SE448190B - Sett att bestemma fc-dels-bindande bakteriella polypeptider - Google Patents

Sett att bestemma fc-dels-bindande bakteriella polypeptider

Info

Publication number: SE448190B
Authority: SE; Sweden
Prior art keywords: protein; polypeptide; antibody; binding; immunological
Prior art date: 1985-06-03

Application number

SE8502722A

Other languages

English (en)

Swedish (sv)

Other versions

SE8502722D0 (sv

SE8502722L (sv

Inventor

A Berglund

M W Inganes

Original Assignee

Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-03

Filing date

1985-06-03

Publication date

1987-01-26

1985-06-03 Application filed by Pharmacia Ab filed Critical Pharmacia Ab

1985-06-03 Priority to SE8502722A priority Critical patent/SE448190B/sv

1985-06-03 Publication of SE8502722D0 publication Critical patent/SE8502722D0/xx

1986-05-21 Priority to CA000509670A priority patent/CA1265999A/en

1986-05-22 Priority to US06/865,853 priority patent/US4752571A/en

1986-05-28 Priority to EP86850190A priority patent/EP0213093B1/de

1986-05-28 Priority to DE8686850190T priority patent/DE3674511D1/de

1986-05-28 Priority to AT86850190T priority patent/ATE57016T1/de

1986-06-02 Priority to JP61127857A priority patent/JPH06100603B2/ja

1986-12-04 Publication of SE8502722L publication Critical patent/SE8502722L/xx

1987-01-26 Publication of SE448190B publication Critical patent/SE448190B/sv

Links

229920001184 polypeptide Polymers 0.000 title claims abstract description 44
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 44
108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 44
230000001580 bacterial effect Effects 0.000 title claims abstract description 7
238000000034 method Methods 0.000 claims abstract description 42
108060003951 Immunoglobulin Proteins 0.000 claims abstract description 15
102000018358 immunoglobulin Human genes 0.000 claims abstract description 15
230000008105 immune reaction Effects 0.000 claims abstract description 7
230000000694 effects Effects 0.000 claims abstract description 6
102000004169 proteins and genes Human genes 0.000 claims description 54
108090000623 proteins and genes Proteins 0.000 claims description 54
230000001900 immune effect Effects 0.000 claims description 11
230000002860 competitive effect Effects 0.000 claims description 7
238000010324 immunological assay Methods 0.000 claims description 7
101710120037 Toxin CcdB Proteins 0.000 claims description 2
238000002360 preparation method Methods 0.000 abstract description 12
VRDIULHPQTYCLN-UHFFFAOYSA-N Prothionamide Chemical compound CCCC1=CC(C(N)=S)=CC=N1 VRDIULHPQTYCLN-UHFFFAOYSA-N 0.000 abstract 1
238000003018 immunoassay Methods 0.000 abstract 1
239000000376 reactant Substances 0.000 description 15
230000009257 reactivity Effects 0.000 description 14
239000000872 buffer Substances 0.000 description 11
239000007790 solid phase Substances 0.000 description 11
238000012360 testing method Methods 0.000 description 10
241001465754 Metazoa Species 0.000 description 9
210000002966 serum Anatomy 0.000 description 9
241000283973 Oryctolagus cuniculus Species 0.000 description 8
229940072221 immunoglobulins Drugs 0.000 description 8
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
239000012634 fragment Substances 0.000 description 7
230000003993 interaction Effects 0.000 description 6
238000005119 centrifugation Methods 0.000 description 5
239000000203 mixture Substances 0.000 description 5
239000008363 phosphate buffer Substances 0.000 description 5
241000282472 Canis lupus familiaris Species 0.000 description 4
239000003463 adsorbent Substances 0.000 description 4
210000004369 blood Anatomy 0.000 description 4
239000008280 blood Substances 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
241001494479 Pecora Species 0.000 description 3
239000008351 acetate buffer Substances 0.000 description 3
239000012491 analyte Substances 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
230000028993 immune response Effects 0.000 description 3
239000003550 marker Substances 0.000 description 3
239000000463 material Substances 0.000 description 3
230000036963 noncompetitive effect Effects 0.000 description 3
239000011780 sodium chloride Substances 0.000 description 3
239000012086 standard solution Substances 0.000 description 3
229920000936 Agarose Polymers 0.000 description 2
241000271566 Aves Species 0.000 description 2
241000282465 Canis Species 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
206010028980 Neoplasm Diseases 0.000 description 2
229920005654 Sephadex Polymers 0.000 description 2
239000012507 Sephadex™ Substances 0.000 description 2
PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
239000007983 Tris buffer Substances 0.000 description 2
239000002671 adjuvant Substances 0.000 description 2
238000001042 affinity chromatography Methods 0.000 description 2
239000000427 antigen Substances 0.000 description 2
102000036639 antigens Human genes 0.000 description 2
108091007433 antigens Proteins 0.000 description 2
