SE7714764L - Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav - Google Patents

Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav

Info

Publication number
SE7714764L
SE7714764L SE7714764A SE7714764A SE7714764L SE 7714764 L SE7714764 L SE 7714764L SE 7714764 A SE7714764 A SE 7714764A SE 7714764 A SE7714764 A SE 7714764A SE 7714764 L SE7714764 L SE 7714764L
Authority
SE
Sweden
Prior art keywords
oxyles
alcoxic
7epsilon
6epsilon
17alfa
Prior art date
Application number
SE7714764A
Other languages
English (en)
Swedish (sv)
Inventor
R M Weier
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7714764L publication Critical patent/SE7714764L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE7714764A 1976-12-27 1977-12-27 Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav SE7714764L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
SE7714764L true SE7714764L (sv) 1978-06-28

Family

ID=25033598

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7714764A SE7714764L (sv) 1976-12-27 1977-12-27 Sett att framstella 7epsilon-(alkoxikarbonyl)-6epsilon-alkyl/halo-17-hydroxi-3-oxo-17alfa-pregn-4-en-21-karboxylsyra-gamma-laktoner och motsvarande 21-karboxylsyror samt estrar och salter derav

Country Status (19)

Country Link
US (1) US4069219A (fr)
JP (1) JPS5382767A (fr)
AU (1) AU518862B2 (fr)
BE (1) BE862365A (fr)
CA (1) CA1099702A (fr)
CH (6) CH637403A5 (fr)
DE (1) DE2758279A1 (fr)
DK (1) DK577377A (fr)
FI (1) FI773936A7 (fr)
FR (1) FR2375253A1 (fr)
GB (1) GB1575986A (fr)
IE (1) IE46128B1 (fr)
IL (1) IL53692A (fr)
NL (1) NL7714428A (fr)
NO (2) NO774464L (fr)
NZ (1) NZ186119A (fr)
PT (1) PT67455B (fr)
SE (1) SE7714764L (fr)
ZA (1) ZA777684B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
WO1997021720A2 (fr) * 1995-12-11 1997-06-19 G.D. Searle And Co. Procedes de preparation de steroides 7.alpha.-carboxylyl9,11-epoxy et intermediaires utiles dans ces procedes et procede general d'epoxydation de liaisons olefiniques doubles
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
EP1487859B1 (fr) * 2002-03-22 2008-08-13 Pharmacia & Upjohn Company LLC Procede de preparation de l'eplerenone
US7196208B2 (en) * 2002-11-06 2007-03-27 Peter Guillaume Marie Wuts Processes for preparing 7-carboxy substituted steroids
RS20050339A (sr) * 2002-11-07 2007-08-03 Pharmacia & Upjohn Company Llc., Postupci za dobijanje c-7 supstituisanih 5-androstena
PT2527356T (pt) 2005-07-21 2018-03-26 Bayer Ip Gmbh Processo para a produção de 3-oxo-pregn-4-eno-21,17-carbolactonas através da oxidação isenta de metais de 17-(3-hidroxipropil)-3,17-diidroxiandrostanos
ES2311927T5 (es) 2005-07-21 2014-09-08 Bayer Pharma Aktiengesellschaft Proceso para la producción de 3-oxo-pregn-4-en-21,17-carbolactonas por la oxidación sin metales de 17-(3-hidroxipropil)-3,17-dihidroxiandrostanos

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
IE46128B1 (en) 1983-02-23
PT67455A (en) 1978-01-01
NZ186119A (en) 1979-08-31
CH637403A5 (de) 1983-07-29
CH635595A5 (de) 1983-04-15
FR2375253B1 (fr) 1981-04-30
GB1575986A (en) 1980-10-01
US4069219A (en) 1978-01-17
IL53692A0 (en) 1978-03-10
PT67455B (en) 1979-05-25
NO774464L (no) 1978-06-28
CH638536A5 (de) 1983-09-30
AU3201277A (en) 1979-06-28
CH637405A5 (de) 1983-07-29
NL7714428A (nl) 1978-06-29
BE862365A (fr) 1978-06-27
IE46128L (en) 1978-06-27
CH637408A5 (de) 1983-07-29
NO820059L (no) 1978-06-28
JPS5382767A (en) 1978-07-21
ZA777684B (en) 1979-08-29
FI773936A7 (fi) 1978-06-28
FR2375253A1 (fr) 1978-07-21
CH637404A5 (de) 1983-07-29
AU518862B2 (en) 1981-10-22
IL53692A (en) 1982-07-30
DK577377A (da) 1978-06-28
DE2758279A1 (de) 1978-06-29
CA1099702A (fr) 1981-04-21

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