SE417526B - Forfarande och medel for enzymatisk bestemning av glukos - Google Patents
Forfarande och medel for enzymatisk bestemning av glukosInfo
- Publication number
- SE417526B SE417526B SE7312284A SE7312284A SE417526B SE 417526 B SE417526 B SE 417526B SE 7312284 A SE7312284 A SE 7312284A SE 7312284 A SE7312284 A SE 7312284A SE 417526 B SE417526 B SE 417526B
- Authority
- SE
- Sweden
- Prior art keywords
- glucose
- mutarotase
- pyridine
- acid
- coenzyme
- Prior art date
Links
- 239000008103 glucose Substances 0.000 title claims description 54
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- 238000000034 method Methods 0.000 title claims description 25
- 239000003795 chemical substances by application Substances 0.000 title claims description 24
- 230000002255 enzymatic effect Effects 0.000 title claims description 15
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 48
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 40
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- 108091022872 aldose 1-epimerase Proteins 0.000 claims description 33
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- 230000000694 effects Effects 0.000 claims description 30
- 239000005515 coenzyme Substances 0.000 claims description 28
- 238000006243 chemical reaction Methods 0.000 claims description 27
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 20
- 239000011780 sodium chloride Substances 0.000 claims description 16
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims description 15
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- WXHLLJAMBQLULT-UHFFFAOYSA-N 2-[[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-n-(2-methyl-6-sulfanylphenyl)-1,3-thiazole-5-carboxamide;hydrate Chemical compound O.C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1S WXHLLJAMBQLULT-UHFFFAOYSA-N 0.000 claims description 5
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- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 4
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722247608 DE2247608C3 (de) | 1972-09-28 | Mittel und Verfahren zur enzymatischen Bestimmung von Glucose |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE417526B true SE417526B (sv) | 1981-03-23 |
Family
ID=5857641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7312284A SE417526B (sv) | 1972-09-28 | 1973-09-10 | Forfarande och medel for enzymatisk bestemning av glukos |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3964974A (fr) |
| JP (1) | JPS5615879B2 (fr) |
| BE (1) | BE805326A (fr) |
| CH (1) | CH581839A5 (fr) |
| CS (1) | CS164231B2 (fr) |
| DD (1) | DD106712A5 (fr) |
| FR (1) | FR2201768A5 (fr) |
| GB (1) | GB1395306A (fr) |
| IL (1) | IL43054A (fr) |
| IT (1) | IT1006085B (fr) |
| NL (1) | NL183659C (fr) |
| SE (1) | SE417526B (fr) |
| ZA (1) | ZA735678B (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012889A1 (fr) * | 1989-04-25 | 1990-11-01 | Migrata Uk Ltd | Procede d'analyse, composition d'agent reactif et utilisation de celle-ci pour la determination du glucose |
| WO1990012890A1 (fr) * | 1989-04-25 | 1990-11-01 | Migrata Uk Ltd | Procede de determination du glucose dans du sang entier, cuvette et photometre pour la realisation dudit procede |
Families Citing this family (111)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4120755A (en) * | 1977-04-28 | 1978-10-17 | Beckman Instruments, Inc. | Kinetic method for determination of glucose concentrations with glucose dehydrogenase |
| US4425427A (en) | 1980-03-13 | 1984-01-10 | Vitafin N.V. | Simultaneous, kinetic, spectrophotometric analysis of blood serum for multiple components |
