SE8004253L - NEW 4-AROYLIMIDAZOL-2-ONER - Google Patents
NEW 4-AROYLIMIDAZOL-2-ONERInfo
- Publication number
- SE8004253L SE8004253L SE8004253A SE8004253A SE8004253L SE 8004253 L SE8004253 L SE 8004253L SE 8004253 A SE8004253 A SE 8004253A SE 8004253 A SE8004253 A SE 8004253A SE 8004253 L SE8004253 L SE 8004253L
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- phenyl
- hydrogen
- alkoxy
- hydroxy
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- -1 pyrrolidino, piperidino, morpholino, piperazino Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000036543 hypotension Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A compound for the alleviation of hypotension or the treatment of cardiac failure, having the formula <IMAGE> wherein R is hydrogen, C1-4 alkyl, (C1-4 alkyl) carbonyl or benzoyl; R1 is hydrogen or C1-4 alkyl; and Ar is 2-furyl; 2-thienyl; phenyl; phenyl monosubstituted by halogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, trifluoromethyl, -SO2N(R2)2, NR3R4, pyrrolidino, piperidino, morpholino, piperazino or N'-alkylpiperazino in which R2, R3 and R4 are independently selected from hydrogen and C1-4 alkyl; disubstituted phenyl in which one substituent is at the para position and the substituents are independently selected from halogen, hydroxy, C1-4 alkyl and C1-4 alkoxy; or 3,4-methylenedioxy- phenyl in which the methylene group is optionally substituted by one or two methyl groups; or a pharmaceutically acceptable salt thereof. Many compounds of formula I are novel.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4980879A | 1979-06-18 | 1979-06-18 | |
| US11920780A | 1980-02-07 | 1980-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8004253L true SE8004253L (en) | 1980-12-19 |
| SE447107B SE447107B (en) | 1986-10-27 |
Family
ID=26727558
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8004253A SE447107B (en) | 1979-06-18 | 1980-06-06 | NEW 4-AROYLIMIDAZOL-2-ONER |
| SE8501452A SE464559B (en) | 1979-06-18 | 1985-03-25 | PHARMACEUTICAL COMPOSITION CONTAINING 4-AROYLIMIDAZOLE-2-ONER WITH ANTIHYPERTENSIVE, CARDIOTONE AND ANTITHROMOBOTIC EFFECTS |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8501452A SE464559B (en) | 1979-06-18 | 1985-03-25 | PHARMACEUTICAL COMPOSITION CONTAINING 4-AROYLIMIDAZOLE-2-ONER WITH ANTIHYPERTENSIVE, CARDIOTONE AND ANTITHROMOBOTIC EFFECTS |
Country Status (20)
| Country | Link |
|---|---|
| AT (1) | AT375349B (en) |
| AU (1) | AU532783B2 (en) |
| CA (1) | CA1132554A (en) |
| CH (1) | CH646155A5 (en) |
| DE (1) | DE3021792A1 (en) |
| DK (1) | DK160269C (en) |
| ES (1) | ES492255A0 (en) |
| FR (1) | FR2459233A1 (en) |
| GB (1) | GB2055364B (en) |
| HK (1) | HK61486A (en) |
| HU (1) | HU186736B (en) |
| IE (1) | IE50646B1 (en) |
| IL (1) | IL60243A (en) |
| IT (1) | IT1143922B (en) |
| MY (1) | MY8600709A (en) |
| NL (2) | NL193752C (en) |
| NO (1) | NO152841C (en) |
| NZ (1) | NZ193935A (en) |
| PH (1) | PH18683A (en) |
| SE (2) | SE447107B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH18106A (en) * | 1981-02-18 | 1985-03-21 | Merrell Dow Pharma | Novel-4-aroylimidazol-2-ones |
| US4405628A (en) * | 1981-03-05 | 1983-09-20 | Merrell Dow Pharmaceuticals Inc. | 4-Pyridylimidazolones and method of use |
| US4381393A (en) * | 1981-05-04 | 1983-04-26 | Merrell Dow Pharmaceuticals Inc. | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4371737A (en) * | 1981-05-04 | 1983-02-01 | Merrell Dow Pharmaceuticals Inc. | 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| ZA822990B (en) * | 1981-05-04 | 1983-03-30 | Merrell Dow Pharma | 4-oxymethyl-5-acyl-1,3-dihydro-2h-imidazol-2-ones |
| US4526981A (en) * | 1981-05-04 | 1985-07-02 | Merrell Dow Pharmaceuticals Inc. | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates |
