SE7600969L - Nya oximetrar och forfaranden for deras framstellning - Google Patents

Nya oximetrar och forfaranden for deras framstellning

Info

Publication number: SE7600969L
Authority: SE; Sweden
Prior art keywords: hal; reacting; alkylene; oxime; cyclohexanethione
Prior art date: 1976-01-27

Application number

SE7600969A

Other languages

English (en)

Other versions

SE410733B (sv

Inventor

Z Budai

A Lay

T Mezei

K Grasser

E Skirt

I Kosoczky

L E Petocz

Original Assignee

Egyt Gyogyszervegyeszeti Gyar

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-01-27

Filing date

1976-01-29

Publication date

1977-07-30

1976-01-27 Priority claimed from US05/652,806 external-priority patent/US4083978A/en

1976-01-27 Priority to GB3176/76A priority Critical patent/GB1493222A/en

1976-01-27 Priority to US05/652,806 priority patent/US4083978A/en

1976-01-27 Priority to DK32576A priority patent/DK149043C/da

1976-01-29 Priority to FI760218A priority patent/FI65615C/fi

1976-01-29 Priority to FR7602460A priority patent/FR2339397A1/fr

1976-01-29 Priority to SE7600969A priority patent/SE410733B/sv

1976-01-29 Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar

1976-01-30 Priority to NLAANVRAGE7600945,A priority patent/NL180585C/xx

1976-02-03 Priority to BE164044A priority patent/BE838213A/xx

1976-02-04 Priority to CA245,043A priority patent/CA1071201A/en

1976-02-07 Priority to JP1273676A priority patent/JPS5295643A/ja

1976-02-23 Priority to AT125076A priority patent/AT339276B/de

1976-02-23 Priority to AT813776A priority patent/AT342019B/de

1976-02-23 Priority claimed from AT125076A external-priority patent/AT339276B/de

1976-02-24 Priority to CH223676A priority patent/CH626058A5/de

1976-02-26 Priority to DD191525A priority patent/DD125547A5/xx

1976-03-04 Priority to DE2609017A priority patent/DE2609017C3/de

1976-12-10 Priority to US05/749,399 priority patent/US4077999A/en

1977-07-30 Publication of SE7600969L publication Critical patent/SE7600969L/sv

1979-10-29 Publication of SE410733B publication Critical patent/SE410733B/sv

Links

238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
125000002947 alkylene group Chemical group 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 abstract 2
230000002401 inhibitory effect Effects 0.000 abstract 2
150000002923 oximes Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
MKJIEFSOBYUXJB-HOCLYGCPSA-N (3S,11bS)-9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one Chemical compound C1CN2C[C@H](CC(C)C)C(=O)C[C@H]2C2=C1C=C(OC)C(OC)=C2 MKJIEFSOBYUXJB-HOCLYGCPSA-N 0.000 abstract 1
WHRIFHXUUBGMNF-UHFFFAOYSA-N 2-benzylidenecyclohexane-1-thione Chemical compound S=C1CCCCC1=CC1=CC=CC=C1 WHRIFHXUUBGMNF-UHFFFAOYSA-N 0.000 abstract 1
101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
208000005392 Spasm Diseases 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
150000003863 ammonium salts Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
239000012752 auxiliary agent Substances 0.000 abstract 1
SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 abstract 1
239000000812 cholinergic antagonist Substances 0.000 abstract 1
KEMACKQQVVYFDT-UHFFFAOYSA-N cyclohexanethione Chemical compound S=C1CCCCC1 KEMACKQQVVYFDT-UHFFFAOYSA-N 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000002048 spasmolytic effect Effects 0.000 abstract 1
229960005333 tetrabenazine Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SE7600969A 1976-01-27 1976-01-29 Sett att framstella vissa angivna oximetrar SE410733B (sv)

Priority Applications (16)

