SE442952B - Sett att framstella en aktiv substans mot litiasis genom extraktion av malda fron av bonor fran slektet dolichos - Google Patents

Sett att framstella en aktiv substans mot litiasis genom extraktion av malda fron av bonor fran slektet dolichos

Info

Publication number: SE442952B
Authority: SE; Sweden
Prior art keywords: acid; water; hydrolysis; carried out; hydrolyzate
Prior art date: 1977-02-09

Application number

SE7801520A

Other languages

English (en)

Swedish (sv)

Other versions

SE7801520L (sv

Inventor

W J Gustowski

M K Kocor

C K Atal

A S Orkiszewska

R S Olszewski

T A Wrocinski

Original Assignee

Polska Akademia Nauk Instytut

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-02-09

Filing date

1978-02-09

Publication date

1986-02-10

1978-02-09 Application filed by Polska Akademia Nauk Instytut filed Critical Polska Akademia Nauk Instytut

1978-08-10 Publication of SE7801520L publication Critical patent/SE7801520L/xx

1986-02-10 Publication of SE442952B publication Critical patent/SE442952B/sv

Links

239000013543 active substance Substances 0.000 title claims description 8
238000000605 extraction Methods 0.000 title claims description 5
241000219764 Dolichos Species 0.000 title description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 24
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
239000000203 mixture Substances 0.000 claims description 18
238000000034 method Methods 0.000 claims description 17
239000002253 acid Substances 0.000 claims description 15
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
239000000284 extract Substances 0.000 claims description 12
235000019441 ethanol Nutrition 0.000 claims description 11
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 9
HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Inorganic materials [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
235000015165 citric acid Nutrition 0.000 claims description 8
238000009835 boiling Methods 0.000 claims description 7
239000002904 solvent Substances 0.000 claims description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 6
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 6
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
230000007062 hydrolysis Effects 0.000 claims description 5
238000006460 hydrolysis reaction Methods 0.000 claims description 5
208000015924 Lithiasis Diseases 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
238000005903 acid hydrolysis reaction Methods 0.000 claims description 4
VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 claims description 4
229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
244000046052 Phaseolus vulgaris Species 0.000 claims description 3
235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 3
150000001298 alcohols Chemical class 0.000 claims description 3
229910052783 alkali metal Inorganic materials 0.000 claims description 3
150000001340 alkali metals Chemical class 0.000 claims description 3
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 3
150000001342 alkaline earth metals Chemical class 0.000 claims description 3
229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
229910021529 ammonia Inorganic materials 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
150000004679 hydroxides Chemical class 0.000 claims description 3
239000004310 lactic acid Substances 0.000 claims description 3
235000014655 lactic acid Nutrition 0.000 claims description 3
229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
235000019260 propionic acid Nutrition 0.000 claims description 3
IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 3
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
150000001242 acetic acid derivatives Chemical class 0.000 claims description 2
125000004432 carbon atom Chemical group C* 0.000 claims description 2
XTEGARKTQYYJKE-UHFFFAOYSA-N chloric acid Chemical compound OCl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-N 0.000 claims description 2
229940005991 chloric acid Drugs 0.000 claims description 2
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 claims description 2
150000002170 ethers Chemical class 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
150000002576 ketones Chemical class 0.000 claims description 2
239000011707 mineral Substances 0.000 claims description 2
150000007524 organic acids Chemical class 0.000 claims description 2
239000002798 polar solvent Substances 0.000 claims description 2
239000011541 reaction mixture Substances 0.000 claims description 2
239000011975 tartaric acid Substances 0.000 claims description 2
235000002906 tartaric acid Nutrition 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 1
239000000243 solution Substances 0.000 description 18
239000004575 stone Substances 0.000 description 16
238000002360 preparation method Methods 0.000 description 12
206010029148 Nephrolithiasis Diseases 0.000 description 7
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
239000003795 chemical substances by application Substances 0.000 description 6
239000003814 drug Substances 0.000 description 6
241000700159 Rattus Species 0.000 description 5
208000000913 Kidney Calculi Diseases 0.000 description 4
229910019142 PO4 Inorganic materials 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
229940079593 drug Drugs 0.000 description 4
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical class [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 4
239000010452 phosphate Substances 0.000 description 4
210000002700 urine Anatomy 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical class CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
244000112675 Lablab purpureus Species 0.000 description 3
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Chemical class OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
208000009911 Urinary Calculi Diseases 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000003921 oil Substances 0.000 description 3
239000002244 precipitate Substances 0.000 description 3
229940108473 renacidin Drugs 0.000 description 3
239000003826 tablet Substances 0.000 description 3
229920001817 Agar Polymers 0.000 description 2
235000003276 Apios tuberosa Nutrition 0.000 description 2
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical class OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Chemical class 0.000 description 2
241000206672 Gelidium Species 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
208000004880 Polyuria Diseases 0.000 description 2
244000170226 Voandzeia subterranea Species 0.000 description 2
235000013030 Voandzeia subterranea Nutrition 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
235000010419 agar Nutrition 0.000 description 2
ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000012259 ether extract Substances 0.000 description 2
229920000159 gelatin Chemical class 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
239000008187 granular material Substances 0.000 description 2
235000007924 ground bean Nutrition 0.000 description 2
