SE468450B - Saett att bestaemma antikroppar mot sporozoiter fraan p. falciparum i humant blod - Google Patents

Saett att bestaemma antikroppar mot sporozoiter fraan p. falciparum i humant blod

Info

Publication number: SE468450B
Authority: SE; Sweden
Prior art keywords: enzyme; conjugate; reaction; asn; polypeptide
Prior art date: 1986-12-23

Application number

SE8705074A

Other languages

English (en)

Swedish (sv)

Other versions

SE8705074L (sv

SE8705074D0 (sv

Inventor

C A Nuzzolo

A Bernardi

A Pessi

A S Verdini

Original Assignee

Eniricerche Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-23

Filing date

1987-12-18

Publication date

1993-01-18

1987-12-18 Application filed by Eniricerche Spa filed Critical Eniricerche Spa

1987-12-18 Publication of SE8705074D0 publication Critical patent/SE8705074D0/xx

1988-06-24 Publication of SE8705074L publication Critical patent/SE8705074L/xx

1993-01-18 Publication of SE468450B publication Critical patent/SE468450B/sv

Links

210000004369 blood Anatomy 0.000 title claims description 15
239000008280 blood Substances 0.000 title claims description 15
241000223960 Plasmodium falciparum Species 0.000 title claims description 5
102000004190 Enzymes Human genes 0.000 claims description 32
108090000790 Enzymes Proteins 0.000 claims description 32
108090000765 processed proteins & peptides Proteins 0.000 claims description 26
238000000034 method Methods 0.000 claims description 24
229920001184 polypeptide Polymers 0.000 claims description 14
102000004196 processed proteins & peptides Human genes 0.000 claims description 14
102000004169 proteins and genes Human genes 0.000 claims description 13
108090000623 proteins and genes Proteins 0.000 claims description 13
238000006243 chemical reaction Methods 0.000 claims description 9
230000000694 effects Effects 0.000 claims description 7
239000000463 material Substances 0.000 claims description 6
239000000758 substrate Substances 0.000 claims description 6
230000002255 enzymatic effect Effects 0.000 claims description 5
239000007787 solid Substances 0.000 claims description 5
150000004676 glycans Chemical class 0.000 claims description 3
229920003023 plastic Polymers 0.000 claims description 3
229920001282 polysaccharide Polymers 0.000 claims description 3
239000005017 polysaccharide Substances 0.000 claims description 3
210000003046 sporozoite Anatomy 0.000 claims description 3
229920000936 Agarose Polymers 0.000 claims description 2
102000002260 Alkaline Phosphatase Human genes 0.000 claims description 2
108020004774 Alkaline Phosphatase Proteins 0.000 claims description 2
108010008038 Synthetic Vaccines Proteins 0.000 claims description 2
239000001913 cellulose Substances 0.000 claims description 2
229920002678 cellulose Polymers 0.000 claims description 2
238000002405 diagnostic procedure Methods 0.000 claims description 2
230000035484 reaction time Effects 0.000 claims 2
SWLOHUMCUDRTCL-ZLUOBGJFSA-N Asn-Ala-Asn Chemical compound C[C@@H](C(=O)N[C@@H](CC(=O)N)C(=O)O)NC(=O)[C@H](CC(=O)N)N SWLOHUMCUDRTCL-ZLUOBGJFSA-N 0.000 claims 1
230000009849 deactivation Effects 0.000 claims 1
238000001514 detection method Methods 0.000 claims 1
230000001900 immune effect Effects 0.000 claims 1
238000005259 measurement Methods 0.000 claims 1
239000000562 conjugate Substances 0.000 description 22
210000002966 serum Anatomy 0.000 description 14
239000000243 solution Substances 0.000 description 13
201000004792 malaria Diseases 0.000 description 11
102000003992 Peroxidases Human genes 0.000 description 9
238000012360 testing method Methods 0.000 description 9
239000000203 mixture Substances 0.000 description 8
238000011161 development Methods 0.000 description 7
150000001413 amino acids Chemical class 0.000 description 5
108040007629 peroxidase activity proteins Proteins 0.000 description 4
239000011541 reaction mixture Substances 0.000 description 4
JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000000872 buffer Substances 0.000 description 3
230000021615 conjugation Effects 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
239000007974 sodium acetate buffer Substances 0.000 description 3
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
238000002965 ELISA Methods 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
239000000427 antigen Substances 0.000 description 2
102000036639 antigens Human genes 0.000 description 2
108091007433 antigens Proteins 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
108010074605 gamma-Globulins Proteins 0.000 description 2
239000011491 glass wool Substances 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
239000008363 phosphate buffer Substances 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
238000002798 spectrophotometry method Methods 0.000 description 2
101710117490 Circumsporozoite protein Proteins 0.000 description 1
-1 E-P compound Chemical class 0.000 description 1
238000004566 IR spectroscopy Methods 0.000 description 1
108060003951 Immunoglobulin Proteins 0.000 description 1
102000035195 Peptidases Human genes 0.000 description 1
108091005804 Peptidases Proteins 0.000 description 1
108700020962 Peroxidase Proteins 0.000 description 1
239000004365 Protease Substances 0.000 description 1
229920002684 Sepharose Polymers 0.000 description 1
238000005903 acid hydrolysis reaction Methods 0.000 description 1
230000002411 adverse Effects 0.000 description 1
102000005840 alpha-Galactosidase Human genes 0.000 description 1
108010030291 alpha-Galactosidase Proteins 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
239000003593 chromogenic compound Substances 0.000 description 1
238000003745 diagnosis Methods 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000011841 epidemiological investigation Methods 0.000 description 1
230000002008 hemorrhagic effect Effects 0.000 description 1
102000018358 immunoglobulin Human genes 0.000 description 1
229940072221 immunoglobulins Drugs 0.000 description 1
239000012528 membrane Substances 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
125000000896 monocarboxylic acid group Chemical group 0.000 description 1
150000007530 organic bases Chemical group 0.000 description 1
230000001590 oxidative effect Effects 0.000 description 1
239000000863 peptide conjugate Substances 0.000 description 1
239000002798 polar solvent Substances 0.000 description 1
230000000379 polymerizing effect Effects 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000000941 radioactive substance Substances 0.000 description 1
239000002994 raw material Substances 0.000 description 1
238000012216 screening Methods 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000005406 washing Methods 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56905—Protozoa
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/947—Microorganisms using protozoa
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/807—Apparatus included in process claim, e.g. physical support structures
- Y10S436/808—Automated or kit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/828—Protein A

