SE443877B - Forfarande for bestemning av fria hormoner i biologiska vetskor - Google Patents

Forfarande for bestemning av fria hormoner i biologiska vetskor

Info

Publication number: SE443877B
Authority: SE; Sweden
Prior art keywords: hormone; solid matrix; free; concentration; biological fluid
Prior art date: 1977-03-10

Application number

SE7802722A

Other languages

English (en)

Swedish (sv)

Other versions

SE7802722L (sv

Inventor

P B Romelli

F Pennisi

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-10

Filing date

1978-03-09

Publication date

1986-03-10

1978-03-09 Application filed by Lepetit Spa filed Critical Lepetit Spa

1978-09-11 Publication of SE7802722L publication Critical patent/SE7802722L/xx

1986-03-10 Publication of SE443877B publication Critical patent/SE443877B/sv

Links

229940088597 hormone Drugs 0.000 title claims description 52
239000005556 hormone Substances 0.000 title claims description 52
238000000034 method Methods 0.000 title claims description 30
239000011159 matrix material Substances 0.000 claims description 35
239000007787 solid Substances 0.000 claims description 28
210000002966 serum Anatomy 0.000 claims description 20
239000013060 biological fluid Substances 0.000 claims description 12
239000011347 resin Substances 0.000 claims description 7
229920005989 resin Polymers 0.000 claims description 7
238000004458 analytical method Methods 0.000 claims description 6
229920005654 Sephadex Polymers 0.000 claims description 4
239000012507 Sephadex™ Substances 0.000 claims description 4
238000010521 absorption reaction Methods 0.000 claims description 4
238000010790 dilution Methods 0.000 claims description 4
239000012895 dilution Substances 0.000 claims description 4
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 claims description 3
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical group IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims description 2
150000004676 glycans Chemical class 0.000 claims description 2
229920001282 polysaccharide Polymers 0.000 claims description 2
239000005017 polysaccharide Substances 0.000 claims description 2
229940034208 thyroxine Drugs 0.000 claims description 2
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims description 2
229940035722 triiodothyronine Drugs 0.000 claims description 2
230000001900 immune effect Effects 0.000 claims 1
238000012360 testing method Methods 0.000 description 23
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
239000000872 buffer Substances 0.000 description 7
239000007788 liquid Substances 0.000 description 7
239000000047 product Substances 0.000 description 7
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
229910052799 carbon Inorganic materials 0.000 description 5
230000002596 correlated effect Effects 0.000 description 5
230000000694 effects Effects 0.000 description 5
229920002307 Dextran Polymers 0.000 description 4
239000007853 buffer solution Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
239000005495 thyroid hormone Substances 0.000 description 4
229940036555 thyroid hormone Drugs 0.000 description 4
102000014914 Carrier Proteins Human genes 0.000 description 3
238000000502 dialysis Methods 0.000 description 3
239000000126 substance Substances 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
210000001685 thyroid gland Anatomy 0.000 description 3
101100298295 Drosophila melanogaster flfl gene Proteins 0.000 description 2
206010020850 Hyperthyroidism Diseases 0.000 description 2
230000002411 adverse Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
108091008324 binding proteins Proteins 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
230000008030 elimination Effects 0.000 description 2
238000003379 elimination reaction Methods 0.000 description 2
XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 description 2
229920000642 polymer Polymers 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
238000003127 radioimmunoassay Methods 0.000 description 2
230000002441 reversible effect Effects 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000001179 sorption measurement Methods 0.000 description 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
206010002383 Angina Pectoris Diseases 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
241000234295 Musa Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
208000024799 Thyroid disease Diseases 0.000 description 1
108050000089 Transthyretin Proteins 0.000 description 1
102100029290 Transthyretin Human genes 0.000 description 1
238000003556 assay Methods 0.000 description 1
238000004364 calculation method Methods 0.000 description 1
150000001720 carbohydrates Chemical group 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
229920001429 chelating resin Polymers 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
230000000875 corresponding effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
238000007435 diagnostic evaluation Methods 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000010828 elution Methods 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000013632 homeostatic process Effects 0.000 description 1
102000051759 human factor J Human genes 0.000 description 1
108700008420 human factor J Proteins 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000003993 interaction Effects 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000012417 linear regression Methods 0.000 description 1
229920002521 macromolecule Polymers 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000036651 mood Effects 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
-1 polyethylene Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
238000003908 quality control method Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
235000021055 solid food Nutrition 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
238000000528 statistical test Methods 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229920003002 synthetic resin Polymers 0.000 description 1
239000000057 synthetic resin Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
STCOOQWBFONSKY-UHFFFAOYSA-N tributyl phosphate Chemical compound CCCCOP(=O)(OCCCC)OCCCC STCOOQWBFONSKY-UHFFFAOYSA-N 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/78—Thyroid gland hormones, e.g. T3, T4, TBH, TBG or their receptors
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/804—Radioisotope, e.g. radioimmunoassay
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
- Y10S436/817—Steroids or hormones
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Immunology (AREA)
Microbiology (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Investigating Or Analysing Biological Materials (AREA)

SE7802722A 1977-03-10 1978-03-09 Forfarande for bestemning av fria hormoner i biologiska vetskor SE443877B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT7721128A IT1206354B (it)	1977-03-10	1977-03-10	Corredo da usarsi per la determinazione degli ormoni liberi nei fluidi biologici

Publications (2)

Publication Number	Publication Date
SE7802722L SE7802722L (sv)	1978-09-11
SE443877B true SE443877B (sv)	1986-03-10

