SE7611261L - Blockerade kolekalciferolderivat - Google Patents

Blockerade kolekalciferolderivat

Info

Publication number
SE7611261L
SE7611261L SE7611261A SE7611261A SE7611261L SE 7611261 L SE7611261 L SE 7611261L SE 7611261 A SE7611261 A SE 7611261A SE 7611261 A SE7611261 A SE 7611261A SE 7611261 L SE7611261 L SE 7611261L
Authority
SE
Sweden
Prior art keywords
kolekalciferol
blocked
derivatives
kolekalciferol derivatives
blocked kolekalciferol
Prior art date
Application number
SE7611261A
Other languages
English (en)
Swedish (sv)
Inventor
D P Jacobus
H Jones
S S Yang
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of SE7611261L publication Critical patent/SE7611261L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE7611261A 1975-10-14 1976-10-11 Blockerade kolekalciferolderivat SE7611261L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62197675A 1975-10-14 1975-10-14

Publications (1)

Publication Number Publication Date
SE7611261L true SE7611261L (sv) 1977-04-15

Family

ID=24492438

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7611261A SE7611261L (sv) 1975-10-14 1976-10-11 Blockerade kolekalciferolderivat

Country Status (12)

Country Link
US (1) US4069321A (fr)
JP (1) JPS5268163A (fr)
AU (1) AU1842976A (fr)
BE (1) BE847223A (fr)
DE (1) DE2646240A1 (fr)
DK (1) DK457176A (fr)
ES (1) ES452198A1 (fr)
FR (1) FR2327790A1 (fr)
GB (1) GB1524418A (fr)
NL (1) NL7611274A (fr)
SE (1) SE7611261L (fr)
ZA (1) ZA766097B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53147051A (en) * 1977-05-24 1978-12-21 Teijin Ltd 1alpha-hydroxy-24-dehydro-vitamin d3 and its preparation
US4145346A (en) * 1977-10-03 1979-03-20 Merck & Co., Inc. Preparation of 3β-hydroxy-27-norcholest-5-ene-25-one and intermediates thereof
US4224230A (en) * 1978-07-26 1980-09-23 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4188345A (en) * 1978-07-26 1980-02-12 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4229357A (en) * 1978-07-26 1980-10-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4263214A (en) * 1978-07-26 1981-04-21 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4225596A (en) * 1978-10-13 1980-09-30 Wisconsin Alumni Research Foundation Method for treating calcium imbalance and improving calcium absorption in mammals
US4284577A (en) * 1979-02-16 1981-08-18 Sachiko Yamada Novel vitamin D3 derivative and process for preparing the same
US4196133A (en) * 1979-03-05 1980-04-01 Wisconsin Alumni Research Foundation 24,24-Difluoro-25-hydroxycholecalciferol
US4201881A (en) * 1979-03-28 1980-05-06 Wisconsin Alumni Research Foundation 24,24-Difluoro-1α,25-dihydroxycholecalciferol
US4230626A (en) * 1979-07-30 1980-10-28 G. D. Searle & Co. 25-Halocholest-5-ene-3β,22-diols and esters thereof
US4230627A (en) * 1979-08-06 1980-10-28 Wisconsin Alumni Research Foundation Fluorovitamin D compounds and processes for their preparation
US4248791A (en) * 1980-02-04 1981-02-03 Wisconsin Alumni Research Foundation 25-Hydroxy-26,26,26,27,27,27-hexafluorocholecalciferol
US4287129A (en) * 1980-07-28 1981-09-01 Diamond Shamrock Corp. Synthesis of 1α-hydroxy-7-dehydrosteroids
EP0070588B1 (fr) * 1981-07-17 1986-05-07 Duphar International Research B.V Procédé de préparation de dérivés de 1 alpha-hydroxy vitamine D ou de 1 alpha-hydroxy prévitamine D et d'adducts de prévitamine D ou de tachysterol avec des diénophiles appropriés
US4634692A (en) * 1981-08-28 1987-01-06 Hoffmann-La Roche Inc. Synthesis of 1α,25-dihydroxy-24R-fluorocholecalciferol and 1α,25-dihydroxy-24S-fluorocholecalciferol
US4428946A (en) * 1982-07-26 1984-01-31 Wisconsin Alumni Research Foundation Method of preventing milk fever in dairy cattle
DK157244C (da) * 1984-02-08 1990-04-23 Hoffmann La Roche Calciferolderivater, disse derivater til brug som farmaceutisk aktive stoffer, disse derivater til brug som antiproliferative og differentieringsinducerende aktive stoffer, samt laegemiddel indeholdende disse
IL77668A (en) * 1986-01-21 1989-03-31 Teva Pharma Production of cholecalciferol derivatives and novel intermediates used therefor
US4929609A (en) * 1987-03-12 1990-05-29 Hoffmann-La Roche Inc. 25, 28-dihydroxyergocalciferol and 1,25,28-trihydroxyergocalciferol compositions thereof and their use in the treatment of hyperproliferative disease
JP2525478B2 (ja) * 1989-03-01 1996-08-21 帝人株式会社 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
US5401731A (en) * 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
ES2140458T3 (es) * 1992-04-15 2000-03-01 Stanford Res Inst Int Aislamiento de esteroides que contienen una funcionalidad 5,7-dieno de una mezcla de esteroles.
JP2905091B2 (ja) * 1994-06-24 1999-06-14 日本バルカー工業株式会社 フッ素樹脂被覆ガスケットの製造方法
KR100756823B1 (ko) * 2001-10-23 2007-09-07 주식회사 엘지생활건강 신규한 폴리에톡실화 콜레칼시페롤 유도체 및 그의 제조방법
US7795427B2 (en) * 2006-02-14 2010-09-14 New York University Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass
US20220204547A1 (en) * 2019-05-09 2022-06-30 Fermenta Biotech Limited Novel method for synthesizing 25-oh cholesterol/calcifediol from phytosterol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862934A (en) * 1955-06-14 1958-12-02 Philips Corp Method of producing tachysterol and dihydrotachysterol
US3833622A (en) * 1969-03-17 1974-09-03 Upjohn Co Crystalline 25-hydroxycholecalciferol hydrate and structurally related compounds
US3607888A (en) * 1969-08-07 1971-09-21 Wisconsin Alumni Res Found 25-hydroxytachysterol3 25-hydroxydihydrotachysterol3 and methods for preparing same

Also Published As

Publication number Publication date
NL7611274A (nl) 1977-04-18
GB1524418A (en) 1978-09-13
DK457176A (da) 1977-04-15
BE847223A (fr) 1977-04-13
DE2646240A1 (de) 1977-04-28
JPS5268163A (en) 1977-06-06
AU1842976A (en) 1978-04-13
US4069321A (en) 1978-01-17
ZA766097B (en) 1978-05-30
ES452198A1 (es) 1977-12-16
FR2327790A1 (fr) 1977-05-13
FR2327790B1 (fr) 1979-07-20

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