SE500941C2 - Förfarande och apparat för snittning av ett preparat - Google Patents
Förfarande och apparat för snittning av ett preparatInfo
- Publication number
- SE500941C2 SE500941C2 SE8902751A SE8902751A SE500941C2 SE 500941 C2 SE500941 C2 SE 500941C2 SE 8902751 A SE8902751 A SE 8902751A SE 8902751 A SE8902751 A SE 8902751A SE 500941 C2 SE500941 C2 SE 500941C2
- Authority
- SE
- Sweden
- Prior art keywords
- sectioning
- slicing
- microtome
- parameter
- knife
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 12
- 238000005520 cutting process Methods 0.000 title claims description 21
- 238000002360 preparation method Methods 0.000 title claims description 18
- 230000001419 dependent effect Effects 0.000 claims abstract description 5
- 238000005457 optimization Methods 0.000 claims description 13
- 239000000470 constituent Substances 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims 1
- 230000003287 optical effect Effects 0.000 abstract 2
- 238000011156 evaluation Methods 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 4
- 238000013459 approach Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 241000078511 Microtome Species 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000004804 winding Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
- G01N2001/065—Drive details
- G01N2001/066—Drive details electric
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/06—Devices for withdrawing samples in the solid state, e.g. by cutting providing a thin slice, e.g. microtome
- G01N2001/068—Illumination means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/04—Processes
- Y10T83/0405—With preparatory or simultaneous ancillary treatment of work
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/141—With means to monitor and control operation [e.g., self-regulating means]
- Y10T83/145—Including means to monitor product
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T83/00—Cutting
- Y10T83/162—With control means responsive to replaceable or selectable information program
- Y10T83/173—Arithmetically determined program
- Y10T83/175—With condition sensor
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8902751A SE500941C2 (sv) | 1989-08-16 | 1989-08-16 | Förfarande och apparat för snittning av ett preparat |
| AU61888/90A AU635959B2 (en) | 1989-08-16 | 1990-08-15 | A method of and an apparatus for sectioning a specimen |
| AT90912312T ATE117076T1 (de) | 1989-08-16 | 1990-08-15 | Vorrichtung und verfahren zum schneiden eines specimens. |
| PCT/SE1990/000527 WO1991002960A1 (fr) | 1989-08-16 | 1990-08-15 | Methode et appareil pour sectionner un specimen au moyen d'un microtome |
| DE69016028T DE69016028T2 (de) | 1989-08-16 | 1990-08-15 | Vorrichtung und verfahren zum schneiden eines specimens. |
| US07/829,067 US5609083A (en) | 1989-08-16 | 1990-08-15 | Method of and an apparatus for sectioning a specimen |
| JP51244790A JP3003216B2 (ja) | 1989-08-16 | 1990-08-15 | 試料を細断する方法および装置 |
| CA 2059545 CA2059545C (fr) | 1989-08-16 | 1990-08-15 | Methode et appareil permettant de decouper un specimen |
| EP19900912312 EP0486571B1 (fr) | 1989-08-16 | 1990-08-15 | Methode et appareil pour sectionner un specimen au moyen d'un microtome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8902751A SE500941C2 (sv) | 1989-08-16 | 1989-08-16 | Förfarande och apparat för snittning av ett preparat |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8902751D0 SE8902751D0 (sv) | 1989-08-16 |
