SE7703223L - 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav - Google Patents

2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Info

Publication number: SE7703223L
Authority: SE; Sweden
Prior art keywords: alkyl; hydrogen; pyrazino; quinoxalin; tetrahydro
Prior art date: 1976-03-22

Application number

SE7703223A

Other languages

English (en)

Swedish (sv)

Inventor

M E Freed

J R Potoski

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-03-22

Filing date

1977-03-21

Publication date

1977-09-23

1977-03-21 Application filed by American Home Prod filed Critical American Home Prod

1977-09-23 Publication of SE7703223L publication Critical patent/SE7703223L/xx

Links

FRZDVWUAWCOHDI-UHFFFAOYSA-N 1,2,3,4,4a,6-hexahydropyrazino[1,2-a]quinoxalin-5-one Chemical compound C1CNCC2C(=O)NC3=CC=CC=C3N21 FRZDVWUAWCOHDI-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 8
239000001257 hydrogen Substances 0.000 abstract 5
229910052739 hydrogen Inorganic materials 0.000 abstract 5
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
229910052801 chlorine Inorganic materials 0.000 abstract 2
239000000460 chlorine Substances 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
239000011737 fluorine Substances 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
241001465754 Metazoa Species 0.000 abstract 1
YNPNZTXNASCQKK-UHFFFAOYSA-N Phenanthrene Natural products C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 abstract 1
DGEZNRSVGBDHLK-UHFFFAOYSA-N [1,10]phenanthroline Chemical compound C1=CN=C2C3=NC=CC=C3C=CC2=C1 DGEZNRSVGBDHLK-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001631 hypertensive effect Effects 0.000 abstract 1
230000001077 hypotensive effect Effects 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

SE7703223A 1976-03-22 1977-03-21 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav SE7703223L (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/668,872 US4032639A (en)	1976-03-22	1976-03-22	2,3,4,4A-Tetrahydro-1H-pyrazino[1,2-a,]quinoxalin-5(6H)-ones and derivatives thereof for relieving hypertension

Publications (1)

Publication Number	Publication Date
SE7703223L true SE7703223L (sv)	1977-09-23

Family

ID=24684079

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7703223A SE7703223L (sv)	1976-03-22	1977-03-21	2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)kinoxalin-5(6h)-on och derivat derav

Country Status (13)

Country	Link
US (1)	US4032639A (fr)
JP (1)	JPS52114000A (fr)
AT (1)	AT357540B (fr)
AU (1)	AU506308B2 (fr)
BE (1)	BE852737A (fr)
CA (1)	CA1093557A (fr)
DE (1)	DE2712573A1 (fr)
DK (1)	DK122377A (fr)
FR (1)	FR2345450A1 (fr)
GB (3)	GB1538987A (fr)
NL (1)	NL7702920A (fr)
SE (1)	SE7703223L (fr)
ZA (1)	ZA771381B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4182872A (en) *	1976-03-22	1980-01-08	American Home Products Corporation	4-(Lower)alkyl-1-(o-nitrophenyl)piperazine-2-carboxylic acid chemical intermediates
US4182869A (en) *	1976-03-22	1980-01-08	American Home Products Corporation	4-Carbobenzoxypiperazine-2-carboxylic acid chemical intermediate
US4089958A (en) *	1976-12-20	1978-05-16	American Home Products Corporation	2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
US4225713A (en) *	1977-08-03	1980-09-30	Freed Meier E	Tetrahydro(1H)pyrazino(1,2-A)azaquinoxalin-5(6H)-ones and derivatives thereof
US4203987A (en) *	1979-05-21	1980-05-20	American Home Products Corporation	3-[Pyridinylalkyl and piperidinylalkyl]-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)-ones
ES2164639T3 (es) *	1991-04-15	2002-03-01	Aventis Pharma Gmbh	Quinoxalinas, procedimiento para su preparacion y su empleo.
US6369057B1 (en)	1991-04-15	2002-04-09	Aventis Pharma Deutschland Gmbh	Quinoxalines, processes for their preparation and their use
US6500948B1 (en)	1995-12-08	2002-12-31	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors-compositions, uses preparation and intermediates thereof
EA003294B1 (ru) *	1995-12-08	2003-04-24	Агурон Фармасьютикалс, Инк.	Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения
US5753653A (en)	1995-12-08	1998-05-19	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US6008243A (en) *	1996-10-24	1999-12-28	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use
US6174915B1 (en)	1997-03-25	2001-01-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
US5985900A (en) *	1997-04-01	1999-11-16	Agouron Pharmaceuticals, Inc.	Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses
HUP0104773A3 (en) *	1998-12-17	2004-10-28	Wyeth Corp	2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists, process for their preparation and medicaments containing them
US6476032B2 (en)	1998-12-17	2002-11-05	Wyeth	2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5(6H)one derivatives
US6372745B1 (en) *	1999-12-06	2002-04-16	American Home Products Corporation	2,3,4,4A-tetrahydro-1H-pyrazino[1,2-A]quinoxalin-5(6H)one derivatives
DE102004058337A1 (de) *	2004-12-02	2006-06-14	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten
US20060211700A1 (en) *	2005-03-21	2006-09-21	Alcon, Inc.	(R)-8,9-dichloro-2,3,4,4a-tetrahydro-1H,6H-pyrazino[1,2-a]quinoxalin-5-one for controlling IOP and treating glaucoma
PL2792667T3 (pl) *	2011-12-14	2018-05-30	Kumiai Chemical Industry Co., Ltd.	Związek difenyloaminowy i sposób jego wytwarzania
WO2014208296A1 (fr) *	2013-06-25	2014-12-31	イハラケミカル工業株式会社	Procédé pour préparer un composé de nitrobenzène
CN114096533B (zh) *	2019-09-10	2024-03-08	四川科伦博泰生物医药股份有限公司	一种三并环类化合物，包含其的药物组合物，其制备方法及其用途

