SE425606B - Sett att framstella (2-isopropyl-4-(2-tenoyl)-5-metyl)-fenoxi-ettiksyra - Google Patents

Sett att framstella (2-isopropyl-4-(2-tenoyl)-5-metyl)-fenoxi-ettiksyra

Info

Publication number: SE425606B
Authority: SE; Sweden
Prior art keywords: isopropyl; tenoyl; methyl; phenoxy; compound
Prior art date: 1977-04-22

Application number

SE7804526A

Other languages

English (en)

Swedish (sv)

Other versions

SE7804526L (sv

Inventor

A Esanu

Original Assignee

Soc D Etudes Prod Chimique

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-22

Filing date

1978-04-20

Publication date

1982-10-18

1978-04-20 Application filed by Soc D Etudes Prod Chimique filed Critical Soc D Etudes Prod Chimique

1978-10-23 Publication of SE7804526L publication Critical patent/SE7804526L/xx

1982-10-18 Publication of SE425606B publication Critical patent/SE425606B/sv

Links

239000002253 acid Substances 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims description 12
PQJJJMRNHATNKG-UHFFFAOYSA-N ethyl bromoacetate Chemical compound CCOC(=O)CBr PQJJJMRNHATNKG-UHFFFAOYSA-N 0.000 claims description 3
238000000034 method Methods 0.000 claims description 3
150000002576 ketones Chemical class 0.000 claims description 2
238000010992 reflux Methods 0.000 claims description 2
239000002904 solvent Substances 0.000 claims description 2
241000700159 Rattus Species 0.000 description 8
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 6
229910052783 alkali metal Inorganic materials 0.000 description 4
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
-1 alkali metal salt Chemical class 0.000 description 3
210000000941 bile Anatomy 0.000 description 3
235000012000 cholesterol Nutrition 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
239000000203 mixture Substances 0.000 description 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
125000004494 ethyl ester group Chemical group 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
229910052708 sodium Inorganic materials 0.000 description 2
239000011734 sodium Substances 0.000 description 2
FKJIJBSJQSMPTI-CAOXKPNISA-M sodium;(4r)-4-[(5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-3,7,12-trioxo-1,2,4,5,6,8,9,11,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoate Chemical compound [Na+].C1CC(=O)C[C@H]2CC(=O)[C@H]3[C@@H]4CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]4(C)C(=O)C[C@@H]3[C@]21C FKJIJBSJQSMPTI-CAOXKPNISA-M 0.000 description 2
238000003756 stirring Methods 0.000 description 2
MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
206010002091 Anaesthesia Diseases 0.000 description 1
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
239000005844 Thymol Substances 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000013543 active substance Substances 0.000 description 1
150000001340 alkali metals Chemical class 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000001989 choleretic effect Effects 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000013078 crystal Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000007903 gelatin capsule Substances 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000013383 initial experiment Methods 0.000 description 1
231100001231 less toxic Toxicity 0.000 description 1
238000005259 measurement Methods 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229910000027 potassium carbonate Inorganic materials 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
239000013558 reference substance Substances 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229960000790 thymol Drugs 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Gastroenterology & Hepatology (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Steroid Compounds (AREA)
Medicinal Preparation (AREA)

SE7804526A 1977-04-22 1978-04-20 Sett att framstella (2-isopropyl-4-(2-tenoyl)-5-metyl)-fenoxi-ettiksyra SE425606B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB16789/77A GB1569404A (en)	1977-04-22	1977-04-22	(2-isopropyl-4-(2'-theonyl)-5-methyl) phenoxy acetic acid

Publications (2)

Publication Number	Publication Date
SE7804526L SE7804526L (sv)	1978-10-23
SE425606B true SE425606B (sv)	1982-10-18

Family

ID=10083695

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7804526A SE425606B (sv)	1977-04-22	1978-04-20	Sett att framstella (2-isopropyl-4-(2-tenoyl)-5-metyl)-fenoxi-ettiksyra

Country Status (29)

