SE7804307L - Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar - Google Patents

Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar

Info

Publication number
SE7804307L
SE7804307L SE7804307A SE7804307A SE7804307L SE 7804307 L SE7804307 L SE 7804307L SE 7804307 A SE7804307 A SE 7804307A SE 7804307 A SE7804307 A SE 7804307A SE 7804307 L SE7804307 L SE 7804307L
Authority
SE
Sweden
Prior art keywords
diarylalkyl
azabicyclo
octane
procedure
preparation
Prior art date
Application number
SE7804307A
Other languages
English (en)
Swedish (sv)
Inventor
C H Yen
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of SE7804307L publication Critical patent/SE7804307L/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
SE7804307A 1977-04-18 1978-04-17 Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar SE7804307L (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/788,189 US4125531A (en) 1977-04-18 1977-04-18 2-Substituted-1-azabicyclo[2.2.2]octanes

Publications (1)

Publication Number Publication Date
SE7804307L true SE7804307L (sv) 1978-10-19

Family

ID=25143721

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7804307A SE7804307L (sv) 1977-04-18 1978-04-17 Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar

Country Status (19)

Country Link
US (1) US4125531A (de)
JP (1) JPS53132596A (de)
AT (1) AT357553B (de)
AU (1) AU3516178A (de)
BE (1) BE866031A (de)
DE (1) DE2816633A1 (de)
DK (1) DK166978A (de)
ES (1) ES468874A1 (de)
FI (1) FI781161A7 (de)
FR (1) FR2387980A1 (de)
GB (1) GB1569249A (de)
IE (1) IE46737B1 (de)
IL (1) IL54519A0 (de)
NL (1) NL7804145A (de)
NO (1) NO781333L (de)
NZ (1) NZ186991A (de)
PT (1) PT67910B (de)
SE (1) SE7804307L (de)
ZA (1) ZA782212B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4203989A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal diaryl-(1-azabicyclo(2.2.2)octan-2-yl)-alkanols and related compounds
US4203990A (en) * 1979-04-30 1980-05-20 G. D. Searle & Co. Anti-diarrheal 2-substituted quinuclidines
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
EP0412798A3 (en) * 1989-08-08 1992-07-01 Merck Sharp & Dohme Ltd. Substituted pyridines, their preparation, formulations and use in dementia
EP0499313B1 (de) * 1991-02-11 1997-06-11 MERCK SHARP & DOHME LTD. Azabicyclische Verbindungen, diese enthaltende pharmazeutische Zubereitungen und ihre therapeutische Verwendung
US5962477A (en) * 1994-04-12 1999-10-05 Adolor Corporation Screening methods for cytokine inhibitors
US6190691B1 (en) 1994-04-12 2001-02-20 Adolor Corporation Methods for treating inflammatory conditions
US6573282B1 (en) 1995-09-12 2003-06-03 Adolor Corporation Peripherally active anti-hyperalgesic opiates
US5849761A (en) * 1995-09-12 1998-12-15 Regents Of The University Of California Peripherally active anti-hyperalgesic opiates
US6353004B1 (en) 1997-07-14 2002-03-05 Adolor Coporation Peripherally acting anti-pruritic opiates
US5849762A (en) * 1997-07-14 1998-12-15 Adolor Corporation Peripherally acting anti-pruritic opiates
CA2811272C (en) 2003-04-08 2016-12-20 Progenics Pharmaceuticals, Inc. Pharmaceutical formulations containing methylnaltrexone
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
TWI489984B (zh) 2006-08-04 2015-07-01 Wyeth Corp 用於非經腸道傳輸化合物之配方及其用途
EP2565195B1 (de) 2007-03-29 2015-05-06 Wyeth LLC Peripherer Opioid-Rezeptor sowie Antagonisten und Verwendungen davon
PL2137191T3 (pl) 2007-03-29 2016-12-30 Antagoniści obwodowego receptora opioidowego i ich zastosowania
JP2010522756A (ja) 2007-03-29 2010-07-08 プロジェニックス ファーマシューティカルズ，インコーポレーテッド 結晶形およびその使用
AU2008349873B2 (en) 2008-02-06 2014-02-13 Progenics Pharmaceuticals, Inc. Preparation and use of (R),(R)-2,2'-bis-methylnaltrexone
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof
CN110372571B (zh) 2018-04-12 2022-11-15 中国科学院大连化学物理研究所 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506672A (en) * 1968-03-29 1970-04-14 Aldrich Chem Co Inc 2-(4,4'-dihalo)-benzhydryl-3-quinuclidinols
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4013667A (en) * 1976-03-08 1977-03-22 G. D. Searle & Co. 2,2-Diaryl-3-(1-azabicyclo[2.2.2]oct-2-yl)propionamides and intermediates thereto