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Urology & Nephrology (AREA)
Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Biotechnology (AREA)
Pathology (AREA)
General Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Microbiology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Analytical Chemistry (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

SE8705074A 1986-12-23 1987-12-18 Saett att bestaemma antikroppar mot sporozoiter fraan p. falciparum i humant blod SE468450B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT22817/86A IT1198233B (it)	1986-12-23	1986-12-23	Metodo per la determinazione di anticorpi antisporozoita di p. falciparum nel sangue umano

Publications (3)

Publication Number	Publication Date
SE8705074D0 SE8705074D0 (sv)	1987-12-18
SE8705074L SE8705074L (sv)	1988-06-24
SE468450B true SE468450B (sv)	1993-01-18

Family

ID=11200776

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8705074A SE468450B (sv)	1986-12-23	1987-12-18	Saett att bestaemma antikroppar mot sporozoiter fraan p. falciparum i humant blod

Country Status (16)

Country	Link
US (1)	US4977079A (fr)
AR (1)	AR241963A1 (fr)
AT (1)	AT397581B (fr)
BE (1)	BE1000850A3 (fr)
CA (1)	CA1299101C (fr)
CH (1)	CH677032A5 (fr)
DE (1)	DE3743903A1 (fr)
ES (1)	ES2005766A6 (fr)
FR (1)	FR2608767B1 (fr)
GB (1)	GB2199140B (fr)
GR (1)	GR871991B (fr)
IT (1)	IT1198233B (fr)
NL (1)	NL8703102A (fr)
OA (1)	OA08792A (fr)
SE (1)	SE468450B (fr)
ZA (1)	ZA879621B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1217582B (it) *	1988-05-13	1990-03-30	Eniricerche Spa	Metodo immunoenzimatico in fase omogenea per la determinazione di anticorpi antisporozoita di plasmodium falciparum nel sangue umano
IT1226712B (it) *	1988-08-05	1991-02-05	Eniricerche Spa	Metodo immunoenzimatico elisa monopiastra con inibizione competitiva per la rivelazione di anticorpi antisporozoitari di plasmodium falciparum.
US5231168A (en) *	1988-09-16	1993-07-27	Statens Seruminstitut	Malaria antigen
ATE114158T1 (de) *	1989-05-19	1994-12-15	Eniricerche Spa	Immunogen-verbindungen und deren benutzung in der herstellung von genetisch unbeschränkten synthetischen impfstoffen und bei der immunoenzymatischer bestimmung von antisporozoiden antikörpern von plasmodium malariae.
US5124141A (en) *	1990-06-14	1992-06-23	Flow Incorporated	Method for diagnosing malaria
US5830772A (en) *	1995-09-08	1998-11-03	United Microelectronicscorp.	Method for fabricating isolating regions for buried conductors
US6514731B1 (en)	1996-05-24	2003-02-04	Chiron Corporation	Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens
US6153394A (en) *	1998-09-18	2000-11-28	Board Of Trustees Operating Michigan State University	Immunoassay for equine protozoal myeloencephalitis in horses