239000007853 buffer solution Substances 0.000 description 2
210000004027 cell Anatomy 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000007979 citrate buffer Substances 0.000 description 2
ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 2
238000001514 detection method Methods 0.000 description 2
229940088598 enzyme Drugs 0.000 description 2
230000003053 immunization Effects 0.000 description 2
238000002649 immunization Methods 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007924 injection Substances 0.000 description 2
239000007791 liquid phase Substances 0.000 description 2
239000002245 particle Substances 0.000 description 2
230000010412 perfusion Effects 0.000 description 2
239000012071 phase Substances 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
238000000746 purification Methods 0.000 description 2
230000035945 sensitivity Effects 0.000 description 2
241000894007 species Species 0.000 description 2
239000000725 suspension Substances 0.000 description 2
238000010998 test method Methods 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 description 1
PMUNIMVZCACZBB-UHFFFAOYSA-N 2-hydroxyethylazanium;chloride Chemical compound Cl.NCCO PMUNIMVZCACZBB-UHFFFAOYSA-N 0.000 description 1
GHCZTIFQWKKGSB-UHFFFAOYSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;phosphoric acid Chemical compound OP(O)(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O GHCZTIFQWKKGSB-UHFFFAOYSA-N 0.000 description 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
241000283707 Capra Species 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
229920002271 DEAE-Sepharose Polymers 0.000 description 1
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
241000283086 Equidae Species 0.000 description 1
241000287828 Gallus gallus Species 0.000 description 1
102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
241000124008 Mammalia Species 0.000 description 1
102000057297 Pepsin A Human genes 0.000 description 1
108090000284 Pepsin A Proteins 0.000 description 1
239000004952 Polyamide Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
241000700159 Rattus Species 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
241000251539 Vertebrata <Metazoa> Species 0.000 description 1
239000013543 active substance Substances 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
239000011324 bead Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
238000012512 characterization method Methods 0.000 description 1
239000003153 chemical reaction reagent Substances 0.000 description 1
235000013330 chicken meat Nutrition 0.000 description 1
VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
239000002131 composite material Substances 0.000 description 1
230000008878 coupling Effects 0.000 description 1
238000010168 coupling process Methods 0.000 description 1
238000005859 coupling reaction Methods 0.000 description 1
230000006735 deficit Effects 0.000 description 1
238000011033 desalting Methods 0.000 description 1
238000003795 desorption Methods 0.000 description 1
238000010586 diagram Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
235000013601 eggs Nutrition 0.000 description 1
239000003480 eluent Substances 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
238000002523 gelfiltration Methods 0.000 description 1
150000004676 glycans Chemical class 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000000760 immunoelectrophoresis Methods 0.000 description 1
230000016784 immunoglobulin production Effects 0.000 description 1
239000003547 immunosorbent Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
239000012535 impurity Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
230000026045 iodination Effects 0.000 description 1
238000006192 iodination reaction Methods 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
238000004255 ion exchange chromatography Methods 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
150000002734 metacrylic acid derivatives Chemical class 0.000 description 1
MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
229940043515 other immunoglobulins in atc Drugs 0.000 description 1
230000007918 pathogenicity Effects 0.000 description 1
229940111202 pepsin Drugs 0.000 description 1
-1 poly (hydroxyalkyl acrylates Chemical class 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
229920001282 polysaccharide Polymers 0.000 description 1
239000005017 polysaccharide Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
238000011002 quantification Methods 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
230000002829 reductive effect Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000007787 solid Substances 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
229960001479 tosylchloramide sodium Drugs 0.000 description 1
238000012549 training Methods 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/6857—Antibody fragments
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/825—Pretreatment for removal of interfering factors from sample
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/828—Protein A