| SE8902751L SE8902751L (sv) | 1991-02-17 |
| SE500941C2 true SE500941C2 (sv) | 1994-10-03 |
Family
ID=20376679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8902751A SE500941C2 (sv) | 1989-08-16 | 1989-08-16 | Förfarande och apparat för snittning av ett preparat |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5609083A (fr) |
| EP (1) | EP0486571B1 (fr) |
| JP (1) | JP3003216B2 (fr) |
| AT (1) | ATE117076T1 (fr) |
| AU (1) | AU635959B2 (fr) |
| CA (1) | CA2059545C (fr) |
| DE (1) | DE69016028T2 (fr) |
| SE (1) | SE500941C2 (fr) |
| WO (1) | WO1991002960A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07109384B2 (ja) * | 1991-08-29 | 1995-11-22 | プリマハム株式会社 | 試料面切り出し装置を具備する自動検査装置 |
| US5678465A (en) * | 1996-06-10 | 1997-10-21 | Krumdieck; Carlos | Tissue slice thickness measuring apparatus and method |
| US6330348B1 (en) * | 1999-01-21 | 2001-12-11 | Resolution Sciences Corporation | Method and apparatus for measurement of microtome performance |
| DE19911173C2 (de) * | 1999-03-12 | 2002-01-31 | Leica Microsystems | Mikrotom mit einem motorischen Zustellantrieb |
| DE19911005A1 (de) * | 1999-03-12 | 2000-09-28 | Leica Microsystems | Verfahren zur Steuerung eines Scheibenmikrotoms |
| DE10258555B4 (de) * | 2002-12-14 | 2005-04-28 | Leica Mikrosysteme Gmbh Wien | Verfahren und System zum Anstellen und Schneiden eines Präparaten in einer Schneideeinrichtung |
| DE502004009529D1 (de) * | 2003-05-02 | 2009-07-09 | Meyer & Co Ag Anton | Halterung mit einem oszillierbar bewegbaren messer eines ultramikrotoms |
| US7677289B2 (en) | 2004-07-08 | 2010-03-16 | President And Fellows Of Harvard College | Methods and apparatuses for the automated production, collection, handling, and imaging of large numbers of serial tissue sections |
| US7437984B2 (en) | 2004-12-10 | 2008-10-21 | Boeckeler Instruments Inc. | Microtome and ultramicrotome with improved carrier arm |
| JP4548357B2 (ja) * | 2006-02-13 | 2010-09-22 | セイコーインスツル株式会社 | 自動薄切片標本作製装置及び自動薄切片標本作製方法 |
| JP4548356B2 (ja) * | 2006-02-13 | 2010-09-22 | セイコーインスツル株式会社 | 自動薄切片標本作製装置及び自動薄切片標本作製方法 |
| WO2008066846A2 (fr) * | 2006-11-28 | 2008-06-05 | President And Fellows Of Harvard College | Procédé et appareil permettant d'obtenir et de traiter des tranches minces de tissu |
| EP2009419B1 (fr) * | 2007-06-25 | 2009-12-23 | Milestone S.r.l. | Mesure de l'épaisseur d'échantillons organiques |
| US8839700B2 (en) * | 2010-06-23 | 2014-09-23 | Tissuevision, Inc. | Oscillating microtome with flexure drive |
| WO2012028524A2 (fr) | 2010-08-30 | 2012-03-08 | F. Hoffmann-La Roche Ag | Procédé de production d'une particule lipidique, particule lipidique elle-même et son utilisation |
| EP2614376B1 (fr) | 2010-09-07 | 2022-11-02 | President and Fellows of Harvard College | Procédés et systèmes pour collecter des sections de tissu |
| US8869666B2 (en) | 2011-03-24 | 2014-10-28 | Sakura Finetek U.S.A., Inc. | Microtome with surface orientation sensor to sense orientation of surface of sample |
| DE102011116555A1 (de) * | 2011-10-21 | 2013-04-25 | Microm International Gmbh | Verfahren und Vorrichtung zur Überwachung einer Mikrotom-Schneideeinrichtung |
| DE102011119719A1 (de) * | 2011-11-30 | 2013-06-06 | GEA CFS Bühl GmbH | Verfahren zum Aufschneiden eines Lebensmittelriegels unter Verwendung eines Schwingungssensors |
