SE8200916L - Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma - Google Patents

Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma

Info

Publication number: SE8200916L
Authority: SE; Sweden
Prior art keywords: same; hearting; procedures; preparing; composition containing
Prior art date: 1981-02-17

Application number

SE8200916A

Other languages

English (en)

Other versions

SE445348B (sv

Inventor

Michiaki Tominaga

Yung-Hsiung Yang

Hidenori Ogawa

Kazuyuki Nakagawa

Original Assignee

Otsuka Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-02-17

Filing date

1982-02-16

Publication date

1982-08-18

1981-02-17 Priority claimed from JP56022437A external-priority patent/JPS57136517A/ja

1981-04-15 Priority claimed from JP56057732A external-priority patent/JPS57171974A/ja

1981-08-12 Priority claimed from JP12714581A external-priority patent/JPS5829766A/ja

1982-02-16 Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd

1982-08-18 Publication of SE8200916L publication Critical patent/SE8200916L/sv

1986-06-16 Publication of SE445348B publication Critical patent/SE445348B/sv

Links

239000000203 mixture Substances 0.000 title abstract 2
LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical class C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
239000004480 active ingredient Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000003177 cardiotonic effect Effects 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Quinoline Compounds (AREA)

SE8200916A 1981-02-17 1982-02-16 Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma SE445348B (sv)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
JP56022437A JPS57136517A (en)	1981-02-17	1981-02-17	Cardiotonic
JP56057732A JPS57171974A (en)	1981-04-15	1981-04-15	Carbostyril derivative
JP12714581A JPS5829766A (ja)	1981-08-12	1981-08-12	カルボスチリル誘導体

Publications (2)

Publication Number	Publication Date
SE8200916L true SE8200916L (sv)	1982-08-18
SE445348B SE445348B (sv)	1986-06-16

Family

ID=27283844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8200916A SE445348B (sv)	1981-02-17	1982-02-16	Karbostyrilderivat, forfarande for framstellning derav och hjertsterkande komposition som innehaller detsamma

Country Status (21)

Country	Link
US (3)	US4487772A (sv)
KR (1)	KR860001337B1 (sv)
AT (1)	AT386198B (sv)
AU (1)	AU530264B2 (sv)
BE (1)	BE892148A (sv)
CA (1)	CA1199915A (sv)
CH (1)	CH651827A5 (sv)
DE (1)	DE3204892A1 (sv)
DK (1)	DK152287C (sv)
ES (2)	ES8305334A1 (sv)
FI (1)	FI77852C (sv)
FR (1)	FR2512818B1 (sv)
GB (1)	GB2094789B (sv)
IT (1)	IT1157002B (sv)
MX (1)	MX156153A (sv)
NL (1)	NL8200593A (sv)
NO (1)	NO159446C (sv)
PH (1)	PH18085A (sv)
PT (1)	PT74440B (sv)
SE (1)	SE445348B (sv)
SU (1)	SU1331426A3 (sv)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH17194A (en) *	1980-03-06	1984-06-19	Otsuka Pharma Co Ltd	Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (sv) *	1981-02-17	1989-05-10	Otsuka Pharma Co Ltd	Förfarande för framställning av nya, såsom hjärtmediciner användbara s ubstituerade amid- och (mättad heterocykel)karbonylkarbostyrilderivat.
AU532361B2 (en) *	1981-09-01	1983-09-29	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives
FI80022C (sv) *	1982-07-05	1990-04-10	Otsuka Pharma Co Ltd	Förfarande för framställning av ett nytt, terapeutiskt användbart karb ostyrilderivat
US4845100A (en) *	1985-04-12	1989-07-04	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivatives and salts thereof, processes for preparing the same and cardiotonic composition containing the same
US4792561A (en) *	1986-05-29	1988-12-20	Syntex (U.S.A.) Inc.	Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4921862A (en) *	1986-05-29	1990-05-01	Syntex (U.S.A.) Inc.	Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
DE3784401T2 (de) *	1986-07-31	1993-08-12	Otsuka Pharma Co Ltd	Karbostyril-derivate und ihre salze, verfahren zu ihrer herstellung und diese enthaltende kardiotonische zusammensetzung.
GB8709448D0 (en) *	1987-04-21	1987-05-28	Pfizer Ltd	Heterobicyclic quinoline derivatives
US5227381A (en) *	1988-05-02	1993-07-13	Otsuka Pharmaceutical Co., Ltd.	Carbostyril derivative
DE3818830A1 (de) *	1988-06-03	1989-12-14	Boehringer Mannheim Gmbh	Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel
JP2686887B2 (ja) *	1992-08-11	1997-12-08	キッセイ薬品工業株式会社	ピペリジノ−３，４−ジヒドロカルボスチリル誘導体
JPH06239858A (ja) *	1993-02-16	1994-08-30	Otsuka Pharmaceut Co Ltd	末梢血管拡張剤
ATE219766T1 (de) *	1993-04-07	2002-07-15	Otsuka Pharma Co Ltd	N-acylierte 4-aminopiperidin derivate als aktive bestandteile von peripher gefässerweiternden wikstoffen
ATE174915T1 (de) *	1994-10-31	1999-01-15	Merck Patent Gmbh	Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren
US6589954B1 (en) *	1998-05-22	2003-07-08	Scios, Inc.	Compounds and methods to treat cardiac failure and other disorders
US6448257B1 (en)	1998-05-22	2002-09-10	Scios, Inc.	Compounds and methods to treat cardiac failure and other disorders
US6867209B1 (en)	1998-05-22	2005-03-15	Scios, Inc.	Indole-type derivatives as inhibitors of p38 kinase
US6340685B1 (en) *	1998-05-22	2002-01-22	Scios, Inc.	Compounds and methods to treat cardiac failure and other disorders
IL146309A (en)	1999-05-21	2008-03-20	Scios Inc	Derivatives of the indole type and pharmaceutical preparations containing them as inhibitors of kinase p38
WO2004014389A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	3,4-dihydroquinolin-2-one, 5,6-fused oxazin-3-one, and 5,6-fused thiazin-3-one derivatives as matrix metalloproteinase inhibitors
EA010592B1 (ru) *	2003-12-10	2008-10-30	Янссен Фармацевтика Н.В.	6-замещённые циклогексилалкил 2-замещённые хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(adp-рибоза)полимеразы
MY142362A (en) *	2004-01-29	2010-11-30	Otsuka Pharma Co Ltd	Pharmaceutical composition for promoting angiogenesis
WO2007124345A2 (en)	2006-04-21	2007-11-01	The Government Of The United States, As Represented By The Secretary Of Health And Human Services	Beta-amyloid pet imaging agents
WO2010021681A2 (en) *	2008-08-18	2010-02-25	Combinatorx (Singapore) Pte. Ltd.	Compositions and methods for treatment of viral diseases
LT2445502T (lt)	2009-06-25	2017-09-25	Alkermes Pharma Ireland Limited	Heterocikliniai junginiai, skirti neurologinių ir fiziologinių susirgimų gydymui
CA2797708C (en)	2010-05-04	2016-08-16	Alkermes Pharma Ireland Limited	Process for synthesizing oxidized lactam compounds
AU2011270701B2 (en)	2010-06-24	2015-05-14	Alkermes Pharma Ireland Limited	Prodrugs of NH-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
EP3717477B1 (en) *	2017-11-28	2022-07-20	F. Hoffmann-La Roche AG	New heterocyclic compounds
WO2019134985A1 (en)	2018-01-08	2019-07-11	F. Hoffmann-La Roche Ag	Octahydropyrido[1,2-alpha]pyrazines as magl inhibitors
CN109651285B (zh) *	2019-01-30	2020-06-30	苏州大学	多溴代苯并[1,3]噁嗪衍生物的合成方法
MX2023002224A (es)	2020-09-03	2023-03-15	Hoffmann La Roche	Compuestos heterociclicos.