239000003112 inhibitor Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
230000007794 irritation Effects 0.000 description 2
239000004137 magnesium phosphate Substances 0.000 description 2
229960002261 magnesium phosphate Drugs 0.000 description 2
229910000157 magnesium phosphate Inorganic materials 0.000 description 2
235000010994 magnesium phosphates Nutrition 0.000 description 2
235000019359 magnesium stearate Nutrition 0.000 description 2
239000006072 paste Substances 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
239000000454 talc Chemical class 0.000 description 2
229910052623 talc Inorganic materials 0.000 description 2
210000001635 urinary tract Anatomy 0.000 description 2
208000008281 urolithiasis Diseases 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-M 4-hydroxybenzoate Chemical compound OC1=CC=C(C([O-])=O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-M 0.000 description 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical class O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
239000004254 Ammonium phosphate Substances 0.000 description 1
240000003291 Armoracia rusticana Species 0.000 description 1
235000011330 Armoracia rusticana Nutrition 0.000 description 1
241000086254 Arnica montana Species 0.000 description 1
240000006914 Aspalathus linearis Species 0.000 description 1
235000012984 Aspalathus linearis Nutrition 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
241000167854 Bourreria succulenta Species 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
235000005979 Citrus limon Nutrition 0.000 description 1
244000131522 Citrus pyriformis Species 0.000 description 1
244000068485 Convallaria majalis Species 0.000 description 1
235000009046 Convallaria majalis Nutrition 0.000 description 1
229920002261 Corn starch Chemical class 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Chemical class OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical class OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical class OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
240000005979 Hordeum vulgare Species 0.000 description 1
235000007340 Hordeum vulgare Nutrition 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
241000219822 Macrotyloma axillare Species 0.000 description 1
235000001504 Macrotyloma uniflorum var. uniflorum Nutrition 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
235000006679 Mentha X verticillata Nutrition 0.000 description 1
235000002899 Mentha suaveolens Nutrition 0.000 description 1
235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
241000699666 Mus <mouse, genus> Species 0.000 description 1
241000699670 Mus sp. Species 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
229920002472 Starch Chemical class 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical class O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
229930006000 Sucrose Chemical class 0.000 description 1
LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 description 1
TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
230000007059 acute toxicity Effects 0.000 description 1
231100000403 acute toxicity Toxicity 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
229910000148 ammonium phosphate Inorganic materials 0.000 description 1
235000019289 ammonium phosphates Nutrition 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000010617 anise oil Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000003434 antitussive agent Substances 0.000 description 1
229940124584 antitussives Drugs 0.000 description 1
QZPSXPBJTPJTSZ-UHFFFAOYSA-N aqua regia Chemical compound Cl.O[N+]([O-])=O QZPSXPBJTPJTSZ-UHFFFAOYSA-N 0.000 description 1
230000004872 arterial blood pressure Effects 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
210000000941 bile Anatomy 0.000 description 1
230000037396 body weight Effects 0.000 description 1
244000309464 bull Species 0.000 description 1
LRHPLDYGYMQRHN-UHFFFAOYSA-N butyl alcohol Substances CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 1
AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
239000000920 calcium hydroxide Substances 0.000 description 1
229910001861 calcium hydroxide Inorganic materials 0.000 description 1
239000002775 capsule Substances 0.000 description 1
150000004649 carbonic acid derivatives Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000001913 cellulose Chemical class 0.000 description 1
229920002678 cellulose Chemical class 0.000 description 1
235000010980 cellulose Nutrition 0.000 description 1
210000003169 central nervous system Anatomy 0.000 description 1
239000013043 chemical agent Substances 0.000 description 1
235000019693 cherries Nutrition 0.000 description 1
229960003920 cocaine Drugs 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
239000000470 constituent Substances 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000008120 corn starch Chemical class 0.000 description 1
230000007423 decrease Effects 0.000 description 1
MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
230000035619 diuresis Effects 0.000 description 1
230000001882 diuretic effect Effects 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229930182470 glycoside Natural products 0.000 description 1
150000002338 glycosides Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
241000411851 herbal medicine Species 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
-1 hydroxybenzoic acid ester Chemical class 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
150000002596 lactones Chemical class 0.000 description 1
239000008101 lactose Chemical class 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
231100001252 long-term toxicity Toxicity 0.000 description 1
239000000395 magnesium oxide Substances 0.000 description 1
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
238000006386 neutralization reaction Methods 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
235000015927 pasta Nutrition 0.000 description 1
239000008177 pharmaceutical agent Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Chemical class 0.000 description 1
229920000036 polyvinylpyrrolidone Chemical class 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000000047 product Substances 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
230000036387 respiratory rate Effects 0.000 description 1
239000011435 rock Substances 0.000 description 1
230000000894 saliuretic effect Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000001624 sedative effect Effects 0.000 description 1
235000011888 snacks Nutrition 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
239000000600 sorbitol Chemical class 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Chemical class 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000005720 sucrose Chemical class 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
229940116269 uric acid Drugs 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
239000001993 wax Substances 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

