SE8302193L - N-(1-substituerade-3-pyrrolidinyl)-bensamider och tiobensamider - Google Patents
N-(1-substituerade-3-pyrrolidinyl)-bensamider och tiobensamiderInfo
- Publication number
- SE8302193L SE8302193L SE8302193A SE8302193A SE8302193L SE 8302193 L SE8302193 L SE 8302193L SE 8302193 A SE8302193 A SE 8302193A SE 8302193 A SE8302193 A SE 8302193A SE 8302193 L SE8302193 L SE 8302193L
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- substituted
- thiobensamides
- benzamides
- pyrrolidinyl
- Prior art date
Links
- -1 1-SUBSTITUTED-3-PYRROLIDINYL Chemical class 0.000 title claims 4
- 229940054066 benzamide antipsychotics Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004663 dialkyl amino group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Otolaryngology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Claims (1)
1. Patentkrav POrfarande for framstgllning av en forening med formeln 2 f'ar reagera med en bensoylklorid med formeln Cl-C dgr R2 betecknar vats, 3:gyre alkyl, lagre alkoxi, halogen, nitro, monoalkylamino, dialkylamino, merkaptometyl, aoetamido, sulfamoyl, cyano, Ivarvio nar R2 betecknar amino eller acetamido istgllet anvAndest 'svarande fbrening innehallande en nitrogrupp sedan utsattes Zr- hydroxi, bensyloxi, trifluormetyl,kannetecknat av att en forening med formelnkatalytisk hydrering till en aminogrupp och eventuollt acyleras till onskad acetaminogrupp.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24084072A | 1972-04-03 | 1972-04-03 | |
| US34041773A | 1973-03-12 | 1973-03-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8302193D0 SE8302193D0 (sv) | 1983-04-19 |
| SE8302193L true SE8302193L (sv) | 1983-04-19 |
| SE431869B SE431869B (sv) | 1984-03-05 |
Family
ID=26933765
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7304619A SE402102B (sv) | 1972-04-03 | 1973-04-02 | Forfarande for framstellning av 4-amino-n-(1-cyklohexyl-3-pyrrolidinyl)-n-alkyl-bensamider, med verdefulla terapeutiska egenskaper |
| SE7711953A SE431868B (sv) | 1972-04-03 | 1977-10-24 | Forfarande for framstellning av n-(1-cyklohexyl-3-pyrrolidinyl)-bensamider med antiemetisk verkan |
| SE8302193A SE431869B (sv) | 1972-04-03 | 1983-04-19 | Forfarande for framstellning av n-(1-cyklohexyl-3-pyrrolidinyl)-bensamider med antiemetisk verkan |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7304619A SE402102B (sv) | 1972-04-03 | 1973-04-02 | Forfarande for framstellning av 4-amino-n-(1-cyklohexyl-3-pyrrolidinyl)-n-alkyl-bensamider, med verdefulla terapeutiska egenskaper |
| SE7711953A SE431868B (sv) | 1972-04-03 | 1977-10-24 | Forfarande for framstellning av n-(1-cyklohexyl-3-pyrrolidinyl)-bensamider med antiemetisk verkan |
Country Status (9)
| Country | Link |
|---|---|
| JP (4) | JPS5620312B2 (sv) |
| CA (1) | CA999003A (sv) |
| CH (1) | CH580582A5 (sv) |
| DK (1) | DK138491B (sv) |
| ES (1) | ES413260A1 (sv) |
| NL (1) | NL178318C (sv) |
| NO (1) | NO142077C (sv) |
| PH (1) | PH15259A (sv) |
| SE (3) | SE402102B (sv) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA732296B (en) * | 1972-04-03 | 1974-11-27 | Robins Co Inc A H | Method for controlling emesis with n-(1-substituted-3-pyrrolidinyl)benzamides and thiobenzamides |
| JPS5423113Y2 (sv) * | 1974-10-08 | 1979-08-09 | ||
| JPS5925784B2 (ja) * | 1975-12-17 | 1984-06-21 | 山之内製薬株式会社 | シンキナカルボンサンアミドユウドウタイノセイホウ |
| JPS5232815U (sv) * | 1975-08-28 | 1977-03-08 | ||
| JPS5925785B2 (ja) * | 1976-01-01 | 1984-06-21 | 山之内製薬株式会社 | 新規なカルボン酸アミド誘導体 |
| JPS5522699A (en) * | 1979-08-10 | 1980-02-18 | Yamanouchi Pharmaceut Co Ltd | Novel 3-amino-1-benzylpyrrolidine derivative |
| JPS6316492U (sv) * | 1986-07-18 | 1988-02-03 | ||
| CN1147248A (zh) * | 1994-04-28 | 1997-04-09 | 山之内制药株式会社 | N-(3-吡咯烷基)苯甲酰胺衍生物 |
| WO2004050024A2 (en) | 2002-11-27 | 2004-06-17 | Incyte Corporation | 3-aminopyrrolidine derivatives as modulators of chemokine receptors |
-
1973
- 1973-04-02 PH PH14480A patent/PH15259A/en unknown
- 1973-04-02 NO NO1334/73A patent/NO142077C/no unknown
- 1973-04-02 CA CA167,654A patent/CA999003A/en not_active Expired
- 1973-04-02 NL NLAANVRAGE7304557,A patent/NL178318C/xx not_active IP Right Cessation
- 1973-04-02 ES ES413260A patent/ES413260A1/es not_active Expired
- 1973-04-02 CH CH469073A patent/CH580582A5/xx not_active IP Right Cessation
- 1973-04-02 SE SE7304619A patent/SE402102B/sv unknown
- 1973-04-02 DK DK177673AA patent/DK138491B/da unknown
- 1973-04-03 JP JP3752273A patent/JPS5620312B2/ja not_active Expired
-
1974
- 1974-03-14 JP JP49028687A patent/JPS5069067A/ja active Pending
- 1974-03-14 JP JP2868674A patent/JPS5527905B2/ja not_active Expired
-
1975
- 1975-11-08 JP JP50134614A patent/JPS5182261A/ja active Pending
-
1977
- 1977-10-24 SE SE7711953A patent/SE431868B/sv not_active IP Right Cessation
-
1983
- 1983-04-19 SE SE8302193A patent/SE431869B/sv not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2316644A1 (de) | 1973-10-18 |
| NL7304557A (sv) | 1973-10-05 |
| JPS5069066A (sv) | 1975-06-09 |
| JPS5182261A (en) | 1976-07-19 |
| ES413260A1 (es) | 1976-05-16 |
| CA999003A (en) | 1976-10-26 |
| SE8302193D0 (sv) | 1983-04-19 |
| NL178318C (nl) | 1986-03-03 |
| SE431869B (sv) | 1984-03-05 |
| SE7711953L (sv) | 1977-10-24 |
| SE431868B (sv) | 1984-03-05 |
| JPS5527905B2 (sv) | 1980-07-24 |
| JPS4913165A (sv) | 1974-02-05 |
| JPS5620312B2 (sv) | 1981-05-13 |
| NO142077C (no) | 1980-06-25 |
| CH580582A5 (sv) | 1976-10-15 |
| PH15259A (en) | 1982-11-02 |
| NO142077B (no) | 1980-03-17 |
| DK138491C (sv) | 1979-04-09 |
| SE402102B (sv) | 1978-06-19 |
| DK138491B (da) | 1978-09-18 |
| JPS5069067A (sv) | 1975-06-09 |
| NL178318B (nl) | 1985-10-01 |
| DE2316644B2 (de) | 1977-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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