SE501183C2 - Matrix composition for tissue strengthening and / or filling - Google Patents

Matrix composition for tissue strengthening and / or filling

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Publication number
SE501183C2
SE501183C2 SE9300852A SE9300852A SE501183C2 SE 501183 C2 SE501183 C2 SE 501183C2 SE 9300852 A SE9300852 A SE 9300852A SE 9300852 A SE9300852 A SE 9300852A SE 501183 C2 SE501183 C2 SE 501183C2
Authority
SE
Sweden
Prior art keywords
matrix composition
matrix
tissue
membrane
composition according
Prior art date
Application number
SE9300852A
Other languages
Swedish (sv)
Other versions
SE9300852L (en
SE9300852D0 (en
Inventor
Bengt Aagerup
Original Assignee
Medinvent Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medinvent Sa filed Critical Medinvent Sa
Priority to SE9300852A priority Critical patent/SE501183C2/en
Publication of SE9300852D0 publication Critical patent/SE9300852D0/en
Priority to EP94910629A priority patent/EP0689464A1/en
Priority to PCT/SE1994/000222 priority patent/WO1994021307A1/en
Priority to AU62944/94A priority patent/AU6294494A/en
Publication of SE9300852L publication Critical patent/SE9300852L/en
Publication of SE501183C2 publication Critical patent/SE501183C2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L35/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical, and containing at least one other carboxyl radical in the molecule, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L35/02—Homopolymers or copolymers of esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/04—Homopolymers or copolymers of monomers containing heterocyclic rings having nitrogen as ring member
    • C08L39/06—Homopolymers or copolymers of N-vinyl-pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/04—Alginic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

The present invention relates to a matrix composition comprising a fibre of degradable biocompatible polymer. The matrix composition is rigid enough at 37 DEG C to hold against a negative tissue pressure of at least 2 cm H2O and at the most 50 cm H2O, and elastic enough to regain its shape after mechanical deformation. The matrix composition is used for tissue reinforcement nad/or filling.

Description

501 183 2 följande exempel utgör en rätt utformad matrixfiber en nära nog idealisk lösning på dessa problem. 501 183 2 the following example is a properly formed matrix fiber one close enough ideal solution to these problems.

Föreliggande uppfinning aktualiserades i samband med att ett stort antal problem uppstod på grund av att kommersiellt tillgängliga men mindre lämpliga lösningar användes.The present invention was brought to light in connection with a large number of problems arose due to commercial available but less suitable solutions were used.

En tillverkare av membran rekommenderade användning av prefabri- cerade distanser att läggas mellan benkanten och ett för ändamålet fabricerat membran för erhållande av benförstoring.A membrane manufacturer recommended the use of prefabricated distances to be laid between the leg edge and one for purpose fabricated membrane for obtaining bone augmentation.

Inom tre veckor hade distansen penetrerat membranet som låg tätt mot benytan med uteblivet resultat som följd.Within three weeks, the spacer had penetrated the membrane, which was tight against the benefit with no result as a result.

Vid ett annat tillfälle utfördes följande ingrepp. En tunn fiber av polymeriserad smörsyra vilken utformats som en bomullssnodd lades in under ett membran som anbringats som ett lock över ett operationshål i skallbenet i samband med att en tumör avlägsnats i hjärnan. Efter två veckor hade mellanrummet mellan membranet och hjärnhinnan resorberats och en fibrös svål hade börjat utvecklats. Tre månader senare hade fortfarande inget ben formats.On another occasion, the following procedures were performed. A thin fiber of polymerized butyric acid which is designed as a cotton cord was placed under a membrane applied as a lid over one surgical holes in the skull in connection with the removal of a tumor in the brain. After two weeks, the gap between the membrane had and the meninges were resorbed and a fibrous rash had begun developed. Three months later still had no legs formats.

I samband med att en bencysta på lårbenet behandlats lades ett armerat hårt membran som ett lock över den sanerade cystan. Vid uppföljning med röntgen sex månader senare hade ingen normalise- ring inträffat. Membranet kunde palperas 7 cm distalt om cystan.In connection with a bone cyst on the femur being treated, one was placed reinforced hard membrane as a cover over the decontaminated cyst. At follow-up with an X-ray six months later, no normalization call occurred. The membrane could be palpated 7 cm distal to the cyst.

