SE7708142L - 5-(2-furoyl)-, 5-(2-tenoyl)-, 5-(3-furoyl)- och 5-(3-tenoyl)-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma - Google Patents

5-(2-furoyl)-, 5-(2-tenoyl)-, 5-(3-furoyl)- och 5-(3-tenoyl)-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma

Info

Publication number: SE7708142L
Authority: SE; Sweden
Prior art keywords: tenoyl; furoyl; pyrrol; pyrrolo; dihydro
Prior art date: 1976-07-14

Application number

SE7708142A

Other languages

English (en)

Other versions

SE434644B (sv

Inventor

J M Muchowski

A F Kluge

Original Assignee

Syntex Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-07-14

Filing date

1977-07-13

Publication date

1978-01-15

1977-02-23 Priority claimed from US05/771,283 external-priority patent/US4087539A/en

1977-07-13 Application filed by Syntex Inc filed Critical Syntex Inc

1978-01-15 Publication of SE7708142L publication Critical patent/SE7708142L/sv

1984-08-06 Publication of SE434644B publication Critical patent/SE434644B/sv

Links

-1 3-FUROYL Chemical class 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
150000001733 carboxylic acid esters Chemical class 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
230000001754 anti-pyretic effect Effects 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
150000001735 carboxylic acids Chemical class 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
229910052801 chlorine Inorganic materials 0.000 abstract 1
230000005494 condensation Effects 0.000 abstract 1
238000009833 condensation Methods 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

SE7708142A 1976-07-14 1977-07-13 Analogiforfarande for framstellning av 5-(2-furoyl)-, 5-(2-tenoyl)-, 5-(3-furoyl)- och 5-(3-tenoyl)-1,2 dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-karbonsyraderivat SE434644B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US70485776A	1976-07-14	1976-07-14
US05/771,283 US4087539A (en)	1976-07-14	1977-02-23	5-(2-Furoyl)-, 5-(2-thenoyl)-, 5-(3-furoyl)- and 5-(3-thenoyl)-1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid derivatives and process for the production thereof

Publications (2)

Publication Number	Publication Date
SE7708142L true SE7708142L (sv)	1978-01-15
SE434644B SE434644B (sv)	1984-08-06

Family

ID=27107392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7708142A SE434644B (sv)	1976-07-14	1977-07-13	Analogiforfarande for framstellning av 5-(2-furoyl)-, 5-(2-tenoyl)-, 5-(3-furoyl)- och 5-(3-tenoyl)-1,2 dihydro-3h-pyrrolo(1,2-a)-pyrrol-1-karbonsyraderivat

Country Status (26)

Country	Link
JP (1)	JPS539789A (sv)
AR (1)	AR218631A1 (sv)
AU (1)	AU513385B2 (sv)
CA (1)	CA1100140A (sv)
CH (2)	CH651045A5 (sv)
CS (1)	CS208724B2 (sv)
DE (1)	DE2731662A1 (sv)
DK (1)	DK152652C (sv)
ES (2)	ES460705A1 (sv)
FI (1)	FI63407C (sv)
FR (1)	FR2361396A1 (sv)
GB (1)	GB1554076A (sv)
GR (1)	GR61607B (sv)
HK (1)	HK17581A (sv)
IE (1)	IE45302B1 (sv)
IL (1)	IL52492A (sv)
IT (1)	IT1117314B (sv)
MY (1)	MY8100371A (sv)
NL (1)	NL7707652A (sv)
NO (1)	NO147563C (sv)
NZ (1)	NZ184611A (sv)
PL (1)	PL111408B1 (sv)
PT (1)	PT66779B (sv)
SE (1)	SE434644B (sv)
SU (2)	SU664566A3 (sv)
YU (2)	YU43156B (sv)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4097579A (en) *	1977-03-31	1978-06-27	Syntex (U.S.A.) Inc.	5-(2-Pyrroyl)-1,2-dihydro-3H-pyrrolo 1,2-a!pyrrole-1-carboxylic acid derivatives and process for the production thereof
US4140698A (en) *	1977-07-25	1979-02-20	Syntex (Usa) Inc.	1,2-Dihydro-3H-pyrrolo[1,2-a]pyrrole-1-nitriles
US4353829A (en) *	1980-11-21	1982-10-12	Syntex (U.S.A.) Inc.	Process for 5-aroylation of 1,2-dihydro-3H-pyrrolo[1,2-a]pyrrole-1-carboxylic esters
US4511724A (en) *	1982-06-10	1985-04-16	Merck & Co., Inc.	5-(Pyrrol-2-oyl)-1,2-dihydro-3H-pyrrolo [1,2-a]pyrrole derivatives as anti-inflammatory and analgesic agents
JPS5910589A (ja) *	1982-06-10	1984-01-20	メルク　エンド　カムパニー　インコーポレーテツド	抗炎症剤および鎮痛剤として新規な５−（ピロ−ル−２−オイル）−１，２−ジヒドロ−３Ｈ−ピロロ〔１，２−ａ〕ピロ−ル誘導体
HU198927B (en) *	1987-01-14	1989-12-28	Richter Gedeon Vegyeszet	Process for producing 1-/substituted aminomethyl/-octa-hydroindolo-(2,3-a)quinolizine derivatives, pharmaceutically applicable acid addition salts thereof, as well as pharmaceutical compositions comprising same
US4874871A (en) *	1987-03-25	1989-10-17	Syntex (U.S.A.) Inc.	Process for preparing (+)-2,3-Dihydro-1H-pyrrolo[1,2-a]pyrrole-1-carboxylic acid and related compounds