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2997474A (en) *	1959-10-12	1961-08-22	Paul A J Janssen	1-aryl-omega-(4-arylpiperazine) alkanols
US3555030A (en) *	1964-11-25	1971-01-12	Smith Kline French Lab	Muscle relaxant and analgesic compositions
US4115569A (en) *	1971-11-19	1978-09-19	Hoechst Aktiengesellschaft	Cyclic diamine derivatives
US4256890A (en) *	1972-09-14	1981-03-17	Otsukapharmaceutical Co., Ltd.	3,4-Dihydrocarbostyril derivatives and process for producing the same
IT998326B (it) *	1973-08-06	1976-01-20	Montedison Spa	Derivati degli acidi chinolin 8 carbossilici ad attivita antiparas sitaria
US4026897A (en) *	1974-01-31	1977-05-31	Otsuka Pharmaceutical Company	5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-hydroxycarbostyril derivatives
US4022784A (en) *	1974-01-31	1977-05-10	Otsuka Pharmaceutical Company Limited	5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
US4145542A (en) *	1974-06-13	1979-03-20	Otsuka Pharmaceutical Co., Ltd.	5- 1-Hydroxy-2-(heterocyclic-amino)!alkyl-8-hydroxy-3,4-dihydrocarbostyril derivatives
US4070470A (en) *	1974-06-24	1978-01-24	Otsuka Pharmaceutical Co., Ltd.	Platelet aggregation inhibiting carbostyrils, their compositions and method of use
JPS51118771A (en) *	1975-04-09	1976-10-18	Otsuka Pharmaceut Co Ltd	Method for preparing carbostyryl derivatives
US3994900A (en) *	1976-01-23	1976-11-30	E. R. Squibb & Sons, Inc.	6-(Or 8)-[[(substituted amino)alkyl]oxy(or thio)]-3,4-dihydro-4-phenyl-2(1H)-quinolinones
US4210753A (en) *	1976-03-17	1980-07-01	Otsuka Pharmaceutical Co., Ltd.	Carbostyril compounds
GB1589871A (en) *	1976-07-19	1981-05-20	Conder Group Serv Ltd	Tank construction
JPS609713B2 (ja) *	1976-10-08	1985-03-12	大塚製薬株式会社	カルボスチリル誘導体
NZ187452A (en) *	1977-06-10	1980-05-27	Otsuka Pharma Co Ltd	N- substituted-aminocarbonylpropoxy-carbostyrils and their preparation
JPS5416478A (en) *	1977-07-08	1979-02-07	Otsuka Pharmaceut Co Ltd	3,4-dihydrocarbostyril herivative
DE2928583A1 (de) *	1979-07-14	1981-01-29	Thomae Gmbh Dr K	Verfahren zur herstellung von carbostyrilderivaten
PH17194A (en) *	1980-03-06	1984-06-19	Otsuka Pharma Co Ltd	Novel carbostyril derivatives,and pharmaceutical composition containing the same
FI77852C (sv) *	1981-02-17	1989-05-10	Otsuka Pharma Co Ltd	Förfarande för framställning av nya, såsom hjärtmediciner användbara s ubstituerade amid- och (mättad heterocykel)karbonylkarbostyrilderivat.