Country	Link
US (2)	US4346100A (de)
JP (1)	JPS53132555A (de)
AR (1)	AR215300A1 (de)
AT (1)	AT359487B (de)
AU (1)	AU518054B2 (de)
BE (1)	BE865422A (de)
CA (1)	CA1109886A (de)
CH (1)	CH629795A5 (de)
DE (1)	DE2817399C3 (de)
DK (1)	DK174578A (de)
EG (1)	EG13312A (de)
ES (1)	ES469022A1 (de)
FI (1)	FI63396C (de)
FR (2)	FR2387976A1 (de)
GB (1)	GB1569404A (de)
HK (1)	HK66580A (de)
IE (1)	IE46803B1 (de)
IN (1)	IN147778B (de)
LU (1)	LU79345A1 (de)
MX (1)	MX4992E (de)
MY (1)	MY8100237A (de)
NL (1)	NL171583C (de)
NO (1)	NO147449C (de)
NZ (1)	NZ186912A (de)
OA (1)	OA05940A (de)
PH (1)	PH13547A (de)
PT (1)	PT67919B (de)
SE (1)	SE425606B (de)
ZA (1)	ZA781746B (de)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE757001A (fr) *	1969-10-10	1971-03-16	Cerpha	Derives heterocycliques d'acides phenoxy acetique et leur preparation
CA1007643A (en) *	1972-10-24	1977-03-29	Janssen Pharmaceutica Naamloze Vennootschap	Aroyl-substituted phenylacetic acid derivatives
US3958004A (en) *	1974-04-23	1976-05-18	Merck & Co., Inc.	Phenoxyacetic acid derivatives as uricosuric agents
US3969508A (en) *	1974-11-27	1976-07-13	Smithkline Corporation	Lowering the concentration of plasma triglycerides
JPS5195049A (en) *	1975-02-12	1976-08-20		* ********so*notsu***************************************nino
US4017632A (en) *	1975-10-22	1977-04-12	Centre European De Recherches Pharmacologiques C.E.R.P.H.A.	Phenoxyacetic acid derivatives
FR2342726A1 (fr) *	1976-02-18	1977-09-30	Smithkline Corp	Nouvelles compositions diuretiques
US4115402A (en) *	1977-06-17	1978-09-19	Merck & Co., Inc.	2,3-Dichloro-4-[(substituted-sulfonyl)-phenoxy]-acetic acids

1977
- 1977-04-22 GB GB16789/77A patent/GB1569404A/en not_active Expired
1978
- 1978-03-28 ZA ZA00781746A patent/ZA781746B/xx unknown
- 1978-03-29 CH CH334178A patent/CH629795A5/fr not_active IP Right Cessation
- 1978-03-29 BE BE186354A patent/BE865422A/xx not_active IP Right Cessation
- 1978-03-30 IN IN233/DEL/78A patent/IN147778B/en unknown
- 1978-03-31 LU LU79345A patent/LU79345A1/xx unknown
- 1978-04-06 AT AT244178A patent/AT359487B/de not_active IP Right Cessation
- 1978-04-07 NL NLAANVRAGE7803728,A patent/NL171583C/xx not_active IP Right Cessation
- 1978-04-07 NZ NZ186912A patent/NZ186912A/xx unknown
- 1978-04-11 EG EG249/78A patent/EG13312A/xx active
- 1978-04-11 FI FI781100A patent/FI63396C/fi not_active IP Right Cessation
- 1978-04-11 AU AU34970/78A patent/AU518054B2/en not_active Expired
- 1978-04-14 OA OA56470A patent/OA05940A/xx unknown
- 1978-04-17 US US05/897,287 patent/US4346100A/en not_active Expired - Lifetime
- 1978-04-19 CA CA301,502A patent/CA1109886A/en not_active Expired
- 1978-04-19 PT PT67919A patent/PT67919B/pt unknown
- 1978-04-20 FR FR7811642A patent/FR2387976A1/fr active Granted
- 1978-04-20 JP JP4598478A patent/JPS53132555A/ja active Granted
- 1978-04-20 FR FR7811641A patent/FR2387651A1/fr active Granted
- 1978-04-20 DE DE2817399A patent/DE2817399C3/de not_active Expired
- 1978-04-20 SE SE7804526A patent/SE425606B/sv unknown
- 1978-04-20 DK DK174578A patent/DK174578A/da not_active Application Discontinuation
- 1978-04-21 MX MX787033U patent/MX4992E/es unknown
- 1978-04-21 IE IE797/78A patent/IE46803B1/en unknown
- 1978-04-21 ES ES469022A patent/ES469022A1/es not_active Expired
- 1978-04-21 NO NO781402A patent/NO147449C/no unknown
- 1978-04-24 PH PH21041A patent/PH13547A/en unknown
- 1978-05-09 AR AR272092A patent/AR215300A1/es active
1979
- 1979-11-21 US US06/097,037 patent/US4254162A/en not_active Expired - Lifetime
1980
- 1980-11-20 HK HK665/80A patent/HK66580A/xx unknown
1981
- 1981-12-30 MY MY237/81A patent/MY8100237A/xx unknown

