SE8303414L - Forbettringar vid framstellning av antibiotika - Google Patents

Forbettringar vid framstellning av antibiotika

Info

Publication number: SE8303414L
Authority: SE; Sweden
Prior art keywords: alpha; reaction; diethylcarbonate; bromo; antibiotics
Prior art date: 1982-06-29

Application number

SE8303414A

Other languages

English (en)

Other versions

SE454879B (sv

SE8303414D0 (sv

Inventor

L Ratti

D R Palmer

R G Tyson

Original Assignee

Astra Laekemedel Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-06-29

Filing date

1983-06-15

Publication date

1983-12-30

1982-06-29 Priority claimed from IT22141/82A external-priority patent/IT1190897B/it

1983-01-07 Priority claimed from GB838300331A external-priority patent/GB8300331D0/en

1983-06-15 Application filed by Astra Laekemedel Ab filed Critical Astra Laekemedel Ab

1983-06-15 Publication of SE8303414D0 publication Critical patent/SE8303414D0/sv

1983-12-30 Publication of SE8303414L publication Critical patent/SE8303414L/sv

1987-06-04 Priority to SE8702321A priority Critical patent/SE500109C2/sv

1988-06-06 Publication of SE454879B publication Critical patent/SE454879B/sv

Links

239000003242 anti bacterial agent Substances 0.000 title 1
229940088710 antibiotic agent Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000006243 chemical reaction Methods 0.000 abstract 3
IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
230000032050 esterification Effects 0.000 abstract 2
238000005886 esterification reaction Methods 0.000 abstract 2
229930182555 Penicillin Natural products 0.000 abstract 1
150000004729 acetoacetic acid derivatives Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 abstract 1
229960000723 ampicillin Drugs 0.000 abstract 1
MOIPGXQKZSZOQX-UHFFFAOYSA-N carbonyl bromide Chemical compound BrC(Br)=O MOIPGXQKZSZOQX-UHFFFAOYSA-N 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
-1 ethylcarbonyloxyethyl esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002960 penicillins Chemical class 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C68/00—Preparation of esters of carbonic or haloformic acids
- C07C68/02—Preparation of esters of carbonic or haloformic acids from phosgene or haloformates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Communicable Diseases (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Catalysts (AREA)
Plural Heterocyclic Compounds (AREA)

SE8303414A 1982-06-29 1983-06-15 Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g SE454879B (sv)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
SE8702321A SE500109C2 (sv)	1982-06-29	1987-06-04	Förfarande för framställning av 1-etoxikarbonyloxietylestern av 6-(D(-)-2-amino-a-fenylacetamido)-penicillansyra

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
IT22141/82A IT1190897B (it)	1982-06-29	1982-06-29	Procedimento per la preparazione dell'estere 1-etossicarbonilossietilico dell'acido 6-(d(-)-alfa aminoalfa fenilacetamido)-penicillanico
GB8226751		1982-09-20
GB8228622		1982-10-06
GB8232629		1982-11-16
GB838300331A GB8300331D0 (en)	1983-01-07	1983-01-07	Preparation of bromo carbonates

Publications (3)

Publication Number	Publication Date
SE8303414D0 SE8303414D0 (sv)	1983-06-15
SE8303414L true SE8303414L (sv)	1983-12-30
SE454879B SE454879B (sv)	1988-06-06

Family

ID=27516485

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SE8303414A SE454879B (sv)	1982-06-29	1983-06-15	Alfa-bromodietylkarbonat samt dess anvendning som mellanprodukt vid framstellning av penicillin g
SE9100548A SE503843C2 (sv)	1982-06-29	1991-02-26	Förfarande för framställning av 1-etoxikarbonyloxietylestern ab 6-(D(-)-a-amino-a-fenyl-acetamido)-penicillansyra

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SE9100548A SE503843C2 (sv)	1982-06-29	1991-02-26	Förfarande för framställning av 1-etoxikarbonyloxietylestern ab 6-(D(-)-a-amino-a-fenyl-acetamido)-penicillansyra

Country Status (23)