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2322533C2 (de) *	1972-11-06	1986-08-28	Pharmacia AB, Uppsala	Verfahren zum Binden von Immunoglobulin und Hilfsmittel zur Durchführung des Verfahrens
US3966898A (en) *	1973-06-28	1976-06-29	Pharmacia Diagnostics Ab	Method and reagent for determining immunologic materials
EP0111216A3 (fr) *	1980-03-31	1985-01-16	Takeda Chemical Industries, Ltd.	Méthode pour essai immunoenzymatique, conjugué peptide-enzyme, son lyophilisat, anticorps et trousse de réactifs
US4659678A (en) *	1982-09-29	1987-04-21	Serono Diagnostics Limited	Immunoassay of antigens
US4591552A (en) *	1982-09-29	1986-05-27	New York Blood Center, Inc.	Detection of hepatitis B surface antigen (or antibody to same) with labeled synthetic peptide
DE3382194D1 (de) *	1982-12-27	1991-04-11	Pasteur Institut	Polypeptidfraktionen die gegen malariaparasiten schuetzende antikoerper induzieren und dieselben enthaltende immunogene zusammensetzungen.
DE3346795A1 (de) *	1983-12-23	1985-07-04	E. Prof. Dr. 3550 Marburg Geyer	Enzymimmunoassay und entsprechendes diagnostikum
US4707357A (en) *	1984-06-26	1987-11-17	The United States Of America As Represented By The Secretary Of The Army	Immunologically active peptides capable of inducing immunization against malaria and genes encoding therefor
ZA855232B (en) *	1984-07-23	1986-02-26	Univ New York	Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein
ZA856655B (en) *	1984-09-12	1986-04-30	Univ New York	Cross-reactive and protective epitopes of circumsporozoite proteins
IT1187710B (it) *	1985-07-25	1987-12-23	Eniricerche Spa	Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche
FR2589062B1 (fr) *	1985-10-28	1990-05-04	Inst Nat Sante Rech Med	Antigenes obtenus a partir de la phase intraerythrocytaire de plasmodium falciparum, leur purification, leur dosage ainsi que celui de leurs anticorps, et vaccins contre le paludisme les renfermant
IT1198225B (it) *	1986-12-04	1988-12-21	Eniricerche Spa	Polipeptidi immunologicamente attivi utili per la preparazione di vaccini antimalaria e di kits diagnostici per la determinazione di anticorpi antisporozoita

1986
- 1986-12-23 IT IT22817/86A patent/IT1198233B/it active
1987
- 1987-12-17 US US07/134,229 patent/US4977079A/en not_active Expired - Fee Related
- 1987-12-18 SE SE8705074A patent/SE468450B/sv unknown
- 1987-12-21 CH CH5001/87A patent/CH677032A5/it not_active IP Right Cessation
- 1987-12-22 AT AT0338987A patent/AT397581B/de not_active IP Right Cessation
- 1987-12-22 ZA ZA879621A patent/ZA879621B/xx unknown
- 1987-12-22 GR GR871991A patent/GR871991B/el unknown
- 1987-12-22 NL NL8703102A patent/NL8703102A/nl not_active Application Discontinuation
- 1987-12-23 DE DE19873743903 patent/DE3743903A1/de active Granted
- 1987-12-23 AR AR87309697A patent/AR241963A1/es active
- 1987-12-23 GB GB8729975A patent/GB2199140B/en not_active Expired - Lifetime
- 1987-12-23 ES ES8800193A patent/ES2005766A6/es not_active Expired
- 1987-12-23 CA CA000555290A patent/CA1299101C/fr not_active Expired - Lifetime
- 1987-12-23 FR FR878718090A patent/FR2608767B1/fr not_active Expired - Lifetime
- 1987-12-23 OA OA59253A patent/OA08792A/xx unknown
- 1987-12-23 BE BE8701477A patent/BE1000850A3/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
FR2608767B1 (fr)	1991-04-05
GR871991B (en)	1988-03-23
FR2608767A1 (fr)	1988-06-24
IT1198233B (it)	1988-12-21
DE3743903C2 (fr)	1990-08-23
AT397581B (de)	1994-05-25
ATA338987A (de)	1993-09-15
GB8729975D0 (en)	1988-02-03
DE3743903A1 (de)	1988-07-07
GB2199140B (en)	1990-08-29
CH677032A5 (fr)	1991-03-28
OA08792A (en)	1989-03-31
ZA879621B (en)	1988-06-17
AR241963A1 (es)	1993-01-29
GB2199140A (en)	1988-06-29
US4977079A (en)	1990-12-11
NL8703102A (nl)	1988-07-18
SE8705074L (sv)	1988-06-24
IT8622817A0 (it)	1986-12-23
SE8705074D0 (sv)	1987-12-18
ES2005766A6 (es)	1989-03-16
BE1000850A3 (fr)	1989-04-18
CA1299101C (fr)	1992-04-21

Legal Events

Date

Code

Title

Description

1995-01-31

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Maizels et al.	1987	Phosphorylcholine‐bearing antigens in filarial nematode parasites: analysis of somatic extracts, in‐vitro secretions and infection sera from Brugia malayi and B. pahangi
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CA1279818C (fr)	1991-02-05	Test pour la detection des anticorps contre certains micro-organismes
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