| US9032854B2 (en) | 2011-12-21 | 2015-05-19 | Sakura Finetek U.S.A., Inc. | Reciprocating microtome drive system |
| CA2863108A1 (fr) | 2012-02-29 | 2013-09-06 | F. Hoffmann-La Roche Ag | Procede de reduction des dephasages 1->3 du cadre de lecture |
| RU2014137623A (ru) | 2012-02-29 | 2016-04-20 | Ф. Хоффманн-Ля Рош Аг | Колоночное ферментативное расщепление |
| CN103522347B (zh) * | 2013-10-12 | 2016-04-20 | 沈阳誉德电子仪器有限公司 | 一种自动对刀系统 |
| CN108871843B (zh) * | 2018-07-31 | 2023-12-01 | 金华克拉泰仪器有限公司 | 一种病理切片机的信号采集装置 |
| DE102019119514A1 (de) * | 2019-07-18 | 2021-01-21 | Leica Biosystems Nussloch Gmbh | Mikrotom |
| KR102254822B1 (ko) * | 2020-12-22 | 2021-05-24 | 한국기초과학지원연구원 | 3차원 이미징용 울트라 마이크로톰 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3937564A (en) * | 1970-08-28 | 1976-02-10 | Lkb-Produkter Ab | Method for trimming of a specimen for a microtome |
| SE349862B (fr) * | 1971-06-30 | 1972-10-09 | Lkb Produkter Ab | |
| DE3127266C2 (de) * | 1981-07-10 | 1984-05-30 | Bernhard Dr. 7801 Buchenbach Wolf | Mikrotom |
| SE431682B (sv) * | 1982-06-28 | 1984-02-20 | Lkb Produkter Ab | Forfarande for att vid en mikrotom mojliggora att spalten mellan knivegg och preparat kan goras ytterst smal |
| GB2130740B (en) * | 1982-11-19 | 1986-08-06 | Anthony George Atkins | Microtomy |
| EP0209369A3 (fr) * | 1985-07-16 | 1988-07-06 | Russell Lee Kerschmann | Dispositif d'enregistrement d'images |
| DE3615715A1 (de) * | 1986-05-09 | 1987-11-12 | Bernhard Dr Wolf | Mikrotom |
| DE3830725A1 (de) * | 1988-09-09 | 1990-03-22 | Leitz Wild Gmbh | Automatische arretierung der antriebseinrichtung eines mikrotoms |
| DE3906091A1 (de) * | 1989-02-27 | 1990-08-30 | Wacker Chemitronic | Verfahren zum zersaegen von stabfoermigen werkstuecken in scheiben mittels innenlochsaege, sowie innenlochsaegen zu seiner durchfuehrung |
| AT399226B (de) * | 1990-04-11 | 1995-04-25 | Sitte Hellmuth | Automatische anschneidevorrichtung für mikrotome, insbesondere ultramikrotome |
-
1989
- 1989-08-16 SE SE8902751A patent/SE500941C2/sv not_active IP Right Cessation
-
1990
- 1990-08-15 CA CA 2059545 patent/CA2059545C/fr not_active Expired - Fee Related
- 1990-08-15 WO PCT/SE1990/000527 patent/WO1991002960A1/fr not_active Ceased
- 1990-08-15 EP EP19900912312 patent/EP0486571B1/fr not_active Expired - Lifetime
- 1990-08-15 AU AU61888/90A patent/AU635959B2/en not_active Ceased
- 1990-08-15 US US07/829,067 patent/US5609083A/en not_active Expired - Fee Related
- 1990-08-15 DE DE69016028T patent/DE69016028T2/de not_active Expired - Fee Related
- 1990-08-15 AT AT90912312T patent/ATE117076T1/de not_active IP Right Cessation
- 1990-08-15 JP JP51244790A patent/JP3003216B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1991002960A1 (fr) | 1991-03-07 |
| SE8902751D0 (sv) | 1989-08-16 |
| JP3003216B2 (ja) | 2000-01-24 |
| EP0486571B1 (fr) | 1995-01-11 |
| JPH04507296A (ja) | 1992-12-17 |
| AU6188890A (en) | 1991-04-03 |
| EP0486571A1 (fr) | 1992-05-27 |
| ATE117076T1 (de) | 1995-01-15 |
| DE69016028D1 (de) | 1995-02-23 |
| CA2059545A1 (fr) | 1991-02-17 |
| AU635959B2 (en) | 1993-04-08 |
| US5609083A (en) | 1997-03-11 |
| CA2059545C (fr) | 2000-02-29 |
| SE8902751L (sv) | 1991-02-17 |
| DE69016028T2 (de) | 1995-06-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |