399T5 (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19915178A DE19915178A1 (de) 1999-04-03 1999-04-03 Hepatitis C Virus Zellkultursystem

Publications (2)

Publication Number Publication Date
SE1043399T3 SE1043399T3 (sv) 2003-07-29
SE1043399T5 true SE1043399T5 (sv) 2003-12-02

Family

ID=7903452

Family Applications (1)

Application Number Title Priority Date Filing Date
SE00105929T SE1043399T5 (sv) 1999-04-03 2000-03-23 Hepatit C virus cellkultursystem

Country Status (11)

Country Link
US (1) US6630343B1 (fr)
EP (1) EP1043399B9 (fr)
JP (1) JP4903929B2 (fr)
AT (1) ATE236988T1 (fr)
AU (1) AU770486B2 (fr)
CA (1) CA2303526C (fr)
DE (2) DE19915178A1 (fr)
DK (1) DK1043399T5 (fr)
ES (1) ES2197031T4 (fr)
PT (1) PT1043399E (fr)
SE (1) SE1043399T5 (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
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US7235394B1 (en) 1995-08-29 2007-06-26 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) * 1998-03-04 2006-05-23 Washington University HCV variants
US6921634B2 (en) * 1999-12-23 2005-07-26 Board Of Regents, The University Of Texas System Replication competent hepatitus C virus and methods of use
US20040005549A1 (en) * 2000-11-07 2004-01-08 Anadys Pharmaceuticals, Inc. Hepatitis C virus constructs characterized by high efficiency replication
AU2002225895A1 (en) * 2000-11-07 2002-05-21 Anadys Pharmaceuticals, Inc. Hepatitis c virus constructs characterized by high efficiency replication
DE60128835T2 (de) * 2000-12-22 2008-03-20 Boehringer Ingelheim (Canada) Ltd., Laval Selbstreplizierendes rna-molekül aus hepatitis-c-virus
EP2050822B1 (fr) 2001-01-23 2013-07-31 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Réplicons de virus de l'hépatite C et cellules améliorées de réplicon
WO2002072803A2 (fr) 2001-03-09 2002-09-19 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Replicons sous-genomiques du la dengue a flavivirus
CN1093172C (zh) * 2001-03-19 2002-10-23 杨凌岱鹰生物工程股份有限公司 丙型肝炎全病毒及其体外细胞培养方法
FR2824072B1 (fr) * 2001-04-27 2004-03-12 Centre Nat Rech Scient Procede de replication et de production du virus de l'hepatite c
CU23244A1 (es) * 2001-07-16 2007-10-17 Ct Ingenieria Genetica Biotech Formulacion vacunal potenciada por la combinacion de un adn con un antigeno
WO2003025209A1 (fr) * 2001-09-21 2003-03-27 Ortho-Clinical Diagnostics, Inc. Utilisation de dosage d'antigene capsidique du vhc pour le criblage de composes antiviraux
US6689559B2 (en) 2001-11-29 2004-02-10 The Research Foundation Of The State University Of New York Efficient hepatitis C virus replicon and its use in identifying antiviral compounds
CA2472759A1 (fr) * 2002-01-15 2003-07-24 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Replicons bases sur le gb virus b et cellules renforcees pour des replicons
EP1490389A4 (fr) * 2002-04-03 2006-08-09 Smithkline Beecham Corp Replicons sous-genomiques du virus de l'hepatite c
WO2003085375A2 (fr) * 2002-04-04 2003-10-16 Achillion Pharmaceuticals, Inc. Dosage pour evaluer l'activite de composes contre le virus de l'hepatite c par utilisation d'un nouveau systeme de detection dans le replicon du virus de l'hepatite c
CA2481171A1 (fr) 2002-04-16 2003-10-30 Merck & Co., Inc. Systemes de dosage du virus de l'hepatite c
CA2483513A1 (fr) * 2002-04-26 2003-11-06 Pfizer Inc. Replicon de virus de l'hepatite c selectionnable par le rapporteur
EP1539921B1 (fr) * 2002-09-16 2007-11-21 Pan-Biotech GmbH Dispositif de mise en culture de cellules, notamment de cellules humaines ou animales
ES2295465T3 (es) 2002-09-16 2008-04-16 Pan-Biotech Gmbh Procedimiento para el cultivo de celulas, en especial de celulas humanas o de animales.
JP2006506074A (ja) * 2002-11-13 2006-02-23 ワシントン ユニヴァーシティー Ｃ型肝炎ウイルスの複製に対して高許容性である細胞系
US7807455B2 (en) * 2003-02-13 2010-10-05 Merck Sharp & Dohme Corp. Method to confer cell culture replication activity to different Hepatitis C virus isolates
US20040214178A1 (en) * 2003-04-24 2004-10-28 Agouron Pharmaceuticals, Inc. Reporter-selectable Hepatitis C virus replicon
CN1833024B (zh) * 2003-05-26 2011-08-31 东丽株式会社 含有衍生自基因型2a丙肝病毒(HCV)基因组的核酸的核酸构建体和具有转移入其中的这样的核酸构建体的细胞
DK1658302T3 (da) 2003-07-25 2010-11-22 Idenix Pharmaceuticals Inc Purinnukleosidanaloge til behandling af sygdomme forårsaget af Flavirividae, herunder hepatitis C
US20050130131A1 (en) * 2003-08-14 2005-06-16 California Institute Of Molecular Medicine Method for isolation and replication of infectious human hepatitis-C virus