Country	Link
JP (2)	JPH0730082B2 (sv)
AT (1)	AT383128B (sv)
AU (1)	AU566803B2 (sv)
BG (3)	BG38335A3 (sv)
CH (2)	CH657620B (sv)
CY (2)	CY1520A (sv)
DD (1)	DD211561A5 (sv)
DE (2)	DE3348299C2 (sv)
DK (3)	DK160039C (sv)
FI (1)	FI79115C (sv)
FR (1)	FR2543957B1 (sv)
GB (3)	GB2168050A (sv)
GR (1)	GR78585B (sv)
HU (1)	HU191534B (sv)
IE (1)	IE56712B1 (sv)
IL (1)	IL68992A (sv)
IS (1)	IS1361B6 (sv)
NL (1)	NL194081C (sv)
NO (3)	NO157696C (sv)
NZ (1)	NZ204736A (sv)
PT (1)	PT76944B (sv)
SE (2)	SE454879B (sv)
YU (2)	YU43926B (sv)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2573756B1 (fr) *	1984-11-23	1987-01-16	Poudres & Explosifs Ste Nale	Procede de preparation des carbonates de bromo-1 ethyle et d'hydrocarbyle et nouveaux carbonates de bromo-1 ethyle et d'hydrocarbyle

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH516593A (de) *	1967-09-29	1971-12-15	Leo Pharm Prod Ltd	Verfahren zur Herstellung von neuen Estern von a-Aminobenzyl-penicillin
US3873521A (en) *	1970-09-17	1975-03-25	Astra Laekemedel Ab	Esters of {60 -amino penicillins
IE35648B1 (en) *	1970-09-25	1976-04-14	Beecham Group Ltd	Penicillins
DE2161420A1 (de) *	1970-12-30	1972-07-27	Toyama Chemical Co. Ltd., Tokio	Penicillinderivate und Verfahren zu deren Herstellung
BE784800A (fr) *	1971-06-15	1972-10-02	Yamanouchi Pharma Co Ltd	Procede de preparation de nouveaux derives esters oxymethyliques de la penicilline et de la cephalosporine
IL41313A (en) *	1972-02-15	1976-08-31	Harrison Ltd	Preparation of the lh-and fsh-releasing hormone and compositions containing it
GB1426717A (en) *	1972-03-13	1976-03-03	Astra Laekemedel Ab	Penicillins
GB1425571A (en) *	1972-03-13	1976-02-18	Astra Laekemedel Ab	Penicillins and cephaosporins
GB1426869A (en) *	1972-03-13	1976-03-03	Astra Laekemedel Ab	Penicillins
SE397981B (sv) *	1973-02-19	1977-11-28	Astra Laekemedel Ab	Nya tetraalkylammoniumsalter av 6-aminopenicillansyra och av bensylpenicillin avsedda att anvendas som mellanprodukter vid framstellning av vissa estrar av 6-aminopenicillansyra och av bensylpenicillin
GB1565656A (en) *	1975-12-13	1980-04-23	Beecham Group Ltd	Preparation of substituted penicillin acid esters
GB1598568A (en) *	1977-04-19	1981-09-23	Glaxo Lab Ltd	Esters of(6r,7r)-3-carbamoyloxymethyl-7-((z)-2-(fur-2-yl)-2-methoxyiminoacetamido)-ceph-3-em-4-carboxylic acid
JPS5444694A (en) *	1977-09-06	1979-04-09	Kou Kamata	Aminobenzylpenicillin derivative
ES8500957A1 (es) *	1982-06-30	1984-11-01	Glaxo Group Ltd	Un procedimiento para preparar compuestos de cefalosporina.
EP0108547B1 (en) *	1982-11-04	1989-06-07	Astra Lakemedel Aktiebolag	Process for the preparation of the 1'-ethoxycarbonyloxyethyl ester of benzylpenicillin