Application Number	Priority Date	Filing Date	Title
GB3176/76A GB1493222A (en)	1976-01-27	1976-01-27	Cycloalkanone oxime ethers and process for the preparation thereof
US05/652,806 US4083978A (en)	1976-01-27	1976-01-27	Oxime ethers
DK32576A DK149043C (da)	1976-01-27	1976-01-27	Analogifremgangsmaade til fremstilling af 2-benzal- eller 2-benzyl-1-(aminoalkoxyimino)-cykloalkaner eller salte eller kvaternaere ammoniumderivater deraf
FI760218A FI65615C (fi)	1976-01-27	1976-01-29	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara oximetrar
FR7602460A FR2339397A1 (fr)	1976-01-27	1976-01-29	Nouveaux ethers d'oximes, procede de preparation de ceux-ci et medicaments les contenant
SE7600969A SE410733B (sv)	1976-01-27	1976-01-29	Sett att framstella vissa angivna oximetrar
NLAANVRAGE7600945,A NL180585C (nl)	1976-01-27	1976-01-30	Werkwijze voor de bereiding van oxim-ethers, alsmede werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten die deze bevatten.
BE164044A BE838213A (fr)	1976-01-27	1976-02-03	Nouveaux ethers d'oximes, procede de preparation de ceux-ci et medicaments les contenant
CA245,043A CA1071201A (en)	1976-01-27	1976-02-04	Oxime ethers and process for the preparation thereof
JP1273676A JPS5295643A (en)	1976-01-27	1976-02-07	Oxim ether and process for preparing same
AT813776A AT342019B (de)	1976-01-27	1976-02-23	Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
AT125076A AT339276B (de)	1976-01-27	1976-02-23	Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
CH223676A CH626058A5 (en)	1976-01-27	1976-02-24	Process for the preparation of basic oxime ethers
DD191525A DD125547A5 (sv)	1976-01-27	1976-02-26
DE2609017A DE2609017C3 (de)	1976-01-27	1976-03-04	Basische Oximäther, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzeimittel
US05/749,399 US4077999A (en)	1976-01-27	1976-12-10	Novel oxime ethers

Applications Claiming Priority (16)

Application Number	Priority Date	Filing Date	Title
GB3176/76A GB1493222A (en)	1976-01-27	1976-01-27	Cycloalkanone oxime ethers and process for the preparation thereof
US05/652,806 US4083978A (en)	1976-01-27	1976-01-27	Oxime ethers
DK32576A DK149043C (da)	1976-01-27	1976-01-27	Analogifremgangsmaade til fremstilling af 2-benzal- eller 2-benzyl-1-(aminoalkoxyimino)-cykloalkaner eller salte eller kvaternaere ammoniumderivater deraf
FI760218A FI65615C (fi)	1976-01-27	1976-01-29	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara oximetrar
FR7602460A FR2339397A1 (fr)	1976-01-27	1976-01-29	Nouveaux ethers d'oximes, procede de preparation de ceux-ci et medicaments les contenant
SE7600969A SE410733B (sv)	1976-01-27	1976-01-29	Sett att framstella vissa angivna oximetrar
NLAANVRAGE7600945,A NL180585C (nl)	1976-01-27	1976-01-30	Werkwijze voor de bereiding van oxim-ethers, alsmede werkwijze voor de bereiding of vervaardiging van farmaceutische preparaten die deze bevatten.
BE164044A BE838213A (fr)	1976-01-27	1976-02-03	Nouveaux ethers d'oximes, procede de preparation de ceux-ci et medicaments les contenant
CA245,043A CA1071201A (en)	1976-01-27	1976-02-04	Oxime ethers and process for the preparation thereof
JP1273676A JPS5295643A (en)	1976-01-27	1976-02-07	Oxim ether and process for preparing same
AT813776A AT342019B (de)	1976-01-27	1976-02-23	Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
AT125076A AT339276B (de)	1976-01-27	1976-02-23	Verfahren zur herstellung von basischen cycloalkanonoximathern und deren saureadditionssalzen
CH223676A CH626058A5 (en)	1976-01-27	1976-02-24	Process for the preparation of basic oxime ethers
DD191525A DD125547A5 (sv)	1976-01-27	1976-02-26
DE2609017A DE2609017C3 (de)	1976-01-27	1976-03-04	Basische Oximäther, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzeimittel
US05/749,399 US4077999A (en)	1976-01-27	1976-12-10	Novel oxime ethers

