SE7503592L - - Google Patents

Info

Publication number: SE7503592L
Authority: SE; Sweden
Prior art keywords: digoxin; digitoxin; acetyl; cardiotonic; cardiac glycoside
Prior art date: 1974-04-01

Application number

SE7503592A

Other languages

Unknown language ( )

English (en)

Other versions

SE408687B (sv

Inventor

C Sadda

Original Assignee

Scherer Ltd R P

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-04-01

Filing date

1975-03-27

Publication date

1975-10-02

1975-03-27 Application filed by Scherer Ltd R P filed Critical Scherer Ltd R P

1975-10-02 Publication of SE7503592L publication Critical patent/SE7503592L/

1979-07-02 Publication of SE408687B publication Critical patent/SE408687B/xx

Links

ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 abstract 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 2
229940097217 cardiac glycoside Drugs 0.000 abstract 2
239000002368 cardiac glycoside Substances 0.000 abstract 2
230000003177 cardiotonic effect Effects 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 2
LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 abstract 2
229930002534 steroid glycoside Natural products 0.000 abstract 2
HPMZBILYSWLILX-UMDUKNJSSA-N 3'''-O-acetyldigitoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HPMZBILYSWLILX-UMDUKNJSSA-N 0.000 abstract 1
HPMZBILYSWLILX-UHFFFAOYSA-N Acetyl-digitoxine Natural products C1C(OC(C)=O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O HPMZBILYSWLILX-UHFFFAOYSA-N 0.000 abstract 1
CKNOLMVLQUPVMU-XOMFLMSUSA-N Digitalin Natural products O(C)[C@H]1[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@@H]([C@H](O)C5)C5=CC(=O)OC5)CC4)CC3)CC2)[C@@H]1O CKNOLMVLQUPVMU-XOMFLMSUSA-N 0.000 abstract 1
LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 abstract 1
239000001828 Gelatine Substances 0.000 abstract 1
JAYAGJDXJIDEKI-UHFFFAOYSA-N Lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(OC(C)=O)C1OC1OC(CO)C(O)C(O)C1O JAYAGJDXJIDEKI-UHFFFAOYSA-N 0.000 abstract 1
JAYAGJDXJIDEKI-PTGWOZRBSA-N Lanatoside C Chemical compound O([C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JAYAGJDXJIDEKI-PTGWOZRBSA-N 0.000 abstract 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
CPFNIKYEDJFRAT-UHFFFAOYSA-N Strospasid Natural products OC1C(OC)C(O)C(C)OC1OC1CC(CCC2C3(CC(O)C(C3(C)CCC32)C=2COC(=O)C=2)O)C3(C)CC1 CPFNIKYEDJFRAT-UHFFFAOYSA-N 0.000 abstract 1
CKNOLMVLQUPVMU-UHFFFAOYSA-N UNPD183315 Natural products O1C(C)C(OC2C(C(O)C(O)C(CO)O2)O)C(OC)C(O)C1OC(C1)CCC2(C)C1CCC(C1(CC3O)O)C2CCC1(C)C3C1=CC(=O)OC1 CKNOLMVLQUPVMU-UHFFFAOYSA-N 0.000 abstract 1
229960003635 acetyldigitoxin Drugs 0.000 abstract 1
229960003304 acetyldigoxin Drugs 0.000 abstract 1
HWKJSYYYURVNQU-DXJNJSHLSA-N acetyldigoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HWKJSYYYURVNQU-DXJNJSHLSA-N 0.000 abstract 1
MGVYFNHJWXJYBE-UHFFFAOYSA-N alpha-Acetyl-digoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(C)OC(CC3OC(=O)C)OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CC(=O)OC8)C4)OC2C MGVYFNHJWXJYBE-UHFFFAOYSA-N 0.000 abstract 1
239000002775 capsule Substances 0.000 abstract 1
229950004590 digitalin Drugs 0.000 abstract 1
CKNOLMVLQUPVMU-YMMLYESFSA-N digitalin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@H]4[C@H]([C@]3(C[C@@H]2O)O)CC[C@H]2[C@]4(C)CC[C@@H](C2)O[C@H]2[C@H](O)[C@H]([C@H]([C@@H](C)O2)O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)OC)=CC(=O)OC1 CKNOLMVLQUPVMU-YMMLYESFSA-N 0.000 abstract 1
229960000648 digitoxin Drugs 0.000 abstract 1
WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 abstract 1
229960005156 digoxin Drugs 0.000 abstract 1
LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 abstract 1
LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 abstract 1
229940113088 dimethylacetamide Drugs 0.000 abstract 1
229920000159 gelatin Polymers 0.000 abstract 1
235000019322 gelatine Nutrition 0.000 abstract 1
235000011187 glycerol Nutrition 0.000 abstract 1
229960002614 lanatoside c Drugs 0.000 abstract 1
229960003746 metildigoxin Drugs 0.000 abstract 1
IYJMSDVSVHDVGT-PEQKVOOWSA-N metildigoxin Chemical compound O1[C@H](C)[C@@H](OC)[C@@H](O)C[C@@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O IYJMSDVSVHDVGT-PEQKVOOWSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Molecular Biology (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7503592A 1974-04-01 1975-03-27 Forfarande for framstellning av en kardiotonisk doseringsenhet innefattande en mjuk gelatinkapsel, vilken bringas att innehalla en flytande kardiotonisk komposition innefattande en hjertglykosid och polyetenglykol SE408687B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB14265/74A GB1508770A (en)	1974-04-01	1974-04-01	Pharmaceutical compositions