Tolkningen av ovanstående försök är att: a. matrix måste vara tillräckligt rigid för att motverka vävnadstryckets negativa påverkan, men tillräckligt mjukt för att följa med i vävnadernas naturliga rörelser. b. ett hårt membran utan matrix kommer i normalfallet att riskera att vandra i vävnaden - alternativt måste en avancerad förankring utföras med därvid tillhöriga olägen- heter . 501 183 3 Föreliggande uppfinning löser' ovanstående problem genom att tillhandahålla en matrixkomposition innefattande en fiber av företrädesvis nedbrytbar biokompatibel polymer. Kompositionen karaktäriseras av att den är tillräckligt styv vid 37°C för att hålla mot ett negativt vävnadstryck av minst 2 cm Hgü och högst 50 cm F50 och tillräckligt elastiskt för att återtaga sin form efter mekanisk deformation. Matrixen utformas för att vara tillräckligt följsam mot vävnaden. Det negativa vätsketrycket, som matrixen ska hålla mot, får inte ligga under det normala, negativa vätsketrycket i kroppen, dvs. ca. 0,5-5 cm H¿L Sökanden har funnit att ett negativt vätsketryck på 2 cm H§)är en lämplig undre gräns för de flesta tillämpningar. Inte heller får det negativa vätsketrycket, som matrixen ska hålla mot, vara högre än ca 50 cm H20 eftersom detta ger en för hård matrix som penetrerar vävnaden och börjar att vandra.The interpretation of the above experiments is that: a. matrix must be sufficiently rigid to counteract negative effect of tissue pressure, but soft enough to follow the natural movements of the tissues. b. a hard membrane without a matrix will normally be risk wandering in the tissue - alternatively one must advanced anchoring is performed with associated inconveniences called . 501 183 3 The present invention solves the above problems by provide a matrix composition comprising a fiber of preferably degradable biocompatible polymer. The composition characterized in that it is sufficiently rigid at 37 ° C to withstand a negative tissue pressure of at least 2 cm Hgü and at most 50 cm F50 and elastic enough to regain its shape after mechanical deformation. The matrix is designed to be sufficiently compliant with the tissue. The negative fluid pressure, which the matrix must withstand must not be below normal, negative fluid pressure in the body, ie. ca. 0.5-5 cm HÃL Applicant have found that a negative liquid pressure of 2 cm H§) is a suitable one lower limit for most applications. Nor does it get it negative fluid pressure, which the matrix must withstand, be higher than about 50 cm H 2 O because this gives a too hard matrix which penetrates the tissue and begins to migrate.

Enligt en annan utföringsform av uppfinningen innehåller kompositionen terapeutiskt aktiva ämnen, t ex. farmakologiskt aktiva ämnen såsom tillväxtmodifierande, bakteriostatiska och cytostatiska ämnen, lämpliga kombinationer därav eller andra för situationen lämpliga ämnen.According to another embodiment of the invention contains the composition therapeutically active substances, e.g. pharmacologically active substances such as growth modifiers, bacteriostatic and cytostatic agents, suitable combinations thereof or others for situation appropriate substances.

Uppfinningen kommer att beskrivas nedan i anslutning till några icke begränsande exempel.The invention will be described below in connection with some non-limiting examples.

EXEMPEL 1 För att fylla ut en grop orsakad av en gammal vaccination på överarmen hos en ung kvinna öppnades huden, det skadade hudav- snittet avlägsnades och underhudsvävnaden fylldes ut med en matrix tillverkad av bovina kollagenfibrer vilka tidigare strålsteriliserats så att rätt egenskaper erhållits. Läkningen skedde utan komplikationer och en naturlig vävnad hade utvecklats vid kontroll tre månader senare.EXAMPLE 1 To fill a pit caused by an old vaccination on the upper arm of a young woman opened the skin, the damaged skin the incision was removed and the subcutaneous tissue was filled in with one matrix made from bovine collagen fibers which previously radiation sterilized so that the right properties are obtained. The healing occurred without complications and a natural tissue had developed at check-in three months later.

Kollagenmaterialet uppvisade följande egenskaper "in vitro" i fysiologisk saltlösning vid 37°C efter 24 timmars inkubation. 501 183 4 Bärkraft: 8 cm IQO. Tid för återgång efter 50% deformation: 7 minuter.The collagen material exhibited the following properties "in vitro" in physiological saline at 37 ° C after 24 hours of incubation. 501 183 4 Load capacity: 8 cm IQO. Time to return after 50% deformation: 7 minutes.