Health & Medical Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Mycology (AREA)
Urology & Nephrology (AREA)
Alternative & Traditional Medicine (AREA)
Biotechnology (AREA)
Botany (AREA)
Medical Informatics (AREA)
Microbiology (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7801520A 1977-02-09 1978-02-09 Sett att framstella en aktiv substans mot litiasis genom extraktion av malda fron av bonor fran slektet dolichos SE442952B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PL1977195886A PL115321B1 (en)	1977-02-09	1977-02-09	Method of obtaining the active component of an anticalculic remedy

Publications (2)

Publication Number	Publication Date
SE7801520L SE7801520L (sv)	1978-08-10
SE442952B true SE442952B (sv)	1986-02-10

Family

ID=19980863

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7801520A SE442952B (sv)	1977-02-09	1978-02-09	Sett att framstella en aktiv substans mot litiasis genom extraktion av malda fron av bonor fran slektet dolichos

Country Status (16)

Country	Link
US (1)	US4156721A (cs)
JP (1)	JPS53121917A (cs)
AT (1)	AT363175B (cs)
BE (1)	BE863522A (cs)
CH (1)	CH633715A5 (cs)
CS (1)	CS194835B2 (cs)
DD (1)	DD133897A5 (cs)
DE (1)	DE2805224C3 (cs)
ES (1)	ES467204A1 (cs)
FR (1)	FR2380029A1 (cs)
GB (1)	GB1546360A (cs)
IN (1)	IN149699B (cs)
NL (1)	NL7801359A (cs)
PL (1)	PL115321B1 (cs)
SE (1)	SE442952B (cs)
SU (1)	SU1220563A3 (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377967A (en) *	1981-03-27	1983-03-29	Mack Trucks, Inc.	Two-piece piston assembly
JPH04109291U (ja) *	1991-03-05	1992-09-22	東洋化学株式会社	配管カバー
JP2548111Y2 (ja) *	1991-12-06	1997-09-17	東京瓦斯株式会社	配管用防護シート
JPH1129490A (ja) *	1997-06-20	1999-02-02	Gem Energy Ind Ltd	薬草抗糖尿病治療薬及びその製造方法
EP0894499A1 (en) *	1997-08-01	1999-02-03	Gem Energy Industry Limited	Herbal anti-diabetic composition
US6866651B2 (en)	2002-03-20	2005-03-15	Corazon Technologies, Inc.	Methods and devices for the in situ dissolution of renal calculi
EP2218455A1 (en) *	2009-02-07	2010-08-18	Cognis IP Management GmbH	Dolichos biflorus extract for use in therapeutic skin treatment
EP2216074A1 (en) *	2009-02-07	2010-08-11	Cognis IP Management GmbH	Dolichos biflorus extract for use in cosmetic skin treatment

1977
- 1977-02-09 PL PL1977195886A patent/PL115321B1/pl unknown
1978
- 1978-01-31 BE BE184796A patent/BE863522A/xx unknown
- 1978-01-31 CH CH103178A patent/CH633715A5/de not_active IP Right Cessation
- 1978-02-06 NL NL7801359A patent/NL7801359A/xx not_active Application Discontinuation
- 1978-02-06 AT AT0079978A patent/AT363175B/de not_active IP Right Cessation
- 1978-02-07 DD DD78203594A patent/DD133897A5/xx not_active IP Right Cessation
- 1978-02-07 SU SU782574202A patent/SU1220563A3/ru active
- 1978-02-08 DE DE2805224A patent/DE2805224C3/de not_active Expired
- 1978-02-08 GB GB4972/78A patent/GB1546360A/en not_active Expired
- 1978-02-08 CS CS78820A patent/CS194835B2/cs unknown
- 1978-02-09 FR FR7803685A patent/FR2380029A1/fr active Granted
- 1978-02-09 ES ES467204A patent/ES467204A1/es not_active Expired
- 1978-02-09 SE SE7801520A patent/SE442952B/sv unknown
- 1978-02-09 IN IN153/CAL/78A patent/IN149699B/en unknown
- 1978-02-09 US US05/876,561 patent/US4156721A/en not_active Expired - Lifetime
- 1978-02-09 JP JP1402378A patent/JPS53121917A/ja active Pending