Family

ID=11177146

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7802722A SE443877B (sv)	1977-03-10	1978-03-09	Forfarande for bestemning av fria hormoner i biologiska vetskor

Country Status (13)

Country	Link
US (1)	US4225574A (da)
JP (1)	JPS53127789A (da)
AU (1)	AU520109B2 (da)
BE (1)	BE864771A (da)
CA (1)	CA1120389A (da)
DE (1)	DE2806860C3 (da)
DK (1)	DK149939C (da)
FR (1)	FR2383445A1 (da)
GB (1)	GB1597859A (da)
IE (1)	IE46765B1 (da)
IT (1)	IT1206354B (da)
NL (1)	NL7802135A (da)
SE (1)	SE443877B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4292296A (en) *	1978-09-12	1981-09-29	Baxter Travenol Laboratories, Inc.	Diagnostic method
DE3000483A1 (de) *	1979-01-09	1980-07-17	Fuji Photo Film Co Ltd	Mikrokapseln fuer immunologische bestimmungen
US4381291A (en) *	1979-02-23	1983-04-26	Ab Fortia	Measurement of free ligands
US4366143A (en) *	1979-09-24	1982-12-28	Amersham International Public Limited Company	Assay for the free portion of substances in biological fluids
US4477577A (en) *	1980-03-17	1984-10-16	University Of Southern California	Non-contaminating direct serum assay of steroid hormones
US4391795A (en) *	1980-03-21	1983-07-05	Becton Dickinson And Company	Assay for free thyroid hormone
US4410633A (en) *	1980-09-25	1983-10-18	Corning Glass Works	Method for the measurement of free thyroxine or 3,5,3'-triiodothyronine in a liquid sample
US4741897A (en) *	1986-07-08	1988-05-03	Baxter Travenol	Thyroxine analogs and reagents for thyroid hormone assays
IT1254858B (it) *	1992-04-14	1995-10-11		Metodo per la determinazione della frazione libera di sostanze presenti nei fluidi biologici.
CN1934449A (zh) *	2004-01-28	2007-03-21	图尔库大学	用于诊断急性冠状动脉综合征的改进的方法
CN114544831B (zh) *	2022-02-21	2024-05-10	成都翼泰生物科技有限公司	分离血液中游离甲状腺激素的方法及其应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3710117A (en) *	1970-04-27	1973-01-09	Yissum Res Dev Co	Vitro test system for assessing thyroid function
US3659104A (en) *	1970-06-29	1972-04-25	Univ Jerusalem The	Method of measuring serum thyroxine
US3776698A (en) *	1972-01-24	1973-12-04	Nuclear Med Lab	Test for thyroid hormone
US3941564A (en) *	1973-09-13	1976-03-02	Miles Laboratories, Inc.	Method for assessing thyroid function
US4020151A (en) *	1976-02-17	1977-04-26	International Diagnostic Technology, Inc.	Method for quantitation of antigens or antibodies on a solid surface
US4015939A (en) *	1976-05-12	1977-04-05	Bio-Rad Laboratories, Inc.	Competitive binding thyroid assay with improved bound-free separation step
US4046870A (en) *	1976-06-30	1977-09-06	Corning Glass Works	Assay for free thyroid hormones

1977
- 1977-03-10 IT IT7721128A patent/IT1206354B/it active
1978
- 1978-02-17 DE DE2806860A patent/DE2806860C3/de not_active Expired
- 1978-02-21 AU AU33449/78A patent/AU520109B2/en not_active Expired
- 1978-02-23 US US05/880,411 patent/US4225574A/en not_active Expired - Lifetime
- 1978-02-27 NL NL7802135A patent/NL7802135A/xx active Search and Examination
- 1978-02-28 FR FR7805659A patent/FR2383445A1/fr active Granted
- 1978-03-07 JP JP2506978A patent/JPS53127789A/ja active Granted
- 1978-03-08 DK DK103478A patent/DK149939C/da not_active IP Right Cessation
- 1978-03-09 CA CA000298590A patent/CA1120389A/en not_active Expired
- 1978-03-09 IE IE484/78A patent/IE46765B1/en not_active IP Right Cessation
- 1978-03-09 GB GB9404/78A patent/GB1597859A/en not_active Expired
- 1978-03-09 SE SE7802722A patent/SE443877B/sv not_active IP Right Cessation
- 1978-03-10 BE BE185830A patent/BE864771A/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
DE2806860A1 (de)	1978-09-14
JPS53127789A (en)	1978-11-08
DK103478A (da)	1978-09-11
FR2383445A1 (fr)	1978-10-06
CA1120389A (en)	1982-03-23
US4225574A (en)	1980-09-30
AU520109B2 (en)	1982-01-14
DE2806860C3 (de)	1982-03-04
IT1206354B (it)	1989-04-21
DK149939C (da)	1987-06-29
AU3344978A (en)	1979-08-30
IE780484L (en)	1978-09-10
DK149939B (da)	1986-10-27
FR2383445B1 (da)	1981-03-06
IE46765B1 (en)	1983-09-21
DE2806860B2 (de)	1981-06-11
BE864771A (fr)	1978-09-11
JPH0159547B2 (da)	1989-12-18
SE7802722L (sv)	1978-09-11
GB1597859A (en)	1981-09-16
NL7802135A (nl)	1978-09-12

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 7802722-4

Effective date: 19931008

Format of ref document f/p: F

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