| JPS56137899A (en) * | 1980-03-27 | 1981-10-28 | Matsushita Electric Ind Co Ltd | Determining method of glucose concentration |
| JPS5886083A (ja) * | 1981-11-12 | 1983-05-23 | Wako Pure Chem Ind Ltd | グリセロ−ル−3−リン酸オキシダ−ゼの安定化剤 |
| EP0094161A1 (fr) * | 1982-05-07 | 1983-11-16 | Imperial Chemical Industries Plc | Méthode pour la détermination de la teneur en glucose de fluides |
| US4394444A (en) * | 1982-06-21 | 1983-07-19 | Miles Laboratories, Inc. | Cofactor indicator compositions |
| DD247808C2 (de) * | 1984-04-09 | 1989-01-11 | Dresden Arzneimittel | Teststreifen zur aufnahme von blutzuckertagesprofilen und verfahren zu seiner herstellung |
| DE3432570A1 (de) * | 1984-09-05 | 1986-03-13 | Merck Patent Gmbh, 6100 Darmstadt | Verfahren zur mikrobiologischen herstellung von aldose-1-epimerase |
| DE3531360A1 (de) * | 1985-09-03 | 1987-05-07 | Merck Patent Gmbh | Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung des enzyms mutarotase aus acinetobacter calcoaceticus |
| JPH0286779A (ja) * | 1988-09-22 | 1990-03-27 | Amano Pharmaceut Co Ltd | 改良型組換えdna、それを含む形質転換体及びそれを用いた耐熱性グルコースデヒドロゲナーゼの製造法 |
| US6395227B1 (en) * | 1989-08-28 | 2002-05-28 | Lifescan, Inc. | Test strip for measuring analyte concentration over a broad range of sample volume |
| US5620863A (en) * | 1989-08-28 | 1997-04-15 | Lifescan, Inc. | Blood glucose strip having reduced side reactions |
| JPH0673478B2 (ja) * | 1990-01-11 | 1994-09-21 | 旭化成工業株式会社 | L―カルニチンの高感度測定法および測定用組成物 |
| JP2677154B2 (ja) * | 1993-03-08 | 1997-11-17 | 日東紡績株式会社 | 総ケトン体の測定方法および測定試薬 |
| JP3167508B2 (ja) * | 1993-06-15 | 2001-05-21 | 富士写真フイルム株式会社 | 無機燐定量用試薬及び乾式分析要素 |
| CA2127172C (fr) * | 1993-08-05 | 1998-07-14 | Amy H. Chu | Dispositif pour detecter une substance a analyser et procede pour ce faire |
| US5567605A (en) * | 1994-11-21 | 1996-10-22 | Uop | Assay for D-allose using a NAD cofactor coupled D-allose dehydrogenase |
| US7192450B2 (en) | 2003-05-21 | 2007-03-20 | Dexcom, Inc. | Porous membranes for use with implantable devices |
| US20050033132A1 (en) * | 1997-03-04 | 2005-02-10 | Shults Mark C. | Analyte measuring device |
| US6001067A (en) | 1997-03-04 | 1999-12-14 | Shults; Mark C. | Device and method for determining analyte levels |
| US8465425B2 (en) | 1998-04-30 | 2013-06-18 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6175752B1 (en) | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US8688188B2 (en) | 1998-04-30 | 2014-04-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8346337B2 (en) | 1998-04-30 | 2013-01-01 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US6949816B2 (en) | 2003-04-21 | 2005-09-27 | Motorola, Inc. | Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same |
| US9066695B2 (en) | 1998-04-30 | 2015-06-30 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8974386B2 (en) | 1998-04-30 | 2015-03-10 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US8480580B2 (en) | 1998-04-30 | 2013-07-09 | Abbott Diabetes Care Inc. | Analyte monitoring device and methods of use |
| US20080076997A1 (en) * | 1998-04-30 | 2008-03-27 | Abbott Diabetes Care, Inc. | Analyte monitoring device and methods of use |
| US6908770B1 (en) | 1998-07-16 | 2005-06-21 | Board Of Regents, The University Of Texas System | Fluid based analysis of multiple analytes by a sensor array |
| US6656697B1 (en) | 1998-09-28 | 2003-12-02 | Lifescan, Inc. | Diagnostics based on tetrazolium compounds |
