SE436028B - Forfarande for rening av tryptofan och derivat av tryptofan - Google Patents

Forfarande for rening av tryptofan och derivat av tryptofan

Info

Publication number: SE436028B
Authority: SE; Sweden
Prior art keywords: tryptophan; sodium dithionite; content; derivatives; purified
Prior art date: 1978-11-18

Application number

SE7909498A

Other languages

English (en)

Swedish (sv)

Other versions

SE7909498L (sv

Inventor

T Lussling

A Maierhofer

P Scherberich

Original Assignee

Degussa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-11-18

Filing date

1979-11-16

Publication date

1984-11-05

1979-11-16 Application filed by Degussa filed Critical Degussa

1980-05-19 Publication of SE7909498L publication Critical patent/SE7909498L/xx

1984-11-05 Publication of SE436028B publication Critical patent/SE436028B/sv

Links

238000000034 method Methods 0.000 title claims description 7
238000004140 cleaning Methods 0.000 title 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 27
JVBXVOWTABLYPX-UHFFFAOYSA-L sodium dithionite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])=O JVBXVOWTABLYPX-UHFFFAOYSA-L 0.000 claims description 11
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 9
239000000758 substrate Substances 0.000 claims description 9
238000001816 cooling Methods 0.000 claims description 7
239000000047 product Substances 0.000 claims description 7
238000010992 reflux Methods 0.000 claims description 7
150000003839 salts Chemical class 0.000 claims description 5
235000005911 diet Nutrition 0.000 claims description 4
230000000378 dietary effect Effects 0.000 claims description 4
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
239000000203 mixture Substances 0.000 claims description 4
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
239000002253 acid Substances 0.000 claims description 2
238000009835 boiling Methods 0.000 claims description 2
235000019253 formic acid Nutrition 0.000 claims description 2
239000012442 inert solvent Substances 0.000 claims description 2
239000012264 purified product Substances 0.000 claims description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
150000007933 aliphatic carboxylic acids Chemical class 0.000 claims 1
239000002904 solvent Substances 0.000 claims 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 16
238000002834 transmittance Methods 0.000 description 15
239000000243 solution Substances 0.000 description 10
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
239000007864 aqueous solution Substances 0.000 description 7
239000000463 material Substances 0.000 description 7
238000004448 titration Methods 0.000 description 7
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
125000000896 monocarboxylic acid group Chemical group 0.000 description 3
229960004799 tryptophan Drugs 0.000 description 3
LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 2
DZTHIGRZJZPRDV-UHFFFAOYSA-N N-acetyltryptophan Chemical compound C1=CC=C2C(CC(NC(=O)C)C(O)=O)=CNC2=C1 DZTHIGRZJZPRDV-UHFFFAOYSA-N 0.000 description 2
238000011109 contamination Methods 0.000 description 2
AHYFYYVVAXRMKB-KRWDZBQOSA-N (2s)-3-(1h-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoic acid Chemical compound N([C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)O)C(=O)OCC1=CC=CC=C1 AHYFYYVVAXRMKB-KRWDZBQOSA-N 0.000 description 1
WPBCXLCJWLNDPV-UHFFFAOYSA-N 2-benzamido-3-(1h-indol-3-yl)propanoic acid Chemical compound C=1NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=CC=C1 WPBCXLCJWLNDPV-UHFFFAOYSA-N 0.000 description 1
KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
-1 alkali metal salts Chemical class 0.000 description 1
238000002845 discoloration Methods 0.000 description 1
RMGVZKRVHHSUIM-UHFFFAOYSA-N dithionic acid Chemical compound OS(=O)(=O)S(O)(=O)=O RMGVZKRVHHSUIM-UHFFFAOYSA-N 0.000 description 1
LDCYZAJDBXYCGN-UHFFFAOYSA-N oxitriptan Natural products C1=C(O)C=C2C(CC(N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-UHFFFAOYSA-N 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Cosmetics (AREA)

