SE459503B - Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g - Google Patents

Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g

Info

Publication number: SE459503B
Authority: SE; Sweden
Prior art keywords: protein; microorganism; dna; igg; fragments
Prior art date: 1985-05-03

Application number

SE8502162A

Other languages

English (en)

Swedish (sv)

Other versions

SE8502162L (sv

SE8502162D0 (sv

Inventor

L H Bjoerck

G Kronvall

C G Lindahl

W H Kastern

Original Assignee

Excorim Kommanditbolag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-05-03

Filing date

1985-05-03

Publication date

1989-07-10

1985-05-03 Application filed by Excorim Kommanditbolag filed Critical Excorim Kommanditbolag

1985-05-03 Priority to SE8502162A priority Critical patent/SE459503B/sv

1985-05-03 Publication of SE8502162D0 publication Critical patent/SE8502162D0/xx

1986-03-27 Priority to EP86104244A priority patent/EP0200909A3/fr

1986-05-02 Priority to JP61102941A priority patent/JPS6225981A/ja

1986-11-04 Publication of SE8502162L publication Critical patent/SE8502162L/

1989-07-05 Priority to US07/376,160 priority patent/US5108894A/en

1989-07-10 Publication of SE459503B publication Critical patent/SE459503B/sv

Links

108020004414 DNA Proteins 0.000 title claims description 60
108090000623 proteins and genes Proteins 0.000 title claims description 19
102000004169 proteins and genes Human genes 0.000 title claims description 19
238000000034 method Methods 0.000 title claims description 16
102000053602 DNA Human genes 0.000 title claims description 13
108091028043 Nucleic acid sequence Proteins 0.000 title claims description 9
101710120037 Toxin CcdB Proteins 0.000 claims description 59
239000012634 fragment Substances 0.000 claims description 25
244000005700 microbiome Species 0.000 claims description 20
241000894006 Bacteria Species 0.000 claims description 11
241000588724 Escherichia coli Species 0.000 claims description 11
239000013598 vector Substances 0.000 claims description 10
210000004027 cell Anatomy 0.000 claims description 7
208000015181 infectious disease Diseases 0.000 claims description 6
102000003992 Peroxidases Human genes 0.000 claims description 5
108040007629 peroxidase activity proteins Proteins 0.000 claims description 5
241001515965 unidentified phage Species 0.000 claims description 3
241000192125 Firmicutes Species 0.000 claims description 2
241000283973 Oryctolagus cuniculus Species 0.000 claims description 2
210000002421 cell wall Anatomy 0.000 claims description 2
210000005253 yeast cell Anatomy 0.000 claims description 2
230000000694 effects Effects 0.000 claims 1
238000001556 precipitation Methods 0.000 claims 1
230000002285 radioactive effect Effects 0.000 claims 1
230000009466 transformation Effects 0.000 claims 1
235000018102 proteins Nutrition 0.000 description 16
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
239000000872 buffer Substances 0.000 description 9
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
238000011534 incubation Methods 0.000 description 6
239000007984 Tris EDTA buffer Substances 0.000 description 5
229920000936 Agarose Polymers 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
239000008188 pellet Substances 0.000 description 4
239000013612 plasmid Substances 0.000 description 4
239000011780 sodium chloride Substances 0.000 description 4
239000000243 solution Substances 0.000 description 4
108090000790 Enzymes Proteins 0.000 description 3
102000004190 Enzymes Human genes 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
230000001580 bacterial effect Effects 0.000 description 3
230000000903 blocking effect Effects 0.000 description 3
229940088598 enzyme Drugs 0.000 description 3
239000000463 material Substances 0.000 description 3
108091008146 restriction endonucleases Proteins 0.000 description 3
239000006228 supernatant Substances 0.000 description 3
QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
206010065042 Immune reconstitution inflammatory syndrome Diseases 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
238000005119 centrifugation Methods 0.000 description 2
238000010367 cloning Methods 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 2
229960005542 ethidium bromide Drugs 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000007858 starting material Substances 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
241000186031 Corynebacteriaceae Species 0.000 description 1
108010067770 Endopeptidase K Proteins 0.000 description 1
102000009109 Fc receptors Human genes 0.000 description 1
108010087819 Fc receptors Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
239000000020 Nitrocellulose Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
239000008272 agar Substances 0.000 description 1
238000000246 agarose gel electrophoresis Methods 0.000 description 1
229960000074 biopharmaceutical Drugs 0.000 description 1
AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
RCTYPNKXASFOBE-UHFFFAOYSA-M chloromercury Chemical compound [Hg]Cl RCTYPNKXASFOBE-UHFFFAOYSA-M 0.000 description 1
230000002759 chromosomal effect Effects 0.000 description 1
238000010276 construction Methods 0.000 description 1
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
235000018417 cysteine Nutrition 0.000 description 1
238000001514 detection method Methods 0.000 description 1
238000000502 dialysis Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
239000003814 drug Substances 0.000 description 1
238000000605 extraction Methods 0.000 description 1
238000001502 gel electrophoresis Methods 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
230000003834 intracellular effect Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
230000002934 lysing effect Effects 0.000 description 1
230000028744 lysogeny Effects 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
230000002101 lytic effect Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
LWJROJCJINYWOX-UHFFFAOYSA-L mercury dichloride Chemical compound Cl[Hg]Cl LWJROJCJINYWOX-UHFFFAOYSA-L 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
239000002245 particle Substances 0.000 description 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
239000013641 positive control Substances 0.000 description 1
108010056508 proteinase R Proteins 0.000 description 1
239000000523 sample Substances 0.000 description 1
239000012192 staining solution Substances 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
239000012137 tryptone Substances 0.000 description 1
238000001262 western blot Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
-1 α-amino-9-ethylcarbazole Chemical compound 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3687—Chemical treatment
- A61M1/3689—Chemical treatment by biological cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Anesthesiology (AREA)
Organic Chemistry (AREA)
Hematology (AREA)
Animal Behavior & Ethology (AREA)
Cardiology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Cell Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