1977
- 1977-05-17 JP JP5697877A patent/JPS539789A/ja active Granted
- 1977-07-07 DK DK307677A patent/DK152652C/da not_active IP Right Cessation
- 1977-07-07 AR AR268357A patent/AR218631A1/es active
- 1977-07-07 GR GR53906A patent/GR61607B/el unknown
- 1977-07-08 CH CH4005/84A patent/CH651045A5/de not_active IP Right Cessation
- 1977-07-08 IL IL52492A patent/IL52492A/xx unknown
- 1977-07-08 IE IE1422/77A patent/IE45302B1/en unknown
- 1977-07-08 NL NL7707652A patent/NL7707652A/xx not_active Application Discontinuation
- 1977-07-08 CH CH848877A patent/CH644861A5/de not_active IP Right Cessation
- 1977-07-08 PT PT66779A patent/PT66779B/pt unknown
- 1977-07-11 FI FI772154A patent/FI63407C/fi not_active IP Right Cessation
- 1977-07-11 NZ NZ184611A patent/NZ184611A/xx unknown
- 1977-07-11 GB GB28923/77A patent/GB1554076A/en not_active Expired
- 1977-07-12 CS CS774647A patent/CS208724B2/cs unknown
- 1977-07-12 CA CA282,600A patent/CA1100140A/en not_active Expired
- 1977-07-12 FR FR7721559A patent/FR2361396A1/fr active Granted
- 1977-07-13 SE SE7708142A patent/SE434644B/sv not_active IP Right Cessation
- 1977-07-13 NO NO772493A patent/NO147563C/no unknown
- 1977-07-13 PL PL1977199602A patent/PL111408B1/pl unknown
- 1977-07-13 SU SU772504151A patent/SU664566A3/ru active
- 1977-07-13 ES ES460705A patent/ES460705A1/es not_active Expired
- 1977-07-13 AU AU26976/77A patent/AU513385B2/en not_active Expired
- 1977-07-13 DE DE19772731662 patent/DE2731662A1/de active Granted
- 1977-07-13 IT IT68631/77A patent/IT1117314B/it active
- 1977-12-29 SU SU772558960A patent/SU793400A3/ru active
1978
- 1978-05-24 ES ES470213A patent/ES470213A1/es not_active Expired
1981
- 1981-04-30 HK HK175/81A patent/HK17581A/xx unknown
- 1981-12-30 MY MY371/81A patent/MY8100371A/xx unknown
1983
- 1983-02-28 YU YU475/83A patent/YU43156B/xx unknown
- 1983-02-28 YU YU476/83A patent/YU43157B/xx unknown

Also Published As

Publication number	Publication date
AR218631A1 (es)	1980-06-30
CH644861A5 (en)	1984-08-31
GR61607B (en)	1978-12-02
YU43157B (en)	1989-04-30
CA1100140A (en)	1981-04-28
DE2731662A1 (de)	1978-01-19
FI63407B (fi)	1983-02-28
HK17581A (en)	1981-05-08
GB1554076A (en)	1979-10-17
FR2361396B1 (sv)	1981-11-27
NZ184611A (en)	1979-03-28
SU664566A3 (ru)	1979-05-25
SU793400A3 (ru)	1980-12-30
IE45302L (en)	1978-01-14
PT66779A (fr)	1977-08-01
FR2361396A1 (fr)	1978-03-10
ES460705A1 (es)	1979-10-01
JPS539789A (en)	1978-01-28
PL199602A1 (pl)	1979-01-29
FI772154A7 (sv)	1978-01-15
MY8100371A (en)	1981-12-31
SE434644B (sv)	1984-08-06
YU43156B (en)	1989-04-30
IL52492A0 (en)	1977-10-31
ES470213A1 (es)	1979-09-16
IE45302B1 (en)	1982-07-28
CS208724B2 (en)	1981-09-15
AU2697677A (en)	1979-01-18
NO772493L (no)	1978-01-17
DK152652C (da)	1988-09-12
DK152652B (da)	1988-04-05
IT1117314B (it)	1986-02-17
PT66779B (fr)	1978-12-18
YU47683A (en)	1984-04-30
YU47583A (en)	1984-06-30
FI63407C (fi)	1983-06-10
AU513385B2 (en)	1980-11-27
DK307677A (da)	1978-01-15
NO147563B (no)	1983-01-24
IL52492A (en)	1981-06-29
CH651045A5 (en)	1985-08-30
NO147563C (no)	1983-05-18
PL111408B1 (en)	1980-08-30
NL7707652A (nl)	1978-01-17
JPS6254110B2 (sv)	1987-11-13
DE2731662C2 (sv)	1989-11-09