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Cell Biology (AREA)
Pathology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Physics & Mathematics (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
Microbiology (AREA)
General Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

SE8502722A 1985-06-03 1985-06-03 Sett att bestemma fc-dels-bindande bakteriella polypeptider SE448190B (sv)

Priority Applications (7)

Application Number	Priority Date	Filing Date	Title
SE8502722A SE448190B (sv)	1985-06-03	1985-06-03	Sett att bestemma fc-dels-bindande bakteriella polypeptider
CA000509670A CA1265999A (en)	1985-06-03	1986-05-21	Method for determining certain bacterial polypeptides and antibodies directed against them
US06/865,853 US4752571A (en)	1985-06-03	1986-05-22	Method for determining certain bacterial polypeptides and antibodies directed against them
EP86850190A EP0213093B1 (de)	1985-06-03	1986-05-28	Immunologische Bestimmungsmethode zum Nachweis von Fc-teilbinden bakteriellen Polypeptiden und/oder entsprechenden Antikörpern
DE8686850190T DE3674511D1 (de)	1985-06-03	1986-05-28	Immunologische bestimmungsmethode zum nachweis von fc-teilbinden bakteriellen polypeptiden und/oder entsprechenden antikoerpern.
AT86850190T ATE57016T1 (de)	1985-06-03	1986-05-28	Immunologische bestimmungsmethode zum nachweis von fc-teilbinden bakteriellen polypeptiden und/oder entsprechenden antikoerpern.
JP61127857A JPH06100603B2 (ja)	1985-06-03	1986-06-02	特定の細菌ポリペプチド及びそれに対する抗体の定量法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8502722A SE448190B (sv)	1985-06-03	1985-06-03	Sett att bestemma fc-dels-bindande bakteriella polypeptider

Publications (3)

Publication Number	Publication Date
SE8502722D0 SE8502722D0 (sv)	1985-06-03
SE8502722L SE8502722L (sv)	1986-12-04
SE448190B true SE448190B (sv)	1987-01-26

Family

ID=20360424

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8502722A SE448190B (sv)	1985-06-03	1985-06-03	Sett att bestemma fc-dels-bindande bakteriella polypeptider

Country Status (7)

Country	Link
US (1)	US4752571A (de)
EP (1)	EP0213093B1 (de)
JP (1)	JPH06100603B2 (de)
AT (1)	ATE57016T1 (de)
CA (1)	CA1265999A (de)
DE (1)	DE3674511D1 (de)
SE (1)	SE448190B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5985599A (en) *	1986-05-29	1999-11-16	The Austin Research Institute	FC receptor for immunoglobulin
WO1991010911A1 (en) *	1990-01-19	1991-07-25	Repligen Corporation	Immunoassay of protein a under acidic conditions
US6706486B1 (en)	1998-06-19	2004-03-16	Amersham Biosciences Ab	Method for the quantitative release of natural or recombinant proteins, polypeptides or peptides
EP1580557A4 (de) *	2002-11-22	2006-09-06	Daiichi Pure Chemicals Co Ltd	Verfahren zur untersuchung von staphylococcus aureus
EP2335076B1 (de) *	2008-09-15	2012-08-08	EMD Millipore Corporation	Verfahren zur quantifizierung des proteinverlusts von affinitätschromatographieharzen auf proteinbasis
WO2014055025A1 (en) *	2012-10-03	2014-04-10	Gyros Patent Ab	Method and kit for analyte determination at acidic conditions
CN120153258A (zh) *	2022-12-30	2025-06-13	上海药明生物技术有限公司	用于检测蛋白a的方法及其试剂盒