SE8502162A 1985-05-03 1985-05-03 Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g SE459503B (sv)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
SE8502162A SE459503B (sv)	1985-05-03	1985-05-03	Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g
EP86104244A EP0200909A3 (fr)	1985-05-03	1986-03-27	Préparation de protéine G et/ou fragments de celle-ci
JP61102941A JPS6225981A (ja)	1985-05-03	1986-05-02	タン白ｇおよび／又はその断片の製造法
US07/376,160 US5108894A (en)	1985-05-03	1989-07-05	Protein g and/or fragments thereof

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE8502162A SE459503B (sv)	1985-05-03	1985-05-03	Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g

Publications (3)

Publication Number	Publication Date
SE8502162D0 SE8502162D0 (sv)	1985-05-03
SE8502162L SE8502162L (sv)	1986-11-04
SE459503B true SE459503B (sv)	1989-07-10

Family

ID=20360060

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8502162A SE459503B (sv)	1985-05-03	1985-05-03	Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g

Country Status (4)

Country	Link
US (1)	US5108894A (fr)
EP (1)	EP0200909A3 (fr)
JP (1)	JPS6225981A (fr)
SE (1)	SE459503B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4956296A (en) *	1987-06-19	1990-09-11	Genex Corporation	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US4954618A (en) *	1986-02-14	1990-09-04	Genex Corporation	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US4977247A (en) *	1986-02-14	1990-12-11	Genex Corporation	Immobilized protein G variants and the use thereof
US5229492A (en) *	1986-02-14	1993-07-20	Pharmacia Lkb Biotechnology Ab	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US5082773A (en) *	1986-02-14	1992-01-21	Pharmacia Lkb Biotechnology Ab	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US5312901A (en) *	1986-02-14	1994-05-17	Pharmacia Lkb Biotechnology Ab	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
EP0293391A4 (fr) *	1986-02-14	1989-06-21	Genex Corp	Genes streptococcyques clones codant la proteine g et leur utilisation pour construire des micro-organismes recombinants produisant la proteine g.
SE459662B (sv) *	1986-03-21	1989-07-24	Pharmacia Ab	Hybrid-dna-molekyl som kodar foer ett protein med samma igg specificitet som protein g, plasmid innehaallande densamma samt foerfarande foer framstaellning av proteinet
DE3780629T2 (de) *	1987-05-13	1993-03-11	Hightech Receptor Ab	Immunoglobulin-a-rezeptor-protein (arp), sowie dessen klonierung und expression.
AU623361B2 (en) *	1987-11-20	1992-05-14	Creative Biomolecules, Inc.	Selective removal of immune complexes
US5243040A (en) *	1987-11-20	1993-09-07	Creative Biomolecules	DNA encoding a protein which enables selective removal of immune complexes
SE466259B (sv)	1990-05-31	1992-01-20	Arne Forsgren	Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
SE9201331D0 (sv) *	1992-04-28	1992-04-28	Hightech Receptor C O Active	Protein l och hybridproteiner daerav
US5753227A (en) *	1993-07-23	1998-05-19	Strahilevitz; Meir	Extracorporeal affinity adsorption methods for the treatment of atherosclerosis, cancer, degenerative and autoimmune diseases
JP3908278B2 (ja) *	1996-01-25	2007-04-25	株式会社カネカ	免疫グロブリンおよびその複合体の吸着材、吸着方法、および吸着装置
WO1998030684A1 (fr)	1997-01-08	1998-07-16	Life Technologies, Inc.	Procedes de production de proteines
GB9910375D0 (en)	1999-05-05	1999-06-30	Lindahl Gunnar	Vaccine composition
US6833134B2 (en) *	2000-06-12	2004-12-21	University Of Saskacthewan	Immunization of dairy cattle with GapC protein against Streptococcus infection
US6866855B2 (en)	2000-06-12	2005-03-15	University Of Saskatchewan	Immunization of dairy cattle with GapC protein against Streptococcus infection
WO2001096379A2 (fr) *	2000-06-12	2001-12-20	University Of Saskatchewan	Immunisation de bovins laitiers a la proteine chimerique gapc contre l'infection au streptococcus
WO2005029055A1 (fr) *	2003-09-19	2005-03-31	Invitrogen Corporation	Compositions composites pour electrophorese
WO2026037175A1 (fr)	2024-08-16	2026-02-19	上海宝济药业股份有限公司	Complexe ciblant des cellules cibles et son utilisation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI64813C (fi) *	1980-12-31	1984-01-10	Ilkka Antero Palva	Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
US5151350A (en) *	1982-10-27	1992-09-29	Repligen Corporation	Cloned genes encoding recombinant protein a
US4617266A (en) *	1983-04-28	1986-10-14	Genex Corporation	Production of Protein A
SE451596B (sv) *	1983-06-22	1987-10-19	Excorim Kb	Forfarande for utvinning av protein g
US4900660A (en) *	1985-11-25	1990-02-13	University Of Florida	Streptococcal fc rc
US4956296A (en) *	1987-06-19	1990-09-11	Genex Corporation	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US4977247A (en) *	1986-02-14	1990-12-11	Genex Corporation	Immobilized protein G variants and the use thereof
US4954618A (en) *	1986-02-14	1990-09-04	Genex Corporation	Cloned streptococcal genes encoding protein G and their use to construct recombinant microorganisms to produce protein G
US4945157A (en) *	1988-05-27	1990-07-31	University Of Florida	Novel Extraction procedure for protein G