EXEMPEL 2 En äldre kvinna hade förlorat en större del av alveolarbenets kant och börjat få problemlmed att hålla tandprotesen. Slemhinnan öppnades och små hål borrades så att kontakt med benmärgen upprättades. En ås utgörande av extruderad laktidpolymer-matrix anbringades och över matrixen lades ett membran av en copolymer av laktid/glykolid belagd med ett tunt skikt av inkapslad vävnadstillväxtfaktor TGF-Bl så att den helt täcktes. Protesen utformades så att en utsparning förhindrade ett konstant tryck över operationsområdet initialt.EXAMPLE 2 An elderly woman had lost a large part of her alveolar bone edge and started to have problems with holding the denture. The mucous membrane was opened and small holes were drilled to contact the bone marrow was established. A ridge consisting of extruded lactide polymer matrix was applied and over the matrix was placed a membrane of a copolymer of lactide / glycolide coated with a thin layer of encapsulated tissue growth factor TGF-β1 so that it was completely covered. The prosthesis was designed so that a recess prevented a constant pressure over the operating area initially.

Efter tre månader kunde en hård vävnad palperas. Efter sex månader förelåg en benpålagring, vilken ett år efter operationen fortfarande bibehöll sin form.After three months, a hard tissue could be palpated. After sex months there was a bone deposition, which one year after the operation still retained its shape.

In vitro mätningar på matrix 24 timmar efter inkubation i 37°C vatten visade en bärkraft av 22 cm P50 och en återgång till ursprungsformen efter en 50% kompression på 4 minuter.In vitro measurements on matrix 24 hours after incubation at 37 ° C water showed a bearing capacity of 22 cm P50 and a return to the original form after a 50% compression of 4 minutes.

EXEMPEL 3 I samband med planering för fixturimplantation uppdagades att benkanten var för tunn för att helt täcka en fixtur. I samband med dess applicering lades matrix enligt uppfinningen och membran över de blottade gängorna på båda sidor av benkanten.EXAMPLE 3 In connection with planning for fixture implantation, it was discovered that the leg edge was too thin to completely cover a fixture. Associated with its application, matrix according to the invention and membrane were added over the exposed threads on both sides of the leg edge.

Efter sex månader öppnades slemhinnan över den s.k. täckskruven och vid inspektion av området befanns hård benvävnad ha ut- vecklats över och mot fixturen. Efter ytterligare sex månader var fixturen fortfarande fast förankrad och benpålagringen intakt. 501 183 5 Matrix var vid "in vitro“ kontroll efter inkubationen i 37°C vatten under 24 timmar. Bärkraft: 18 cm Hg). Återgång efter 50% kompression: 2 minuter.After six months, the mucosa over the so-called the cover screw and upon inspection of the area, hard bone tissue was found to have folded over and against the fixture. After another six months each the fixture is still firmly anchored and the bone bearing is intact. 501 183 5 Matrix was at "in vitro" control after incubation at 37 ° C water for 24 hours. Load capacity: 18 cm Hg). Return after 50% compression: 2 minutes.

EXEMPEL 4 I samband med rekonstruktion av skallbenet efter en trafikskada önskade man regenerera skallbenet på främre sidans vänstra kant.EXAMPLE 4 In connection with the reconstruction of the skull after a traffic injury wanted to regenerate the skull on the left edge of the front side.

En rå bindväv hade utvecklats och efter två år hade ingen benutveckling inträffat.A raw connective tissue had developed and after two years no one had bone development occurred.

En spalt, 20 mm lång och 6 mm bred behövde överbryggas med ben.A gap, 20 mm long and 6 mm wide, needed to be bridged with legs.

Den råa bindväven avlägsnades och kontakt med intakt benyta samt benmärg etablerades.The crude connective tissue was removed and contact with intact bone surface as well bone marrow was established.

Spalter fylldes med polyaktid matrix och ett copolymer membran (enligt Exempel 2) lades även så att det täckte spalter med 10 mm överlappning. Membranet fästes och fixerades med ett ned- brytbart cement av copolymer. Vid kontroll av benvävnaden senare befanns spalten fylld med benliknande hård vävnad medan övrig rå bindväv var intakt.Gaps were filled with polyactide matrix and a copolymer membrane (according to Example 2) was also laid so that it covered gaps with 10 mm overlap. The membrane was attached and fixed with a breakable cement of copolymer. When checking the bone tissue later the gap was filled with bone-like hard tissue while the rest was raw connective tissue was intact.