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2322533C2 (de) *	1972-11-06	1986-08-28	Pharmacia AB, Uppsala	Verfahren zum Binden von Immunoglobulin und Hilfsmittel zur Durchführung des Verfahrens
US3966868A (en) *	1974-12-09	1976-06-29	Hope Henry F	Strip straightening apparatus, product and method
SE8003732L (sv) *	1980-05-19	1981-11-20	Pharmacia Diagnostics Ab	Sett vid bestemningsmetoder involverande biospecifika affinitetsreaktioner
US4409330A (en) *	1980-11-24	1983-10-11	American Hoechst Corporation	Material and method for removing immunoglobulins from whole blood
US4471058A (en) *	1982-07-26	1984-09-11	Board Of Trustees Operating Michigan State University	Method for the detection and/or determination of a polyvalent antigen using at least two different monoclonal antibodies
US4590168A (en) *	1983-02-14	1986-05-20	The Children's Medical Center Corporation	Protein immunoassaying and purification
US4617266A (en) *	1983-04-28	1986-10-14	Genex Corporation	Production of Protein A

1985
- 1985-06-03 SE SE8502722A patent/SE448190B/sv not_active IP Right Cessation
1986
- 1986-05-21 CA CA000509670A patent/CA1265999A/en not_active Expired - Fee Related
- 1986-05-22 US US06/865,853 patent/US4752571A/en not_active Expired - Fee Related
- 1986-05-28 DE DE8686850190T patent/DE3674511D1/de not_active Expired - Fee Related
- 1986-05-28 AT AT86850190T patent/ATE57016T1/de not_active IP Right Cessation
- 1986-05-28 EP EP86850190A patent/EP0213093B1/de not_active Expired - Lifetime
- 1986-06-02 JP JP61127857A patent/JPH06100603B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE57016T1 (de)	1990-10-15
SE8502722D0 (sv)	1985-06-03
SE8502722L (sv)	1986-12-04
JPH06100603B2 (ja)	1994-12-12
EP0213093B1 (de)	1990-09-26
EP0213093A1 (de)	1987-03-04
DE3674511D1 (de)	1990-10-31
CA1265999A (en)	1990-02-20
US4752571A (en)	1988-06-21
JPS6212859A (ja)	1987-01-21

Legal Events

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1995-01-31

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Szymanski et al.	1982	An autoanalyzer test to determine immunoglobulin class and IgG subclass of blood group antibodies
Magnusson et al.	1981	An automated particle‐counting immunoassay (PACaIA) for serum IgE
Yarmush et al.	1977	The inheritance of antibody V regions in the rabbit: linkage of an H-chain-specific idiotype to immunoglobulin allotypes.
Gray et al.	1982	Interaction of 125I-protein A with erythrocyte-bound IgG
Natali et al.	1980	Isolation of soluble immune complexes from serum using protein A bearing Staphylococcus aureus bacteria: separation of the antigen from immune complex and production of antisera
Casey et al.	1972	A study of the characteristics of certain Rh antibodies preferentially detectable by enzyme technique
Rossen et al.	1967	The identification of low molecular weight bentonite flocculating antibodies in the serum of the rabbit, monkey and man
Lim et al.	1990	A tube latex test based on colour separation for the detection of IgM antibodies to either one of two different microorganisms
Gilead et al.	1979	A technique for the purification of immune complexes using rheumatoid factor
Huschka et al.	1982	Rapid separation of immunoglobulin M by immunoaffinity chromatography for detection of specific antibodies to Rubella and Treponema pallidum
Viljoen et al.	1985	Isolation of Cowdria ruminantium by cellular affinity chromatography and detection by an enzyme-linked immunosorbent assay
FI104219B (fi)	1999-11-30	Diagnostinen menetelmä ja testaustarvikesarja multippeliskleroosin määrittämiseksi