| US4329471A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones |
| US4329470A (en) * | 1981-05-04 | 1982-05-11 | Merrell Dow Pharmaceuticals Inc. | 5-(4-Phenyl 1-piperidinyl)methyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives |
| US4367236A (en) | 1981-11-04 | 1983-01-04 | Merrell Dow Pharmaceuticals Inc. | Method for the treatment of cardiac failure with alkanoylimidazol-2-one derivatives |
| US4410540A (en) * | 1981-11-04 | 1983-10-18 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 4-aroylimidazolidin-2-ones |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2007530566A (en) * | 2004-03-22 | 2007-11-01 | ミオゲン インコーポレイティッド | (R) -Enoximone sulfoxide and its use in the treatment of PDE-III mediated diseases |
| EP1737448A1 (en) * | 2004-03-22 | 2007-01-03 | Myogen, Inc. | (s) - enoximone sulfoxide and its use in the treatment of pde-iii mediated diseases |
| US8067433B2 (en) | 2005-11-09 | 2011-11-29 | Zalicus Inc. | Methods, compositions, and kits for the treatment of ophthalmic disorders |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2627848T3 (en) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2624828T3 (en) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| MX357121B (en) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Process of preparing guanylate cyclase c agonists. |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP2958577A2 (en) | 2013-02-25 | 2015-12-30 | Synergy Pharmaceuticals Inc. | Guanylate cyclase receptor agonists for use in colonic cleansing |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| PL3004138T3 (en) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
| CA2920856C (en) | 2013-08-09 | 2026-03-03 | Ardelyx, Inc. | Ph modulating compounds for inhibiting gastrointestinal phosphate uptake |
| JP2022533251A (en) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | Combinations to lower serum phosphate in patients |
| CN114539157B (en) * | 2022-03-03 | 2023-12-22 | 曲靖师范学院 | Method for preparing 4-iodo-N-aryl pyrazole compound by iodine-promoted oxidation method |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2441933A (en) * | 1945-07-30 | 1948-05-18 | Hoffmann La Roche | Substituted imidazolones and process of making them |
-
1980
- 1980-06-04 NZ NZ193935A patent/NZ193935A/en unknown
- 1980-06-05 IE IE1162/80A patent/IE50646B1/en not_active IP Right Cessation
- 1980-06-06 AU AU59118/80A patent/AU532783B2/en not_active Expired
- 1980-06-06 IL IL60243A patent/IL60243A/en unknown
- 1980-06-06 SE SE8004253A patent/SE447107B/en not_active IP Right Cessation
- 1980-06-09 ES ES492255A patent/ES492255A0/en active Granted
- 1980-06-11 DE DE19803021792 patent/DE3021792A1/en active Granted
- 1980-06-13 AT AT0314280A patent/AT375349B/en not_active IP Right Cessation
- 1980-06-16 PH PH24143A patent/PH18683A/en unknown
- 1980-06-16 CH CH462780A patent/CH646155A5/en not_active IP Right Cessation
- 1980-06-17 CA CA354,197A patent/CA1132554A/en not_active Expired
- 1980-06-17 DK DK259080A patent/DK160269C/en not_active IP Right Cessation
- 1980-06-17 NL NL8003498A patent/NL193752C/en not_active IP Right Cessation
- 1980-06-17 FR FR8013434A patent/FR2459233A1/en active Granted
- 1980-06-17 NO NO801796A patent/NO152841C/en unknown
- 1980-06-17 HU HU801506A patent/HU186736B/en unknown
- 1980-06-17 IT IT48997/80A patent/IT1143922B/en active Protection Beyond IP Right Term
- 1980-06-18 GB GB8019898A patent/GB2055364B/en not_active Expired
-
1985
- 1985-03-25 SE SE8501452A patent/SE464559B/en not_active IP Right Cessation
-
1986
- 1986-08-21 HK HK614/86A patent/HK61486A/en not_active IP Right Cessation
- 1986-12-30 MY MY709/86A patent/MY8600709A/en unknown
-
2000
- 2000-09-04 NL NL300015C patent/NL300015I1/en unknown
Also Published As
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