| US7022517B1 (en) | 1999-07-16 | 2006-04-04 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| AU773679B2 (en) | 1999-07-16 | 2004-06-03 | Board Of Regents, The University Of Texas System | Method and apparatus for the delivery of samples to a chemical sensor array |
| US6541216B1 (en) | 1999-12-22 | 2003-04-01 | Roche Diagnostics Corporation | Amperometric biosensor test strip |
| CA2401782A1 (fr) | 2000-01-31 | 2001-08-02 | John T. Mcdevitt | Systeme a reseau de capteurs portable |
| US6420128B1 (en) * | 2000-09-12 | 2002-07-16 | Lifescan, Inc. | Test strips for detecting the presence of a reduced cofactor in a sample and method for using the same |
| US6560471B1 (en) | 2001-01-02 | 2003-05-06 | Therasense, Inc. | Analyte monitoring device and methods of use |
| WO2002061392A2 (fr) * | 2001-01-31 | 2002-08-08 | Board Of Regents, The University Of Texas System | Procede et appareil de confinement de materiaux dans un reseau de capteurs chimiques microusines |
| AU2002309528A1 (en) | 2001-04-02 | 2002-10-15 | Therasense, Inc. | Blood glucose tracking apparatus and methods |
| US20030032874A1 (en) | 2001-07-27 | 2003-02-13 | Dexcom, Inc. | Sensor head for use with implantable devices |
| US6702857B2 (en) | 2001-07-27 | 2004-03-09 | Dexcom, Inc. | Membrane for use with implantable devices |
| US8010174B2 (en) | 2003-08-22 | 2011-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
| US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
| US8257967B2 (en) * | 2002-04-26 | 2012-09-04 | Board Of Regents, The University Of Texas System | Method and system for the detection of cardiac risk factors |
| KR101002194B1 (ko) * | 2002-05-16 | 2011-01-13 | 에프. 호프만-라 로슈 아게 | 중합체 층의 제조 방법 |
| US7875293B2 (en) | 2003-05-21 | 2011-01-25 | Dexcom, Inc. | Biointerface membranes incorporating bioactive agents |
| US20070173709A1 (en) * | 2005-04-08 | 2007-07-26 | Petisce James R | Membranes for an analyte sensor |
| US7651596B2 (en) | 2005-04-08 | 2010-01-26 | Dexcom, Inc. | Cellulosic-based interference domain for an analyte sensor |
| US8423113B2 (en) | 2003-07-25 | 2013-04-16 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US7761130B2 (en) | 2003-07-25 | 2010-07-20 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8369919B2 (en) | 2003-08-01 | 2013-02-05 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8845536B2 (en) | 2003-08-01 | 2014-09-30 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7925321B2 (en) | 2003-08-01 | 2011-04-12 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US7778680B2 (en) | 2003-08-01 | 2010-08-17 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US7774145B2 (en) | 2003-08-01 | 2010-08-10 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20100168542A1 (en) | 2003-08-01 | 2010-07-01 | Dexcom, Inc. | System and methods for processing analyte sensor data |
| US8275437B2 (en) | 2003-08-01 | 2012-09-25 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
| US7494465B2 (en) | 2004-07-13 | 2009-02-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7519408B2 (en) | 2003-11-19 | 2009-04-14 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
| US8160669B2 (en) | 2003-08-01 | 2012-04-17 | Dexcom, Inc. | Transcutaneous analyte sensor |
| US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
| US9135402B2 (en) | 2007-12-17 | 2015-09-15 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
| US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
| US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US8233959B2 (en) | 2003-08-22 | 2012-07-31 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
| US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