1983
- 1983-06-15 IL IL68992A patent/IL68992A/xx not_active IP Right Cessation
- 1983-06-15 SE SE8303414A patent/SE454879B/sv not_active IP Right Cessation
- 1983-06-20 IE IE1445/83A patent/IE56712B1/en not_active IP Right Cessation
- 1983-06-24 DE DE3348299A patent/DE3348299C2/de not_active Expired - Lifetime
- 1983-06-24 DE DE3322783A patent/DE3322783A1/de active Granted
- 1983-06-27 GB GB08528958A patent/GB2168050A/en not_active Withdrawn
- 1983-06-28 BG BG068052A patent/BG38335A3/xx unknown
- 1983-06-28 NO NO832351A patent/NO157696C/no not_active IP Right Cessation
- 1983-06-28 NZ NZ204736A patent/NZ204736A/en unknown
- 1983-06-28 CH CH527585A patent/CH657620B/de not_active IP Right Cessation
- 1983-06-28 HU HU832325A patent/HU191534B/hu unknown
- 1983-06-28 CH CH3540/83A patent/CH656377A5/de not_active IP Right Cessation
- 1983-06-28 NL NL8302286A patent/NL194081C/nl not_active IP Right Cessation
- 1983-06-28 GR GR71790A patent/GR78585B/el unknown
- 1983-06-28 FI FI832363A patent/FI79115C/sv not_active IP Right Cessation
- 1983-06-28 PT PT76944A patent/PT76944B/pt unknown
- 1983-06-28 BG BG068053A patent/BG38336A3/xx unknown
- 1983-06-28 BG BG061516A patent/BG37527A3/xx unknown
- 1983-06-28 DK DK296683A patent/DK160039C/da not_active IP Right Cessation
- 1983-06-28 AU AU16328/83A patent/AU566803B2/en not_active Expired
- 1983-06-29 AT AT0238483A patent/AT383128B/de not_active IP Right Cessation
- 1983-06-29 DD DD83252531A patent/DD211561A5/de unknown
- 1983-06-29 YU YU1415/83A patent/YU43926B/xx unknown
- 1983-06-29 IS IS2825A patent/IS1361B6/is unknown
- 1983-12-30 FR FR8321138A patent/FR2543957B1/fr not_active Expired
1985
- 1985-03-28 NO NO851254A patent/NO851254L/no unknown
- 1985-03-28 NO NO851255A patent/NO851255L/no unknown
- 1985-09-16 GB GB08522827A patent/GB2169287B/en not_active Expired
- 1985-09-16 GB GB08522826A patent/GB2168699B/en not_active Expired
1986
- 1986-02-14 YU YU218/86A patent/YU43693B/xx unknown
1990
- 1990-04-30 DK DK106090A patent/DK167807B1/da not_active IP Right Cessation
- 1990-04-30 DK DK105990A patent/DK159821C/da not_active IP Right Cessation
- 1990-11-16 CY CY1520A patent/CY1520A/en unknown
- 1990-11-16 CY CY1519A patent/CY1519A/en unknown
1991
- 1991-02-26 SE SE9100548A patent/SE503843C2/sv not_active IP Right Cessation
- 1991-04-30 JP JP3124441A patent/JPH0730082B2/ja not_active Expired - Lifetime
- 1991-04-30 JP JP3124442A patent/JPH0819052B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2543957A1 (fr)	1984-10-12
YU43693B (en)	1989-10-31
PT76944B (en)	1986-04-09
IL68992A (en)	1991-06-10
DK106090A (da)	1990-04-30
DK296683D0 (da)	1983-06-28
GB2168050A (en)	1986-06-11
DE3322783C2 (sv)	1991-01-31
JPH0543583A (ja)	1993-02-23
SE454879B (sv)	1988-06-06
AU566803B2 (en)	1987-10-29
DE3322783A1 (de)	1984-02-09
DK167807B1 (da)	1993-12-20
NZ204736A (en)	1986-11-12
CY1519A (en)	1990-11-16
FI79115B (fi)	1989-07-31
YU21886A (en)	1987-10-31
IE831445L (en)	1983-12-29
DK105990A (da)	1990-04-30
BG38336A3 (en)	1985-11-15
SE503843C2 (sv)	1996-09-16
AU1632883A (en)	1984-01-05
NL194081C (nl)	2001-06-05
BG38335A3 (en)	1985-11-15
NO851255L (no)	1983-12-30
NL8302286A (nl)	1984-01-16
DK160039C (da)	1991-06-10
JPH0730082B2 (ja)	1995-04-05
CY1520A (en)	1990-11-16
PT76944A (en)	1983-07-01
SE9100548D0 (sv)	1991-02-26
HU191534B (en)	1987-03-30
GB2168699A (en)	1986-06-25
YU141583A (en)	1986-06-30
NO832351L (no)	1983-12-30
DK106090D0 (da)	1990-04-30
DK160039B (da)	1991-01-21
GR78585B (sv)	1984-09-27
NO157696B (no)	1988-01-25
NO157696C (no)	1988-05-04
JPH0819052B2 (ja)	1996-02-28
CH656377A5 (de)	1986-06-30
NL194081B (nl)	2001-02-01
FI832363L (fi)	1983-12-30
BG37527A3 (en)	1985-06-14
DK159821C (da)	1991-04-29
SE9100548L (sv)	1991-02-26
DK159821B (da)	1990-12-10
GB2169287A (en)	1986-07-09
SE8303414D0 (sv)	1983-06-15
NO851254L (no)	1983-12-30
ATA238483A (de)	1986-10-15
DK296683A (da)	1983-12-30
IS1361B6 (is)	1989-05-25
IS2825A7 (is)	1984-07-08
DK105990D0 (da)	1990-04-30
IE56712B1 (en)	1991-11-20
JPH0717918A (ja)	1995-01-20
FI832363A0 (fi)	1983-06-28
DD211561A5 (de)	1984-07-18
YU43926B (en)	1989-12-31
FR2543957B1 (fr)	1986-10-24
DE3348299C2 (sv)	1990-12-20
GB8522827D0 (en)	1985-10-23
GB2168699B (en)	1987-04-15
GB2169287B (en)	1987-04-08
GB8528958D0 (en)	1986-01-02
GB8522826D0 (en)	1985-10-23
AT383128B (de)	1987-05-25
CH657620B (sv)	1986-09-15
FI79115C (sv)	1989-11-10