Legal Events

Date

Code

Title

Description

1995-01-31

NUG

Patent has lapsed

Ref document number: 7708142-0

Effective date: 19910211

Format of ref document f/p: F

Publication	Publication Date	Title
DE69411625D1 (de)	1998-08-20	Benzofuranyl- und Thiophenylalkancarbonsäurederivate
NO792119L (no)	1979-12-28	Analogifremgangsmaate for fremstilling av 2-(2-alkoksyetyl)-2`hydroksyl-6,7-benzomorfaner og syreaddisjonssalter derav
ES526673A0 (es)	1984-07-01	Procedimiento para la obtencion de 1,2,3,4-tetrahidropiridinas
SE7713722L (sv)	1978-06-04	Derivat av tiazolidinkarbonsyror och dermed beslektade syror
SE7708142L (sv)	1978-01-15	5-(2-furoyl)-, 5-(2-tenoyl)-, 5-(3-furoyl)- och 5-(3-tenoyl)-1,2-dihydro-3h-pyrrolo (1,2-a) pyrrol-1-karbonsyraderivat och sett att framstella desamma
NO924949D0 (no)	1992-12-21	Piperidylsubstituerte indoler
PT73050A (fr)	1981-06-01	Procede de preparation de nouveaux derives de l'acide 4-hydroxy-3-quinoleine carboxylique substitues en 2
GB1554075A (en)	1979-10-17	1,2-dihydro-3h-pyrrolo-(1,2-a)-pyrrole-1-carboxylic acid derivatives and process for the production thereof
ES467154A1 (es)	1979-01-16	Procedimiento para la preparacion de materiales organicos aclarados opticamente
SE7605819L (sv)	1976-11-25	Nya propargyl-2-fenylaminoimidazolin-(2), dess syraadditionssalter, lekemedel innehallande dessa och forfarande for framstellning derav
SE7811455L (sv)	1979-07-02	2-imino-imidazolidin-derivat
DE69324066D1 (de)	1999-04-29	4-Phenylcarbamoyl-3-isoxazolecarbonsäure-Derivate mit entzündungshemmender Aktivität
ATE29721T1 (de)	1987-10-15	5-(4-vinyl- oder 4-ethynylbenzoyl)-1,2-dihydro-3h-pyrrolo-(1,2-a -pyrrol-1-carbosaeure und deren derivate.
ATE614T1 (de)	1982-02-15	Substituierte 2-(benzoyl)-glycinanilid-derivate, ihre herstellung und ihre verwendung in anxiolytischen arzneimitteln.
NO792389L (no)	1980-01-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive fenylamino-imidazolin-derivater
ATE2527T1 (de)	1983-03-15	Thienylbenzoesaeurederivate, verfahren zu ihrer herstellung und pharmazeutische praeparate auf basis dieser verbindungen.
ES398802A1 (es)	1974-08-16	Procedimiento para la preparacion de acidos propionicos sustituidos por fenilo en la posicion 2.
SE7706693L (sv)	1977-12-12	Sett att framstella hydrazinopyridazinderivat
AU519287B2 (en)	1981-11-19	Imidazo(1,2-alpha) imidazole derivatives
SE8402361L (sv)	1984-11-05	Nya acylaminofenolderivat
SE7606497L (sv)	1976-12-11	Substituerade 4-fenylimidazoliner, deras syraadditinossalter och forfarande for framstellning derav
FI803969L (fi)	1981-06-22	Nya substituerade 2-fenylamino-imidazoliner-(2) deras syraadditionssalter dessa innehaollande laekemedel och foerfarande foer deras framstaellning
ATE2076T1 (de)	1983-01-15	Verfahren zur herstellung von 5-(2,2,2-
FI910894A0 (sv)	1991-02-25	Förfarande för framställning av terapeutiskt användbara N-cykloalkylalkylaminer
SE7503274L (sv)	1975-10-13	Cefalosporin