| EP2239567B1 (fr) | 2003-12-05 | 2015-09-02 | DexCom, Inc. | Techniques d'étalonnage pour capteur d'analytes en continu |
| US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8774886B2 (en) | 2006-10-04 | 2014-07-08 | Dexcom, Inc. | Analyte sensor |
| US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
| US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
| EP2316331B1 (fr) | 2003-12-09 | 2016-06-29 | Dexcom, Inc. | Traitement de signal pour capteur d'analyte continu |
| US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| US8105849B2 (en) * | 2004-02-27 | 2012-01-31 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements |
| US8101431B2 (en) | 2004-02-27 | 2012-01-24 | Board Of Regents, The University Of Texas System | Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems |
| US7857760B2 (en) | 2004-07-13 | 2010-12-28 | Dexcom, Inc. | Analyte sensor |
| US8989833B2 (en) | 2004-07-13 | 2015-03-24 | Dexcom, Inc. | Transcutaneous analyte sensor |
| EP4111962B1 (fr) | 2004-07-13 | 2023-08-30 | Dexcom, Inc. | Capteur d'analyte transcutanée |
| US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
| WO2006127694A2 (fr) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Detecteur d'analyte |
| US20060252027A1 (en) * | 2005-05-05 | 2006-11-09 | Petisce James R | Cellulosic-based resistance domain for an analyte sensor |
| US8744546B2 (en) | 2005-05-05 | 2014-06-03 | Dexcom, Inc. | Cellulosic-based resistance domain for an analyte sensor |
| WO2007053186A2 (fr) | 2005-05-31 | 2007-05-10 | Labnow, Inc. | Méthodes et compositions en rapport avec la détermination et l’utilisation de la numération de globules blancs |
| CA2613078A1 (fr) * | 2005-06-24 | 2007-01-04 | Board Of Regents, The University Of Texas System | Systemes et procedes faisant appel a des cartouches autonomes comprenant des systemes de detection et des systemes de distribution de fluides |
| TW200718785A (en) * | 2005-11-10 | 2007-05-16 | Toyo Boseki | A process for improving the thermal stability of a composition containing a soluble coenzyme conjugated glucose dehydrogenase (GDH) |
| EP3366201B1 (fr) | 2006-01-17 | 2024-02-28 | DexCom, Inc. | Faible teneur en oxygène d'un capteur d'analyte in vivo |
| EP1986543B2 (fr) | 2006-02-22 | 2022-03-09 | DexCom, Inc. | Sonde d'analyte |
| EP4218548A1 (fr) | 2006-03-09 | 2023-08-02 | Dexcom, Inc. | Systèmes et procédés de traitement de données de capteur de substance à analyser |
| US20080071158A1 (en) | 2006-06-07 | 2008-03-20 | Abbott Diabetes Care, Inc. | Analyte monitoring system and method |
| US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
| EP2227132B1 (fr) | 2007-10-09 | 2023-03-08 | DexCom, Inc. | Système d'administration d'insuline intégré avec un capteur de glucose en continu |
| US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US9839395B2 (en) | 2007-12-17 | 2017-12-12 | Dexcom, Inc. | Systems and methods for processing sensor data |
| US8591455B2 (en) | 2008-02-21 | 2013-11-26 | Dexcom, Inc. | Systems and methods for customizing delivery of sensor data |
| EP2106784B1 (fr) * | 2008-04-03 | 2015-04-22 | Rohm and Haas Company | Composition de coiffage |
| EP2228645B1 (fr) * | 2008-05-16 | 2013-09-04 | Panasonic Corporation | Procédé de mesure, dispositif de mesure et appareil de mesure de la concentration en créatinine et procédé de mesure, dispositif de mesure et appareil de mesure de la quantité de salinité à l'aide de ceux-ci |
| WO2012007446A1 (fr) | 2010-07-13 | 2012-01-19 | Dsm Ip Assets B.V. | Utilisation de mutarotase dans la production de poudres déshydratées |