1982
- 1982-02-03 FI FI820338A patent/FI77852C/sv not_active IP Right Cessation
- 1982-02-12 DE DE19823204892 patent/DE3204892A1/de active Granted
- 1982-02-15 SU SU823394100A patent/SU1331426A3/ru active
- 1982-02-15 PH PH26870A patent/PH18085A/en unknown
- 1982-02-15 BE BE0/207321A patent/BE892148A/fr not_active IP Right Cessation
- 1982-02-15 MX MX8210261A patent/MX156153A/es unknown
- 1982-02-16 SE SE8200916A patent/SE445348B/sv not_active IP Right Cessation
- 1982-02-16 KR KR8200668A patent/KR860001337B1/ko not_active Expired
- 1982-02-16 AT AT0059582A patent/AT386198B/de not_active IP Right Cessation
- 1982-02-16 NL NL8200593A patent/NL8200593A/nl not_active Application Discontinuation
- 1982-02-16 NO NO820479A patent/NO159446C/no unknown
- 1982-02-16 US US06/348,709 patent/US4487772A/en not_active Expired - Lifetime
- 1982-02-16 AU AU80528/82A patent/AU530264B2/en not_active Ceased
- 1982-02-16 PT PT74440A patent/PT74440B/pt not_active IP Right Cessation
- 1982-02-16 DK DK066582A patent/DK152287C/da active
- 1982-02-16 CA CA000396327A patent/CA1199915A/en not_active Expired
- 1982-02-16 FR FR8202479A patent/FR2512818B1/fr not_active Expired
- 1982-02-17 CH CH996/82A patent/CH651827A5/de not_active IP Right Cessation
- 1982-02-17 GB GB8204581A patent/GB2094789B/en not_active Expired
- 1982-02-17 IT IT67177/82A patent/IT1157002B/it active
- 1982-02-17 ES ES509693A patent/ES8305334A1/es not_active Expired
- 1982-12-16 ES ES518303A patent/ES8401959A1/es not_active Expired
1983
- 1983-08-22 US US06/525,284 patent/US4468402A/en not_active Expired - Lifetime
- 1983-08-22 US US06/525,812 patent/US4454130A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DK152287B (da)	1988-02-15
CA1199915A (en)	1986-01-28
PT74440A (en)	1982-03-01
NO820479L (no)	1982-08-18
DK66582A (da)	1982-08-18
FI77852C (sv)	1989-05-10
IT8267177A0 (it)	1982-02-17
NO159446C (no)	1988-12-28
DE3204892C2 (sv)	1988-03-24
FR2512818B1 (fr)	1985-06-21
AT386198B (de)	1988-07-11
CH651827A5 (de)	1985-10-15
BE892148A (fr)	1982-08-16
SE445348B (sv)	1986-06-16
IT1157002B (it)	1987-02-11
FI77852B (fi)	1989-01-31
NL8200593A (nl)	1982-09-16
ES518303A0 (es)	1984-01-01
US4468402A (en)	1984-08-28
ES509693A0 (es)	1983-04-01
NO159446B (no)	1988-09-19
FI820338L (fi)	1982-08-18
FR2512818A1 (fr)	1983-03-18
AU530264B2 (en)	1983-07-07
ES8305334A1 (es)	1983-04-01
KR860001337B1 (ko)	1986-09-15
SU1331426A3 (ru)	1987-08-15
DK152287C (da)	1988-07-11
US4454130A (en)	1984-06-12
KR830009036A (ko)	1983-12-17
GB2094789B (en)	1985-01-23
DE3204892A1 (de)	1982-09-23
PH18085A (en)	1985-03-20
US4487772A (en)	1984-12-11
ATA59582A (de)	1987-12-15
AU8052882A (en)	1982-11-11
PT74440B (en)	1983-08-24
MX156153A (es)	1988-07-19
GB2094789A (en)	1982-09-22
ES8401959A1 (es)	1984-01-01

Legal Events

Date

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1995-01-31

NAL

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1999-11-01

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