SE7513882L - NEW ORGANIC ASSOCIATIONS - Google Patents
NEW ORGANIC ASSOCIATIONSInfo
- Publication number
- SE7513882L SE7513882L SE7513882A SE7513882A SE7513882L SE 7513882 L SE7513882 L SE 7513882L SE 7513882 A SE7513882 A SE 7513882A SE 7513882 A SE7513882 A SE 7513882A SE 7513882 L SE7513882 L SE 7513882L
- Authority
- SE
- Sweden
- Prior art keywords
- amino
- methylcyclohexylamine
- formula
- acid addition
- new organic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
N-(2-Amino-3,5-dibromobenzyl)-N-methylcyclohexylamine of the formula I <IMAGE> and its acid addition salts are prepared by a novel process in which an ester of 2-amino-3,5-dibromobenzyl alcohol, whose amino group can be protected, is reacted with N-methylcyclohexylamine, any amino protective groups are eliminated, and the product of the process is converted, where appropriate, into an acid addition salt. The compound of the formula I effectively dissolves mucus from the respiratory tract and is used to produce cough-suppressant medicaments.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI78673 | 1973-03-15 | ||
| FI2122/73A FI55647C (en) | 1973-07-02 | 1973-07-02 | PROCEDURE FOR THERAPEUTIC PREPARATION OF THERAPEUTIC 2-AMINO-N-CYCLOHEXYL-3,5-DIBROM-N-METHYLBENYLAMINE OCH DESS SYRAADDITIONSSALTER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE7513882L true SE7513882L (en) | 1975-12-09 |
Family
ID=26156383
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7310071A SE396216B (en) | 1973-03-15 | 1973-07-18 | PROCEDURE FOR THE PREPARATION OF N- (2-AMINO-3,5-DIBROMBENZYL) -N-METHYLYCLOHEXYLAMINE |
| SE7513882A SE7513882L (en) | 1973-03-15 | 1975-12-09 | NEW ORGANIC ASSOCIATIONS |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7310071A SE396216B (en) | 1973-03-15 | 1973-07-18 | PROCEDURE FOR THE PREPARATION OF N- (2-AMINO-3,5-DIBROMBENZYL) -N-METHYLYCLOHEXYLAMINE |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JPS5328906B2 (en) |
| AT (1) | AT333249B (en) |
| BG (1) | BG23745A3 (en) |
| CH (1) | CH613938A5 (en) |
| DE (1) | DE2411848A1 (en) |
| ES (1) | ES424272A1 (en) |
| HU (1) | HU166949B (en) |
| NL (1) | NL7403155A (en) |
| NO (1) | NO139558C (en) |
| RO (1) | RO69817A (en) |
| SE (2) | SE396216B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8771807B2 (en) * | 2011-05-24 | 2014-07-08 | Air Products And Chemicals, Inc. | Organoaminosilane precursors and methods for making and using same |
| CN102924295B (en) * | 2012-10-09 | 2014-10-29 | 石家庄东方药业有限公司 | Bromhexine hydrochloride crystal as well as preparation method and application of crystal |
| CN103145564B (en) * | 2013-03-15 | 2014-06-18 | 湖北美林药业有限公司 | Bromhexine hydrochloride compound and pharmaceutical composition thereof |
| CN109535010B (en) * | 2018-12-27 | 2021-10-26 | 广州一品红制药有限公司 | Preparation method of bromhexine hydrochloride |
-
1973
- 1973-07-18 SE SE7310071A patent/SE396216B/en unknown
- 1973-07-31 NO NO306373A patent/NO139558C/en unknown
-
1974
- 1974-03-08 NL NL7403155A patent/NL7403155A/xx not_active Application Discontinuation
- 1974-03-12 DE DE2411848A patent/DE2411848A1/en active Pending
- 1974-03-13 BG BG026039A patent/BG23745A3/en unknown
- 1974-03-13 HU HUTO000957 patent/HU166949B/hu unknown
- 1974-03-13 RO RO7800574A patent/RO69817A/en unknown
- 1974-03-14 AT AT212974A patent/AT333249B/en not_active IP Right Cessation
- 1974-03-14 ES ES424272A patent/ES424272A1/en not_active Expired
- 1974-03-15 CH CH366874A patent/CH613938A5/en not_active IP Right Cessation
- 1974-03-15 JP JP2986274A patent/JPS5328906B2/ja not_active Expired
-
1975
- 1975-12-09 SE SE7513882A patent/SE7513882L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ATA212974A (en) | 1976-03-15 |
| RO69817A (en) | 1980-12-30 |
| BG23745A3 (en) | 1977-10-12 |
| AT333249B (en) | 1976-11-10 |
| JPS5328906B2 (en) | 1978-08-17 |
| DE2411848A1 (en) | 1974-09-26 |
| NL7403155A (en) | 1974-09-17 |
| NO139558C (en) | 1979-04-04 |
| ES424272A1 (en) | 1976-05-16 |
| HU166949B (en) | 1975-06-28 |
| NO139558B (en) | 1978-12-27 |
| JPS5046643A (en) | 1975-04-25 |
| CH613938A5 (en) | 1979-10-31 |
| SE396216B (en) | 1977-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 7513882-6 |