Legal Events

Date

Code

Title

Description

1995-01-31

NAL

Patent in force

Ref document number: 8303414-0

Format of ref document f/p: F

2003-07-29

NUG

Patent has lapsed

Publication	Publication Date	Title
SE8002292L (sv)	1980-09-27	4-amino-3-kinolinkarboxylsyror och estrar som antisekretoriska anti-ulcerosa foreningar
DE69207705D1 (de)	1996-02-29	Verfahren zur Herstellung von Äthylacetat
IT1039185B (it)	1979-12-10	Sistema combinato per l iniezione e l accensione di vaporidi combu stibile
RU95112522A (ru)	1997-02-10	Способ получения клавулановой кислоты, соль клавулановой кислоты и амина
SE437851B (sv)	1985-03-18	Forfarande for enzymatisk hydrolys av racemiska hydantoiner till d-formen av optiskt aktiva aminosyror
NO860512L (no)	1986-02-12	Karboksylsyreesterderivater av deglukoteicoplanin.
DE69207387D1 (de)	1996-02-15	Herstellung von Carbonsäureestern
SE9100548L (sv)	1991-02-26	Foerbaettringar vid framstaellning av antibiotika
IE45696L (en)	1978-03-28	Derivatives of 2-(3-phenyl-2-amino-propionyloxy)-acetic acid
AU507034B2 (en)	1980-01-31	Sulphur-containing phenethy derivatives of acetic acid
AU498160B2 (en)	1979-02-15	Blends of copolyesters and ethylene/carboxylic acid copolymers
NO143402C (no)	1981-02-04	Analogifremgangsmaate til fremstilling av et terapeutisk virksomt fenyleddiksyrederivat
SE7807225L (sv)	1978-06-26	Sett att framstella 4-hydroxicinnolin-derivat
IE44886L (en)	1977-08-27	Quinoline carboxylic acid esters
DK529580A (da)	1981-06-13	Propionsyreestere
IE790146L (en)	1979-08-02	1-naphthyl-acetic acid derivatives
NO944336L (no)	1994-11-14	Enzymatisk fremgangsmåte for fremstilling av S-6-metoksy- -metyl-2-naftaleneddiksyre
KR910009723A (ko)	1991-06-28	4-카르바모일-1-β-D-리보푸라노실 이미다졸륨-5-올레이트 무수결정
MY101937A (en)	1992-02-15	Process for the production of 1-ethoxycarbonyloxthyl ester of 6-(d-(-)-&-amino-&-phenylacetamido) penicillanic acid
DE69305250D1 (de)	1996-11-14	Herstellung von Alkandicarbonsäurederivaten
AU564328B2 (en)	1987-08-06	2 - (formylamino) -n- (1h-tetrazol-5-yl) - benzimide
ES458764A1 (es)	1978-03-01	Procedimiento para la preparacion de un nuevo agente antiin-flamatorio.
BE787116A (fr)	1973-02-05	Transesterification d'esters d'acides quinoxaline-2- carboxyliques
IE42125L (en)	1976-02-12	Anti-inflammatory and anti rheumatic isoglutamine¹compounds
JPS5227792A (en)	1977-03-02	Synthesis of cephalosporin compounds