I ovanstående Exempel 2-4 och i andra fall då matrixen behöver täckas Över, kan kroppseget såväl som för detta ändamål special- tillverkat material användas. Företrädesvis används i det senare fallet ett membran och ett tätningsmedel av biologiskt nedbrytbar typ såsom beskrivs i sökandens internationella patentansökning publicerings nr WO93/00936.In the above Examples 2-4 and in other cases when the matrix needs covered, the body itself as well as for this purpose can be specially manufactured material can be used. Preferably used in the latter case a membrane and a sealant of biodegradable type as described in the applicant's international patent application Publication No. WO93 / 00936.

Claims (6)

501 183 PATENTKRAV501 183 PATENT REQUIREMENTS 1. Matrixkomposition k ä n n e t e c k n a d av att den innefattar en fiber av nedbrytbar biokompatibel polymer som är tillräckligt styv vid 37°C för att hålla mot ett negativt vävnadstryck av minst 2 cm }gO och högst 50 cm P50 och till- räckligt elastisk för att àtertaga sin form efter mekanisk deformation.Matrix composition characterized in that it comprises a fiber of degradable biocompatible polymer which is sufficiently rigid at 37 ° C to withstand a negative tissue pressure of not less than 2 cm} gO and not more than 50 cm P50 and sufficiently elastic to absorb its shape after mechanical deformation. 2. Matrixkomposition enligt krav 1, k ä n n e t e c k n a d av att polymeren är kollagen eller polylaktid.Matrix composition according to claim 1, characterized in that the polymer is collagen or polylactide. 3. Matrixkomposition enligt krav 1 eller 2, k ä n n e t e c k - n a d av att den innefattar ett nedbrytbart polymermembran.A matrix composition according to claim 1 or 2, characterized in that it comprises a degradable polymeric membrane. 4. Membran enligt krav 3, k ä n n e t e c k n a d av att den innefattar ett nedbrytbart polymerklister.A membrane according to claim 3, characterized in that it comprises a degradable polymer adhesive. 5. Matrixkomposition enligt krav 1, k ä n n e t e c k n a d a v att den dessutom innefattar terapeutiskt aktiva ämnen.A matrix composition according to claim 1, characterized in that it further comprises therapeutically active substances. 6. Matrixkomposition enligt krav 5, k ä n n e t e c k n a d av att det aktiva ämnet är valt band gruppen bestående av tillväxtmodifierande, bakteriostatiska och cytostatiska ämnen eller lämpliga kombinationer därav.Matrix composition according to claim 5, characterized in that the active substance is selected from the group consisting of growth-modifying, bacteriostatic and cytostatic substances or suitable combinations thereof.
SE9300852A 1993-03-15 1993-03-15 Matrix composition for tissue strengthening and / or filling SE501183C2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
SE9300852A SE501183C2 (en) 1993-03-15 1993-03-15 Matrix composition for tissue strengthening and / or filling
EP94910629A EP0689464A1 (en) 1993-03-15 1994-03-15 Matrix composition for tissue reinforcement and/or filling
PCT/SE1994/000222 WO1994021307A1 (en) 1993-03-15 1994-03-15 Matrix composition for tissue reinforcement and/or filling
AU62944/94A AU6294494A (en) 1993-03-15 1994-03-15 Matrix composition for tissue reinforcement and/or filling

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9300852A SE501183C2 (en) 1993-03-15 1993-03-15 Matrix composition for tissue strengthening and / or filling

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SE9300852D0 SE9300852D0 (en) 1993-03-15
SE9300852L SE9300852L (en) 1994-09-16
SE501183C2 true SE501183C2 (en) 1994-12-05

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SE (1) SE501183C2 (en)
WO (1) WO1994021307A1 (en)

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US5588960A (en) * 1994-12-01 1996-12-31 Vidamed, Inc. Transurethral needle delivery device with cystoscope and method for treatment of urinary incontinence

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8804641D0 (en) * 1988-12-23 1988-12-23 Procordia Oratech Ab SURGICAL BARRIER
SE469109B (en) * 1991-06-17 1993-05-17 Bengt Hjalmar Aagerup Med Firm SEALANT CONTAINING A MEMBRANE AND A Glue, WHICH ARE BADA BIODEGRADABLE

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AU6294494A (en) 1994-10-11
SE9300852L (en) 1994-09-16
EP0689464A1 (en) 1996-01-03
WO1994021307A1 (en) 1994-09-29
SE9300852D0 (en) 1993-03-15

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