NO774464L - Fremgangsmaate til fremstilling av 7xi-(alkoksykarbonyl)-6xi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyre gamma-lakton og tilsvarende 21-karboksylsyrer, deres salter og estere. - Google Patents

Fremgangsmaate til fremstilling av 7xi-(alkoksykarbonyl)-6xi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyre gamma-lakton og tilsvarende 21-karboksylsyrer, deres salter og estere.

Info

Publication number
NO774464L
NO774464L NO774464A NO774464A NO774464L NO 774464 L NO774464 L NO 774464L NO 774464 A NO774464 A NO 774464A NO 774464 A NO774464 A NO 774464A NO 774464 L NO774464 L NO 774464L
Authority
NO
Norway
Prior art keywords
compound
hydroxy
oxo
parts
carbon atoms
Prior art date
Application number
NO774464A
Other languages
English (en)
Norwegian (no)
Inventor
Richard Mathias Weier
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of NO774464L publication Critical patent/NO774464L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/001—Lactones
    • C07J21/003—Lactones at position 17
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
NO774464A 1976-12-27 1977-12-27 Fremgangsmaate til fremstilling av 7xi-(alkoksykarbonyl)-6xi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyre gamma-lakton og tilsvarende 21-karboksylsyrer, deres salter og estere. NO774464L (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/754,136 US4069219A (en) 1976-12-27 1976-12-27 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters

Publications (1)

Publication Number Publication Date
NO774464L true NO774464L (no) 1978-06-28

Family

ID=25033598

Family Applications (2)

Application Number Title Priority Date Filing Date
NO774464A NO774464L (no) 1976-12-27 1977-12-27 Fremgangsmaate til fremstilling av 7xi-(alkoksykarbonyl)-6xi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyre gamma-lakton og tilsvarende 21-karboksylsyrer, deres salter og estere.
NO820059A NO820059L (no) 1976-12-27 1982-01-11 Analogifremgangsmaate for fremstilling av terapeutisk virksomme 7ksi-(alkoksykarbonyl)-6ksi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyrer, deres salter og deres estere

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO820059A NO820059L (no) 1976-12-27 1982-01-11 Analogifremgangsmaate for fremstilling av terapeutisk virksomme 7ksi-(alkoksykarbonyl)-6ksi-alkyl/halogen-17-hydroksy-3-okso-17alfa-pregn-4-en-21-karboksylsyrer, deres salter og deres estere

Country Status (19)

Country Link
US (1) US4069219A (fr)
JP (1) JPS5382767A (fr)
AU (1) AU518862B2 (fr)
BE (1) BE862365A (fr)
CA (1) CA1099702A (fr)
CH (6) CH637403A5 (fr)
DE (1) DE2758279A1 (fr)
DK (1) DK577377A (fr)
FI (1) FI773936A7 (fr)
FR (1) FR2375253A1 (fr)
GB (1) GB1575986A (fr)
IE (1) IE46128B1 (fr)
IL (1) IL53692A (fr)
NL (1) NL7714428A (fr)
NO (2) NO774464L (fr)
NZ (1) NZ186119A (fr)
PT (1) PT67455B (fr)
SE (1) SE7714764L (fr)
ZA (1) ZA777684B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3111951A1 (de) * 1981-03-23 1982-09-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen 7(alpha)-alkoxycarbonyl-15ss-methylen-4-androstene, verfahren zu ihrer herstellung und verwendung als arzneimittel
JPS5921698A (ja) * 1982-07-22 1984-02-03 シエ−リング・アクチエンゲゼルシヤフト １７α−プレグネ−４−エン−３−オキソ−２１−カルボン酸エステル、その製法およびこれを含有する抗アンドロゲン作用を有する医薬
DE3330084A1 (de) * 1983-08-17 1985-03-07 Schering AG, 1000 Berlin und 4709 Bergkamen 7(alpha)-alkoxycarbonyl-3-oxo-17(alpha)-pregn-4-en-21,17-carbolactone und deren 21-carbonsaeuresalze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
CN100384866C (zh) * 1995-12-11 2008-04-30 G·D·瑟尔公司 制备7α-羧基9,11-环氧甾族化合物的方法和其中使用的中间体以及烯双键环氧化作用的一般方法
US7411006B2 (en) * 2000-10-23 2008-08-12 Shanbrom Technologies, Llc Enhanced production of blood clotting factors and fibrin fabric
US8389687B2 (en) * 2000-10-23 2013-03-05 Shanbrom Technologies, Llc Polyvinylpyrrolidone cryoprecipitate extraction of clotting factors
US7297716B2 (en) * 2000-10-23 2007-11-20 Shanbrom Technologies, Llc Enhanced production of blood components, blood cells and plasma without freezing
EP1490390A2 (fr) * 2002-03-22 2004-12-29 Pharmacia Corporation Spirolactonisation c-17 et oxydation 6,7 de steroides
AU2003213807A1 (en) * 2002-11-06 2004-06-03 Pharmacia & Upjohn Company Llc Processes for preparing 7-carboxy substituted steroids
TWI280133B (en) * 2002-11-07 2007-05-01 Upjohn Co Process for preparing C-7 substituted steroids
SI1746101T2 (sl) 2005-07-21 2014-09-30 Bayer Pharma Aktiengesellschaft Postopek za pripravo 3-okso-pregn-4-en-21,17-karbolaktonov z oksidacijo 17-(3-hidroksipropil)-3,17-dihidroksiandrostanov brez uporabe kovine
EA016411B1 (ru) 2005-07-21 2012-04-30 Байер Фарма Акциенгезельшафт Способ получения 3-оксо-прегн-4-ен-21,17-карболактонов с помощью окисления 17-(3-гидроксипропил)-3,17-дигидроксиандростанов без использования металла

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE787940A (fr) * 1971-08-25 1973-02-26 Searle & Co Nouveaux medicaments diuretiques et hypotenseurs et procede de leur preparation
GB1368006A (en) * 1972-08-24 1974-09-25 Searle & Co 4alpha,7alpha-carbonyl-5-cyano-17-hzydroxy-3-oxo-5beta,17alpha- pregnane-21-carboxylic acid ypsilon-lactone
US3972871A (en) * 1975-09-22 1976-08-03 G. D. Searle & Co. 6β,17-Dihydroxy-7α-(lower alkoxy)carbonyl-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and congeners

Also Published As

Publication number Publication date
PT67455A (en) 1978-01-01
BE862365A (fr) 1978-06-27
IE46128L (en) 1978-06-27
CH637405A5 (de) 1983-07-29
JPS5382767A (en) 1978-07-21
CH637404A5 (de) 1983-07-29
CA1099702A (fr) 1981-04-21
IL53692A0 (en) 1978-03-10
PT67455B (en) 1979-05-25
NL7714428A (nl) 1978-06-29
CH638536A5 (de) 1983-09-30
GB1575986A (en) 1980-10-01
DK577377A (da) 1978-06-28
AU3201277A (en) 1979-06-28
SE7714764L (sv) 1978-06-28
NZ186119A (en) 1979-08-31
CH635595A5 (de) 1983-04-15
NO820059L (no) 1978-06-28
US4069219A (en) 1978-01-17
IE46128B1 (en) 1983-02-23
ZA777684B (en) 1979-08-29
AU518862B2 (en) 1981-10-22
FI773936A7 (fi) 1978-06-28
FR2375253A1 (fr) 1978-07-21
FR2375253B1 (fr) 1981-04-30
IL53692A (en) 1982-07-30
DE2758279A1 (de) 1978-06-29
CH637403A5 (de) 1983-07-29
CH637408A5 (de) 1983-07-29

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