Also Published As

Publication number Publication date
AU3516178A (en) 1979-10-25
ZA782212B (en) 1979-11-28
DK166978A (da) 1978-10-19
IL54519A0 (en) 1978-07-31
PT67910A (en) 1978-05-01
BE866031A (fr) 1978-10-17
PT67910B (en) 1979-11-14
NL7804145A (nl) 1978-10-20
AT357553B (de) 1980-07-25
ATA266178A (de) 1979-12-15
NZ186991A (en) 1979-12-11
FR2387980A1 (fr) 1978-11-17
GB1569249A (en) 1980-06-11
JPS53132596A (en) 1978-11-18
IE46737B1 (en) 1983-09-07
NO781333L (no) 1978-10-19
FI781161A7 (fi) 1978-10-19
IE780745L (en) 1978-10-18
DE2816633A1 (de) 1978-10-19
US4125531A (en) 1978-11-14
ES468874A1 (es) 1978-12-01

Similar Documents

Publication Publication Date Title
SE7804307L (sv) Forfarande for framstellning av 2-(2,2-diarylalkyl)-1-azabicyklo(2.2.2)oktan och beslektade foreningar
NO803851L (no) Fremgangsmaate til fremstilling av 4,1`,6`-triklor-4,1`,6`-trideoksy-galaktosukrose
NO794327L (no) Fremgangsmaate ved fremstilling av nye peptidylargininaldehyd-derivater.
NO155434C (no) Fremgangsmaate for fremstilling av forfalskningssikre dokumenter.
SE434946B (sv) Forfarande for framstellning av acylsackariner och acyl-3-oxo-1,2-densisotiazoliner
NO803591L (no) Fremgangsmaate for fremstilling av fiskemel.
SE7813441L (sv) N-substituerade omega-aminoalkanoyl-omega-aminoalkansyror, anvendning derav och forfaranden for framstellning derav samt lekemedel innehallande dessa foreningar
NO148959C (no) Fremgangsmaate ved fremstilling av tumor-motvirkende antracyklinglykosidantibiotika, betegnet ma 144
SE7804400L (sv) Cefalosporinforeningar och forfarande for framstellning derav
NO800338L (no) Fremgangsmaate ved fremstilling av nye 4-(nafthylmethyl)piperidinderivater.
NO149957C (no) Fremgangsmaate for fremstilling av 4-(6`-metoksy-2`-naftyl)butan-2-on.
NO771159L (no) Fremgangsm}te ved fremstilling av titantetraklorid.
NO800627L (no) Fremgangsmaate for fremstilling av lateks.
NO156086C (no) Analogifremgangsmaate for fremstilling av substituerte heterocykliske fenoksyaminer.
RO77485A (ro) Procedeu pentru prepararea 1,2,3-tiadiazol-3-in-5-ilidenureelor
NO153431C (no) Fremgangsmaate ved fremstilling av 6alfa-halogen-3-keto-delta1,4-pregnadiener.
NO153853C (no) Fremgangsmaate for fremstilling av 17beta-hydroksy-17alfa-pregn-5-en-21-karboksylsyre-gamma-laktoner.
SE436026B (sv) Forfarande for framstellning av 13,14-dehydroprostaglandiner
RO81212A (ro) Procedeu pentru prepararea unor 2',6'-dialchil-n-(alcoximetil)2-cloracetanilide
NO152645C (no) Fremgangsmaate for fremstilling av klordioksyd.
NO801142L (no) Fremgangsmaate til fremstilling av klordioksyd.
NO155539C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme isokinolinderivater.
SE7804878L (sv) Forfarande for framstellning av 1,2-dikloretan
NO152840C (no) Fremgangsmaate for fremstilling av dibenzyletere.
RO75739A (ro) Procedeu pentru prepararea unor carbamoil triazolil-o,n-acetali