Publications (2)

Publication Number	Publication Date
SE7600969L true SE7600969L (sv)	1977-07-30
SE410733B SE410733B (sv)	1979-10-29

Family

ID=27585558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7600969A SE410733B (sv)	1976-01-27	1976-01-29	Sett att framstella vissa angivna oximetrar

Country Status (13)

Country	Link
JP (1)	JPS5295643A (sv)
AT (1)	AT342019B (sv)
BE (1)	BE838213A (sv)
CA (1)	CA1071201A (sv)
CH (1)	CH626058A5 (sv)
DD (1)	DD125547A5 (sv)
DE (1)	DE2609017C3 (sv)
DK (1)	DK149043C (sv)
FI (1)	FI65615C (sv)
FR (1)	FR2339397A1 (sv)
GB (1)	GB1493222A (sv)
NL (1)	NL180585C (sv)
SE (1)	SE410733B (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2658938A1 (de) *	1976-12-24	1978-07-06	Hoechst Ag	Neue basisch substituierte 0-propyloxime, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
HU180739B (en) *	1979-07-03	1983-04-29	Egyt Gyogyszervegyeszeti Gyar	Process for producing basic oxime-ethers
FR2518090A1 (fr) *	1981-12-11	1983-06-17	Univablot	Ethers d'oximes a-b insatures, leur procede de preparation et leur utilisation comme medicament
HU190387B (en) *	1982-05-25	1986-08-28	Egyt Gyogyszervegyeszeti Gyar,Hu	Process for producing 2-bracket-z-bracket closed-phenyl-methylene-cycloheptane derivatives
HU188250B (en) *	1983-02-08	1986-03-28	Egyt Gyogyszervegyeszeti Gyar,Hu	Process for producing of basical oxim-ethers
HU189226B (en) *	1983-02-08	1986-06-30	Egyt Gyogyszervegyeszeti Gyar,Hu	Process for producing basic oxime-ethers
HU197205B (en) *	1984-07-10	1989-03-28	Egyt Gyogyszervegyeszeti Gyar	Process for production of medical compositions against angine
HU202195B (en) *	1987-12-31	1991-02-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing new substituted styrene derivatives and medical compositions comprising such compounds
CA2006309C (fr) *	1988-12-29	2001-12-18	Jean Hutt	Azolylmethylcyclopentane benzylidene fongicide
HU212415B (en) *	1989-08-25	1996-06-28	Egyt Gyogyszervegyeszeti Gyar	Process for producing new cyclic oxym derivatives and pharmaceutical compositions containing them as active components
HUT67314A (en) *	1993-04-09	1995-03-28	Egyt Gyogyszervegyeszeti Gyar	Process for prepg. new trisubstituted cykloalkane deriv.s and pharmaceutical compn.s contg. them

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3262975A (en)	1963-02-12	1966-07-26	Upjohn Co	1-chloro-3, 4-dihydro 2-naphthaldehyde oxime and ethers thereof
US3937841A (en)	1967-04-05	1976-02-10	U.S. Philips Corporation	Treatment of depression
CH512184A (de)	1969-08-06	1971-09-15	Ciba Geigy Ag	Verwendung von Cyclohexanon- resp. Cyclohexenon-N-Alkylcarbamoyloximen zur Bekämpfung von Zecken
CA943138A (en)	1969-11-10	1974-03-05	Don R. Baker	Certain oxime compositions and their use in controlling fungi
US3928446A (en)	1974-04-11	1975-12-23	Hoffmann La Roche	Preparation of 3-oxo-19-nor-{66 {hu 4{b -steroids from 10-{8 3-substituted-alkyl{9 -desasteroids