Also Published As

Publication number	Publication date
DE2805224B2 (de)	1980-11-20
SU1220563A3 (ru)	1986-03-23
JPS53121917A (en)	1978-10-24
ATA79978A (de)	1980-12-15
CH633715A5 (de)	1982-12-31
FR2380029A1 (fr)	1978-09-08
IN149699B (cs)	1982-03-20
AT363175B (de)	1981-07-10
FR2380029B1 (cs)	1980-08-29
CS194835B2 (en)	1979-12-31
US4156721A (en)	1979-05-29
ES467204A1 (es)	1978-11-16
NL7801359A (nl)	1978-08-11
BE863522A (fr)	1978-05-16
DE2805224C3 (de)	1981-07-30
DD133897A5 (de)	1979-01-31
PL115321B1 (en)	1981-03-31
DE2805224A1 (de)	1978-08-10
SE7801520L (sv)	1978-08-10
PL195886A1 (pl)	1979-09-10
GB1546360A (en)	1979-05-23

Publication	Publication Date	Title
US10967030B2 (en)	2021-04-06	Traditional Chinese medicine composition for treating psoriasis and method for preparing the same
JPS60214741A (ja)	1985-10-28	血糖降下剤
Tanmoy et al.	2014	Pharmacological actions and phytoconstituents of Amaranthus spinosus Linn: a review
SE442952B (sv)	1986-02-10	Sett att framstella en aktiv substans mot litiasis genom extraktion av malda fron av bonor fran slektet dolichos
KR101715520B1 (ko)	2017-03-13	통풍 치료용 약학 조성물
JP2535559B2 (ja)	1996-09-18	魚類のせっそう病の予防及び治療剤
EP0281656B1 (de)	1992-01-29	Verwendung von Petasites-Extrakten zur Herstellung eines Arzneimittels zur Behandlung von gastrointestinalen Erkrankungen
CN105616896A (zh)	2016-06-01	大蒜提取物的制备方法及其产品和应用
JP2535555B2 (ja)	1996-09-18	魚類の連鎖球菌症の予防及び治療剤
JP2599160B2 (ja)	1997-04-09	鶏のブドウ球菌症の予防及び治療剤
JP2701385B2 (ja)	1998-01-21	脳浮腫抑制剤
KR20130094487A (ko)	2013-08-26	백합나무 수피 추출물을 유효 성분으로 함유하는 약학적 조성물
JP3292869B2 (ja)	2002-06-17	ヒアルロニダーゼ阻害剤
CN101588810A (zh)	2009-11-25	用于治疗和预防炎性疾病的包括络石藤和日本鹿蹄草提取物的组合物
JPH04300836A (ja)	1992-10-23	肝機能障害予防剤及び肝機能障害予防作用を有する機能性食品
CN109528881A (zh)	2019-03-29	中药组合物、制备方法及其应用
JP2599163B2 (ja)	1997-04-09	家畜および家禽のサルモネラ・テイフィムリウム感染症の予防及び治療剤
CN107753532A (zh)	2018-03-06	一种刺果番荔枝根提取物及其抗糖尿病用途
CN109464488B (zh)	2021-12-28	金银花总黄酮及其制备方法和应用
JP2535557B2 (ja)	1996-09-18	魚類のビブリオ・オルダリ感染症の予防及び治療剤
CN108938710A (zh)	2018-12-07	烟豆或其提取物在制备治疗和/或预防关节炎的药物中的用途
JPS625126B2 (cs)	1987-02-03
JPH08208501A (ja)	1996-08-13	ガルシニアマンゴスタナｌ．の抽出物を含有する抗ヘリコバクター・ピロリ薬
Aminabee et al.	2015	GASTROPROTECTIVE ACTIVITY OF MICHELIA NILAGIRICA IN RATS: POSSIBLE INVOLVEMENT OF H+-K+-ATPASE INHIBITION.
CN113214350B (zh)	2024-01-12	金钱松三萜内酯及其制法、药物组合物与用途