SE8302193L - N- (1-SUBSTITUTED-3-PYRROLIDINYL) -BENZAMIDES AND THIOBENSAMIDES - Google Patents

N- (1-SUBSTITUTED-3-PYRROLIDINYL) -BENZAMIDES AND THIOBENSAMIDES

Info

Publication number
SE8302193L
SE8302193L SE8302193A SE8302193A SE8302193L SE 8302193 L SE8302193 L SE 8302193L SE 8302193 A SE8302193 A SE 8302193A SE 8302193 A SE8302193 A SE 8302193A SE 8302193 L SE8302193 L SE 8302193L
Authority
SE
Sweden
Prior art keywords
formula
substituted
thiobensamides
benzamides
pyrrolidinyl
Prior art date
Application number
SE8302193A
Other languages
Swedish (sv)
Other versions
SE431869B (en
SE8302193D0 (en
Inventor
Jr A D Cale
C A Leonard
Original Assignee
Robins Co Inc A H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robins Co Inc A H filed Critical Robins Co Inc A H
Publication of SE8302193L publication Critical patent/SE8302193L/en
Publication of SE8302193D0 publication Critical patent/SE8302193D0/en
Publication of SE431869B publication Critical patent/SE431869B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (1)

1. Patentkrav POrfarande for framstgllning av en forening med formeln 2 f'ar reagera med en bensoylklorid med formeln Cl-C dgr R2 betecknar vats, 3:gyre alkyl, lagre alkoxi, halogen, nitro, monoalkylamino, dialkylamino, merkaptometyl, aoetamido, sulfamoyl, cyano, Ivarvio nar R2 betecknar amino eller acetamido istgllet anvAndest 'svarande fbrening innehallande en nitrogrupp sedan utsattes Zr- hydroxi, bensyloxi, trifluormetyl,kannetecknat av att en forening med formelnkatalytisk hydrering till en aminogrupp och eventuollt acyleras till onskad acetaminogrupp.A process for the preparation of a compound of formula 2 for reacting with a benzoyl chloride of formula C1-C when R2 represents hydrogen, 3: lower alkyl, lower alkoxy, halogen, nitro, monoalkylamino, dialkylamino, mercaptomethyl, acetamido, sulfamoyl , cyano, Ivarvion when R 2 represents amino or acetamido substituted compound containing a nitro group then Zr-hydroxy, benzyloxy, trifluoromethyl is exposed, characterized in that a compound of formula catalytic hydrogenation to an amino group and optionally acylamine to onskamine
SE8302193A 1972-04-03 1983-04-19 PROCEDURE FOR PREPARING N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -BENZAMIDES WITH ANTI-MEMICAL EFFECT SE431869B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24084072A 1972-04-03 1972-04-03
US34041773A 1973-03-12 1973-03-12

Publications (3)

Publication Number Publication Date
SE8302193L true SE8302193L (en) 1983-04-19
SE8302193D0 SE8302193D0 (en) 1983-04-19
SE431869B SE431869B (en) 1984-03-05

Family

ID=26933765

Family Applications (3)

Application Number Title Priority Date Filing Date
SE7304619A SE402102B (en) 1972-04-03 1973-04-02 PROCEDURE FOR THE PREPARATION OF 4-AMINO-N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -N-ALKYL-BENZAMIDE, WITH VALUABLE THERAPEUTIC PROPERTIES
SE7711953A SE431868B (en) 1972-04-03 1977-10-24 PROCEDURE FOR PREPARING N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -BENZAMIDES WITH ANTI-MEMICAL EFFECT
SE8302193A SE431869B (en) 1972-04-03 1983-04-19 PROCEDURE FOR PREPARING N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -BENZAMIDES WITH ANTI-MEMICAL EFFECT

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SE7304619A SE402102B (en) 1972-04-03 1973-04-02 PROCEDURE FOR THE PREPARATION OF 4-AMINO-N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -N-ALKYL-BENZAMIDE, WITH VALUABLE THERAPEUTIC PROPERTIES
SE7711953A SE431868B (en) 1972-04-03 1977-10-24 PROCEDURE FOR PREPARING N- (1-CYCLOHEXYL-3-PYRROLIDINYL) -BENZAMIDES WITH ANTI-MEMICAL EFFECT

Country Status (9)

Country Link
JP (4) JPS5620312B2 (en)
CA (1) CA999003A (en)
CH (1) CH580582A5 (en)
DK (1) DK138491B (en)
ES (1) ES413260A1 (en)
NL (1) NL178318C (en)
NO (1) NO142077C (en)
PH (1) PH15259A (en)
SE (3) SE402102B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA732296B (en) * 1972-04-03 1974-11-27 Robins Co Inc A H Method for controlling emesis with n-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides
JPS5423113Y2 (en) * 1974-10-08 1979-08-09
JPS5925784B2 (en) * 1975-12-17 1984-06-21 山之内製薬株式会社 Synquina carbon amide
JPS5232815U (en) * 1975-08-28 1977-03-08
JPS5925785B2 (en) * 1976-01-01 1984-06-21 山之内製薬株式会社 Novel carboxylic acid amide derivative
JPS5522699A (en) * 1979-08-10 1980-02-18 Yamanouchi Pharmaceut Co Ltd Novel 3-amino-1-benzylpyrrolidine derivative
JPS6316492U (en) * 1986-07-18 1988-02-03
WO1995029891A1 (en) * 1994-04-28 1995-11-09 Yamanouchi Pharmaceutical Co., Ltd. N-(3-pyrrolidinyl)benzamide derivative
MXPA05005660A (en) 2002-11-27 2005-10-18 Incyte Corp 3-aminopyrrolidine derivatives as modulators of chemokine receptors.

Also Published As

Publication number Publication date
DK138491B (en) 1978-09-18
DK138491C (en) 1979-04-09
PH15259A (en) 1982-11-02
NO142077B (en) 1980-03-17
SE402102B (en) 1978-06-19
NO142077C (en) 1980-06-25
NL178318B (en) 1985-10-01
SE7711953L (en) 1977-10-24
JPS5182261A (en) 1976-07-19
CA999003A (en) 1976-10-26
DE2316644A1 (en) 1973-10-18
NL7304557A (en) 1973-10-05
SE431868B (en) 1984-03-05
JPS5069067A (en) 1975-06-09
ES413260A1 (en) 1976-05-16
SE431869B (en) 1984-03-05
JPS5527905B2 (en) 1980-07-24
CH580582A5 (en) 1976-10-15
SE8302193D0 (en) 1983-04-19
DE2316644B2 (en) 1977-04-28
NL178318C (en) 1986-03-03
JPS5620312B2 (en) 1981-05-13
JPS5069066A (en) 1975-06-09
JPS4913165A (en) 1974-02-05

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