1976
- 1976-01-27 DK DK32576A patent/DK149043C/da not_active IP Right Cessation
- 1976-01-27 GB GB3176/76A patent/GB1493222A/en not_active Expired
- 1976-01-29 FI FI760218A patent/FI65615C/fi not_active IP Right Cessation
- 1976-01-29 SE SE7600969A patent/SE410733B/sv not_active IP Right Cessation
- 1976-01-29 FR FR7602460A patent/FR2339397A1/fr active Granted
- 1976-01-30 NL NLAANVRAGE7600945,A patent/NL180585C/xx not_active IP Right Cessation
- 1976-02-03 BE BE164044A patent/BE838213A/xx not_active IP Right Cessation
- 1976-02-04 CA CA245,043A patent/CA1071201A/en not_active Expired
- 1976-02-07 JP JP1273676A patent/JPS5295643A/ja active Granted
- 1976-02-23 AT AT813776A patent/AT342019B/de not_active IP Right Cessation
- 1976-02-24 CH CH223676A patent/CH626058A5/de not_active IP Right Cessation
- 1976-02-26 DD DD191525A patent/DD125547A5/xx unknown
- 1976-03-04 DE DE2609017A patent/DE2609017C3/de not_active Expired

Also Published As

Publication number	Publication date
FI760218A7 (sv)	1977-07-30
FR2339397B1 (sv)	1979-10-05
AT342019B (de)	1978-03-10
DE2609017A1 (de)	1977-09-08
DK32576A (da)	1977-07-28
DD125547A5 (sv)	1977-05-04
BE838213A (fr)	1976-05-28
SE410733B (sv)	1979-10-29
NL7600945A (nl)	1977-08-02
CH626058A5 (en)	1981-10-30
FI65615B (fi)	1984-02-29
CA1071201A (en)	1980-02-05
JPS5715746B2 (sv)	1982-04-01
ATA813776A (de)	1977-07-15
NL180585B (nl)	1986-10-16
DK149043C (da)	1986-05-26
DE2609017C3 (de)	1981-05-27
DE2609017B2 (de)	1980-10-09
NL180585C (nl)	1987-03-16
DK149043B (da)	1985-12-30
GB1493222A (en)	1977-11-30
FR2339397A1 (fr)	1977-08-26
FI65615C (fi)	1984-06-11
JPS5295643A (en)	1977-08-11

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 7600969-5

Effective date: 19940810

Format of ref document f/p: F

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FI850140A0 (fi)	1985-01-11	Kemiska foereningar.
GB1345880A (en)	1974-02-06	Pyridazine derivatives
ES8507130A1 (es)	1985-08-16	Procedimiento para preparar derivados de piperazina
GB1184497A (en)	1970-03-18	Enamines and Enaminium Salts and Methods of Preparing them
GB1493222A (en)	1977-11-30	Cycloalkanone oxime ethers and process for the preparation thereof
GB1147379A (en)	1969-04-02	4-alkyl-dialkoxy-ª‡-methylphenethylamines and pharmacologically acceptable salts
ATE59632T1 (de)	1991-01-15	Dihydrodibenzocycloheptylidenethylamin-derivate
GB1369249A (en)	1974-10-02	Amines the preparation thereof and their use in pharmaceutical compositions
NZ212525A (en)	1989-02-24	Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such
ES447011A1 (es)	1977-11-16	Procedimiento para preparar 1,1,1,-triaril-alquilaminas.
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ES343003A1 (es)	1968-08-16	Un procedimiento para la preparacion de un compuesto tetra-hidro-isoquinoleina.
GB1443692A (en)	1976-07-21	1,2-diphenylethanolamine derivatives and their salts and the preparation thereof
ES418827A1 (es)	1977-02-01	Un procedimiento para preparar nuevos derivados 2-aminoinda-no.
DK311683D0 (da)	1983-07-05	Fremgangsmade til fremstilling af pyridylalkylnitratforbindelser
GB1043519A (en)	1966-09-21	New basic alcohols
GB1433078A (en)	1976-04-22	Substituted phenethylamines
GB1239567A (sv)	1971-07-21
GB1098983A (en)	1968-01-10	Isoxazole compounds, their non-toxic salts, and the preparation thereof
GB1512653A (en)	1978-06-01	Indazoles and the like
GB1082571A (en)	1967-09-06	New heterocyclic amino compounds, their salts and a process for the preparation thereof
GB1048812A (en)	1966-11-23	Substituted amino-guanidines
ES2014041A6 (es)	1990-06-16	Un procedimiento para preparar un derivado de amina.