SE7909498A 1978-11-18 1979-11-16 Forfarande for rening av tryptofan och derivat av tryptofan SE436028B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19782850074 DE2850074A1 (de)	1978-11-18	1978-11-18	Verfahren zur reinigung von tryptophan und derivaten des tryptophans

Publications (2)

Publication Number	Publication Date
SE7909498L SE7909498L (sv)	1980-05-19
SE436028B true SE436028B (sv)	1984-11-05

Family

ID=6055006

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7909498A SE436028B (sv)	1978-11-18	1979-11-16	Forfarande for rening av tryptofan och derivat av tryptofan

Country Status (13)

Country	Link
US (1)	US4283337A (fr)
JP (1)	JPS5919937B2 (fr)
AT (1)	AT373874B (fr)
BE (1)	BE880009A (fr)
CA (1)	CA1108157A (fr)
CH (1)	CH642628A5 (fr)
DE (1)	DE2850074A1 (fr)
ES (1)	ES483076A1 (fr)
FR (1)	FR2441612A1 (fr)
GB (1)	GB2035319B (fr)
IT (1)	IT1164760B (fr)
NL (1)	NL7905633A (fr)
SE (1)	SE436028B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH078357B2 (ja) *	1987-11-26	1995-02-01	松下電器産業株式会社	水殺菌浄化装置
KR101109737B1 (ko) *	2009-10-09	2012-02-15	미원상사주식회사	지방산 아미노에스테르 및 이를 함유하는 피부미백용 화장료
CN102146052B (zh) *	2010-12-24	2013-08-21	山东鲁抗医药股份有限公司	一种制备色氨酸的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2435125A (en) *	1944-10-23	1948-01-27	Dow Chemical Co	Purification of tryptophane
US2565354A (en) *	1948-01-14	1951-08-21	Standard Oil Dev Co	Chemical process for removal of organic peroxides
CS150016B1 (fr) *	1970-09-25	1973-09-04

1978
- 1978-11-18 DE DE19782850074 patent/DE2850074A1/de not_active Withdrawn
1979
- 1979-07-19 NL NL7905633A patent/NL7905633A/nl not_active Application Discontinuation
- 1979-08-02 ES ES483076A patent/ES483076A1/es not_active Expired
- 1979-08-27 FR FR7921436A patent/FR2441612A1/fr active Granted
- 1979-11-13 BE BE6/46998A patent/BE880009A/fr not_active IP Right Cessation
- 1979-11-14 GB GB7939470A patent/GB2035319B/en not_active Expired
- 1979-11-15 US US06/094,801 patent/US4283337A/en not_active Expired - Lifetime
- 1979-11-15 CA CA339,966A patent/CA1108157A/fr not_active Expired
- 1979-11-16 SE SE7909498A patent/SE436028B/sv not_active IP Right Cessation
- 1979-11-16 AT AT0732179A patent/AT373874B/de active
- 1979-11-16 IT IT50846/79A patent/IT1164760B/it active
- 1979-11-16 CH CH1027079A patent/CH642628A5/de not_active IP Right Cessation
- 1979-11-19 JP JP54149015A patent/JPS5919937B2/ja not_active Expired

Also Published As

Publication number	Publication date
JPS5572164A (en)	1980-05-30
ES483076A1 (es)	1980-04-16
IT1164760B (it)	1987-04-15
DE2850074A1 (de)	1980-05-22
SE7909498L (sv)	1980-05-19
GB2035319A (en)	1980-06-18
IT7950846A0 (it)	1979-11-16
CA1108157A (fr)	1981-09-01
GB2035319B (en)	1983-05-05
FR2441612B1 (fr)	1982-11-19
AT373874B (de)	1984-02-27
FR2441612A1 (fr)	1980-06-13
NL7905633A (nl)	1980-05-20
JPS5919937B2 (ja)	1984-05-09
US4283337A (en)	1981-08-11
BE880009A (fr)	1980-05-13
ATA732179A (de)	1983-07-15
CH642628A5 (de)	1984-04-30

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Legal Events

Date

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Title

Description

1995-01-31

NUG

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