US8022197B2 (en) * 2003-09-19 2011-09-20 Tokyo Metropolitan Organization For Medical Research Nucleic acid and gene derived from novel HCV strain and replicon-replicating cell using said gene
US7790448B2 (en) * 2003-09-19 2010-09-07 Tokyo Metropolitan Organization For Medical Research Nucleic acid and gene derived from novel HCV strain and replicon-replicating cell using said gene
CA2543846C (fr) 2003-11-05 2011-04-12 Merck & Co., Inc. Replicons du vhc renfermant la ns5b issue du genotype 2b
ES2415106T3 (es) * 2003-12-01 2013-07-24 Board Of Regents, The University Of Texas System Virus de la hepatitis C capaz de replicación y métodos de uso
KR20120090077A (ko) 2004-01-30 2012-08-16 얀센 알 앤드 디 아일랜드 Ｈｃｖ ｎｓ?３ 세린 프로테아제 저해제
CN102206663B (zh) * 2004-02-20 2014-02-05 公益财团法人东京都医学综合研究所 含人丙型肝炎病毒全长基因组的核酸构建物及其用途
AU2005218183B2 (en) 2004-03-02 2012-06-07 Virco Bvba Estimation of clinical cut-offs
US7985541B2 (en) * 2004-03-24 2011-07-26 Achillion Pharmaceuticals, Inc. Quantitative assay for detection of newly synthesized RNA in a cell-free system and identification of RNA synthesis inhibitors
EP1769248A1 (fr) * 2004-07-16 2007-04-04 Universiteit Gent Methodes de prediction d'efficacite ou de resultat de traitement du vhc
GB0419189D0 (en) * 2004-08-27 2004-09-29 Angeletti P Ist Richerche Bio New uses
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
EP1874952A2 (fr) * 2005-04-11 2008-01-09 Achillion Pharmaceuticals, Inc. Compositions pharmaceutiques et methodes d'inhibition de la replication du vhc
US7465537B2 (en) * 2005-05-01 2008-12-16 The Board Of Trustees Of The University Of Arkansas Compounds and methods for inhibiting hepatitis C virus replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1956087B1 (fr) 2005-09-30 2010-05-26 JAPAN as represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES Système de production en grande quantité d'une particule du virus de l'hépatite c infectieuse
EP1801116A1 (fr) * 2005-12-21 2007-06-27 F. Hoffmann-La Roche Ag Vecteurs navette de replicon du VHC
US8211444B2 (en) * 2006-03-09 2012-07-03 Transgene S.A. Hepatitis C virus non structural fusion protein
FR2901807B1 (fr) * 2006-05-30 2013-08-23 Univ Victor Segalen Bordeaux 2 Nouveau traitement d'une infection par le vhc
WO2008148671A1 (fr) * 2007-06-06 2008-12-11 F. Hoffmann-La Roche Ag Vecteurs navettes de réplicon ns3 de vhc
GB0716292D0 (en) 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
US8829174B2 (en) * 2008-10-29 2014-09-09 The Trustees Of The University Of Pennsylvania HCV vaccines and methods for using the same
EP2385116A4 (fr) 2008-12-26 2013-09-18 Toray Industries Acide nucléique dérivé du virus de l'hépatite c, et vecteur d'expression, cellules transformées et particules de virus de l'hépatite c préparés à partir dudit acide nucléique
EP2376524B1 (fr) 2008-12-31 2017-03-15 Cypralis Limited Dérivés de cyclosporine a
US20100173281A1 (en) * 2009-01-06 2010-07-08 Roche Palo Alto Llc HCV NS3 protease replicon shuttle vectors
EP2417133A1 (fr) 2009-04-06 2012-02-15 PTC Therapeutics, Inc. Composés et procédés pour un traitement antiviral
HUE052510T2 (hu) 2009-05-27 2021-05-28 Ptc Therapeutics Inc Módszerek a rák és a nem daganatos állapotok kezelésére
JPWO2011024875A1 (ja) 2009-08-28 2013-01-31 公益財団法人東京都医学総合研究所 Ｃ型肝炎ウイルスの新規株由来のポリヌクレオチド及びその利用
US20110144005A1 (en) 2009-12-09 2011-06-16 Scynexis, Inc. Novel cyclic peptides
AU2010339460A1 (en) 2009-12-30 2012-07-19 Scynexis Inc. Cyclosporine analogues
WO2012122625A1 (fr) 2011-03-14 2012-09-20 National Research Council Of Canada Procédé de production virale dans des cellules
EP2692861A4 (fr) 2011-03-31 2014-12-17 Jp Nat Inst Infectious Disease Construction d'acide nucléique contenant de l'acide nucléique dérivé du génome du vhc du génotype 1b, cellules de réplication de génome du vhc transfectées par celui-ci, et procédé de production de particules de vhc infectieuses
WO2012165542A1 (fr) 2011-05-31 2012-12-06 国立感染症研究所長が代表する日本国 Réplicon mutant dérivé du génome de la souche j6cf du virus de l'hépatite c
CN104126008B (zh) 2011-08-31 2017-03-22 日本国立感染症研究所 包含来自基因型3a的丙型肝炎病毒基因组的核酸的核酸构建物
EP2902485A4 (fr) 2012-09-28 2016-03-16 Nat Univ Corp Univ Kobe Promoteur de la formation de particules de virus de l'hépatite c, et méthode de production de particules de virus de l'hépatite c
WO2014166429A1 (fr) * 2013-04-12 2014-10-16 中国科学院上海生命科学研究院 Procédé de détection de la stabilité de protéines et ses utilisations