1985
- 1985-05-03 SE SE8502162A patent/SE459503B/sv not_active Application Discontinuation
1986
- 1986-03-27 EP EP86104244A patent/EP0200909A3/fr not_active Withdrawn
- 1986-05-02 JP JP61102941A patent/JPS6225981A/ja active Pending
1989
- 1989-07-05 US US07/376,160 patent/US5108894A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US5108894A (en)	1992-04-28
SE8502162L (sv)	1986-11-04
EP0200909A3 (fr)	1987-01-07
EP0200909A2 (fr)	1986-11-12
SE8502162D0 (sv)	1985-05-03
JPS6225981A (ja)	1987-02-03

Legal Events

Date	Code	Title	Description
1997-03-24	NAV	Patent application has lapsed	Ref document number: 8502162-4

Publication	Publication Date	Title
SE459503B (sv)	1989-07-10	Hybrid-dna-molekyl innefattande dna-sekvens som kodar foer protein g samt foerfarande foer framstaellning av protein g
Dao et al.	1985	Streptococcus-Escherichia coli shuttle vector pSA3 and its use in the cloning of streptococcal genes
US5151350A (en)	1992-09-29	Cloned genes encoding recombinant protein a
Kinashi et al.	1991	Physical characterization of SCP1, a giant linear plasmid from Streptomyces coelicolor
Minsavage et al.	1990	Plasmid-mediated resistance to streptomycin in Xanthomonas campestris pv. vesicatoria.
DE3390105C2 (fr)	1993-01-07
JPH0665305B2 (ja)	1994-08-24	組換えｄｎａ含有宿主細胞の安定化法
Keen et al.	1988	Isolation and characterization of a linear DNA plasmid from Streptomyces clavuligerus
US4332900A (en)	1982-06-01	Construction of co-integrate plasmids from plasmids of Streptomyces and Escherichia
Machlin et al.	1988	Genetic and physical analyses of Methylobacterium organophilum XX genes encoding methanol oxidation
JP2867374B2 (ja)	1999-03-08	百日咳毒素遺伝子
Herrera et al.	1994	Construction of a bioinsecticidal strain of Pseudomonas fluorescens active against the sugarcane borer, Eldana saccharina
US4338400A (en)	1982-07-06	Co-integrate plasmids and their construction from plasmids of Escherichia and Streptomyces
AU2437292A (en)	1993-04-05	Streptolysin o derivatives
US4340674A (en)	1982-07-20	Cointegrate plasmids and their construction from plasmids of Escherichia and Streptomyces
LeBlanc et al.	1982	Characterization of two tetracycline resistance determinants in Streptococcus faecalis JH1
EP0293391A1 (fr)	1988-12-07	Genes streptococcyques clones codant la proteine g et leur utilisation pour construire des micro-organismes recombinants produisant la proteine g
JPH06511145A (ja)	1994-12-15	ミコバクテリア内での挿入突然変異
Buck et al.	1981	Physical mapping of beta-converting and gamma-nonconverting corynebacteriophage genomes
SE459816B (sv)	1989-08-07	Vektor med stark genexpression
US4343906A (en)	1982-08-10	Hybrid plasmid of pBR322 and Streptomyces plasmid and E. coli containing same
JPH04211382A (ja)	1992-08-03	プラーク阻害表現型を付与するｄｎａ配列
CN113214364B (zh)	2022-11-22	一种多重耐药鲍曼不动杆菌识别元件的挖掘与验证
Mikesell et al.	1981	Isolation of plasmids in Legionella pneumophila and Legionella-like organisms
Johnson et al.	1982	Plasmids of serogroup 1 strains of Legionella pneumophila