Also Published As

Publication number	Publication date
ES469022A1 (es)	1978-11-16
EG13312A (en)	1981-03-31
FI781100A7 (fi)	1978-10-23
CA1109886A (en)	1981-09-29
ZA781746B (en)	1979-03-28
JPS53132555A (en)	1978-11-18
SE7804526L (sv)	1978-10-23
FR2387651B1 (de)	1980-08-29
GB1569404A (en)	1980-06-11
HK66580A (en)	1980-11-28
NL7803728A (nl)	1978-10-24
PT67919B (en)	1979-11-14
AU3497078A (en)	1979-10-18
DE2817399A1 (de)	1978-10-26
MX4992E (es)	1983-01-31
NL171583B (nl)	1982-11-16
MY8100237A (en)	1981-12-31
PH13547A (en)	1980-06-26
NO147449B (no)	1983-01-03
US4346100A (en)	1982-08-24
NL171583C (nl)	1983-04-18
FR2387976B1 (de)	1980-08-29
NO781402L (no)	1978-10-24
DE2817399C3 (de)	1980-06-19
DE2817399B2 (de)	1979-09-27
CH629795A5 (fr)	1982-05-14
FI63396B (fi)	1983-02-28
AR215300A1 (es)	1979-09-28
BE865422A (fr)	1978-07-17
NO147449C (no)	1983-04-13
DK174578A (da)	1979-01-04
IE46803B1 (en)	1983-09-21
AT359487B (de)	1980-11-10
LU79345A1 (fr)	1978-07-13
AU518054B2 (en)	1981-09-10
JPS5426533B2 (de)	1979-09-04
FR2387651A1 (fr)	1978-11-17
ATA244178A (de)	1980-04-15
US4254162A (en)	1981-03-03
OA05940A (fr)	1981-06-30
FR2387976A1 (fr)	1978-11-17
PT67919A (en)	1978-05-01
NZ186912A (en)	1979-06-19
FI63396C (fi)	1983-06-10
IN147778B (de)	1980-06-28
IE780797L (en)	1978-10-22

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JPS62230722A (ja)	1987-10-09	肥満および／または関連状態の治療剤
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SE450251B (sv)	1987-06-15	Xantatforeningar for terapeutisk anvendning, nya xantatforeningar samt terapeutiska kompositioner innehallande dessa foreningar
JPS63135351A (ja)	1988-06-07	グリチルレチン酸誘導体、その製法及び該化合物を有効成分とする抗潰瘍剤
US4206213A (en)	1980-06-03	Dithienylalkylamines and process for their production
DE68915555T2 (de)	1994-10-20	Arzneimittel für Leberkrankheiten und Piperazin-Derivate.
KR840000763B1 (ko)	1984-06-08	2-아미노-3-벤조일-페닐아세트아미드의 제조방법
DE69509091T2 (de)	1999-09-09	Salze von 2-[(2,6-dichlorophenyl)amin]phenylacetoxyessigsäure mit organischen basischen kationen
JPS6399057A (ja)	1988-04-30	グリシン誘導体
SE442300B (sv)	1985-12-16	6,7-dihydro-8h-pyrano/3,2-g/kromon-2-karboxylsyraderivat samt deras anvendning i antiallergiskt verksamma terapeutiska kompositioner
JPS6222992B2 (de)	1987-05-20
SE453293B (sv)	1988-01-25	3,3-dialkyl- och 3,3-alkylen-indolinderivat, sett att framstella dessa och farmaceutiska kompositioner innehallande desamma
US4346100A (en)	1982-08-24	Phenoxy acetic acid derivative, its preparation and therapeutic use
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US5508280A (en)	1996-04-16	5H-Dibenzo (A,D) cycloheptenes as muscarinic receptor antagonists
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EP0558321A1 (de)	1993-09-01	N-Cycloalkyl-Verbindungen mit antiviraler Wirkung
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AT334350B (de)	1976-01-10	Verfahren zur herstellung von neuen 3- (4-biphenylyl) -buttersauren, deren estern, amiden und salzen
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