| WO2012007445A1 (fr) | 2010-07-13 | 2012-01-19 | Dsm Ip Assets B.V. | Mutarotase pour la cristallisation |
| US9848809B2 (en) | 2011-04-15 | 2017-12-26 | Dexcom, Inc. | Advanced analyte sensor calibration and error detection |
| US9347958B2 (en) | 2014-06-27 | 2016-05-24 | Hemocue Ab | Device and method for determination of an analyte in blood |
| FR3038723B1 (fr) | 2015-07-07 | 2019-06-14 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Procede d’estimation d’une quantite d’analyte dans un liquide |
| FR3049062B1 (fr) | 2016-03-17 | 2023-06-02 | Commissariat Energie Atomique | Procede de caracterisation d’un echantillon liquide comportant des particules |
| US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
| EP3928687B1 (fr) | 2017-10-24 | 2024-06-26 | Dexcom, Inc. | Dispositif portable avec un capteur d'analyte préconnecté |
| CN110715923A (zh) * | 2019-11-24 | 2020-01-21 | 天津市宝坻区人民医院 | α-D-葡萄糖检测试剂盒 |
| CN112630216A (zh) * | 2020-11-27 | 2021-04-09 | 上海绅道生物科技有限公司 | 一种检测1,5-ag的试剂盒和检测方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3290228A (en) * | 1964-07-29 | 1966-12-06 | Miles Lab | Test composition and device for detecting glucose |
| US3335069A (en) * | 1964-12-14 | 1967-08-08 | Miles Lab | Composition and method for determining uric acid |
| US3413198A (en) * | 1966-06-30 | 1968-11-26 | Calbiochem | Reagents and method for assaying biological samples |
| DE1930059C3 (de) * | 1969-06-13 | 1975-11-13 | Boehringer Mannheim Gmbh | Stabilisiertes Nicotinamid-adenindinucleotid oder bzw. und Nicotinamld-adenin-dinucleotidphosphat |
| US3703591A (en) * | 1970-12-16 | 1972-11-21 | Calbiochem | Triglyceride hydrolysis and assay |
-
1973
- 1973-08-15 CS CS5761A patent/CS164231B2/cs unknown
- 1973-08-20 GB GB3928273A patent/GB1395306A/en not_active Expired
- 1973-08-20 ZA ZA735678A patent/ZA735678B/xx unknown
- 1973-08-21 NL NLAANVRAGE7311508,A patent/NL183659C/xx not_active IP Right Cessation
- 1973-08-22 IL IL43054A patent/IL43054A/en unknown
- 1973-09-06 JP JP9977473A patent/JPS5615879B2/ja not_active Expired
- 1973-09-10 SE SE7312284A patent/SE417526B/sv unknown
- 1973-09-10 DD DD173383A patent/DD106712A5/xx unknown
- 1973-09-10 US US05/395,547 patent/US3964974A/en not_active Expired - Lifetime
- 1973-09-11 FR FR7332591A patent/FR2201768A5/fr not_active Expired
- 1973-09-11 CH CH1298073A patent/CH581839A5/xx not_active IP Right Cessation
- 1973-09-12 IT IT28822/73A patent/IT1006085B/it active
- 1973-09-26 BE BE136051A patent/BE805326A/fr not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012889A1 (fr) * | 1989-04-25 | 1990-11-01 | Migrata Uk Ltd | Procede d'analyse, composition d'agent reactif et utilisation de celle-ci pour la determination du glucose |
| WO1990012890A1 (fr) * | 1989-04-25 | 1990-11-01 | Migrata Uk Ltd | Procede de determination du glucose dans du sang entier, cuvette et photometre pour la realisation dudit procede |
Also Published As
| Publication number | Publication date |
|---|---|
| IT1006085B (it) | 1976-09-30 |
| DE2247608B2 (de) | 1976-07-08 |
| NL183659B (nl) | 1988-07-18 |
| BE805326A (fr) | 1974-03-26 |
| NL183659C (nl) | 1988-12-16 |
| NL7311508A (fr) | 1974-04-01 |
| CS164231B2 (fr) | 1975-11-07 |
| ZA735678B (en) | 1974-07-31 |
| FR2201768A5 (fr) | 1974-04-26 |
| GB1395306A (en) | 1975-05-21 |
| CH581839A5 (fr) | 1976-11-15 |
| IL43054A0 (en) | 1973-11-28 |
| JPS4973193A (fr) | 1974-07-15 |
| DE2247608A1 (de) | 1974-04-04 |
| JPS5615879B2 (fr) | 1981-04-13 |
| DD106712A5 (fr) | 1974-06-20 |
| IL43054A (en) | 1976-08-31 |
| US3964974A (en) | 1976-06-22 |
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