1976
- 1976-03-22 US US05/668,872 patent/US4032639A/en not_active Expired - Lifetime
1977
- 1977-03-08 ZA ZA00771381A patent/ZA771381B/xx unknown
- 1977-03-09 AU AU23048/77A patent/AU506308B2/en not_active Expired
- 1977-03-11 CA CA273,768A patent/CA1093557A/fr not_active Expired
- 1977-03-17 GB GB1313/78A patent/GB1538987A/en not_active Expired
- 1977-03-17 GB GB11243/77A patent/GB1538986A/en not_active Expired
- 1977-03-17 GB GB28412/78A patent/GB1538988A/en not_active Expired
- 1977-03-17 NL NL7702920A patent/NL7702920A/xx not_active Application Discontinuation
- 1977-03-18 AT AT189377A patent/AT357540B/de not_active IP Right Cessation
- 1977-03-21 DK DK122377A patent/DK122377A/da unknown
- 1977-03-21 SE SE7703223A patent/SE7703223L/xx not_active Application Discontinuation
- 1977-03-21 FR FR7708408A patent/FR2345450A1/fr active Granted
- 1977-03-22 JP JP3201577A patent/JPS52114000A/ja active Pending
- 1977-03-22 BE BE175997A patent/BE852737A/fr unknown
- 1977-03-22 DE DE19772712573 patent/DE2712573A1/de not_active Withdrawn

Also Published As

Publication number	Publication date
AU2304877A (en)	1978-09-14
GB1538986A (en)	1979-01-24
AU506308B2 (en)	1979-12-20
DE2712573A1 (de)	1977-09-29
ATA189377A (de)	1979-12-15
FR2345450A1 (fr)	1977-10-21
AT357540B (de)	1980-07-10
BE852737A (fr)	1977-09-22
GB1538988A (en)	1979-01-24
ZA771381B (en)	1978-10-25
US4032639A (en)	1977-06-28
NL7702920A (nl)	1977-09-26
FR2345450B1 (fr)	1980-05-09
GB1538987A (en)	1979-01-24
DK122377A (da)	1977-09-23
CA1093557A (fr)	1981-01-13
JPS52114000A (en)	1977-09-24

Legal Events

Date

Code

Title

Description

1995-02-28

NAV

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ES475677A1 (es)	1979-04-16	Procedimiento para la preparacion de nuevos 4-hidroxi-2h-1,2-benzotiazin-3-carboxamido-1,1-dioxidos.
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ATE24001T1 (de)	1986-12-15	Substituierte 1-hydroxyethyl-triazolyl-derivate.
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SE8503415D0 (sv)	1985-07-09	Novel isoindolinyl-alkyl-piperazines
DK603789A (da)	1990-06-10	Substituerede imidazolderivater og fremstilling og anvendelse deraf
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ES477803A1 (es)	1980-05-16	Procedimiento para la obtencion de compuestos de fenilaceta-mida.
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ATE29721T1 (de)	1987-10-15	5-(4-vinyl- oder 4-ethynylbenzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a -pyrrol-1-carbosaeure und deren derivate.
ES480391A1 (es)	1980-08-16	Un procedimiento para la preparacion de derivados de difeni-lamina.
FI861934A0 (fi)	1986-05-09	Nya isoxazolderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska preparat.
DE3464602D1 (en)	1987-08-13	4-alkylimidazole derivatives, their preparation and their application
FI840743A0 (fi)	1984-02-23	N-(3-trifluormetylfenyl)-n'-propargylpiperazin, dess framstaellning och anvaendning
GB2128190B (en)	1986-07-02	Chemical compounds
IE802690L (en)	1981-06-21	Substituted 2-phenylamino-imidazolines-(2)
SE7901316L (sv)	1979-08-16	Derivat av dehydrocykliciminsyror
GB2001963A (en)	1979-02-14	Esters of mercaptopropanoic acids