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GB1554662A (en) 1976-05-05 1979-10-24 Inverni Della Beffa Spa Polyhydroxyphenylchromanones
CH683594A5 (de) 1991-01-24 1994-04-15 Flachsmann Ag Emil Verfahren zur Herstellung eines Pflanzenextrakt enthaltenden Masse, welche insbesondere für die Einkapselung in ein festes Umhüllungsmaterial geeignet ist.
DE19501266A1 (de) 1995-01-18 1996-07-25 Madaus Ag Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
US5874565A (en) * 1995-08-29 1999-02-23 Washington University Nucleic acids comprising a highly conserved novel 3 terminal sequence element of the hepatitis C virus
US6127116A (en) * 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US5851758A (en) * 1995-10-25 1998-12-22 Childrens Research Institute Cytopathic replication of hepatitis C virus in a new cell line
US6153421A (en) * 1997-07-18 2000-11-28 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Cloned genomes of infectious hepatitis C viruses and uses thereof
WO1999067394A1 (fr) * 1998-06-24 1999-12-29 Chugai Seiyaku Kabushiki Kaisha Vecteur exprimant le gene pleine longueur de virus a arn et son utilisation

Also Published As

Publication number Publication date
ATE236988T1 (de) 2003-04-15
HK1034094A1 (en) 2001-10-12
JP4903929B2 (ja) 2012-03-28
JP2001017187A (ja) 2001-01-23
US6630343B1 (en) 2003-10-07
EP1043399B9 (fr) 2003-10-08
ES2197031T4 (es) 2004-05-16
AU770486B2 (en) 2004-02-26
AU2518000A (en) 2000-10-19
PT1043399E (pt) 2003-08-29
ES2197031T3 (es) 2004-01-01
CA2303526A1 (fr) 2000-10-03
EP1043399B1 (fr) 2003-04-09
EP1043399A3 (fr) 2002-05-08
CA2303526C (fr) 2005-11-01
DK1043399T5 (da) 2004-01-05
SE1043399T3 (sv) 2003-07-29
DE50001673D1 (de) 2003-05-15
DK1043399T3 (da) 2003-07-28
EP1043399A2 (fr) 2000-10-11
DE19915178A1 (de) 2000-10-05

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