Publications (2)

Publication Number	Publication Date
SE7503592L true SE7503592L (mo)	1975-10-02
SE408687B SE408687B (sv)	1979-07-02

Family

ID=10038031

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7503592A SE408687B (sv)	1974-04-01	1975-03-27	Forfarande for framstellning av en kardiotonisk doseringsenhet innefattande en mjuk gelatinkapsel, vilken bringas att innehalla en flytande kardiotonisk komposition innefattande en hjertglykosid och polyetenglykol

Country Status (12)

Country	Link
JP (1)	JPS5644045B2 (mo)
AT (1)	AT342777B (mo)
AU (1)	AU500001B2 (mo)
BE (1)	BE827349A (mo)
CA (1)	CA1046410A (mo)
DE (1)	DE2513601A1 (mo)
DK (1)	DK137436B (mo)
FI (1)	FI63671C (mo)
FR (1)	FR2265353B1 (mo)
GB (1)	GB1508770A (mo)
NL (1)	NL7503881A (mo)
SE (1)	SE408687B (mo)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2380030A1 (fr) *	1977-02-09	1978-09-08	Christiaens Sa A	Composition pharmaceutique contenant de la gitoxine
ES2308955T5 (es)	1993-09-28	2012-04-03	R.P. Scherer Gmbh	Fabricación de cápsulas de gelatina blanda

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1481411A (en) *	1973-07-20	1977-07-27	Scherer Ltd R	Pharmaceutical compositions
NL7502121A (nl) *	1974-02-22	1975-08-26	Wellcome Found	Werkwijze ter vervaardiging van een farmaceu- tisch preparaat dat digoxin bevat.

1974
- 1974-04-01 GB GB14265/74A patent/GB1508770A/en not_active Expired
1975
- 1975-03-27 DE DE19752513601 patent/DE2513601A1/de active Granted
- 1975-03-27 SE SE7503592A patent/SE408687B/xx not_active IP Right Cessation
- 1975-03-28 BE BE154915A patent/BE827349A/xx not_active IP Right Cessation
- 1975-04-01 CA CA223,484A patent/CA1046410A/en not_active Expired
- 1975-04-01 JP JP3968275A patent/JPS5644045B2/ja not_active Expired
- 1975-04-01 DK DK138675AA patent/DK137436B/da not_active IP Right Cessation
- 1975-04-01 AT AT244575A patent/AT342777B/de not_active IP Right Cessation
- 1975-04-01 FI FI750964A patent/FI63671C/fi not_active IP Right Cessation
- 1975-04-01 FR FR7510180A patent/FR2265353B1/fr not_active Expired
- 1975-04-01 AU AU79663/75A patent/AU500001B2/en not_active Expired
- 1975-04-01 NL NL7503881A patent/NL7503881A/xx not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE2513601C2 (mo)	1988-05-26
FR2265353A1 (mo)	1975-10-24
FI63671C (fi)	1983-08-10
ATA244575A (de)	1977-08-15
FI750964A7 (mo)	1975-10-02
DE2513601A1 (de)	1975-10-02
GB1508770A (en)	1978-04-26
NL7503881A (nl)	1975-10-03
AU7966375A (en)	1976-10-07
DK138675A (mo)	1975-10-02
FI63671B (fi)	1983-04-29
JPS517117A (mo)	1976-01-21
DK137436B (da)	1978-03-06
SE408687B (sv)	1979-07-02
DK137436C (mo)	1978-08-21
AT342777B (de)	1978-04-25
BE827349A (fr)	1975-09-29
FR2265353B1 (mo)	1980-02-15
CA1046410A (en)	1979-01-16
JPS5644045B2 (mo)	1981-10-16
AU500001B2 (en)	1979-05-10

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1995-01-31

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